Abstract:
:Implanted brain electrodes construct the only means to electrically interface with individual neurons in vivo, but their recording efficacy and biocompatibility pose limitations on scientific and clinical applications. We showed that nanoelectronic thread (NET) electrodes with subcellular dimensions, ultraflexibility, and cellular surgical footprints form reliable, glial scar-free neural integration. We demonstrated that NET electrodes reliably detected and tracked individual units for months; their impedance, noise level, single-unit recording yield, and the signal amplitude remained stable during long-term implantation. In vivo two-photon imaging and postmortem histological analysis revealed seamless, subcellular integration of NET probes with the local cellular and vasculature networks, featuring fully recovered capillaries with an intact blood-brain barrier and complete absence of chronic neuronal degradation and glial scar.
journal_name
Sci Advjournal_title
Science advancesauthors
Luan L,Wei X,Zhao Z,Siegel JJ,Potnis O,Tuppen CA,Lin S,Kazmi S,Fowler RA,Holloway S,Dunn AK,Chitwood RA,Xie Cdoi
10.1126/sciadv.1601966subject
Has Abstractpub_date
2017-02-15 00:00:00pages
e1601966issue
2issn
2375-2548pii
1601966journal_volume
3pub_type
杂志文章相关文献
Science Advances文献大全abstract::Human and murine skin wounding commonly results in fibrotic scarring, but the murine wounding model wound-induced hair neogenesis (WIHN) can frequently result in a regenerative repair response. Here, we show in single-cell RNA sequencing comparisons of semi-regenerative and fibrotic WIHN wounds, increased expression o...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aay3704
更新日期:2020-03-20 00:00:00
abstract::Plants produce a myriad of taxonomically restricted specialized metabolites. This diversity-and our ability to correlate genotype with phenotype-makes the evolution of these ecologically and medicinally important compounds interesting and experimentally tractable. Trichomes of tomato and other nightshade family plants...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaw3754
更新日期:2019-04-24 00:00:00
abstract::Present-day dermatological diagnostic tools are expensive, time-consuming, require substantial operational expertise, and typically probe only the superficial layers of skin (~15 μm). We introduce a soft, battery-free, noninvasive, reusable skin hydration sensor (SHS) adherable to most of the body surface. The platfor...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abd7146
更新日期:2020-12-04 00:00:00
abstract::Protected areas (PAs) are essential to biodiversity conservation, but their static boundaries may undermine their potential for protecting species under climate change. We assessed how the climatic conditions within global terrestrial PAs may change over time. By 2070, protection is expected to decline in cold and war...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aay0814
更新日期:2020-06-17 00:00:00
abstract::The established model-free methods for the processing of two-electron dipolar spectroscopy data [DEER (double electron-electron resonance), PELDOR (pulsed electron double resonance), DQ-EPR (double-quantum electron paramagnetic resonance), RIDME (relaxation-induced dipolar modulation enhancement), etc.] use regularize...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aat5218
更新日期:2018-08-24 00:00:00
abstract::Gender inequality in contemporary U.S. society is a well-documented, widespread phenomenon. However, little is known about gender disparities in product markets. This study is the first to use actual market data to study the behavior of women and men as sellers and buyers and differences in market outcomes. We analyze...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1500599
更新日期:2016-02-19 00:00:00
abstract::The spin-polarized surface states of topological insulators (TIs) are attractive for applications in spintronics and quantum computing. A central challenge with these materials is to reliably tune the chemical potential of their electrons with respect to the Dirac point and the bulk bands. We demonstrate persistent, b...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1500640
更新日期:2015-10-09 00:00:00
abstract::The high-lying vibrational states of the magnesium dimer (Mg2), which has been recognized as an important system in studies of ultracold and collisional phenomena, have eluded experimental characterization for half a century. Until now, only the first 14 vibrational states of Mg2 have been experimentally resolved, alt...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aay4058
更新日期:2020-04-03 00:00:00
abstract::Mesoscale turbulence in the ocean strongly affects the circulation, water mass formation, and transport of tracers. Little is known, however, about how mixing varies on climate timescales. We present the first time-resolved global dataset of lateral mesoscale eddy diffusivities at the ocean surface, obtained by applyi...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aav5014
更新日期:2019-01-23 00:00:00
abstract::The integration of structure and function for tissue engineering scaffolds is of great importance in mimicking native bone tissue. However, the complexity of hierarchical structures, the requirement for mechanical properties, and the diversity of bone resident cells are the major challenges in constructing biomimetic ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaz6725
更新日期:2020-03-20 00:00:00
abstract::Natural genetic variation affects circadian rhythms across the evolutionary tree, but the underlying molecular mechanisms are poorly understood. We investigated population-level, molecular circadian clock variation by generating >700 tissue-specific transcriptomes of Drosophila melanogaster (w1118 ) and 141 Drosophila...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abc3781
更新日期:2021-01-29 00:00:00
abstract::Nanofluidic platforms offering tunable material transport are applicable in biosensing, chemical detection, and filtration. Prior studies have achieved selective and controllable ion transport through electrical, optical, or chemical gating of complex nanostructures. Here, we mechanically control nanofluidic transport...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abd0126
更新日期:2020-11-13 00:00:00
abstract::Dynamic modulation of soft helix in terms of the molecular organization, handedness, and pitch length could result in a sophisticated control over its functions, opening numerous possibilities toward the exploration of previously unidentified applications. Here, we report a dynamic and reversible transformation of a s...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aax9501
更新日期:2019-10-04 00:00:00
abstract::Changes in the Atlantic Meridional Overturning Circulation (AMOC) are moderate in most climate model projections under increasing greenhouse gas forcing. This intermodel consensus may be an artifact of common model biases that favor a stable AMOC. Observationally based freshwater budget analyses suggest that the AMOC ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1601666
更新日期:2017-01-04 00:00:00
abstract::Over millions of years, the oxidation of organic carbon contained within sedimentary rocks is one of the main sources of carbon dioxide to the atmosphere, yet the controls on this emission remain poorly constrained. We use rhenium to track the oxidation of rock-bound organic carbon in the mountain watersheds of New Ze...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1701107
更新日期:2017-10-04 00:00:00
abstract::Traumatic spinal cord injury (SCI) brings numerous inflammatory cells, including macrophages, from the circulating blood to lesions, but pathophysiological impact resulting from spatiotemporal dynamics of macrophages is unknown. Here, we show that macrophages centripetally migrate toward the lesion epicenter after inf...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aav5086
更新日期:2019-05-15 00:00:00
abstract::G protein-coupled receptors (GPCRs) play a fundamental role in the modulation of synaptic transmission. A pivotal example is provided by the metabotropic glutamate receptor type 4 (mGluR4), which inhibits glutamate release at presynaptic active zones (AZs). However, how GPCRs are organized within AZs to regulate neuro...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aay7193
更新日期:2020-04-15 00:00:00
abstract::[This corrects the article DOI: 10.1126/sciadv.aar3761.]. ...
