Reliable, low-cost, fully integrated hydration sensors for monitoring and diagnosis of inflammatory skin diseases in any environment.

abstract：:Electron interferometry via phase-contrast microscopy, holography, or picodiffraction can provide a direct visualization of the static electric and magnetic fields inside or around a material at subatomic precision, but understanding the electromagnetic origin of light-matter interaction requires time resolution as we...

journal_title：Science advances

authors： Mohler KJ,Ehberger D,Gronwald I,Lange C,Huber R,Baum P

更新日期：2020-11-20 00:00:00

abstract：:The miraculously preserved 2000-year-old Dead Sea Scrolls, ancient texts of invaluable historical significance, were discovered in the mid-20th century in the caves of the Judean desert. The texts were mainly written on parchment and exhibit vast diversity in their states of preservation. One particular scroll, the 8-...

journal_title：Science advances

authors： Schuetz R,Maragh JM,Weaver JC,Rabin I,Masic A

更新日期：2019-09-06 00:00:00

abstract：:Over the past decade, the Arctic has warmed by 0.75°C, far outpacing the global average, while Antarctic temperatures have remained comparatively stable. As Earth approaches 2°C warming, the Arctic and Antarctic may reach 4°C and 2°C mean annual warming, and 7°C and 3°C winter warming, respectively. Expected consequen...

journal_title：Science advances

authors： Post E,Alley RB,Christensen TR,Macias-Fauria M,Forbes BC,Gooseff MN,Iler A,Kerby JT,Laidre KL,Mann ME,Olofsson J,Stroeve JC,Ulmer F,Virginia RA,Wang M

更新日期：2019-12-04 00:00:00

abstract：:The locally accumulated damage by tropical cyclones (TCs) can intensify substantially when these cyclones move more slowly. While some observational evidence suggests that TC motion might have slowed significantly since the mid-20th century (1), the robustness of the observed trend and its relation to anthropogenic wa...

journal_title：Science advances

authors： Zhang G,Murakami H,Knutson TR,Mizuta R,Yoshida K

更新日期：2020-04-22 00:00:00

abstract：:Earth's night sky continuously produces a faint chemiluminescence known as nightglow. Two prominent nighttime emissions around 90 km are the O2 Atmospheric and the OH Meinel band systems. Despite a plethora of studies since their identification seven decades ago, substantial gaps persist in our understanding of the me...

journal_title：Science advances

authors： Kalogerakis KS

更新日期：2019-03-20 00:00:00

abstract：:Dynamic nuclear polarization (DNP) is an important technique that uses polarization transfer from electron to nuclear spins to achieve nuclear hyperpolarization. Combining efficient DNP with optically polarized nitrogen-vacancy (NV) centers offers promising opportunities for novel technological applications, including...

journal_title：Science advances

authors： Schwartz I,Scheuer J,Tratzmiller B,Müller S,Chen Q,Dhand I,Wang ZY,Müller C,Naydenov B,Jelezko F,Plenio MB

更新日期：2018-08-31 00:00:00

abstract：:Using theory and experiments, we study the interface between two immiscible domains in a colloidal membrane composed of rigid rods of different lengths. Geometric considerations of rigid rod packing imply that a domain of sufficiently short rods in a background membrane of long rods is more susceptible to twist than t...

journal_title：Science advances

authors： Miller JM,Hall D,Robaszewski J,Sharma P,Hagan MF,Grason GM,Dogic Z

更新日期：2020-07-29 00:00:00

abstract：:Low-dimensional materials usually exhibit mechanical properties from those of their bulk counterparts. Here, we show in two-dimensional (2D) rhenium disulfide (ReS2) that the fracture processes are dominated by a variety of previously unidentified phenomena, which are not present in bulk materials. Through direct tran...

journal_title：Science advances

authors： Huang L,Zheng F,Deng Q,Thi QH,Wong LW,Cai Y,Wang N,Lee CS,Lau SP,Ly TH,Zhao J

更新日期：2020-11-18 00:00:00

abstract：:Ascomycota, the largest and most well-studied phylum of fungi, contains three subphyla: Saccharomycotina (budding yeasts), Pezizomycotina (filamentous fungi), and Taphrinomycotina (fission yeasts). Despite its importance, we lack a comprehensive genome-scale phylogeny or understanding of the similarities and differenc...

journal_title：Science advances

authors： Shen XX,Steenwyk JL,LaBella AL,Opulente DA,Zhou X,Kominek J,Li Y,Groenewald M,Hittinger CT,Rokas A

更新日期：2020-11-04 00:00:00

abstract：:Modeling a complex system is almost invariably a challenging task. The incorporation of experimental observations can be used to improve the quality of a model and thus to obtain better predictions about the behavior of the corresponding system. This approach, however, is affected by a variety of different errors, esp...

