Response thresholds in bacterial chemotaxis.

abstract：:It is fascinating but challenging for nanoscientists to organize nanoparticles (NPs) into ordered architectures just as it is for chemists to manipulate atoms and molecules to form functional molecules and supramolecules. We explore a strategy to assemble anisotropic NPs into open frame-like superstructures via orient...

journal_title：Science advances

authors： Nai J,Guan BY,Yu L,Lou XWD

更新日期：2017-08-23 00:00:00

abstract：:Respiratory complex I is a redox-driven proton pump, accounting for a large part of the electrochemical gradient that powers mitochondrial adenosine triphosphate synthesis. Complex I dysfunction is associated with severe human diseases. Assembly of the one-megadalton complex I in the inner mitochondrial membrane requi...

journal_title：Science advances

authors： Parey K,Haapanen O,Sharma V,Köfeler H,Züllig T,Prinz S,Siegmund K,Wittig I,Mills DJ,Vonck J,Kühlbrandt W,Zickermann V

更新日期：2019-12-11 00:00:00

abstract：:Gravel-bed river floodplains in mountain landscapes disproportionately concentrate diverse habitats, nutrient cycling, productivity of biota, and species interactions. Although stream ecologists know that river channel and floodplain habitats used by aquatic organisms are maintained by hydrologic regimes that mobilize...

journal_title：Science advances

authors： Hauer FR,Locke H,Dreitz VJ,Hebblewhite M,Lowe WH,Muhlfeld CC,Nelson CR,Proctor MF,Rood SB

更新日期：2016-06-24 00:00:00

abstract：:Quantum phenomena have the potential to speed up the solution of hard optimization problems. For example, quantum annealing, based on the quantum tunneling effect, has recently been shown to scale exponentially better with system size than classical simulated annealing. However, current realizations of quantum anneale...

journal_title：Science advances

authors： Nigg SE,Lörch N,Tiwari RP

更新日期：2017-04-07 00:00:00

abstract：:[This corrects the article DOI: 10.1126/sciadv.aao6652.]. ...

journal_title：Science advances

authors：

更新日期：2018-07-13 00:00:00

abstract：:The first example of a homogeneous silver(I)-catalyzed aerobic oxidation of aldehydes in water is reported. More than 50 examples of different aliphatic and aromatic aldehydes, including natural products, were tested, and all of them successfully underwent aerobic oxidation to give the corresponding carboxylic acids i...

journal_title：Science advances

authors： Liu M,Wang H,Zeng H,Li CJ

更新日期：2015-03-27 00:00:00

abstract：:The pathways and transformations of dense water overflows, which depend on small-scale interactions between flow dynamics and erosional-depositional processes, are a central piece in the ocean's large-scale circulation. A novel, high-resolution current and hydrographic data set highlights the intricate pathway travell...

journal_title：Science advances

authors： Sánchez-Leal RF,Bellanco MJ,Fernández-Salas LM,García-Lafuente J,Gasser-Rubinat M,González-Pola C,Hernández-Molina FJ,Pelegrí JL,Peliz A,Relvas P,Roque D,Ruiz-Villarreal M,Sammartino S,Sánchez-Garrido JC

更新日期：2017-11-15 00:00:00

abstract：:Several forms of hair loss in humans are characterized by the inability of hair follicles to enter the growth phase (anagen) of the hair cycle after being arrested in the resting phase (telogen). Current pharmacologic therapies have been largely unsuccessful in targeting pathways that can be selectively modulated to i...

journal_title：Science advances

authors： Harel S,Higgins CA,Cerise JE,Dai Z,Chen JC,Clynes R,Christiano AM

更新日期：2015-10-23 00:00:00

abstract：:Understanding the precise atomic structure of ice surfaces is critical for revealing the mechanisms of physical and chemical phenomena at the surfaces, such as ice growth, melting, and chemical reactions. Nevertheless, no conclusive structure has been established. In this study, noncontact atomic force microscopy was ...

journal_title：Science advances

authors： Kawakami N,Iwata K,Shiotari A,Sugimoto Y

更新日期：2020-09-11 00:00:00

abstract：:Complex behaviors demand temporal coordination among functionally distinct brain regions. The basal forebrain's afferent and efferent structure suggests a capacity for mediating this coordination at a large scale. During performance of a spatial orientation task, synaptic activity in this region was dominated by four ...

journal_title：Science advances

authors： Tingley D,Alexander AS,Quinn LK,Chiba AA,Nitz D

更新日期：2018-08-01 00:00:00

abstract：:Measuring motor skill proficiency is critical for the certification of highly skilled individuals in numerous fields. However, conventional measures use subjective metrics that often cannot distinguish between expertise levels. We present an advanced optical neuroimaging methodology that can objectively and successful...

