Abstract:
:The integration of structure and function for tissue engineering scaffolds is of great importance in mimicking native bone tissue. However, the complexity of hierarchical structures, the requirement for mechanical properties, and the diversity of bone resident cells are the major challenges in constructing biomimetic bone tissue engineering scaffolds. Herein, a Haversian bone-mimicking scaffold with integrated hierarchical Haversian bone structure was successfully prepared via digital laser processing (DLP)-based 3D printing. The compressive strength and porosity of scaffolds could be well controlled by altering the parameters of the Haversian bone-mimicking structure. The Haversian bone-mimicking scaffolds showed great potential for multicellular delivery by inducing osteogenic, angiogenic, and neurogenic differentiation in vitro and accelerated the ingrowth of blood vessels and new bone formation in vivo. The work offers a new strategy for designing structured and functionalized biomaterials through mimicking native complex bone tissue for tissue regeneration.
journal_name
Sci Advjournal_title
Science advancesauthors
Zhang M,Lin R,Wang X,Xue J,Deng C,Feng C,Zhuang H,Ma J,Qin C,Wan L,Chang J,Wu Cdoi
10.1126/sciadv.aaz6725subject
Has Abstractpub_date
2020-03-20 00:00:00pages
eaaz6725issue
12issn
2375-2548pii
aaz6725journal_volume
6pub_type
杂志文章相关文献
Science Advances文献大全abstract::We tested how sediment trapping by hydroelectric dams affects tropical estuaries by comparing two dammed and two undammed rivers on Mexico's Pacific coast. We found that dams demonstrably affected the stability and productivity of the estuaries. The two rivers dammed for hydroelectricity had a rapid coastal recession ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aau9875
更新日期:2019-03-13 00:00:00
abstract::Transistors with exfoliated two-dimensional (2D) materials on a SiO2/Si substrate have been applied and have been proven effective in a wide range of applications, such as circuits, memory, photodetectors, gas sensors, optical modulators, valleytronics, and spintronics. However, these devices usually suffer from limit...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1602246
更新日期:2017-05-19 00:00:00
abstract::Fluid catalytic cracking (FCC) particles account for 40 to 45% of worldwide gasoline production. The hierarchical complex particle pore structure allows access of long-chain feedstock molecules into active catalyst domains where they are cracked into smaller, more valuable hydrocarbon products (for example, gasoline)....
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1400199
更新日期:2015-04-03 00:00:00
abstract::Infants' remarkable learning abilities allow them to rapidly acquire many complex skills. It has been suggested that infants achieve this learning by optimally allocating their attention to relevant stimuli in the environment, but the underlying mechanisms remain poorly understood. Here, we modeled infants' looking be...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb5053
更新日期:2020-09-23 00:00:00
abstract::Black phosphorus (BP) offers considerable promise for infrared and visible photonics. Efficient tuning of the bandgap and higher subbands in BP by modulation of the Fermi level or application of vertical electric fields has been previously demonstrated, allowing electrical control of its above-bandgap optical properti...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abd4623
更新日期:2021-01-08 00:00:00
abstract::Leukemia is a complex heterogeneous disease often driven by the expression of oncogenic fusion proteins with different molecular and biochemical properties. Whereas several fusion proteins induce leukemogenesis by activating Hox gene expression (Hox-activating fusions), others impinge on different pathways that do not...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1600972
更新日期:2016-10-07 00:00:00
abstract::Anti-programmed cell death 1 ligand 1 (PD-L1) therapy is extraordinarily effective in select patients with cancer. However, insufficient lymphocytic infiltration, weak T cell-induced inflammation, and immunosuppressive cell accumulation in the tumor microenvironment (TME) may greatly diminish the efficacy. Here, we re...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaz9240
更新日期:2020-05-15 00:00:00
abstract::Can mating influence cognitive functions such as learning and memory in a permanent way? We have addressed this question using a combined behavioral and in vivo imaging approach, finding that aversive long-term memory performance strongly increases in Drosophila females in response to sperm transfer following mating. ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aax3432
更新日期:2019-11-20 00:00:00
abstract::Soft robotics may enable many new technologies in which humans and robots physically interact, yet the necessary high-performance soft actuators still do not exist. The optimal soft actuators need to be fast and forceful and have programmable shape changes. Furthermore, they should be energy efficient for untethered a...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aay0855
更新日期:2019-11-22 00:00:00
abstract::Achieving perovskite-based high-color purity blue-emitting light-emitting diodes (LEDs) is still challenging. Here, we report successful synthesis of a series of blue-emissive two-dimensional Ruddlesden-Popper phase single crystals and their high-color purity blue-emitting LED demonstrations. Although this approach su...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aay4045
更新日期:2020-01-24 00:00:00
abstract::Driven by advances in materials and computer science, researchers are attempting to design systems where the computer and material are one and the same entity. Using theoretical and computational modeling, we design a hybrid material system that can autonomously transduce chemical, mechanical, and electrical energy to...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1601114
更新日期:2016-09-02 00:00:00
abstract::Kozmin et al. contend that observations previously reported regarding the antimicrobial and antitumor activities of 6-N-hydroxy aminopurine (6-HAP) were incorrect. Their conclusions rely on poorly characterized reagents and focus strictly on in vitro techniques without validation in relevant mammalian model systems. W...
