The polar regions in a 2°C warmer world.

abstract：:Two-dimensional (2D) semiconductors have shown great potential for electronic and optoelectronic applications. However, their development is limited by a large Schottky barrier (SB) at the metal-semiconductor junction (MSJ), which is difficult to tune by using conventional metals because of the effect of strong Fermi ...

journal_title：Science advances

authors： Liu Y,Stradins P,Wei SH

更新日期：2016-04-22 00:00:00

abstract：:The integration of structure and function for tissue engineering scaffolds is of great importance in mimicking native bone tissue. However, the complexity of hierarchical structures, the requirement for mechanical properties, and the diversity of bone resident cells are the major challenges in constructing biomimetic ...

journal_title：Science advances

authors： Zhang M,Lin R,Wang X,Xue J,Deng C,Feng C,Zhuang H,Ma J,Qin C,Wan L,Chang J,Wu C

更新日期：2020-03-20 00:00:00

abstract：:Resistances that exceed the Mott-Ioffe-Regel limit (known as bad metal behavior) and non-Fermi liquid behavior are ubiquitous features of the normal state of many strongly correlated materials. We establish the conditions that lead to bad metal and non-Fermi liquid phases in NdNiO3, which exhibits a prototype bandwidt...

journal_title：Science advances

authors： Mikheev E,Hauser AJ,Himmetoglu B,Moreno NE,Janotti A,Van de Walle CG,Stemmer S

更新日期：2015-11-06 00:00:00

abstract：:Detection of amyloid-β (Aβ) aggregates contributes to the diagnosis of Alzheimer disease (AD). Plasma Aβ is deemed a less invasive and more accessible hallmark of AD, as Aβ can penetrate blood-brain barriers. However, correlations between biofluidic Aβ concentrations and AD progression has been tenuous. Here, we intro...

journal_title：Science advances

authors： Kim Y,Yoo YK,Kim HY,Roh JH,Kim J,Baek S,Lee JC,Kim HJ,Chae MS,Jeong D,Park D,Lee S,Jang H,Kim K,Lee JH,Byun BH,Park SY,Ha JH,Lee KC,Cho WW,Kim JS,Koh JY,Lim SM,Hwang KS

更新日期：2019-04-17 00:00:00

abstract：:Cues sent by political elites are known to influence public attitudes and behavior. Polarization in elite rhetoric may hinder effective responses to public health crises, when accurate information and rapid behavioral change can save lives. We examine polarization in cues sent to the public by current members of the U...

journal_title：Science advances

authors： Green J,Edgerton J,Naftel D,Shoub K,Cranmer SJ

更新日期：2020-07-10 00:00:00

abstract：:Dysregulated physical stresses are generated during tumorigenesis that affect the surrounding compliant tissues including adipocytes. However, the effect of physical stressors on the behavior of adipocytes and their cross-talk with tumor cells remain elusive. Here, we demonstrate that compression of cells, resulting f...

journal_title：Science advances

authors： Li Y,Mao AS,Seo BR,Zhao X,Gupta SK,Chen M,Han YL,Shih TY,Mooney DJ,Guo M

更新日期：2020-01-22 00:00:00

abstract：:Six percent of Americans, including 3 million high schoolers, use e-cigarettes, which contain potentially toxic substances, volatile organic compounds, and metals. We present the first human study on the effects of e-cigarette exposure in the oral cavity. By interrogating both immunoinflammatory responses and microbia...

journal_title：Science advances

authors： Ganesan SM,Dabdoub SM,Nagaraja HN,Scott ML,Pamulapati S,Berman ML,Shields PG,Wewers ME,Kumar PS

更新日期：2020-05-27 00:00:00

abstract：:Nanometer-scale skyrmions are prospective candidates for information bits in low-power consumption devices owing to their topological nature and controllability with low current density. Studies on skyrmion dynamics in different classes of materials have exploited the topological Hall effect and current-driven fast mo...

journal_title：Science advances

authors： Yu XZ,Morikawa D,Nakajima K,Shibata K,Kanazawa N,Arima T,Nagaosa N,Tokura Y

更新日期：2020-06-17 00:00:00

abstract：:Human settlement of the Caribbean represents the only example in the Americas of peoples colonizing islands that were not visible from surrounding mainland areas or other islands. Unfortunately, many interpretive models have relied on radiocarbon determinations that do not meet standard criteria for reporting because ...

journal_title：Science advances

authors： Napolitano MF,DiNapoli RJ,Stone JH,Levin MJ,Jew NP,Lane BG,O'Connor JT,Fitzpatrick SM

更新日期：2019-12-18 00:00:00

abstract：:The inherent specificity and electrochemical reversibility of enzymes poise them as the biorecognition element of choice for a wide range of metabolites. To use enzymes efficiently in biosensors, the redox centers of the protein should have good electrical communication with the transducing electrode, which requires e...

