Pharmacologic inhibition of JAK-STAT signaling promotes hair growth.

abstract：:Injection-induced earthquakes pose a serious seismic hazard but also offer an opportunity to gain insight into earthquake physics. Currently used models relating the maximum magnitude of injection-induced earthquakes to injection parameters do not incorporate rupture physics. We develop theoretical estimates, validate...

journal_title：Science advances

authors： Galis M,Ampuero JP,Mai PM,Cappa F

更新日期：2017-12-20 00:00:00

abstract：:Preventing the degradation of metal perovskite solar cells (PSCs) by humid air poses a substantial challenge for their future deployment. We introduce here a two-dimensional (2D) A2PbI4 perovskite layer using pentafluorophenylethylammonium (FEA) as a fluoroarene cation inserted between the 3D light-harvesting perovski...

journal_title：Science advances

authors： Liu Y,Akin S,Pan L,Uchida R,Arora N,Milić JV,Hinderhofer A,Schreiber F,Uhl AR,Zakeeruddin SM,Hagfeldt A,Dar MI,Grätzel M

更新日期：2019-06-07 00:00:00

abstract：:[This corrects the article DOI: 10.1126/sciadv.aar3761.]. ...

journal_title：Science advances

authors：

更新日期：2018-07-06 00:00:00

abstract：:Dendritic cells (DCs) are adept at cross-presentation and initiation of antigen-specific immunity. Clinically, however, DCs produced by in vitro differentiation of monocytes in the presence of exogenous cytokines have been met with limited success. We hypothesized that DCs produced in a physiological manner may be mor...

journal_title：Science advances

authors： Han P,Hanlon D,Arshad N,Lee JS,Tatsuno K,Robinson E,Filler R,Sobolev O,Cote C,Rivera-Molina F,Toomre D,Fahmy T,Edelson R

更新日期：2020-03-11 00:00:00

abstract：:Perforin-2 (MPEG1) is thought to enable the killing of invading microbes engulfed by macrophages and other phagocytes, forming pores in their membranes. Loss of perforin-2 renders individual phagocytes and whole organisms significantly more susceptible to bacterial pathogens. Here, we reveal the mechanism of perforin-...

journal_title：Science advances

authors： Ni T,Jiao F,Yu X,Aden S,Ginger L,Williams SI,Bai F,Pražák V,Karia D,Stansfeld P,Zhang P,Munson G,Anderluh G,Scheuring S,Gilbert RJC

更新日期：2020-01-29 00:00:00

abstract：:The spin-polarized surface states of topological insulators (TIs) are attractive for applications in spintronics and quantum computing. A central challenge with these materials is to reliably tune the chemical potential of their electrons with respect to the Dirac point and the bulk bands. We demonstrate persistent, b...

journal_title：Science advances

authors： Yeats AL,Pan Y,Richardella A,Mintun PJ,Samarth N,Awschalom DD

更新日期：2015-10-09 00:00:00

abstract：:Correlating spatial chemical information with the morphology of closely packed nanostructures remains a challenge for the scientific community. For example, supramolecular self-assembly, which provides a powerful and low-cost way to create nanoscale patterns and engineered nanostructures, is not easily interrogated in...

journal_title：Science advances

authors： Nowak D,Morrison W,Wickramasinghe HK,Jahng J,Potma E,Wan L,Ruiz R,Albrecht TR,Schmidt K,Frommer J,Sanders DP,Park S

更新日期：2016-03-25 00:00:00

abstract：:Marine ecosystems are responsible for virtually all production of omega-3 (ω3) long-chain polyunsaturated fatty acids (PUFA), which are essential nutrients for vertebrates. Current consensus is that marine microbes account for this production, given their possession of key enzymes including methyl-end (or "ωx") desatu...

journal_title：Science advances

authors： Kabeya N,Fonseca MM,Ferrier DEK,Navarro JC,Bay LK,Francis DS,Tocher DR,Castro LFC,Monroig Ó

更新日期：2018-05-02 00:00:00

abstract：:The ability of cytosolic lipopolysaccharide (LPS) to activate caspase-11-dependent nonclassical inflammasome is intricately controlled to avoid excessive inflammatory responses. However, very little is known about the regulatory role of various metabolic pathways in the control of caspase-11 activation. Here, we demon...

journal_title：Science advances

authors： Chen R,Zeng L,Zhu S,Liu J,Zeh HJ,Kroemer G,Wang H,Billiar TR,Jiang J,Tang D,Kang R

更新日期：2019-05-22 00:00:00

abstract：:Pressure is a key parameter in the physics and chemistry of planet formation and evolution. Previous studies have erroneously assumed that internal pressures monotonically increase with the mass of a body. Using smoothed particle hydrodynamics and potential field method calculations, we demonstrate that the hot, rapid...

