Abstract:
:Intrinsic immune defenses mediated by restriction factors inhibit productive viral infections. Select viruses rapidly establish latent infections and, with gene expression profiles that imply cell-autonomous intrinsic defenses, may be the most effective immune control measure against latent reservoirs. We illustrate that lysine-specific demethylases (KDMs) are restriction factors that prevent human cytomegalovirus from establishing latency by removing repressive epigenetic modifications from histones associated with the viral major immediate early promoter (MIEP), stimulating the expression of a viral lytic phase target of cell-mediated adaptive immunity. The viral UL138 protein negates this defense by preventing KDM association with the MIEP. The presence of an intrinsic defense against latency and the emergence of a cognate neutralizing viral factor indicate that "arms races" between hosts and viruses over lifelong colonization exist at the cellular level.
journal_name
Sci Advjournal_title
Science advancesauthors
Lee SH,Albright ER,Lee JH,Jacobs D,Kalejta RFdoi
10.1126/sciadv.1501164subject
Has Abstractpub_date
2015-11-27 00:00:00pages
e1501164issue
10issn
2375-2548pii
1501164journal_volume
1pub_type
杂志文章相关文献
Science Advances文献大全abstract::Eruptive phenomena at all scales, from hydrothermal geysers to flood basalts, can potentially be initiated or modulated by external mechanical perturbations. We present evidence for the triggering of magmatism on a global scale by the Chicxulub meteorite impact at the Cretaceous-Paleogene (K-Pg) boundary, recorded by ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aao2994
更新日期:2018-02-07 00:00:00
abstract::Increasing occurrence of moderate to severe intrauterine adhesion (IUA) is seriously affecting the quality of human life. The aim of the study was to establish IUA models in nonhuman primates and to explore the dual repair effects of human umbilical cord-derived mesenchymal stem cells (huMSCs) loaded on autocrosslinke...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aba6357
更新日期:2020-05-22 00:00:00
abstract::Wearable sweat analysis devices for monitoring of multiple health-related biomarkers with high sensitivity are highly desired for noninvasive and real-time monitoring of human health. Here, we report a flexible sweat analysis patch based on a silk fabric-derived carbon textile for simultaneous detection of six health-...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aax0649
更新日期:2019-11-08 00:00:00
abstract::The importance of comets for the origin of life on Earth has been advocated for many decades. Amino acids are key ingredients in chemistry, leading to life as we know it. Many primitive meteorites contain amino acids, and it is generally believed that these are formed by aqueous alterations. In the collector aerogel a...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1600285
更新日期:2016-05-27 00:00:00
abstract::The role of sialyloligosaccharides on the surface of secreted glycoproteins is still unclear because of the difficulty in the preparation of sialylglycoproteins in a homogeneous form. We selected erythropoietin (EPO) as a target molecule and designed an efficient synthetic strategy for the chemical synthesis of a homo...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1500678
更新日期:2016-01-15 00:00:00
abstract::Extinction of conditioned fear necessitates the dynamic involvement of hippocampus, medial prefrontal cortex (mPFC), and basolateral amygdala (BLA), but key molecular players that regulate these circuits to achieve fear extinction remain largely unknown. Here, we report that acid-sensing ion channel 1a (ASIC1a) is a c...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aau3075
更新日期:2018-10-24 00:00:00
abstract::Photoresponsive liquid crystalline elastomers (LCEs) constitute ideal actuators for soft robots because their light-induced macroscopic shape changes can be harnessed to perform specific articulated motions. Conventional LCEs, however, do not typically exhibit complex modes of bending and twisting necessary to perform...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aay5349
更新日期:2020-03-27 00:00:00
abstract::Approaching predators cast expanding shadows (i.e., looming) that elicit innate defensive responses in most animals. Where looming is first detected and how critical parameters of predatory approaches are extracted are unclear. In mice, we identify a retinal interneuron (the VG3 amacrine cell) that responds robustly t...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abc9920
更新日期:2020-11-18 00:00:00
abstract::In vitro selection of antibodies from large repertoires of immunoglobulin (Ig) combining sites using combinatorial libraries is a powerful tool, with great potential for generating in vivo scavengers for toxins. However, addition of a maturation function is necessary to enable these selected antibodies to more closely...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1501695
更新日期:2016-10-19 00:00:00
abstract::Immune regulatory metabolites are key features of the tumor microenvironment (TME), yet with a few exceptions, their identities remain largely unknown. Here, we profiled tumor and T cells from tumor and ascites of patients with high-grade serous carcinoma (HGSC) to uncover the metabolomes of these distinct TME compart...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abe1174
更新日期:2021-01-20 00:00:00
abstract::The single-span membrane protein KCNE3 modulates a variety of voltage-gated ion channels in diverse biological contexts. In epithelial cells, KCNE3 regulates the function of the KCNQ1 potassium ion (K(+)) channel to enable K(+) recycling coupled to transepithelial chloride ion (Cl(-)) secretion, a physiologically crit...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1501228
更新日期:2016-09-09 00:00:00
abstract::Transistors with exfoliated two-dimensional (2D) materials on a SiO2/Si substrate have been applied and have been proven effective in a wide range of applications, such as circuits, memory, photodetectors, gas sensors, optical modulators, valleytronics, and spintronics. However, these devices usually suffer from limit...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1602246
更新日期:2017-05-19 00:00:00
abstract::Biogenesis in prokaryotes and eukaryotes requires the insertion of α-helical proteins into cellular membranes for which they use universally conserved cellular machineries. In bacterial inner membranes, insertion is facilitated by YidC insertase and SecYEG translocon working individually or cooperatively. How insertas...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aau6824
更新日期:2019-01-30 00:00:00
abstract::Behavioral and clinical studies suggest a critical role of substance P (SP)/neurokinin-1 receptor (NK-1R) signaling in alcohol dependence. Here, we examined regulation of GABA transmission in the medial subdivision of the central amygdala (CeM) by the SP/NK-1R system, and its neuroadaptation following chronic alcohol ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaz1050
