The inositol pyrophosphate 5-InsP7 drives sodium-potassium pump degradation by relieving an autoinhibitory domain of PI3K p85α.

abstract：:Detecting associations between genomic changes and phenotypic differences is fundamental to understanding how phenotypes evolved. By systematically screening for parallel amino acid substitutions, we detected known as well as novel cases (Strc, Tecta, and Cabp2) of parallelism between echolocating bats and toothed wha...

journal_title：Science advances

authors： Lee JH,Lewis KM,Moural TW,Kirilenko B,Borgonovo B,Prange G,Koessl M,Huggenberger S,Kang C,Hiller M

更新日期：2018-09-26 00:00:00

abstract：:The human bronchial epithelium is composed of multiple distinct cell types that cooperate to defend against environmental insults. While studies have shown that smoking alters bronchial epithelial function and morphology, its precise effects on specific cell types and overall tissue composition are unclear. We used si...

journal_title：Science advances

authors： Duclos GE,Teixeira VH,Autissier P,Gesthalter YB,Reinders-Luinge MA,Terrano R,Dumas YM,Liu G,Mazzilli SA,Brandsma CA,van den Berge M,Janes SM,Timens W,Lenburg ME,Spira A,Campbell JD,Beane J

更新日期：2019-12-11 00:00:00

abstract：:One of the most elusive scientific challenges for over 150 years has been to explain why cooperation survives despite being a seemingly inferior strategy from an evolutionary point of view. Over the years, various theoretical scenarios aimed at solving the evolutionary puzzle of cooperation have been proposed, eventua...

journal_title：Science advances

authors： Wang Z,Jusup M,Wang RW,Shi L,Iwasa Y,Moreno Y,Kurths J

更新日期：2017-03-29 00:00:00

abstract：:Estimating minimum ice volume during the last interglacial based on local sea-level indicators requires that these indicators are corrected for processes that alter local sea level relative to the global average. Although glacial isostatic adjustment is generally accounted for, global scale dynamic changes in topograp...

journal_title：Science advances

authors： Austermann J,Mitrovica JX,Huybers P,Rovere A

更新日期：2017-07-07 00:00:00

abstract：:Many insects use nectar as their principal diet and have mouthparts specialized in nectarivory, whereas most nectar-feeding vertebrates are opportunistic users of floral resources and only a few species show distinct morphological specializations. Specialized nectar-feeding bats extract nectar from flowers using elong...

journal_title：Science advances

authors： Tschapka M,Gonzalez-Terrazas TP,Knörnschild M

更新日期：2015-09-25 00:00:00

abstract：:Adjacent neurons in visual cortex have overlapping receptive fields within and across area boundaries, an arrangement theorized to minimize wiring cost. This constraint is traditionally thought to create retinotopic maps of opposing field signs (mirror and nonmirror visual field representations) in adjacent areas, a c...

journal_title：Science advances

authors： Yu HH,Rowley DP,Price NSC,Rosa MGP,Zavitz E

更新日期：2020-10-28 00:00:00

abstract：:A trimer-of-hairpins motif has been identified in triggering virus-cell fusion within a variety of viral envelopes. Chemically manipulating such a motif represents current repertoire of viral fusion inhibitors. Here, we report that triterpenoids, a class of natural products, antagonize this trimer-of-hairpins via its ...

journal_title：Science advances

authors： Si L,Meng K,Tian Z,Sun J,Li H,Zhang Z,Soloveva V,Li H,Fu G,Xia Q,Xiao S,Zhang L,Zhou D

更新日期：2018-11-21 00:00:00

abstract：:Glass-forming ability (GFA) is the ability of a liquid to avoid crystallization during cooling. Metal-organic frameworks (MOFs) are a new class of glass formers (1-3), with hitherto unknown dynamic and thermodynamic properties. We report the discovery of a new series of tetrahedral glass systems, zeolitic imidazolate ...

journal_title：Science advances

authors： Qiao A,Bennett TD,Tao H,Krajnc A,Mali G,Doherty CM,Thornton AW,Mauro JC,Greaves GN,Yue Y

更新日期：2018-03-09 00:00:00

abstract：:Meteorite impact craters are one of the most common geological features in the solar system. An impact event is a near-instantaneous process that releases a huge amount of energy over a very small region on a planetary surface. This results in characteristic changes in the target rocks, from vaporization and melting t...

journal_title：Science advances

authors： Osinski GR,Ferrière L

更新日期：2016-08-05 00:00:00

abstract：:Dewetting is a ubiquitous phenomenon in nature; many different thin films of organic and inorganic substances (such as liquids, polymers, metals, and semiconductors) share this shape instability driven by surface tension and mass transport. Via templated solid-state dewetting, we frame complex nanoarchitectures of mon...

journal_title：Science advances

authors： Naffouti M,Backofen R,Salvalaglio M,Bottein T,Lodari M,Voigt A,David T,Benkouider A,Fraj I,Favre L,Ronda A,Berbezier I,Grosso D,Abbarchi M,Bollani M

