Structure and mechanism of bactericidal mammalian perforin-2, an ancient agent of innate immunity.

abstract：:The picture of how a gap closes in a semiconductor has been radically transformed by topological concepts. Instead of the gap closing and immediately reopening, topological arguments predict that, in the absence of inversion symmetry, a metallic phase protected by Weyl nodes persists over a finite interval of the tuni...

journal_title：Science advances

authors： Liang T,Kushwaha S,Kim J,Gibson Q,Lin J,Kioussis N,Cava RJ,Ong NP

更新日期：2017-05-31 00:00:00

abstract：:G protein-coupled receptor 54 (GPR54), the key receptor for the neuropeptide hormone kisspeptin, plays essential roles in regulating puberty development and cancer metastasis. However, its role in the antiviral innate immune response is unknown. We report that virus-induced type I interferon (IFN-I) production was sig...

journal_title：Science advances

authors： Huang H,Xiong Q,Wang N,Chen R,Ren H,Siwko S,Han H,Liu M,Qian M,Du B

更新日期：2018-08-08 00:00:00

abstract：:Two-dimensional (2D) polymers hold great promise in the rational materials design tailored for next-generation applications. However, little is known about the grain boundaries in 2D polymers, not to mention their formation mechanisms and potential influences on the material's functionalities. Using aberration-correct...

journal_title：Science advances

authors： Qi H,Sahabudeen H,Liang B,Položij M,Addicoat MA,Gorelik TE,Hambsch M,Mundszinger M,Park S,Lotsch BV,Mannsfeld SCB,Zheng Z,Dong R,Heine T,Feng X,Kaiser U

更新日期：2020-08-14 00:00:00

abstract：:The discovery of high-temperature superconductivity in cuprates ranks among the major scientific milestones of the past half century, yet pivotal questions regarding the complex phase diagram of these materials remain unanswered. Generally thought of as doped charge-transfer insulators, these complex oxides exhibit ps...

journal_title：Science advances

authors： Pelc D,Popčević P,Požek M,Greven M,Barišić N

更新日期：2019-01-25 00:00:00

abstract：:Lymphatic filariasis and onchocerciasis are two important neglected tropical diseases (NTDs) that cause severe disability. Control efforts are hindered by the lack of a safe macrofilaricidal drug. Targeting the Wolbachia bacterial endosymbionts in these parasites with doxycycline leads to a macrofilaricidal outcome, b...

journal_title：Science advances

authors： Johnston KL,Cook DAN,Berry NG,David Hong W,Clare RH,Goddard M,Ford L,Nixon GL,O'Neill PM,Ward SA,Taylor MJ

更新日期：2017-09-27 00:00:00

abstract：:The impact of the FMR1 premutation on human health is the subject of considerable controversy. A fundamental unanswered question is whether carrying the premutation allele is directly correlated with clinical phenotypes. A challenging problem in past genotype-phenotype studies of the FMR1 premutation is ascertainment ...

journal_title：Science advances

authors： Movaghar A,Page D,Brilliant M,Baker MW,Greenberg J,Hong J,DaWalt LS,Saha K,Kuusisto F,Stewart R,Berry-Kravis E,Mailick MR

更新日期：2019-08-21 00:00:00

abstract：:Nitrogen oxides, released from fossil fuel use and other combustion processes, affect air quality and climate. From the mid-1990s onward, nitrogen dioxide (NO2) has been monitored from space, and since 2004 with relatively high spatial resolution by the Ozone Monitoring Instrument. Strong upward NO2 trends have been o...

journal_title：Science advances

authors： Lelieveld J,Beirle S,Hörmann C,Stenchikov G,Wagner T

更新日期：2015-08-21 00:00:00

abstract：:Earth's night sky continuously produces a faint chemiluminescence known as nightglow. Two prominent nighttime emissions around 90 km are the O2 Atmospheric and the OH Meinel band systems. Despite a plethora of studies since their identification seven decades ago, substantial gaps persist in our understanding of the me...

journal_title：Science advances

authors： Kalogerakis KS

更新日期：2019-03-20 00:00:00

abstract：:Spin caloritronics has recently emerged from the combination of spintronics and thermoelectricity. Here, we show that flexible, macroscopic spin caloritronic devices based on large-area interconnected magnetic nanowire networks can be used to enable controlled Peltier cooling of macroscopic electronic components with ...

journal_title：Science advances

authors： da Câmara Santa Clara Gomes T,Abreu Araujo F,Piraux L

更新日期：2019-03-01 00:00:00

abstract：:Understanding the remarkable excitonic effects and controlling the exciton binding energies in two-dimensional (2D) semiconductors are crucial in unlocking their full potential for use in future photonic and optoelectronic devices. Here, we demonstrate large excitonic effects and gate-tunable exciton binding energies ...

