Micronutrient-fortified rice can be a significant source of dietary bioavailable iron in schoolchildren from rural Ghana.

Abstract:

:Iron deficiency and anemia are prominent contributors to the preventable disease burden worldwide. A substantial proportion of people with inadequate dietary iron rely on rice as a staple food, but fortification efforts are limited by low iron bioavailability. Furthermore, using high iron fortification dosages may not always be prudent in tropical regions. To identify alternative fortification formulations with enhanced absorption, we screened different iron compounds for their suitability as rice fortificants, measured in vitro gastric solubility, and assessed dietary iron bioavailability using stable isotopic labels in rural Ghanaian children. Isotopic incorporation in red blood cells indicates that in the two age groups of children investigated (4 to 6 and 7 to 10 years), formulations provided 36 and 51% of the median daily requirement in absorbed iron, respectively. We describe approaches to enhancing iron bioavailability from fortified rice, which can substantially contribute to the prevention of iron deficiency in rice-eating populations.

journal_name

Sci Adv

journal_title

Science advances

authors

Hackl LS,Abizari AR,Speich C,Zungbey-Garti H,Cercamondi CI,Zeder C,Zimmermann MB,Moretti D

doi

10.1126/sciadv.aau0790

subject

Has Abstract

pub_date

2019-03-27 00:00:00

pages

eaau0790

issue

3

issn

2375-2548

pii

aau0790

journal_volume

5

pub_type

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