更新日期：2017-11-10 00:00:00

abstract：:Many applications in modern technology, such as self-cleaning surfaces and digital microfluidics, require control over individual fluid droplets on flat surfaces. Existing techniques may suffer from side effects resulting from high electric fields and high temperatures. Here, we introduce a markedly different method, ...

journal_title：Science advances

authors： De Jong E,Wang Y,Den Toonder JMJ,Onck PR

更新日期：2019-06-14 00:00:00

abstract：:Noble metal foams (NMFs) are a new class of functional materials featuring properties of both noble metals and monolithic porous materials, providing impressive prospects in diverse fields. Among reported synthetic methods, the sol-gel approach manifests overwhelming advantages for versatile synthesis of nanostructure...

journal_title：Science advances

authors： Du R,Hu Y,Hübner R,Joswig JO,Fan X,Schneider K,Eychmüller A

更新日期：2019-05-24 00:00:00

abstract：:The retinoic acid-inducible gene I (RIG-I) innate immune receptor is an important immunotherapeutic target, but we lack approaches for monitoring the physical basis for its activation in vitro. This gap in our understanding has led to confusion about mechanisms of RIG-I activation and difficulty discovering agonists a...

journal_title：Science advances

authors： Dickey TH,Song B,Pyle AM

更新日期：2019-10-02 00:00:00

abstract：:A new set of time-of-day-dependent global maps of the lunar near-infrared water/hydroxyl (H2O/OH) absorption band strength near 2.8 to 3.0 μm constructed on the basis of Moon Mineralogy Mapper (M3) data is presented. The analyzed absorption band near 2.8 to 3.0 μm indicates the presence of surficial H2O/OH. To remove ...

journal_title：Science advances

authors： Wöhler C,Grumpe A,Berezhnoy AA,Shevchenko VV

更新日期：2017-09-08 00:00:00

abstract：:Efforts at altering the dismal prognosis of pediatric midline gliomas focus on direct delivery strategies like convection-enhanced delivery (CED), where a cannula is implanted into tumor. Successful CED treatments require confirmation of tumor coverage, dosimetry, and longitudinal in vivo pharmacokinetic monitoring. T...

journal_title：Science advances

authors： Tosi U,Kommidi H,Adeuyan O,Guo H,Maachani UB,Chen N,Su T,Zhang G,Pisapia DJ,Dahmane N,Ting R,Souweidane MM

更新日期：2020-07-24 00:00:00

abstract：:Yearly, a quarter billion people are infected and a half a million killed by the mosquito-borne disease malaria. Lack of real-time observational tools for continuously assessing the unperturbed mosquito flight activity in situ limits progress toward improved vector control. We deployed a high-resolution entomological ...

journal_title：Science advances

authors： Brydegaard M,Jansson S,Malmqvist E,Mlacha YP,Gebru A,Okumu F,Killeen GF,Kirkeby C

更新日期：2020-05-13 00:00:00

abstract：:Transcription in eukaryotes correlates with major chromatin changes, including the replacement of old nucleosomal histones by new histones at the promoters of genes. The role of these histone exchange events in transcription remains unclear. In particular, the causal relationship between histone exchange and activator...

journal_title：Science advances

authors： Kassem S,Ferrari P,Hughes AL,Soudet J,Rando OJ,Strubin M

更新日期：2020-09-02 00:00:00

abstract：:The miraculously preserved 2000-year-old Dead Sea Scrolls, ancient texts of invaluable historical significance, were discovered in the mid-20th century in the caves of the Judean desert. The texts were mainly written on parchment and exhibit vast diversity in their states of preservation. One particular scroll, the 8-...

journal_title：Science advances

authors： Schuetz R,Maragh JM,Weaver JC,Rabin I,Masic A

更新日期：2019-09-06 00:00:00

abstract：:Metal-organic frameworks (MOFs) have been attracting intensive attention because of their commendable potential in many applications. Postsynthetic modification for redesigning chemical characteristics and pore structures can greatly improve performance and expand functionality of MOF materials. Here, we develop a ver...

journal_title：Science advances

authors： Wu W,Su J,Jia M,Li Z,Liu G,Li W

更新日期：2020-05-01 00:00:00

abstract：:Increasing occurrence of moderate to severe intrauterine adhesion (IUA) is seriously affecting the quality of human life. The aim of the study was to establish IUA models in nonhuman primates and to explore the dual repair effects of human umbilical cord-derived mesenchymal stem cells (huMSCs) loaded on autocrosslinke...

journal_title：Science advances

authors： Wang L,Yu C,Chang T,Zhang M,Song S,Xiong C,Su P,Xiang W

更新日期：2020-05-22 00:00:00

abstract：:Metabolic reprogramming is widely considered a hallmark of cancer, and understanding metabolic dynamics described by the conversion rates or "fluxes" of metabolites can shed light onto biological processes of tumorigenesis and response to therapy. For real-time analysis of metabolic flux in intact cells or organisms, ...

journal_title：Science advances

authors： Jeong S,Eskandari R,Park SM,Alvarez J,Tee SS,Weissleder R,Kharas MG,Lee H,Keshari KR