journal_title：Science advances

authors： Qiu Z,Trushin M,Fang H,Verzhbitskiy I,Gao S,Laksono E,Yang M,Lyu P,Li J,Su J,Telychko M,Watanabe K,Taniguchi T,Wu J,Neto AHC,Yang L,Eda G,Adam S,Lu J

更新日期：2019-07-19 00:00:00

abstract：:Solar-thermal desalination (STD) is a potentially low-cost, sustainable approach for providing high-quality fresh water in the absence of water and energy infrastructures. Despite recent efforts to advance STD by improving heat-absorbing materials and system designs, the best strategies for maximizing STD performance ...

journal_title：Science advances

authors： Wang Z,Horseman T,Straub AP,Yip NY,Li D,Elimelech M,Lin S

更新日期：2019-07-26 00:00:00

abstract：:Previous studies have extensively investigated the impact of Arctic sea ice anomalies on the midlatitude circulation and associated surface climate in winter. However, there is an ongoing scientific debate regarding whether and how sea ice retreat results in the observed cold anomaly over the adjacent continents. We p...

journal_title：Science advances

authors： Zhang P,Wu Y,Simpson IR,Smith KL,Zhang X,De B,Callaghan P

更新日期：2018-07-25 00:00:00

abstract：:Most crystalline inorganic materials, except for metals and some layer materials, exhibit bad flexibility because of strong ionic or covalent bonds, while amorphous materials usually display poor electrical properties due to structural disorders. Here, we report the simultaneous realization of extraordinary room tempe...

journal_title：Science advances

authors： He S,Li Y,Liu L,Jiang Y,Feng J,Zhu W,Zhang J,Dong Z,Deng Y,Luo J,Zhang W,Chen G

更新日期：2020-04-10 00:00:00

abstract：:Can mating influence cognitive functions such as learning and memory in a permanent way? We have addressed this question using a combined behavioral and in vivo imaging approach, finding that aversive long-term memory performance strongly increases in Drosophila females in response to sperm transfer following mating. ...

journal_title：Science advances

authors： Scheunemann L,Lampin-Saint-Amaux A,Schor J,Preat T

更新日期：2019-11-20 00:00:00

abstract：:Charge order is universal among high-Tc cuprates, but its relation to superconductivity is unclear. While static order competes with superconductivity, dynamic order may be favorable and even contribute to Cooper pairing. Using time-resolved resonant soft x-ray scattering at a free-electron laser, we show that the cha...

journal_title：Science advances

authors： Mitrano M,Lee S,Husain AA,Delacretaz L,Zhu M,de la Peña Munoz G,Sun SX,Joe YI,Reid AH,Wandel SF,Coslovich G,Schlotter W,van Driel T,Schneeloch J,Gu GD,Hartnoll S,Goldenfeld N,Abbamonte P

更新日期：2019-08-16 00:00:00

abstract：:Over the past decade, a growing number of studies have revealed that progressive changes to epigenetic information accompany aging in both dividing and nondividing cells. Functional studies in model organisms and humans indicate that epigenetic changes have a huge influence on the aging process. These epigenetic chang...

journal_title：Science advances

authors： Pal S,Tyler JK

更新日期：2016-07-29 00:00:00

abstract：:Neurochemical dysregulation underlies many pathologies and can be monitored by measuring the composition of brain interstitial fluid (ISF). Existing in vivo tools for sampling ISF do not enable measuring large rare molecules, such as proteins and neuropeptides, and thus cannot generate a complete picture of the neuroc...

journal_title：Science advances

authors： Raman R,Rousseau EB,Wade M,Tong A,Cotler MJ,Kuang J,Lugo AA,Zhang E,Graybiel AM,White FM,Langer R,Cima MJ

更新日期：2020-09-25 00:00:00

abstract：:Interaction of swimming bacteria with flows controls their ability to explore complex environments, crucial to many societal and environmental challenges and relevant for microfluidic applications such as cell sorting. Combining experimental, numerical, and theoretical analysis, we present a comprehensive study of the...

journal_title：Science advances

authors： Jing G,Zöttl A,Clément É,Lindner A

更新日期：2020-07-10 00:00:00

abstract：:Eruptive phenomena at all scales, from hydrothermal geysers to flood basalts, can potentially be initiated or modulated by external mechanical perturbations. We present evidence for the triggering of magmatism on a global scale by the Chicxulub meteorite impact at the Cretaceous-Paleogene (K-Pg) boundary, recorded by ...

journal_title：Science advances

authors： Byrnes JS,Karlstrom L

更新日期：2018-02-07 00:00:00

abstract：:Kozmin et al. contend that observations previously reported regarding the antimicrobial and antitumor activities of 6-N-hydroxy aminopurine (6-HAP) were incorrect. Their conclusions rely on poorly characterized reagents and focus strictly on in vitro techniques without validation in relevant mammalian model systems. W...