journal_title：Science advances

authors： Nemani A,Yücel MA,Kruger U,Gee DW,Cooper C,Schwaitzberg SD,De S,Intes X

更新日期：2018-10-03 00:00:00

abstract：:Nitrogen oxides, released from fossil fuel use and other combustion processes, affect air quality and climate. From the mid-1990s onward, nitrogen dioxide (NO2) has been monitored from space, and since 2004 with relatively high spatial resolution by the Ozone Monitoring Instrument. Strong upward NO2 trends have been o...

journal_title：Science advances

authors： Lelieveld J,Beirle S,Hörmann C,Stenchikov G,Wagner T

更新日期：2015-08-21 00:00:00

abstract：:In 2018-2019, New York City experienced the largest measles outbreak in the United States in nearly three decades. To identify key contributing factors, we modeled the transmission dynamics of this outbreak. Results indicate that delayed vaccination of 1- to 4-year-olds enabled the initial spread and that increased in...

journal_title：Science advances

authors： Yang W

更新日期：2020-05-27 00:00:00

abstract：:Fungi have major, negative socioeconomic impacts, but control with bioactive agents is increasingly restricted, while resistance is growing. Here, we describe an alternative fungal control strategy via materials operating passively (i.e., no killing effect). We screened hundreds of (meth)acrylate polymers in high thro...

journal_title：Science advances

authors： Vallieres C,Hook AL,He Y,Crucitti VC,Figueredo G,Davies CR,Burroughs L,Winkler DA,Wildman RD,Irvine DJ,Alexander MR,Avery SV

更新日期：2020-06-05 00:00:00

abstract：:B cell activation is regulated by the stimulatory or inhibitory co-receptors of B cell receptors (BCRs). Here, we investigated the signaling mechanism of Fc receptor-like 1 (FcRL1), a newly identified BCR co-receptor. FcRL1 was passively recruited into B cell immunological synapses upon BCR engagement in the absence o...

journal_title：Science advances

authors： Zhao X,Xie H,Zhao M,Ahsan A,Li X,Wang F,Yi J,Yang Z,Wu C,Raman I,Li QZ,Kim TJ,Liu W

更新日期：2019-07-17 00:00:00

abstract：:Low-dimensional perovskites offer a rare opportunity to investigate lattice dynamics and charge carrier behavior in bulk quantum-confined solids, in addition to them being the leading materials in optoelectronic applications. In particular, zero-dimensional (0D) inorganic perovskites of the Cs4PbX6 (X = Cl, Br, or I) ...

journal_title：Science advances

authors： Yin J,Maity P,De Bastiani M,Dursun I,Bakr OM,Brédas JL,Mohammed OF

更新日期：2017-12-15 00:00:00

abstract：:Since its domestication in the Fertile Crescent ~8000 to 10,000 years ago, wheat has undergone a complex history of spread, adaptation, and selection. To get better insights into the wheat phylogeography and genetic diversity, we describe allele distribution through time using a set of 4506 landraces and cultivars ori...

journal_title：Science advances

authors： Balfourier F,Bouchet S,Robert S,De Oliveira R,Rimbert H,Kitt J,Choulet F,International Wheat Genome Sequencing Consortium.,BreedWheat Consortium.,Paux E

更新日期：2019-05-29 00:00:00

abstract：:Cholesterol-dependent cytolysins (CDCs) form pores in cholesterol-rich membranes, but cholesterol alone is insufficient to explain their cell and host tropism. Here, we show that all eight major CDCs have high-affinity lectin activity that identifies glycans as candidate cellular receptors. Streptolysin O, vaginolysin...

journal_title：Science advances

authors： Shewell LK,Day CJ,Jen FE,Haselhorst T,Atack JM,Reijneveld JF,Everest-Dass A,James DBA,Boguslawski KM,Brouwer S,Gillen CM,Luo Z,Kobe B,Nizet V,von Itzstein M,Walker MJ,Paton AW,Paton JC,Torres VJ,Jennings MP

更新日期：2020-05-22 00:00:00

abstract：:Fifty years after its discovery, the ovonic threshold switching (OTS) phenomenon, a unique nonlinear conductivity behavior observed in some chalcogenide glasses, has been recently the source of a real technological breakthrough in the field of data storage memories. This breakthrough was achieved because of the succes...

journal_title：Science advances

authors： Noé P,Verdy A,d'Acapito F,Dory JB,Bernard M,Navarro G,Jager JB,Gaudin J,Raty JY

更新日期：2020-02-28 00:00:00

abstract：:Ants (Hymenoptera: Formicidae) are diverse and ubiquitous, and their ability to sting is familiar to many of us. However, their venoms remain largely unstudied. We provide the first comprehensive characterization of a polypeptidic ant venom, that of the giant red bull ant, Myrmecia gulosa. We reveal a suite of novel p...

journal_title：Science advances

authors： Robinson SD,Mueller A,Clayton D,Starobova H,Hamilton BR,Payne RJ,Vetter I,King GF,Undheim EAB