journal_title:Science advances
pub_type: 杂志文章,已发布勘误
doi:10.1126/sciadv.aau4713
更新日期:2018-07-06 00:00:00
abstract::Previous identification of the inducible nitric oxide synthase (NOS2) gene as a risk allele for psoriasis (Ps) and psoriatic arthritis (PsA) suggests a possible pathogenic role of nitric oxide (NO). Using a mouse model of mannan-induced Ps and PsA (MIP), where macrophages play a regulatory role by releasing reactive o...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aas9864
更新日期:2018-05-16 00:00:00
abstract::Changes in extreme weather, such as tropical cyclones, are one of the most serious ways society experiences the impact of climate change. Advance forecasted conditional attribution statements, using a numerical model, were made about the anthropogenic climate change influence on an individual tropical cyclone, Hurrica...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaw9253
更新日期:2020-01-01 00:00:00
abstract::Candida albicans is a pathogenic yeast that causes mucosal and systematic infections with high mortality. The absence of facile molecular genetics has been a major impediment to analysis of pathogenesis. The lack of meiosis coupled with the absence of plasmids makes genetic engineering cumbersome, especially for essen...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1500248
更新日期:2015-01-01 00:00:00
abstract::Perovskite oxides exhibit potential for use as electrocatalysts in the oxygen evolution reaction (OER). However, their low specific surface area is the main obstacle to realizing a high mass-specific activity that is required to be competitive against the state-of-the-art precious metal-based catalysts. We report the ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1603206
更新日期:2017-06-21 00:00:00
abstract::Increasing occurrence of moderate to severe intrauterine adhesion (IUA) is seriously affecting the quality of human life. The aim of the study was to establish IUA models in nonhuman primates and to explore the dual repair effects of human umbilical cord-derived mesenchymal stem cells (huMSCs) loaded on autocrosslinke...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aba6357
更新日期:2020-05-22 00:00:00
abstract::Dewetting is a ubiquitous phenomenon in nature; many different thin films of organic and inorganic substances (such as liquids, polymers, metals, and semiconductors) share this shape instability driven by surface tension and mass transport. Via templated solid-state dewetting, we frame complex nanoarchitectures of mon...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aao1472
更新日期:2017-11-10 00:00:00
abstract::The geothermal heat flux is a critical thermal boundary condition that influences the melting, flow, and mass balance of ice sheets, but measurements of this parameter are difficult to make in ice-covered regions. We report the first direct measurement of geothermal heat flux into the base of the West Antarctic Ice Sh...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1500093
更新日期:2015-07-10 00:00:00
abstract::The Late Paleogene surface height and paleoenvironment for the core area of the Qinghai-Tibetan Plateau (QTP) remain critically unresolved. Here, we report the discovery of the youngest well-preserved fossil palm leaves from Tibet. They were recovered from the Late Paleogene (Chattian), ca. 25.5 ± 0.5 million years, p...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aav2189
更新日期:2019-03-06 00:00:00
abstract::Leukemia is a complex heterogeneous disease often driven by the expression of oncogenic fusion proteins with different molecular and biochemical properties. Whereas several fusion proteins induce leukemogenesis by activating Hox gene expression (Hox-activating fusions), others impinge on different pathways that do not...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1600972
更新日期:2016-10-07 00:00:00
abstract::By introducing a superconducting gap in Weyl or Dirac semimetals, the superconducting state inherits the nontrivial topology of their electronic structure. As a result, Weyl superconductors are expected to host exotic phenomena, such as nonzero-momentum pairing due to their chiral node structure, or zero-energy Majora...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1602983
更新日期:2017-05-24 00:00:00
abstract::Annexin-A1 (ANXA1) has recently been proposed to play a role in microglial activation after brain ischemia, but the underlying mechanism remains poorly understood. Here, we demonstrated that ANXA1 is modified by SUMOylation, and SUMOylated ANXA1 could promote the beneficial phenotype polarization of microglia. Mechani...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abc5539
更新日期:2021-01-20 00:00:00
abstract::Organophosphate-based pesticides inhibit acetylcholinesterase (AChE), which plays a pivotal role in neuromuscular function. While spraying in the field, farmworkers get exposed to pesticides through the dermal route. Internalized pesticide inhibits AChE, which leads to neurotoxicity, cardiotoxicity, cognitive dysfunct...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aau1780
更新日期:2018-10-17 00:00:00