journal_title：Science advances

authors： Pappa AM,Ohayon D,Giovannitti A,Maria IP,Savva A,Uguz I,Rivnay J,McCulloch I,Owens RM,Inal S

更新日期：2018-06-22 00:00:00

abstract：:The wiring of vertebrate and invertebrate brains provides the anatomical skeleton for cognition and behavior. Connections among brain regions are characterized by heterogeneous strength that is parsimoniously described by the wiring cost and homophily principles. Moreover, brains exhibit a characteristic global networ...

journal_title：Science advances

authors： Goulas A,Betzel RF,Hilgetag CC

更新日期：2019-06-12 00:00:00

abstract：:Metabolic reprogramming is widely considered a hallmark of cancer, and understanding metabolic dynamics described by the conversion rates or "fluxes" of metabolites can shed light onto biological processes of tumorigenesis and response to therapy. For real-time analysis of metabolic flux in intact cells or organisms, ...

journal_title：Science advances

authors： Jeong S,Eskandari R,Park SM,Alvarez J,Tee SS,Weissleder R,Kharas MG,Lee H,Keshari KR

更新日期：2017-06-16 00:00:00

abstract：:The ability of cytosolic lipopolysaccharide (LPS) to activate caspase-11-dependent nonclassical inflammasome is intricately controlled to avoid excessive inflammatory responses. However, very little is known about the regulatory role of various metabolic pathways in the control of caspase-11 activation. Here, we demon...

journal_title：Science advances

authors： Chen R,Zeng L,Zhu S,Liu J,Zeh HJ,Kroemer G,Wang H,Billiar TR,Jiang J,Tang D,Kang R

更新日期：2019-05-22 00:00:00

abstract：:Photonic crystal nanocavities, which have modal volumes of the order of a cubic wavelength in the material, are of great interest as flexible platforms for manipulating photons. Recent developments in ultra-high quality factor nanocavities with long photon lifetimes have encouraged us to develop an ultra-compact and f...

journal_title：Science advances

authors： Konoike R,Nakagawa H,Nakadai M,Asano T,Tanaka Y,Noda S

更新日期：2016-05-20 00:00:00

abstract：:Improved constraints on lower-mantle composition are fundamental to understand the accretion, differentiation, and thermochemical evolution of our planet. Cosmochemical arguments indicate that lower-mantle rocks may be enriched in Si relative to upper-mantle pyrolite, whereas seismic tomography images suggest whole-ma...

journal_title：Science advances

authors： Ballmer MD,Schmerr NC,Nakagawa T,Ritsema J

更新日期：2015-12-10 00:00:00

abstract：:One of the most plausible scenarios of the origin of life assumes the preceding prebiotic autotrophic metabolism in sulfide-rich hydrothermal vent environments. However, geochemical mechanisms to harness the reductive power provided by hydrothermal systems remain to be elucidated. Here, we show that, under a geoelectr...

journal_title：Science advances

authors： Kitadai N,Nakamura R,Yamamoto M,Takai K,Yoshida N,Oono Y

更新日期：2019-06-19 00:00:00

abstract：:The high-lying vibrational states of the magnesium dimer (Mg2), which has been recognized as an important system in studies of ultracold and collisional phenomena, have eluded experimental characterization for half a century. Until now, only the first 14 vibrational states of Mg2 have been experimentally resolved, alt...

journal_title：Science advances

authors： Yuwono SH,Magoulas I,Piecuch P

更新日期：2020-04-03 00:00:00

abstract：:The progression in the hair follicle cycle from the telogen to the anagen phase is the key to regulating hair regrowth. Dermal papilla (DP) cells support hair growth and regulate the hair cycle. However, they gradually lose key inductive properties upon culture. DP cells can partially restore their capacity to promote...

journal_title：Science advances

authors： Hu S,Li Z,Lutz H,Huang K,Su T,Cores J,Dinh PC,Cheng K

更新日期：2020-07-24 00:00:00

abstract：:Like most homeostatic systems, adiposity in mammals is defended between upper and lower boundary conditions. While leptin and melanocortin-4 receptor (MC4R) signaling are required for defending energy set point, mechanisms controlling upper and lower homeostatic boundaries are less well understood. In contrast to the ...

journal_title：Science advances

authors： Ghamari-Langroudi M,Cakir I,Lippert RN,Sweeney P,Litt MJ,Ellacott KLJ,Cone RD

更新日期：2018-08-22 00:00:00

abstract：:Mesoscale turbulence in the ocean strongly affects the circulation, water mass formation, and transport of tracers. Little is known, however, about how mixing varies on climate timescales. We present the first time-resolved global dataset of lateral mesoscale eddy diffusivities at the ocean surface, obtained by applyi...

journal_title：Science advances

authors： Busecke JJM,Abernathey RP

更新日期：2019-01-23 00:00:00

abstract：:Surface plasmon resonance microscopy (SPRM) with single-direction illumination is a powerful platform for biomedical imaging because of its wide-field, label-free, and high-surface-sensitivity imaging capabilities. However, two disadvantages prevent wider use of SPRM. The first is its poor spatial resolution that can ...