journal_title：Science advances

authors： Bonomi M,Camilloni C,Cavalli A,Vendruscolo M

更新日期：2016-01-22 00:00:00

abstract：:The spin-polarized surface states of topological insulators (TIs) are attractive for applications in spintronics and quantum computing. A central challenge with these materials is to reliably tune the chemical potential of their electrons with respect to the Dirac point and the bulk bands. We demonstrate persistent, b...

journal_title：Science advances

authors： Yeats AL,Pan Y,Richardella A,Mintun PJ,Samarth N,Awschalom DD

更新日期：2015-10-09 00:00:00

abstract：:The retinoic acid-inducible gene I (RIG-I) innate immune receptor is an important immunotherapeutic target, but we lack approaches for monitoring the physical basis for its activation in vitro. This gap in our understanding has led to confusion about mechanisms of RIG-I activation and difficulty discovering agonists a...

journal_title：Science advances

authors： Dickey TH,Song B,Pyle AM

更新日期：2019-10-02 00:00:00

abstract：:l-DOPA treatment for Parkinson's disease frequently leads to dyskinesias, the pathophysiology of which is poorly understood. We used MALDI-MSI to map the distribution of l-DOPA and monoaminergic pathways in brains of dyskinetic and nondyskinetic primates. We report elevated levels of l-DOPA, and its metabolite 3-O-met...

journal_title：Science advances

authors： Fridjonsdottir E,Shariatgorji R,Nilsson A,Vallianatou T,Odell LR,Schembri LS,Svenningsson P,Fernagut PO,Crossman AR,Bezard E,Andrén PE

更新日期：2021-01-06 00:00:00

abstract：:Transistors with exfoliated two-dimensional (2D) materials on a SiO2/Si substrate have been applied and have been proven effective in a wide range of applications, such as circuits, memory, photodetectors, gas sensors, optical modulators, valleytronics, and spintronics. However, these devices usually suffer from limit...

journal_title：Science advances

authors： Xu J,Chen L,Dai YW,Cao Q,Sun QQ,Ding SJ,Zhu H,Zhang DW

更新日期：2017-05-19 00:00:00

abstract：:Polyphosphate, an energy-rich polymer conserved in all kingdoms of life, is integral to many cellular stress responses, including nutrient deprivation, and yet, the mechanisms that underlie its biological roles are not well understood. In this work, we elucidate the physiological function of this polymer in the acclim...

journal_title：Science advances

authors： Sanz-Luque E,Saroussi S,Huang W,Akkawi N,Grossman AR

更新日期：2020-09-30 00:00:00

abstract：:Rising temperatures in the Arctic Ocean region are responsible for changes such as reduced ice cover, permafrost thawing, and increased river discharge, which, together, alter nutrient and carbon cycles over the vast Arctic continental shelf. We show that the concentration of radium-228, sourced to seawater through se...

journal_title：Science advances

authors： Kipp LE,Charette MA,Moore WS,Henderson PB,Rigor IG

更新日期：2018-01-03 00:00:00

abstract：:Artificial liquid-repellent surfaces have attracted substantial scientific and industrial attention with a focus on creating functional topological features; however, the role of the underlying structures has been overlooked. Recent developments in micro-nanofabrication allow us now to construct a skin-muscle type sys...

journal_title：Science advances

authors： Hu S,Cao X,Reddyhoff T,Puhan D,Vladescu SC,Wang J,Shi X,Peng Z,deMello AJ,Dini D

更新日期：2020-08-05 00:00:00

abstract：:Cell lines are commonly used as cancer models. The tissue of origin provides context for understanding biological mechanisms and predicting therapy response. We therefore systematically examined whether cancer cell lines exhibit features matching the presumed cancer type of origin. Gene expression and DNA methylation ...

journal_title：Science advances

authors： Salvadores M,Fuster-Tormo F,Supek F

更新日期：2020-07-01 00:00:00

abstract：:Understanding the principles that led to the current complexity of the genetic code is a central question in evolution. Expansion of the genetic code required the selection of new transfer RNAs (tRNAs) with specific recognition signals that allowed them to be matured, modified, aminoacylated, and processed by the ribo...

journal_title：Science advances

authors： Saint-Léger A,Bello C,Dans PD,Torres AG,Novoa EM,Camacho N,Orozco M,Kondrashov FA,Ribas de Pouplana L

更新日期：2016-04-29 00:00:00

abstract：:Dual-comb spectroscopy allows for high-resolution spectra to be measured over broad bandwidths, but an essential requirement for coherent integration is the availability of a phase reference. Usually, this means that the combs' phase and timing errors must be measured and either minimized by stabilization or removed b...

journal_title：Science advances

authors： Burghoff D,Yang Y,Hu Q

更新日期：2016-11-11 00:00:00

abstract：:Hypertrophic cardiomyopathy (HCM) is a heterogeneous genetic heart muscle disease characterized by hypertrophy with preserved or increased ejection fraction in the absence of secondary causes. However, recent studies have demonstrated that a substantial proportion of individuals with HCM also have comorbid diabetes me...

