Structural basis for KCNE3 modulation of potassium recycling in epithelia.

abstract：:Ants (Hymenoptera: Formicidae) are diverse and ubiquitous, and their ability to sting is familiar to many of us. However, their venoms remain largely unstudied. We provide the first comprehensive characterization of a polypeptidic ant venom, that of the giant red bull ant, Myrmecia gulosa. We reveal a suite of novel p...

journal_title：Science advances

authors： Robinson SD,Mueller A,Clayton D,Starobova H,Hamilton BR,Payne RJ,Vetter I,King GF,Undheim EAB

更新日期：2018-09-12 00:00:00

abstract：:Peptidyl arginine deiminase 4 (PAD4) is a nuclear enzyme that converts arginine residues to citrulline. Although increasingly implicated in inflammatory disease and cancer, the mechanism of action of PAD4 and its functionally relevant pathways remains unclear. E2F transcription factors are a family of master regulator...

journal_title：Science advances

authors： Ghari F,Quirke AM,Munro S,Kawalkowska J,Picaud S,McGouran J,Subramanian V,Muth A,Williams R,Kessler B,Thompson PR,Fillipakopoulos P,Knapp S,Venables PJ,La Thangue NB

更新日期：2016-02-05 00:00:00

abstract：:Understanding the remarkable excitonic effects and controlling the exciton binding energies in two-dimensional (2D) semiconductors are crucial in unlocking their full potential for use in future photonic and optoelectronic devices. Here, we demonstrate large excitonic effects and gate-tunable exciton binding energies ...

journal_title：Science advances

authors： Qiu Z,Trushin M,Fang H,Verzhbitskiy I,Gao S,Laksono E,Yang M,Lyu P,Li J,Su J,Telychko M,Watanabe K,Taniguchi T,Wu J,Neto AHC,Yang L,Eda G,Adam S,Lu J

更新日期：2019-07-19 00:00:00

abstract：:Microsupercapacitors (MSCs) have garnered considerable attention as a promising power source for microelectronics and miniaturized portable/wearable devices. However, their practical application has been hindered by the manufacturing complexity and dimensional limits. Here, we develop a new class of ultrahigh areal nu...

journal_title：Science advances

authors： Lee KH,Lee SS,Ahn DB,Lee J,Byun D,Lee SY

更新日期：2020-03-06 00:00:00

abstract：:Neurodegeneration in mitochondrial disorders is considered irreversible because of limited metabolic plasticity in neurons, yet the cell-autonomous implications of mitochondrial dysfunction for neuronal metabolism in vivo are poorly understood. Here, we profiled the cell-specific proteome of Purkinje neurons undergoin...

journal_title：Science advances

authors： Motori E,Atanassov I,Kochan SMV,Folz-Donahue K,Sakthivelu V,Giavalisco P,Toni N,Puyal J,Larsson NG

更新日期：2020-08-28 00:00:00

abstract：:Ultraviolet (UV) reception is useful for such basic behaviors as mate choice, foraging, predator avoidance, communication, and navigation, whereas violet reception improves visual resolution and subtle contrast detection. UV and violet reception are mediated by the short wavelength-sensitive (SWS1) pigments that absor...

journal_title：Science advances

authors： Yokoyama S,Altun A,Jia H,Yang H,Koyama T,Faggionato D,Liu Y,Starmer WT

更新日期：2015-09-18 00:00:00

abstract：:Quantitative three-dimensional (3D) computed tomography (CT) imaging of living single cells enables orientation-independent morphometric analysis of the intricacies of cellular physiology. Since its invention, x-ray CT has become indispensable in the clinic for diagnostic and prognostic purposes due to its quantitativ...

journal_title：Science advances

authors： Kelbauskas L,Shetty R,Cao B,Wang KC,Smith D,Wang H,Chao SH,Gangaraju S,Ashcroft B,Kritzer M,Glenn H,Johnson RH,Meldrum DR

更新日期：2017-12-06 00:00:00

abstract：:Transcription factors control gene expression in all life. This raises the question of what is the smallest protein that can support such activity. In nature, Cro from bacteriophage λ is one of the smallest known repressors (66 amino acids), and activators are typically much larger (e.g., λ cI, 237 amino acids). Previ...

journal_title：Science advances

authors： Brödel AK,Rodrigues R,Jaramillo A,Isalan M

更新日期：2020-06-10 00:00:00

abstract：:Tumor angiogenesis provides critical nutrients for cancer progression and may also facilitate pathways for dissemination during the process of metastasis. It is well established that cells that metastasize display characteristics of stem cells; however, the prevailing paradigm points to these stem-like cells residing ...

journal_title：Science advances

authors： Lee J,Abdeen AA,Hedhli J,Wycislo KL,Dobrucka IT,Fan TM,Dobrucki LW,Kilian KA

更新日期：2017-10-25 00:00:00

abstract：:Altered cerebral glucose uptake is one of the hallmarks of Alzheimer's disease (AD). A dynamic glucose-enhanced (DGE) magnetic resonance imaging (MRI) approach was developed to simultaneously monitor d-glucose uptake and clearance in both brain parenchyma and cerebrospinal fluid (CSF). We observed substantially higher...