journal_title：Science advances

authors： Kuai Y,Chen J,Tang X,Xiang Y,Lu F,Kuang C,Xu L,Shen W,Cheng J,Gui H,Zou G,Wang P,Ming H,Liu J,Liu X,Lakowicz JR,Zhang D

更新日期：2019-03-29 00:00:00

abstract：:Human genome-wide association studies have linked single-nucleotide polymorphisms (SNPs) in NEMP1 (nuclear envelope membrane protein 1) with early menopause; however, it is unclear whether NEMP1 has any role in fertility. We show that whole-animal loss of NEMP1 homologs in Drosophila, Caenorhabditis elegans, zebrafish...

journal_title：Science advances

authors： Tsatskis Y,Rosenfeld R,Pearson JD,Boswell C,Qu Y,Kim K,Fabian L,Mohammad A,Wang X,Robson MI,Krchma K,Wu J,Gonçalves J,Hodzic D,Wu S,Potter D,Pelletier L,Dunham WH,Gingras AC,Sun Y,Meng J,Godt D,Schedl T,Ciru

更新日期：2020-08-28 00:00:00

abstract：:Oncogenic RAS mutant (RASMUT) proteins have been considered undruggable via conventional antibody regimens owing to the intracellular location restricting conventional-antibody accessibility. Here, we report a pan-RAS-targeting IgG antibody, inRas37, which directly targets the intracellularly activated form of various...

journal_title：Science advances

authors： Shin SM,Kim JS,Park SW,Jun SY,Kweon HJ,Choi DK,Lee D,Cho YB,Kim YS

更新日期：2020-01-15 00:00:00

abstract：:Oocyte numbers, a critical determinant of female reproductive fitness, are highly regulated, yet the mechanisms underlying this regulation remain largely undefined. In the Caenorhabditis elegans gonad, RAS/extracellular signal-regulated kinase (ERK) signaling regulates oocyte numbers; mechanisms are unknown. We show t...

journal_title：Science advances

authors： Das D,Chen SY,Arur S

更新日期：2020-10-30 00:00:00

abstract：:Artificial liquid-repellent surfaces have attracted substantial scientific and industrial attention with a focus on creating functional topological features; however, the role of the underlying structures has been overlooked. Recent developments in micro-nanofabrication allow us now to construct a skin-muscle type sys...

journal_title：Science advances

authors： Hu S,Cao X,Reddyhoff T,Puhan D,Vladescu SC,Wang J,Shi X,Peng Z,deMello AJ,Dini D

更新日期：2020-08-05 00:00:00

abstract：:Hedgehog signaling is central in embryonic development and tissue regeneration. Disruption of the pathway is linked to genetic diseases and cancer. Binding of the secreted ligand, Sonic hedgehog (ShhN) to its receptor Patched (PTCH1) activates the signaling pathway. Here, we describe a 3.4-Å cryo-EM structure of the h...

journal_title：Science advances

authors： Qi C,Di Minin G,Vercellino I,Wutz A,Korkhov VM

更新日期：2019-09-18 00:00:00

abstract：:Massive declines in population abundances of marine animals have been documented over century-long time scales. However, analogous loss of spatial extent of habitat-forming organisms is less well known because georeferenced data are rare over long time scales, particularly in subtidal, tropical marine regions. We use ...

journal_title：Science advances

authors： McClenachan L,O'Connor G,Neal BP,Pandolfi JM,Jackson JBC

更新日期：2017-09-06 00:00:00

abstract：:Analog machine learning hardware platforms promise to be faster and more energy efficient than their digital counterparts. Wave physics, as found in acoustics and optics, is a natural candidate for building analog processors for time-varying signals. Here, we identify a mapping between the dynamics of wave physics and...

journal_title：Science advances

authors： Hughes TW,Williamson IAD,Minkov M,Fan S

更新日期：2019-12-20 00:00:00

abstract：:The natural selection and the evolutionary optimization of complex shapes in nature are closely related to their functions. Mechanostabilization of shape of biological structure via morphogenesis has several beautiful examples. With the help of simple mechanics-based modeling and experiments, we show an important caus...

journal_title：Science advances

authors： Tiwary CS,Kishore S,Sarkar S,Mahapatra DR,Ajayan PM,Chattopadhyay K

更新日期：2015-05-15 00:00:00

abstract：:Fractures and faults riddle the Earth's crust on all scales, and the deformation associated with them is presumed to have had significant effects on its petrological and structural evolution. However, despite the abundance of directly observable earthquake activity, unequivocal evidence for seismic slip rates along an...

journal_title：Science advances

authors： Austrheim H,Dunkel KG,Plümper O,Ildefonse B,Liu Y,Jamtveit B

更新日期：2017-02-22 00:00:00