更新日期：2017-06-16 00:00:00

abstract：:V1-ATPase is an ATP-driven rotary motor that is composed of a ring-shaped A3B3 complex and a central DF shaft. The nucleotide-free A3B3 complex of Enterococcus hirae, composed of three identical A1B1 heterodimers, showed a unique asymmetrical structure, probably due to the strong binding of the N-terminal barrel domai...

journal_title：Science advances

authors： Maruyama S,Suzuki K,Imamura M,Sasaki H,Matsunami H,Mizutani K,Saito Y,Imai FL,Ishizuka-Katsura Y,Kimura-Someya T,Shirouzu M,Uchihashi T,Ando T,Yamato I,Murata T

更新日期：2019-01-30 00:00:00

abstract：:Present-day dermatological diagnostic tools are expensive, time-consuming, require substantial operational expertise, and typically probe only the superficial layers of skin (~15 μm). We introduce a soft, battery-free, noninvasive, reusable skin hydration sensor (SHS) adherable to most of the body surface. The platfor...

journal_title：Science advances

authors： Madhvapathy SR,Wang H,Kong J,Zhang M,Lee JY,Park JB,Jang H,Xie Z,Cao J,Avila R,Wei C,D'Angelo V,Zhu J,Chung HU,Coughlin S,Patel M,Winograd J,Lim J,Banks A,Xu S,Huang Y,Rogers JA

更新日期：2020-12-04 00:00:00

abstract：:The cyclic GMP-AMP synthase (cGAS), a sensor of cytosolic DNA, is critical for the innate immune response. Here, we show that loss of cGAS in untransformed and cancer cells results in uncontrolled DNA replication, hyperproliferation, and genomic instability. While the majority of cGAS is cytoplasmic, a fraction of cGA...

journal_title：Science advances

authors： Chen H,Chen H,Zhang J,Wang Y,Simoneau A,Yang H,Levine AS,Zou L,Chen Z,Lan L

更新日期：2020-10-14 00:00:00

abstract：:Among the existing elemental characterization techniques, particle-induced x-ray emission (PIXE) and energy-dispersive x-ray (EDX) spectroscopy are two of the most widely used in different scientific and technological fields. Here, we present the first quantitative laser-driven PIXE and laser-driven EDX experimental i...

journal_title：Science advances

authors： Mirani F,Maffini A,Casamichiela F,Pazzaglia A,Formenti A,Dellasega D,Russo V,Vavassori D,Bortot D,Huault M,Zeraouli G,Ospina V,Malko S,Apiñaniz JI,Pérez-Hernández JA,De Luis D,Gatti G,Volpe L,Pola A,Passoni M

更新日期：2021-01-15 00:00:00

abstract：:Stimulation of Escherichia coli by exponential ramps of chemoattractants generates step changes in the concentration of the response regulator, CheY-P. Because flagellar motors are ultrasensitive, this should change the fraction of time that motors spin clockwise, the CWbias. However, early work failed to show changes...

journal_title：Science advances

authors： Lele PP,Shrivastava A,Roland T,Berg HC

更新日期：2015-10-16 00:00:00

abstract：:The urea channel of Helicobacterpylori (HpUreI) is an ideal drug target for preventing gastric cancer but incomplete understanding of its gating mechanism has hampered development of inhibitors for the eradication of H. pylori. Here, we present the cryo-EM structures of HpUreI in closed and open conformations, both at...

journal_title：Science advances

authors： Cui Y,Zhou K,Strugatsky D,Wen Y,Sachs G,Zhou ZH,Munson K

更新日期：2019-03-20 00:00:00

abstract：:The key component currently missing for the next generation of transparent and flexible displays is a high-performance polymer material that is flexible, while showing optical and thermal properties of glass. It must be transparent to visible light and show a low coefficient of thermal expansion (CTE). While specialty...

journal_title：Science advances

authors： Kim SD,Lee B,Byun T,Chung IS,Park J,Shin I,Ahn NY,Seo M,Lee Y,Kim Y,Kim WY,Kwon H,Moon H,Yoo S,Kim SY

更新日期：2018-10-26 00:00:00

abstract：:Topological superconductors are an interesting and frontier topic in condensed matter physics. In the superconducting state, an order parameter will be established with the basic or subsidiary symmetry of the crystalline lattice. In doped Bi2Se3 or Bi2Te3 with a basic threefold symmetry, it was predicted, however, tha...

journal_title：Science advances

authors： Chen M,Chen X,Yang H,Du Z,Wen HH

更新日期：2018-06-08 00:00:00

abstract：:Recent research on piezoelectric materials is predominantly devoted to enhancing the piezoelectric coefficient, but overlooks its sign, largely because almost all of them exhibit positive longitudinal piezoelectricity. The only experimentally known exception is ferroelectric polymer poly(vinylidene fluoride) and its c...

journal_title：Science advances

authors： You L,Zhang Y,Zhou S,Chaturvedi A,Morris SA,Liu F,Chang L,Ichinose D,Funakubo H,Hu W,Wu T,Liu Z,Dong S,Wang J

更新日期：2019-04-19 00:00:00