journal_title:Science advances
pub_type: 评论,杂志文章
doi:10.1126/sciadv.aay5611
更新日期:2019-09-11 00:00:00
abstract::The accelerating global spread of arboviruses, such as Zika virus (ZIKV), highlights the need for more proactive mosquito surveillance. However, a major challenge during arbovirus outbreaks has been the lack of rapid and affordable tests for pathogen detection in mosquitoes. We show for the first time that near-infrar...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aat0496
更新日期:2018-05-23 00:00:00
abstract::We studied a bilayer system hosting two-dimensional electron systems (2DESs) in close proximity but isolated from one another by a thin barrier. One 2DES has low electron density and forms a Wigner solid (WS) at high magnetic fields. The other has much higher density and, in the same field, exhibits fractional quantum...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aao2848
更新日期:2019-03-15 00:00:00
abstract::Superomniphobic textures are at the frontier of surface design for vast arrays of applications. Despite recent substantial advances in fabrication methods for reentrant and doubly reentrant microstructures, design optimization remains a major challenge. We overcome this in two stages. First, we develop readily general...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aav7328
更新日期:2019-06-21 00:00:00
abstract::Telomerase is a ribonucleoprotein complex that catalyzes addition of telomeric DNA repeats to maintain telomeres in replicating cells. Here, we demonstrate that the telomerase protein hTERT performs an additional role at telomeres that is independent of telomerase catalytic activity yet essential for telomere integrit...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aav4409
更新日期:2019-10-02 00:00:00
abstract::Tumor-associated macrophages (TAMs) influence lung tumor development by inducing immunosuppression. Transcriptome analysis of TAMs isolated from human lung tumor tissues revealed an up-regulation of the Wnt/β-catenin pathway. These findings were reproduced in a newly developed in vitro "trained" TAM model. Pharmacolog...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaz6105
更新日期:2020-06-05 00:00:00
abstract::There have been increasing attempts to reverse habitat degradation through active restoration, but few large-scale successes are reported to guide these efforts. Here, we report outcomes from a unique and very successful seagrass restoration project: Since 1999, over 70 million seeds of a marine angiosperm, eelgrass (...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abc6434
更新日期:2020-10-07 00:00:00
abstract::Metal-organic frameworks (MOFs) have been attracting intensive attention because of their commendable potential in many applications. Postsynthetic modification for redesigning chemical characteristics and pore structures can greatly improve performance and expand functionality of MOF materials. Here, we develop a ver...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aax7270
更新日期:2020-05-01 00:00:00
abstract::Chiral fermions in solid state feature "Fermi arc" states, connecting the surface projections of the bulk chiral nodes. The surface Fermi arc is a signature of nontrivial bulk topology. Unconventional chiral fermions with an extensive Fermi arc traversing the whole Brillouin zone have been theoretically proposed in Co...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaw9485
更新日期:2019-12-20 00:00:00
abstract::Cues sent by political elites are known to influence public attitudes and behavior. Polarization in elite rhetoric may hinder effective responses to public health crises, when accurate information and rapid behavioral change can save lives. We examine polarization in cues sent to the public by current members of the U...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abc2717
更新日期:2020-07-10 00:00:00
abstract::Development of composite indicators for integrated health in populations typically relies on a priori assumptions rather than model-free, data-driven evidence. Traditional variable selection processes tend not to consider relatedness and redundancy among variables, instead considering only individual correlations. In ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1701088
更新日期:2018-02-02 00:00:00
abstract::The fabrication of three-dimensional (3D) objects by polymer self-assembly in solution is extremely challenging. Here, multi-tori mesostructures were obtained from the crystallization-driven self-assembly of a coil-crystalline block copolymer (BCP) in mixed solvents. The formation of these structures follows a multist...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaz7301
更新日期:2020-04-15 00:00:00
abstract::Low-dimensional materials usually exhibit mechanical properties from those of their bulk counterparts. Here, we show in two-dimensional (2D) rhenium disulfide (ReS2) that the fracture processes are dominated by a variety of previously unidentified phenomena, which are not present in bulk materials. Through direct tran...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abc2282
更新日期:2020-11-18 00:00:00
abstract::Quantum teleportation, which is the transfer of an unknown quantum state from one station to another over a certain distance with the help of nonlocal entanglement shared by a sender and a receiver, has been widely used as a fundamental element in quantum communication and quantum computation. Optical fibers are cruci...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aas9401
更新日期:2018-10-19 00:00:00
abstract::Iron deficiency and anemia are prominent contributors to the preventable disease burden worldwide. A substantial proportion of people with inadequate dietary iron rely on rice as a staple food, but fortification efforts are limited by low iron bioavailability. Furthermore, using high iron fortification dosages may not...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aau0790
更新日期:2019-03-27 00:00:00
abstract::The homotrimeric molecular chaperone Skp of Gram-negative bacteria facilitates the transport of outer membrane proteins across the periplasm. It has been unclear how its activity is modulated during its functional cycle. Here, we report an atomic-resolution characterization of the Escherichia coli Skp monomer-trimer t...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abc5822
更新日期:2020-10-21 00:00:00
abstract::Intrinsic immune defenses mediated by restriction factors inhibit productive viral infections. Select viruses rapidly establish latent infections and, with gene expression profiles that imply cell-autonomous intrinsic defenses, may be the most effective immune control measure against latent reservoirs. We illustrate t...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1501164
更新日期:2015-11-27 00:00:00
abstract::Noble metal foams (NMFs) are a new class of functional materials featuring properties of both noble metals and monolithic porous materials, providing impressive prospects in diverse fields. Among reported synthetic methods, the sol-gel approach manifests overwhelming advantages for versatile synthesis of nanostructure...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaw4590
更新日期:2019-05-24 00:00:00
abstract::Selective nerve transfers surgically rewire motor neurons and are used in extremity reconstruction to restore muscle function or to facilitate intuitive prosthetic control. We investigated the neurophysiological effects of rewiring motor axons originating from spinal motor neuron pools into target muscles with lower i...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aau2956
更新日期:2019-01-02 00:00:00