journal_title：Science advances

authors： Huang J,van Zijl PCM,Han X,Dong CM,Cheng GWY,Tse KH,Knutsson L,Chen L,Lai JHC,Wu EX,Xu J,Chan KWY

更新日期：2020-05-13 00:00:00

abstract：:Approaching predators cast expanding shadows (i.e., looming) that elicit innate defensive responses in most animals. Where looming is first detected and how critical parameters of predatory approaches are extracted are unclear. In mice, we identify a retinal interneuron (the VG3 amacrine cell) that responds robustly t...

journal_title：Science advances

authors： Kim T,Shen N,Hsiang JC,Johnson KP,Kerschensteiner D

更新日期：2020-11-18 00:00:00

abstract：:Fifty years after its discovery, the ovonic threshold switching (OTS) phenomenon, a unique nonlinear conductivity behavior observed in some chalcogenide glasses, has been recently the source of a real technological breakthrough in the field of data storage memories. This breakthrough was achieved because of the succes...

journal_title：Science advances

authors： Noé P,Verdy A,d'Acapito F,Dory JB,Bernard M,Navarro G,Jager JB,Gaudin J,Raty JY

更新日期：2020-02-28 00:00:00

abstract：:[This corrects the article DOI: 10.1126/sciadv.aaz7822.]. ...

journal_title：Science advances

authors：

更新日期：2020-07-08 00:00:00

abstract：:Biodiversity loss is a social and ecological emergency, and calls have been made for the global expansion of protected areas (PAs) to tackle this crisis. It is unclear, however, where best to locate new PAs to protect biodiversity cost-effectively. To answer this question, we conducted a spatial meta-analysis by overl...

journal_title：Science advances

authors： Yang R,Cao Y,Hou S,Peng Q,Wang X,Wang F,Tseng TH,Yu L,Carver S,Convery I,Zhao Z,Shen X,Li S,Zheng Y,Liu H,Gong P,Ma K

更新日期：2020-09-09 00:00:00

abstract：:Nanofluidic platforms offering tunable material transport are applicable in biosensing, chemical detection, and filtration. Prior studies have achieved selective and controllable ion transport through electrical, optical, or chemical gating of complex nanostructures. Here, we mechanically control nanofluidic transport...

journal_title：Science advances

authors： Rabinowitz J,Whittier E,Liu Z,Jayant K,Frank J,Shepard K

更新日期：2020-11-13 00:00:00

abstract：:Natural genetic variation affects circadian rhythms across the evolutionary tree, but the underlying molecular mechanisms are poorly understood. We investigated population-level, molecular circadian clock variation by generating >700 tissue-specific transcriptomes of Drosophila melanogaster (w1118 ) and 141 Drosophila...

journal_title：Science advances

authors： Litovchenko M,Meireles-Filho ACA,Frochaux MV,Bevers RPJ,Prunotto A,Anduaga AM,Hollis B,Gardeux V,Braman VS,Russeil JMC,Kadener S,Dal Peraro M,Deplancke B

更新日期：2021-01-29 00:00:00

abstract：:Solar-thermal desalination (STD) is a potentially low-cost, sustainable approach for providing high-quality fresh water in the absence of water and energy infrastructures. Despite recent efforts to advance STD by improving heat-absorbing materials and system designs, the best strategies for maximizing STD performance ...

journal_title：Science advances

authors： Wang Z,Horseman T,Straub AP,Yip NY,Li D,Elimelech M,Lin S

更新日期：2019-07-26 00:00:00

abstract：:We describe an approach to print composite polymers in high-resolution three-dimensional (3D) architectures that can be rapidly transformed to a new permanent configuration directly by heating. The permanent shape of a component results from the programmed time evolution of the printed shape upon heating via the desig...

journal_title：Science advances

authors： Ding Z,Yuan C,Peng X,Wang T,Qi HJ,Dunn ML

更新日期：2017-04-12 00:00:00

abstract：:Low-dimensional perovskites offer a rare opportunity to investigate lattice dynamics and charge carrier behavior in bulk quantum-confined solids, in addition to them being the leading materials in optoelectronic applications. In particular, zero-dimensional (0D) inorganic perovskites of the Cs4PbX6 (X = Cl, Br, or I) ...

journal_title：Science advances

authors： Yin J,Maity P,De Bastiani M,Dursun I,Bakr OM,Brédas JL,Mohammed OF

更新日期：2017-12-15 00:00:00

abstract：:Unraveling the genetic and epigenetic determinants of phenotypes is critical for understanding and re-engineering biology and would benefit from improved methods to separate cells based on phenotypes. Here, we report SPOTlight, a versatile high-throughput technique to isolate individual yeast or human cells with uniqu...

journal_title：Science advances

authors： Lee J,Liu Z,Suzuki PH,Ahrens JF,Lai S,Lu X,Guan S,St-Pierre F

更新日期：2020-10-23 00:00:00

abstract：:Marine ecosystems are responsible for virtually all production of omega-3 (ω3) long-chain polyunsaturated fatty acids (PUFA), which are essential nutrients for vertebrates. Current consensus is that marine microbes account for this production, given their possession of key enzymes including methyl-end (or "ωx") desatu...

