解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Demyelinating diseases involve loss of myelin sheaths and eventually lead to neurological problems. Unfortunately, the precise mechanisms remain unknown, and there are no effective therapies. To overcome these limitations, a reliable and physiologically relevant in vitro model is required. Here, we present a three-dim...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abd9749
更新日期:2021-01-29 00:00:00
abstract::Natural genetic variation affects circadian rhythms across the evolutionary tree, but the underlying molecular mechanisms are poorly understood. We investigated population-level, molecular circadian clock variation by generating >700 tissue-specific transcriptomes of Drosophila melanogaster (w1118 ) and 141 Drosophila...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abc3781
更新日期:2021-01-29 00:00:00
abstract::Oxygen isotope speleothem records exhibit coherent variability over the pan-Asian summer monsoon (AM) region. The hydroclimatic representation of these oxygen isotope records for the AM, however, has remained poorly understood. Here, combining an isotope-enabled Earth system model in transient experiments with proxy r...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abe2611
更新日期:2021-01-22 00:00:00
abstract::We investigate the emergence of global alignment in colonies of dividing rod-shaped cells under confinement. Using molecular dynamics simulations and continuous modeling, we demonstrate that geometrical anisotropies in the confining environment give rise to an imbalance in the normal stresses, which, in turn, drives a...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abc8685
更新日期:2021-01-22 00:00:00
abstract::Immune regulatory metabolites are key features of the tumor microenvironment (TME), yet with a few exceptions, their identities remain largely unknown. Here, we profiled tumor and T cells from tumor and ascites of patients with high-grade serous carcinoma (HGSC) to uncover the metabolomes of these distinct TME compart...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abe1174
更新日期:2021-01-20 00:00:00
abstract::Annexin-A1 (ANXA1) has recently been proposed to play a role in microglial activation after brain ischemia, but the underlying mechanism remains poorly understood. Here, we demonstrated that ANXA1 is modified by SUMOylation, and SUMOylated ANXA1 could promote the beneficial phenotype polarization of microglia. Mechani...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abc5539
更新日期:2021-01-20 00:00:00
abstract::Researchers have documented race and gender inequality in science, technology, engineering, and math (STEM) for decades. Do lesbian, gay, bisexual, transgender, and queer (LGBTQ) professionals face parallel experiences of disadvantage in STEM? Using representative survey data from 21 STEM professional societies (Nsamp...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abe0933
更新日期:2021-01-15 00:00:00
abstract::Among the existing elemental characterization techniques, particle-induced x-ray emission (PIXE) and energy-dispersive x-ray (EDX) spectroscopy are two of the most widely used in different scientific and technological fields. Here, we present the first quantitative laser-driven PIXE and laser-driven EDX experimental i...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abc8660
更新日期:2021-01-15 00:00:00
abstract::Dendritic actin networks develop from a first actin filament through branching by the Arp2/3 complex. At the surface of endosomes, the WASH complex activates the Arp2/3 complex and interacts with the capping protein for unclear reasons. Here, we show that the WASH complex interacts with dynactin and uncaps it through ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abd5956
更新日期:2021-01-13 00:00:00
abstract::Projections of ice sheet behavior hinge on how ice flow velocity evolves and the extent to which marine-based grounding lines are stable. Ice flow and grounding line retreat are variably governed by the coupling between the ice and underlying terrain. We ask to what degree catchment-scale bed characteristics determine...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb6291
更新日期:2021-01-13 00:00:00
abstract::Band structure theory plays an essential role in exploring physics in both solid-state systems and photonics. Here, we demonstrate a direct experimental measurement of the dynamic band structure in a synthetic space including the frequency axis of light, realized in a ring resonator under near-resonant dynamic modulat...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abe4335
更新日期:2021-01-08 00:00:00
abstract::Black phosphorus (BP) offers considerable promise for infrared and visible photonics. Efficient tuning of the bandgap and higher subbands in BP by modulation of the Fermi level or application of vertical electric fields has been previously demonstrated, allowing electrical control of its above-bandgap optical properti...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abd4623
更新日期:2021-01-08 00:00:00
abstract::l-DOPA treatment for Parkinson's disease frequently leads to dyskinesias, the pathophysiology of which is poorly understood. We used MALDI-MSI to map the distribution of l-DOPA and monoaminergic pathways in brains of dyskinetic and nondyskinetic primates. We report elevated levels of l-DOPA, and its metabolite 3-O-met...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abe5948
更新日期:2021-01-06 00:00:00