journal_title：Science advances

authors： Dhandapany PS,Kang S,Kashyap DK,Rajagopal R,Sundaresan NR,Singh R,Thangaraj K,Jayaprakash S,Manjunath CN,Shenthar J,Lebeche D

更新日期：2021-01-06 00:00:00

abstract：:Ice-templating holds promise to become a powerful technique to construct high-performance bioinspired materials. Both ice nucleation and growth during the freezing process are crucial for the final architecture of the ice-templated material. However, effective ways to control these two very important factors are still...

journal_title：Science advances

authors： Zhao N,Li M,Gong H,Bai H

更新日期：2020-07-31 00:00:00

abstract：:Goat domestication was critical for agriculture and civilization, but its underlying genetic changes and selection regimes remain unclear. Here, we analyze the genomes of worldwide domestic goats, wild caprid species, and historical remains, providing evidence of an ancient introgression event from a West Caucasian tu...

journal_title：Science advances

authors： Zheng Z,Wang X,Li M,Li Y,Yang Z,Wang X,Pan X,Gong M,Zhang Y,Guo Y,Wang Y,Liu J,Cai Y,Chen Q,Okpeku M,Colli L,Cai D,Wang K,Huang S,Sonstegard TS,Esmailizadeh A,Zhang W,Zhang T,Xu Y,Xu N,Yang Y,Han J,C

更新日期：2020-05-20 00:00:00

abstract：:Metabolites of the intestinal microbiota are thought to be generated through metabolic pathways spanning multiple taxa of intestinal bacteria. We have previously shown that the level of putrescine, a polyamine found abundantly in the human intestinal lumen, is increased in the colonic lumen following administration of...

journal_title：Science advances

authors： Kitada Y,Muramatsu K,Toju H,Kibe R,Benno Y,Kurihara S,Matsumoto M

更新日期：2018-06-27 00:00:00

abstract：:Spatial patterns of gene expression in living organisms orchestrate cell decisions in development, homeostasis, and disease. However, most methods for reconstructing gene patterning in 3D cell culture and artificial tissues are restricted by patterning depth and scale. We introduce a depth- and scale-flexible method t...

journal_title：Science advances

authors： Corbett DC,Fabyan WB,Grigoryan B,O'Connor CE,Johansson F,Batalov I,Regier MC,DeForest CA,Miller JS,Stevens KR

更新日期：2020-09-30 00:00:00

abstract：:We introduce two photochromic proteins for cell-specific in vivo optoacoustic (OA) imaging with signal unmixing in the temporal domain. We show highly sensitive, multiplexed visualization of T lymphocytes, bacteria, and tumors in the mouse body and brain. We developed machine learning-based software for commercial ima...

journal_title：Science advances

authors： Mishra K,Stankevych M,Fuenzalida-Werner JP,Grassmann S,Gujrati V,Huang Y,Klemm U,Buchholz VR,Ntziachristos V,Stiel AC

更新日期：2020-06-12 00:00:00

abstract：:The outbreak of the highly contagious and deadly severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also known as coronavirus disease 2019 (COVID-19), has posed a serious threat to public health across the globe, calling for the development of effective diagnostic markers and therapeutics. Here, we report a...

journal_title：Science advances

authors： Park HH,Kim HN,Kim H,Yoo Y,Shin H,Choi EY,Bae JS,Lee W

更新日期：2020-07-31 00:00:00

abstract：:A growing body of empirical evidence is revealing the value of nature experience for mental health. With rapid urbanization and declines in human contact with nature globally, crucial decisions must be made about how to preserve and enhance opportunities for nature experience. Here, we first provide points of consensu...

journal_title：Science advances

authors： Bratman GN,Anderson CB,Berman MG,Cochran B,de Vries S,Flanders J,Folke C,Frumkin H,Gross JJ,Hartig T,Kahn PH Jr,Kuo M,Lawler JJ,Levin PS,Lindahl T,Meyer-Lindenberg A,Mitchell R,Ouyang Z,Roe J,Scarlett L,Smith JR,

更新日期：2019-07-24 00:00:00

abstract：:Nanoparticles have been extensively used for inflammation imaging and photodynamic therapy of cancer. However, the major translational barriers to most nanoparticle-based imaging and therapy applications are the limited depth of tissue penetration, inevitable requirement of external irradiation, and poor biocompatibil...

journal_title：Science advances

authors： Xu X,An H,Zhang D,Tao H,Dou Y,Li X,Huang J,Zhang J

更新日期：2019-01-09 00:00:00

abstract：:During the Last Glacial Maximum, expansive continental ice sheets lowered globally averaged sea level ~130 m, exposing a land bridge at the Bering Strait. During the subsequent deglaciation, sea level rose rapidly and ultimately flooded the Bering Strait, linking the Arctic and Pacific Oceans. Observational records of...

journal_title：Science advances

authors： Pico T,Mitrovica JX,Mix AC

更新日期：2020-02-26 00:00:00