更新日期:2020-03-18 00:00:00
abstract::The Paris Agreement aims to mitigate the potential impacts of climate change on ecological and social systems. Using an ensemble of climate-marine ecosystem and economic models, we explore the effects of implementing the Agreement on fish, fishers, and seafood consumers worldwide. We find that implementing the Agreeme...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aau3855
更新日期:2019-02-27 00:00:00
abstract::Human sleep is highly regulated by temperature. Might climate change-through increases in nighttime heat-disrupt sleep in the future? We conduct the inaugural investigation of the relationship between climatic anomalies, reports of insufficient sleep, and projected climate change. Using data from 765,000 U.S. survey r...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1601555
更新日期:2017-05-26 00:00:00
abstract::Dendritic actin networks develop from a first actin filament through branching by the Arp2/3 complex. At the surface of endosomes, the WASH complex activates the Arp2/3 complex and interacts with the capping protein for unclear reasons. Here, we show that the WASH complex interacts with dynactin and uncaps it through ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abd5956
更新日期:2021-01-13 00:00:00
abstract::Granular dynamics govern earthquakes, avalanches, and landslides and are of fundamental importance in a variety of industries ranging from energy to pharmaceuticals to agriculture. Nonetheless, our understanding of the underlying physics is poor because we lack spatially and temporally resolved experimental measuremen...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1701879
更新日期:2017-09-15 00:00:00
abstract::We propose a method to use artificial neural networks to approximate light scattering by multilayer nanoparticles. We find that the network needs to be trained on only a small sampling of the data to approximate the simulation to high precision. Once the neural network is trained, it can simulate such optical processe...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aar4206
更新日期:2018-06-01 00:00:00
abstract::Neurochemical dysregulation underlies many pathologies and can be monitored by measuring the composition of brain interstitial fluid (ISF). Existing in vivo tools for sampling ISF do not enable measuring large rare molecules, such as proteins and neuropeptides, and thus cannot generate a complete picture of the neuroc...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb0657
更新日期:2020-09-25 00:00:00
abstract::Pathological cardiac hypertrophy eventually leads to heart failure without adequate treatment. The immunoproteasome is an inducible form of the proteasome that is intimately involved in inflammatory diseases. Here, we found that the expression and activity of immunoproteasome catalytic subunit β5i were significantly u...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aau0495
更新日期:2019-05-08 00:00:00
abstract::Materials with a stochastic microstructure, like foams, typically exhibit low mechanical stiffness, whereas lattices with a designed microarchitecture often show notably improved stiffness. These periodic architected materials have previously been designed by rule, using the Maxwell criterion to ensure that their defo...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaw1937
更新日期:2019-09-27 00:00:00
abstract::Organic carbonyl compounds represent a promising class of electrode materials for secondary batteries; however, the storage mechanism still remains unclear. We take Na2C6H2O4 as an example to unravel the mechanism. It consists of alternating Na-O octahedral inorganic layer and π-stacked benzene organic layer in spatia...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1500330
更新日期:2015-09-18 00:00:00
abstract::Functional materials with specific surface wettability play an important role in a wide variety of areas. Inspired by nature's Nepenthes pitcher plant, we present a novel slippery film with tunable wettability based on a shape-memory graphene sponge. The porous graphene sponge coated with shape-memory polymer was used...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1700004
更新日期:2017-06-02 00:00:00
abstract::Dewetting is a ubiquitous phenomenon in nature; many different thin films of organic and inorganic substances (such as liquids, polymers, metals, and semiconductors) share this shape instability driven by surface tension and mass transport. Via templated solid-state dewetting, we frame complex nanoarchitectures of mon...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aao1472
更新日期:2017-11-10 00:00:00
abstract::For natural microswimmers, the interplay of swimming activity and external flow can promote robust directed motion, for example, propulsion against (upstream rheotaxis) or perpendicular to the direction of flow. These effects are generally attributed to their complex body shapes and flagellar beat patterns. Using cata...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aao1755
更新日期:2018-01-26 00:00:00
abstract::Quantum teleportation, which is the transfer of an unknown quantum state from one station to another over a certain distance with the help of nonlocal entanglement shared by a sender and a receiver, has been widely used as a fundamental element in quantum communication and quantum computation. Optical fibers are cruci...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aas9401
更新日期:2018-10-19 00:00:00
abstract::The mammalian retina system consists of a complicated photoreceptor structure, which exhibits extensive random synaptic connections. To study retinal development and degeneration, various experimental models have been used previously, but these models are often uncontrollable, are difficult to manipulate, and do not p...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aas9274
更新日期:2018-05-09 00:00:00
abstract::Sodium/potassium-transporting adenosine triphosphatase (Na+/K+-ATPase) is one of the most abundant cell membrane proteins and is essential for eukaryotes. Endogenous negative regulators have long been postulated to play an important role in regulating the activity and stability of Na+/K+-ATPase, but characterization o...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb8542
更新日期:2020-10-28 00:00:00
abstract::V1-ATPase is an ATP-driven rotary motor that is composed of a ring-shaped A3B3 complex and a central DF shaft. The nucleotide-free A3B3 complex of Enterococcus hirae, composed of three identical A1B1 heterodimers, showed a unique asymmetrical structure, probably due to the strong binding of the N-terminal barrel domai...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aau8149
更新日期:2019-01-30 00:00:00