Abstract:
:Kozmin et al. contend that observations previously reported regarding the antimicrobial and antitumor activities of 6-N-hydroxy aminopurine (6-HAP) were incorrect. Their conclusions rely on poorly characterized reagents and focus strictly on in vitro techniques without validation in relevant mammalian model systems. We are pleased to be able to illuminate the weaknesses in their technical comment. The totality of current results continues to support our original conclusion that a strain of the common human commensal skin bacterium, Staphylococcus epidermidis, produces 6-HAP that can inhibit tumor growth.
journal_name
Sci Advjournal_title
Science advancesauthors
Nakatsuji T,Fenical W,Gallo RLdoi
10.1126/sciadv.aay5611subject
Has Abstractpub_date
2019-09-11 00:00:00pages
eaay5611issue
9issn
2375-2548pii
aay5611journal_volume
5pub_type
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