journal_title：Science advances

authors： Kabeya N,Fonseca MM,Ferrier DEK,Navarro JC,Bay LK,Francis DS,Tocher DR,Castro LFC,Monroig Ó

更新日期：2018-05-02 00:00:00

abstract：:The ongoing conservation treatment program of the Ghent Altarpiece by Hubert and Jan Van Eyck, one of the iconic paintings of the west, has revealed that the designs of the paintings were changed several times, first by the original artists, and then during later restorations. The central motif, The Lamb of God, repre...

journal_title：Science advances

authors： Van der Snickt G,Dooley KA,Sanyova J,Dubois H,Delaney JK,Gifford EM,Legrand S,Laquiere N,Janssens K

更新日期：2020-07-29 00:00:00

abstract：:Honeybees use the waggle dance to share information about food-site locations with nestmates. However, the importance of this behavior in colony foraging success remains unclear. We tested whether spatial dance information affects colony foraging success in a human-modified temperate environment by comparing colonies ...

journal_title：Science advances

authors： I'Anson Price R,Dulex N,Vial N,Vincent C,Grüter C

更新日期：2019-02-13 00:00:00

abstract：:After European colonization, the ancestral remains of Indigenous people were often collected for scientific research or display in museum collections. For many decades, Indigenous people, including Native Americans and Aboriginal Australians, have fought for their return. However, many of these remains have no recorde...

journal_title：Science advances

authors： Wright JL,Wasef S,Heupink TH,Westaway MC,Rasmussen S,Pardoe C,Fourmile GG,Young M,Johnson T,Slade J,Kennedy R,Winch P,Pappin M Sr,Wales T,Bates WB,Hamilton S,Whyman N,van Holst Pellekaan S,McAllister PJ,Taçon PSC,

更新日期：2018-12-19 00:00:00

abstract：:Respiratory complex I is a redox-driven proton pump, accounting for a large part of the electrochemical gradient that powers mitochondrial adenosine triphosphate synthesis. Complex I dysfunction is associated with severe human diseases. Assembly of the one-megadalton complex I in the inner mitochondrial membrane requi...

journal_title：Science advances

authors： Parey K,Haapanen O,Sharma V,Köfeler H,Züllig T,Prinz S,Siegmund K,Wittig I,Mills DJ,Vonck J,Kühlbrandt W,Zickermann V

更新日期：2019-12-11 00:00:00

abstract：:An immense demand in biomedical imaging is to develop efficient photoluminescent probes with high biocompatibility and quantum yield, as well as multiphoton absorption performance to improve penetration depth and spatial resolution. Here, iron selenide (FeSe) quantum dots (QDs) are reported to meet these criteria. The...

journal_title：Science advances

authors： Kwon J,Jun SW,Choi SI,Mao X,Kim J,Koh EK,Kim YH,Kim SK,Hwang DY,Kim CS,Lee J

更新日期：2019-12-06 00:00:00

abstract：:The Wiedemann-Franz (WF) law has been tested in numerous solids, but the extent of its relevance to the anomalous transverse transport and the topological nature of the wave function, remains an open question. Here, we present a study of anomalous transverse response in the noncollinear antiferromagnet Mn3Ge extended ...

journal_title：Science advances

authors： Xu L,Li X,Lu X,Collignon C,Fu H,Koo J,Fauqué B,Yan B,Zhu Z,Behnia K

更新日期：2020-04-24 00:00:00

abstract：:Cost-benefit trade-offs for individuals participating in social behaviors are the basis for current theories on the evolution of social behaviors and societies. However, research on social strategies has largely ignored solitary animals, in which we assume that rare interactions are explained by courtship or territori...

journal_title：Science advances

authors： Elbroch LM,Levy M,Lubell M,Quigley H,Caragiulo A

更新日期：2017-10-11 00:00:00

abstract：:A rapid, direct, and low-cost method for detecting bacterial toxins associated with common gastrointestinal diseases remains a great challenge despite numerous studies and clinical assays. Motion-based detection through tracking the emerging micro- and nanorobots has shown great potential in chemo- and biosensing due ...

journal_title：Science advances

authors： Zhang Y,Zhang L,Yang L,Vong CI,Chan KF,Wu WKK,Kwong TNY,Lo NWS,Ip M,Wong SH,Sung JJY,Chiu PWY,Zhang L

更新日期：2019-01-11 00:00:00

abstract：:The investigation of materials that exhibit quantum phase transition provides valuable insights into fundamental problems in physics. We present neutron scattering under pressure in a triangular-lattice antiferromagnet that has a quantum disorder in the low-pressure phase and a noncollinear structure in the high-press...

journal_title：Science advances

authors： Hayashida S,Matsumoto M,Hagihala M,Kurita N,Tanaka H,Itoh S,Hong T,Soda M,Uwatoko Y,Masuda T

更新日期：2019-10-18 00:00:00