更新日期：2018-09-12 00:00:00

abstract：:The biophysical and biochemical properties of live tissues are important in the context of development and disease. Methods for evaluating these properties typically involve destroying the tissue or require specialized technology and complicated analyses. Here, we present a novel, noninvasive methodology for determini...

journal_title：Science advances

authors： Gross-Thebing S,Truszkowski L,Tenbrinck D,Sánchez-Iranzo H,Camelo C,Westerich KJ,Singh A,Maier P,Prengel J,Lange P,Hüwel J,Gaede F,Sasse R,Vos BE,Betz T,Matis M,Prevedel R,Luschnig S,Diz-Muñoz A,Burger M,Raz E

更新日期：2020-12-04 00:00:00

abstract：:Identifying key players in coupled individual systems is a fundamental problem in network theory. We investigate synchronizable network-coupled dynamical systems such as high-voltage electric power grids and coupled oscillators on complex networks. We define key players as nodes that, once perturbed, generate the larg...

journal_title：Science advances

authors： Tyloo M,Pagnier L,Jacquod P

更新日期：2019-11-22 00:00:00

abstract：:Dual-comb spectroscopy allows for high-resolution spectra to be measured over broad bandwidths, but an essential requirement for coherent integration is the availability of a phase reference. Usually, this means that the combs' phase and timing errors must be measured and either minimized by stabilization or removed b...

journal_title：Science advances

authors： Burghoff D,Yang Y,Hu Q

更新日期：2016-11-11 00:00:00

abstract：:Intrinsic immune defenses mediated by restriction factors inhibit productive viral infections. Select viruses rapidly establish latent infections and, with gene expression profiles that imply cell-autonomous intrinsic defenses, may be the most effective immune control measure against latent reservoirs. We illustrate t...

journal_title：Science advances

authors： Lee SH,Albright ER,Lee JH,Jacobs D,Kalejta RF

更新日期：2015-11-27 00:00:00

abstract：:The histone demethylase LSD1 is deregulated in several tumors, including leukemias, providing the rationale for the clinical use of LSD1 inhibitors. In acute promyelocytic leukemia (APL), pharmacological doses of retinoic acid (RA) induce differentiation of APL cells, triggering degradation of the PML-RAR oncogene. AP...

journal_title：Science advances

authors： Ravasio R,Ceccacci E,Nicosia L,Hosseini A,Rossi PL,Barozzi I,Fornasari L,Zuffo RD,Valente S,Fioravanti R,Mercurio C,Varasi M,Mattevi A,Mai A,Pavesi G,Bonaldi T,Minucci S

更新日期：2020-04-08 00:00:00

abstract：:Precise protein folding is essential for the survival of all cells, and protein misfolding causes a number of diseases that lack effective therapies, yet the general principles governing protein folding in the cell remain poorly understood. In vivo, folding can begin cotranslationally and protein quality control at th...

journal_title：Science advances

authors： Samelson AJ,Bolin E,Costello SM,Sharma AK,O'Brien EP,Marqusee S

更新日期：2018-05-30 00:00:00

abstract：:Hydrogen sulfide (H2S) is a gasotransmitter and a potential therapeutic agent. However, molecular targets relevant to its therapeutic actions remain enigmatic. Sulfide-quinone oxidoreductase (SQR) irreversibly oxidizes H2S. Therefore, SQR is assumed to inhibit H2S signaling. We now report that SQR-mediated oxidation o...

journal_title：Science advances

authors： Jia J,Wang Z,Zhang M,Huang C,Song Y,Xu F,Zhang J,Li J,He M,Li Y,Ao G,Hong C,Cao Y,Chin YE,Hua ZC,Cheng J

更新日期：2020-08-26 00:00:00

abstract：:The control of product distribution in a multistep catalytic selective hydrogenation reaction is challenging. For instance, the deep hydrogenation of dimethyl oxalate (DMO) is inclined to proceed over Cu/SiO2 catalysts because of inevitable coexistence of Cu+ and Cu0, leading to hard acquisition of the preliminary hyd...

journal_title：Science advances

authors： Sun J,Yu J,Ma Q,Meng F,Wei X,Sun Y,Tsubaki N

更新日期：2018-12-21 00:00:00

abstract：:Animal collective motion arises from the intricate interactions between the natural variability among individuals, and the homogenizing effect of the group, working to generate synchronization and maintain coherence. Here, these interactions were studied using marching locust nymphs under controlled laboratory setting...

journal_title：Science advances

authors： Knebel D,Ayali A,Guershon M,Ariel G

更新日期：2019-01-02 00:00:00

abstract：:Transistors with exfoliated two-dimensional (2D) materials on a SiO2/Si substrate have been applied and have been proven effective in a wide range of applications, such as circuits, memory, photodetectors, gas sensors, optical modulators, valleytronics, and spintronics. However, these devices usually suffer from limit...

journal_title：Science advances

authors： Xu J,Chen L,Dai YW,Cao Q,Sun QQ,Ding SJ,Zhu H,Zhang DW

更新日期：2017-05-19 00:00:00