abstract::Optical investigation and manipulation constitute the core of biological experiments. Here, we introduce a new borosilicate glass material that contains the rare-earth ion terbium(III) (Tb3+), which emits green fluorescence upon blue light excitation, similar to green fluorescent protein (GFP), and thus is widely comp...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abd2529
更新日期:2021-01-06 00:00:00
abstract::Hypertrophic cardiomyopathy (HCM) is a heterogeneous genetic heart muscle disease characterized by hypertrophy with preserved or increased ejection fraction in the absence of secondary causes. However, recent studies have demonstrated that a substantial proportion of individuals with HCM also have comorbid diabetes me...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb3991
更新日期:2021-01-06 00:00:00
abstract::Copper-containing nitrite reductases (CuNiRs), encoded by nirK gene, are found in all kingdoms of life with only 5% of CuNiR denitrifiers having two or more copies of nirK Recently, we have identified two copies of nirK genes in several α-proteobacteria of the order Rhizobiales including Bradyrhizobium sp. ORS 375, en...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abd8523
更新日期:2021-01-01 00:00:00
abstract::In Arabidopsis, the root clock regulates the spacing of lateral organs along the primary root through oscillating gene expression. The core molecular mechanism that drives the root clock periodicity and how it is modified by exogenous cues such as auxin and gravity remain unknown. We identified the key elements of the...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abd4722
更新日期:2021-01-01 00:00:00
abstract::We present results from a study in the Democratic Republic of the Congo that uses mobile money networks to run rotating savings and credit associations (ROSCAs), peer-to-peer finance groups ubiquitous across the developing world. We find high rates of contribution and ROSCA success. The unexpected success of such e-RO...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abc5831
更新日期:2021-01-01 00:00:00
abstract::We review recent advances in our understanding of magnetism in the solar nebula and protoplanetary disks (PPDs). We discuss the implications of theory, meteorite measurements, and astronomical observations for planetary formation and nebular evolution. Paleomagnetic measurements indicate the presence of fields of 0.54...
journal_title:Science advances
pub_type: 杂志文章,评审
doi:10.1126/sciadv.aba5967
更新日期:2021-01-01 00:00:00
abstract::Present-day dermatological diagnostic tools are expensive, time-consuming, require substantial operational expertise, and typically probe only the superficial layers of skin (~15 μm). We introduce a soft, battery-free, noninvasive, reusable skin hydration sensor (SHS) adherable to most of the body surface. The platfor...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abd7146
更新日期:2020-12-04 00:00:00
abstract::The biophysical and biochemical properties of live tissues are important in the context of development and disease. Methods for evaluating these properties typically involve destroying the tissue or require specialized technology and complicated analyses. Here, we present a novel, noninvasive methodology for determini...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abc5546
更新日期:2020-12-04 00:00:00
abstract::Computer vision (CV) has the potential to change medicine fundamentally. Expert knowledge provided by CV can enhance diagnosis. Unfortunately, existing algorithms often remain below expectations, as databases used for training are usually too small, incomplete, and heterogeneous in quality. Moreover, data protection i...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb7973
更新日期:2020-12-02 00:00:00
abstract::Changes in CO2 emissions during the COVID-19 pandemic have been estimated from indicators on activities like transportation and electricity generation. Here, we instead use satellite observations together with bottom-up information to track the daily dynamics of CO2 emissions during the pandemic. Unlike activity data,...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abd4998
更新日期:2020-12-02 00:00:00
abstract::How mechanical forces regulate plant growth is a fascinating and long-standing question. After germination underground, buried seedlings have to dynamically adjust their growth to respond to mechanical stimulation from soil barriers. Here, we designed a lid touch assay and used atomic force microscopy to investigate t...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abc9294
更新日期:2020-11-27 00:00:00
abstract::Skin-mountable microelectronics are garnering substantial interest for various promising applications including human-machine interfaces, biointegrated devices, and personalized medicine. However, it remains a critical challenge to develop e-skins to mimic the human somatosensory system in full working range. Here, we...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb5367
更新日期:2020-11-27 00:00:00
abstract::Peripheral blood mononuclear cells (PBMCs) may provide insight into the pathogenesis of Alzheimer's disease (AD) or Parkinson's disease (PD). We investigated PBMC samples from 132 well-characterized research participants using seven canonical immune stimulants, mass cytometric identification of 35 PBMC subsets, and si...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abd5575
更新日期:2020-11-25 00:00:00
abstract::Fibulin-4 is a matricellular protein required for extracellular matrix (ECM) assembly. Mice deficient in fibulin-4 (Fbln4-/- ) have disrupted collagen and elastin fibers and die shortly after birth from aortic and diaphragmatic rupture. The function of fibulin-4 in ECM assembly, however, remains elusive. Here, we show...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abc1404