journal_title：Science advances

authors： Lock SJ,Stewart ST

更新日期：2019-09-04 00:00:00

abstract：:Cancer cells often encounter oxidative stress. However, it is unclear whether normal and cancer cells differentially respond to oxidative stress. Here, we demonstrated that under oxidative stress, hepatocellular carcinoma (HCC) cells exhibit increased antioxidative response and survival rates compared to normal hepato...

journal_title：Science advances

authors： Xu D,Li X,Shao F,Lv G,Lv H,Lee JH,Qian X,Wang Z,Xia Y,Du L,Zheng Y,Wang H,Lyu J,Lu Z

更新日期：2019-04-24 00:00:00

abstract：:Previous breakthroughs in stretchable electronics stem from strain engineering and nanocomposite approaches. Routes toward intrinsically stretchable molecular materials remain scarce but, if successful, will enable simpler fabrication processes, such as direct printing and coating, mechanically robust devices, and mor...

journal_title：Science advances

authors： Wang Y,Zhu C,Pfattner R,Yan H,Jin L,Chen S,Molina-Lopez F,Lissel F,Liu J,Rabiah NI,Chen Z,Chung JW,Linder C,Toney MF,Murmann B,Bao Z

更新日期：2017-03-10 00:00:00

abstract：:The most abundant components of primitive meteorites (chondrites) are millimeter-sized glassy spherical chondrules formed by transient melting events in the solar protoplanetary disk. Using Pb-Pb dates of 22 individual chondrules, we show that primary production of chondrules in the early solar system was restricted t...

journal_title：Science advances

authors： Bollard J,Connelly JN,Whitehouse MJ,Pringle EA,Bonal L,Jørgensen JK,Nordlund Å,Moynier F,Bizzarro M

更新日期：2017-08-09 00:00:00

abstract：:Here, an integrated cascade nanozyme with a formulation of Pt@PCN222-Mn is developed to eliminate excessive reactive oxygen species (ROS). This nanozyme mimics superoxide dismutase by incorporation of a Mn-[5,10,15,20-tetrakis(4-carboxyphenyl)porphyrinato]-based metal-organic framework compound capable of transforming...

journal_title：Science advances

authors： Liu Y,Cheng Y,Zhang H,Zhou M,Yu Y,Lin S,Jiang B,Zhao X,Miao L,Wei CW,Liu Q,Lin YW,Du Y,Butch CJ,Wei H

更新日期：2020-07-17 00:00:00

abstract：:Projections of ice sheet behavior hinge on how ice flow velocity evolves and the extent to which marine-based grounding lines are stable. Ice flow and grounding line retreat are variably governed by the coupling between the ice and underlying terrain. We ask to what degree catchment-scale bed characteristics determine...

journal_title：Science advances

authors： Greenwood SL,Simkins LM,Winsborrow MCM,Bjarnadóttir LR

更新日期：2021-01-13 00:00:00

abstract：:Nitrogen oxides (NO x ) emitted from human activities are believed to regulate the atmospheric oxidation capacity of the troposphere. However, observational evidence is limited for the low-to-median NO x concentrations prevalen...

journal_title：Science advances

authors： Liu Y,Seco R,Kim S,Guenther AB,Goldstein AH,Keutsch FN,Springston SR,Watson TB,Artaxo P,Souza RAF,McKinney KA,Martin ST

更新日期：2018-04-11 00:00:00

abstract：:Ontogenetic studies provide clues for understanding important paleobiological aspects of extinct species. When compared to that of modern humans, the adult Neanderthal thorax was shorter, deeper, and wider. This is related to the wide Neanderthal body and is consistent with their hypothetical large requirements for en...

journal_title：Science advances

authors： García-Martínez D,Bastir M,Gómez-Olivencia A,Maureille B,Golovanova L,Doronichev V,Akazawa T,Kondo O,Ishida H,Gascho D,Zollikofer CPE,de León MP,Heuzé Y

更新日期：2020-10-07 00:00:00

abstract：:Bacterial chemotaxis-a fundamental example of directional navigation in the living world-is key to many biological processes, including the spreading of bacterial infections. Many bacterial species were recently reported to exhibit several distinct swimming modes-the flagella may, for example, push the cell body or wr...

journal_title：Science advances

authors： Alirezaeizanjani Z,Großmann R,Pfeifer V,Hintsche M,Beta C

更新日期：2020-05-27 00:00:00

abstract：:Multicellular organisms are composed of tissues that have distinct functions requiring specialized proteomes. To define the proteome of a live animal with tissue and subcellular resolution, we adapted a localized proteomics technology for use in the multicellular model organism Caenorhabditis elegans. This approach co...

journal_title：Science advances

authors： Reinke AW,Mak R,Troemel ER,Bennett EJ

更新日期：2017-05-10 00:00:00

abstract：:The integration of structure and function for tissue engineering scaffolds is of great importance in mimicking native bone tissue. However, the complexity of hierarchical structures, the requirement for mechanical properties, and the diversity of bone resident cells are the major challenges in constructing biomimetic ...