journal_title：Science advances

authors： Nakatsuji T,Fenical W,Gallo RL

更新日期：2019-09-11 00:00:00

abstract：:When a medium is rapidly heated and cooled, heat transfers to its surroundings as sound. A controllable source of this sound is realized through joule heating of thin, conductive films by an alternating current. Here, we show that arrays of these sources generate sound unique to this mechanism. From the sound alone, w...

journal_title：Science advances

authors： Tatnell DM,Heath MS,Hepplestone SP,Hibbins AP,Hornett SM,Horsley SAR,Horsell DW

更新日期：2020-07-01 00:00:00

abstract：:Six percent of Americans, including 3 million high schoolers, use e-cigarettes, which contain potentially toxic substances, volatile organic compounds, and metals. We present the first human study on the effects of e-cigarette exposure in the oral cavity. By interrogating both immunoinflammatory responses and microbia...

journal_title：Science advances

authors： Ganesan SM,Dabdoub SM,Nagaraja HN,Scott ML,Pamulapati S,Berman ML,Shields PG,Wewers ME,Kumar PS

更新日期：2020-05-27 00:00:00

abstract：:Self-propelling micromotors are emerging as a promising micro- and nanoscale tool for single-cell analysis. We have recently shown that the field gradients necessary to manipulate matter via dielectrophoresis can be induced at the surface of a polarizable active ("self-propelling") metallodielectric Janus particle (JP...

journal_title：Science advances

authors： Wu Y,Fu A,Yossifon G

更新日期：2020-01-29 00:00:00

abstract：:Implanted brain electrodes construct the only means to electrically interface with individual neurons in vivo, but their recording efficacy and biocompatibility pose limitations on scientific and clinical applications. We showed that nanoelectronic thread (NET) electrodes with subcellular dimensions, ultraflexibility,...

journal_title：Science advances

authors： Luan L,Wei X,Zhao Z,Siegel JJ,Potnis O,Tuppen CA,Lin S,Kazmi S,Fowler RA,Holloway S,Dunn AK,Chitwood RA,Xie C

更新日期：2017-02-15 00:00:00

abstract：:E2F is a family of master transcription regulators involved in mediating diverse cell fates. Here, we show that residue-specific arginine methylation (meR) by PRMT5 enables E2F1 to regulate many genes at the level of alternative RNA splicing, rather than through its classical transcription-based mechanism. The p100/TS...

journal_title：Science advances

authors： Roworth AP,Carr SM,Liu G,Barczak W,Miller RL,Munro S,Kanapin A,Samsonova A,La Thangue NB

更新日期：2019-06-26 00:00:00

abstract：:Functional materials with specific surface wettability play an important role in a wide variety of areas. Inspired by nature's Nepenthes pitcher plant, we present a novel slippery film with tunable wettability based on a shape-memory graphene sponge. The porous graphene sponge coated with shape-memory polymer was used...

journal_title：Science advances

authors： Wang J,Sun L,Zou M,Gao W,Liu C,Shang L,Gu Z,Zhao Y

更新日期：2017-06-02 00:00:00

abstract：:The Tulare Basin in Central California is a site of intensive agricultural activity and extraction of groundwater, with pronounced ground subsidence and degradation of water resources over the past century. Spatially extensive observations of ground displacements from satellite-based remote sensing allow us to infer t...

journal_title：Science advances

authors： Murray KD,Lohman RB

更新日期：2018-08-29 00:00:00

abstract：:The progression in the hair follicle cycle from the telogen to the anagen phase is the key to regulating hair regrowth. Dermal papilla (DP) cells support hair growth and regulate the hair cycle. However, they gradually lose key inductive properties upon culture. DP cells can partially restore their capacity to promote...

journal_title：Science advances

authors： Hu S,Li Z,Lutz H,Huang K,Su T,Cores J,Dinh PC,Cheng K

更新日期：2020-07-24 00:00:00

abstract：:Ferroelectric domain walls are atomically sharp topological defects that separate regions of uniform polarization. The discovery of electrical conductivity in specific types of walls gave rise to "domain wall nanoelectronics," a technology in which the wall (rather than the domain) stores information. This paradigm sh...

journal_title：Science advances

authors： Sharma P,Zhang Q,Sando D,Lei CH,Liu Y,Li J,Nagarajan V,Seidel J

更新日期：2017-06-23 00:00:00

abstract：:Deep CO2 emissions characterize many nonvolcanic, seismically active regions worldwide, and the involvement of deep CO2 in the earthquake cycle is now generally recognized. However, no long-time records of such emissions have been published, and the temporal relations between earthquake occurrence and tectonic CO2 rel...

journal_title：Science advances

authors： Chiodini G,Cardellini C,Di Luccio F,Selva J,Frondini F,Caliro S,Rosiello A,Beddini G,Ventura G

更新日期：2020-08-26 00:00:00