更新日期:2020-11-25 00:00:00
abstract::Electron interferometry via phase-contrast microscopy, holography, or picodiffraction can provide a direct visualization of the static electric and magnetic fields inside or around a material at subatomic precision, but understanding the electromagnetic origin of light-matter interaction requires time resolution as we...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abc8804
更新日期:2020-11-20 00:00:00
abstract::Strong coupling between a cavity and transition dipole moments in emitters leads to vacuum Rabi splitting. Researchers have not reported strong coupling between a single emitter and a dielectric cavity at room temperature until now. In this study, we investigated the photoluminescence (PL) spectra of colloidal quantum...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb3095
更新日期:2020-11-20 00:00:00
abstract::Approaching predators cast expanding shadows (i.e., looming) that elicit innate defensive responses in most animals. Where looming is first detected and how critical parameters of predatory approaches are extracted are unclear. In mice, we identify a retinal interneuron (the VG3 amacrine cell) that responds robustly t...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abc9920
更新日期:2020-11-18 00:00:00
abstract::Low-dimensional materials usually exhibit mechanical properties from those of their bulk counterparts. Here, we show in two-dimensional (2D) rhenium disulfide (ReS2) that the fracture processes are dominated by a variety of previously unidentified phenomena, which are not present in bulk materials. Through direct tran...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abc2282
更新日期:2020-11-18 00:00:00
abstract::Nanofluidic platforms offering tunable material transport are applicable in biosensing, chemical detection, and filtration. Prior studies have achieved selective and controllable ion transport through electrical, optical, or chemical gating of complex nanostructures. Here, we mechanically control nanofluidic transport...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abd0126
更新日期:2020-11-13 00:00:00
abstract::Neurodegenerative disorders are caused by progressive neuronal loss, and there is no complete treatment available yet. Neuroinflammation is a common feature across neurodegenerative disorders and implicated in the progression of neurodegeneration. Dysregulated activation of microglia causes neuroinflammation and has b...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abc1428
更新日期:2020-11-13 00:00:00
abstract::Diets rich in sugar, salt, and fat alter taste perception and food preference, contributing to obesity and metabolic disorders, but the molecular mechanisms through which this occurs are unknown. Here, we show that in response to a high sugar diet, the epigenetic regulator Polycomb Repressive Complex 2.1 (PRC2.1) pers...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abc8492
更新日期:2020-11-11 00:00:00
abstract::Chaotic itinerancy is a frequently observed phenomenon in high-dimensional nonlinear dynamical systems and is characterized by itinerant transitions among multiple quasi-attractors. Several studies have pointed out that high-dimensional activity in animal brains can be observed to exhibit chaotic itinerancy, which is ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb3989
更新日期:2020-11-11 00:00:00
abstract::In mammals, the daily rhythms of physiological functions are timed by the central circadian clock located in the suprachiasmatic nucleus (SCN) of the hypothalamus. Although the importance of the SCN for the regulation of sleep/wakefulness has been suggested, little is known about the neuronal projections from the SCN,...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abd0384
更新日期:2020-11-06 00:00:00
abstract::Arthropod herbivores cause substantial economic costs that drive an increasing need to develop environmentally sustainable approaches to herbivore control. Increasing plant diversity is expected to limit herbivory by altering plant-herbivore and predator-herbivore interactions, but the simultaneous influence of these ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb6603
更新日期:2020-11-06 00:00:00
abstract::Ascomycota, the largest and most well-studied phylum of fungi, contains three subphyla: Saccharomycotina (budding yeasts), Pezizomycotina (filamentous fungi), and Taphrinomycotina (fission yeasts). Despite its importance, we lack a comprehensive genome-scale phylogeny or understanding of the similarities and differenc...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abd0079
更新日期:2020-11-04 00:00:00
abstract::Spider silk fiber rapidly assembles from spidroin protein in soluble state via an incompletely understood mechanism. Here, we present an integrated model for silk formation that incorporates the effects of multiple chemical and physical gradients on the different spidroin functional domains. Central to the process is ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb6030
更新日期:2020-11-04 00:00:00
abstract::Oocyte numbers, a critical determinant of female reproductive fitness, are highly regulated, yet the mechanisms underlying this regulation remain largely undefined. In the Caenorhabditis elegans gonad, RAS/extracellular signal-regulated kinase (ERK) signaling regulates oocyte numbers; mechanisms are unknown. We show t...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abc5580
更新日期:2020-10-30 00:00:00