journal_title：Science advances

authors： Zhang M,Lin R,Wang X,Xue J,Deng C,Feng C,Zhuang H,Ma J,Qin C,Wan L,Chang J,Wu C

更新日期：2020-03-20 00:00:00

abstract：:Embodied models suggest that moral judgments are strongly intertwined with first-hand somatic experiences, with some pointing to disgust, and others arguing for a role of pain/harm. Both disgust and pain are unpleasant, arousing experiences, with strong relevance for survival, but with distinctive sensory qualities an...

journal_title：Science advances

authors： Sharvit G,Lin E,Vuilleumier P,Corradi-Dell'Acqua C

更新日期：2020-10-16 00:00:00

abstract：:Many insects use nectar as their principal diet and have mouthparts specialized in nectarivory, whereas most nectar-feeding vertebrates are opportunistic users of floral resources and only a few species show distinct morphological specializations. Specialized nectar-feeding bats extract nectar from flowers using elong...

journal_title：Science advances

authors： Tschapka M,Gonzalez-Terrazas TP,Knörnschild M

更新日期：2015-09-25 00:00:00

abstract：:Asymmetric interactions such as entropic (e.g., encoded by nonspherical shapes) or surface forces (e.g., encoded by patterned surface chemistry or DNA hybridization) provide access to functional states of colloidal matter, but versatile approaches for engineering asymmetric van der Waals interactions have the potentia...

journal_title：Science advances

authors： Fuster HA,Wang X,Wang X,Bukusoglu E,Spagnolie SE,Abbott NL

更新日期：2020-06-19 00:00:00

abstract：:We reveal an intriguing manifestation of topology, which appears in the depletion rate of topological states of matter in response to an external drive. This phenomenon is presented by analyzing the response of a generic two-dimensional (2D) Chern insulator subjected to a circular time-periodic perturbation. Because o...

journal_title：Science advances

authors： Tran DT,Dauphin A,Grushin AG,Zoller P,Goldman N

更新日期：2017-08-18 00:00:00

abstract：:Transcription factors control gene expression in all life. This raises the question of what is the smallest protein that can support such activity. In nature, Cro from bacteriophage λ is one of the smallest known repressors (66 amino acids), and activators are typically much larger (e.g., λ cI, 237 amino acids). Previ...

journal_title：Science advances

authors： Brödel AK,Rodrigues R,Jaramillo A,Isalan M

更新日期：2020-06-10 00:00:00

abstract：:Porous membranes with ultrafast ion permeation and high ion selectivity are highly desirable for efficient mineral separation, water purification, and energy conversion, but it is still a huge challenge to efficiently separate monatomic ions of the same valence and similar sizes using synthetic membranes. We report me...

journal_title：Science advances

authors： Zhang H,Hou J,Hu Y,Wang P,Ou R,Jiang L,Liu JZ,Freeman BD,Hill AJ,Wang H

更新日期：2018-02-09 00:00:00

abstract：:Peptidyl arginine deiminase 4 (PAD4) is a nuclear enzyme that converts arginine residues to citrulline. Although increasingly implicated in inflammatory disease and cancer, the mechanism of action of PAD4 and its functionally relevant pathways remains unclear. E2F transcription factors are a family of master regulator...

journal_title：Science advances

authors： Ghari F,Quirke AM,Munro S,Kawalkowska J,Picaud S,McGouran J,Subramanian V,Muth A,Williams R,Kessler B,Thompson PR,Fillipakopoulos P,Knapp S,Venables PJ,La Thangue NB

更新日期：2016-02-05 00:00:00

abstract：:When a medium is rapidly heated and cooled, heat transfers to its surroundings as sound. A controllable source of this sound is realized through joule heating of thin, conductive films by an alternating current. Here, we show that arrays of these sources generate sound unique to this mechanism. From the sound alone, w...

journal_title：Science advances

authors： Tatnell DM,Heath MS,Hepplestone SP,Hibbins AP,Hornett SM,Horsley SAR,Horsell DW

更新日期：2020-07-01 00:00:00

abstract：:Wächtershäuser's proposal of the autotrophic origin of life theory and subsequent laboratory demonstrations of relevant organic reactions have opened a new gate for the exploration of the origin of life. However, this scenario remains controversial because, at present, it requires a high pressure of CO as a source of ...

journal_title：Science advances

authors： Kitadai N,Nakamura R,Yamamoto M,Takai K,Li Y,Yamaguchi A,Gilbert A,Ueno Y,Yoshida N,Oono Y

更新日期：2018-04-04 00:00:00

abstract：:The human transfer RNA methyltransferase 9-like gene (TRM9L, also known as KIAA1456) encodes a negative regulator of tumor growth that is frequently silenced in many forms of cancer. While TRM9L can inhibit tumor cell growth in vivo, the molecular mechanisms underlying the tumor inhibition activity of TRM9L are unknow...

journal_title：Science advances

authors： Gu C,Ramos J,Begley U,Dedon PC,Fu D,Begley TJ

更新日期：2018-07-11 00:00:00