Abstract:
:Behavioral and clinical studies suggest a critical role of substance P (SP)/neurokinin-1 receptor (NK-1R) signaling in alcohol dependence. Here, we examined regulation of GABA transmission in the medial subdivision of the central amygdala (CeM) by the SP/NK-1R system, and its neuroadaptation following chronic alcohol exposure. In naïve rats, SP increased action potential-dependent GABA release, and the selective NK-1R antagonist L822429 decreased it, demonstrating SP regulation of CeM activity under basal conditions. SP induced a larger GABA release in alcohol-dependent rats accompanied by decreased NK-1R expression compared to naïve controls, suggesting NK-1R hypersensitivity which persisted during protracted alcohol withdrawal. The NK-1R antagonist blocked acute alcohol-induced GABA release in alcohol-dependent and withdrawn but not in naïve rats, indicating that dependence engages the SP/NK-1R system to mediate acute effects of alcohol. Collectively, we report long-lasting CeA NK-1R hypersensitivity corroborating that NK-1Rs are promising targets for the treatment of alcohol use disorder.
journal_name
Sci Advjournal_title
Science advancesauthors
Khom S,Steinkellner T,Hnasko TS,Roberto Mdoi
10.1126/sciadv.aaz1050subject
Has Abstractpub_date
2020-03-18 00:00:00pages
eaaz1050issue
12issn
2375-2548pii
aaz1050journal_volume
6pub_type
杂志文章相关文献
Science Advances文献大全abstract::An understanding of the normal state in the high-temperature superconducting cuprates is crucial to the ultimate understanding of the long-standing problem of the origin of the superconductivity itself. This so-called "strange metal" state is thought to be associated with a quantum critical point (QCP) hidden beneath ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aav6753
更新日期:2019-05-17 00:00:00
abstract::Two-dimensional (2D) polymers hold great promise in the rational materials design tailored for next-generation applications. However, little is known about the grain boundaries in 2D polymers, not to mention their formation mechanisms and potential influences on the material's functionalities. Using aberration-correct...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb5976
更新日期:2020-08-14 00:00:00
abstract::The tet methylcytosine dioxygenase 2 (TET2) enzyme catalyzes the conversion of the modified DNA base 5-methylcytosine to 5-hydroxymethylcytosine. TET2 is frequently mutated or dysregulated in multiple human cancers, and loss of TET2 is associated with changes in DNA methylation patterns. Here, using newly developed TE...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aau6986
更新日期:2018-11-07 00:00:00
abstract::Ciliary oscillations driven by molecular motors cause fluid motion at micron scale. Stable oscillations require a substantial source of dissipation to balance the energy input of motors. Conventionally, it stems from external fluid. We show, in contrast, that external fluid friction is negligible compared to internal ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb0503
更新日期:2020-08-12 00:00:00
abstract::The key to the development of advanced materials is to understand their electronic structure-property relationship. Utilization of this understanding to design new electronic materials with desired properties led to modern epitaxial growth approaches for synthesizing artificial lattices, which for almost half a centur...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1602754
更新日期:2017-06-07 00:00:00
abstract::Hedgehog signaling is central in embryonic development and tissue regeneration. Disruption of the pathway is linked to genetic diseases and cancer. Binding of the secreted ligand, Sonic hedgehog (ShhN) to its receptor Patched (PTCH1) activates the signaling pathway. Here, we describe a 3.4-Å cryo-EM structure of the h...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaw6490
更新日期:2019-09-18 00:00:00
abstract::The ability of a material to adopt multiple structures, known as polymorphism, is a fascinating natural phenomenon. Various polymorphs with unusual properties are routinely synthesized by compression under positive pressure. However, changing a material's structure by applying tension under negative pressure is much m...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaq1442
更新日期:2018-04-20 00:00:00
abstract::We have developed a way to map brain-wide networks using focal pulsed infrared neural stimulation in ultrahigh-field magnetic resonance imaging (MRI). The patterns of connections revealed are similar to those of connections previously mapped with anatomical tract tracing methods. These include connections between cort...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aau7046
更新日期:2019-04-24 00:00:00
abstract::The spin Hall effect allows the generation of spin current when charge current is passed along materials with large spin-orbit coupling. It has been recently predicted that heat current in a nonmagnetic metal can be converted into spin current via a process referred to as the spin Nernst effect. We report the observat...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1701503
更新日期:2017-11-03 00:00:00
abstract::Immunoglobulin heavy chain (IgH) genes are assembled by two sequential DNA rearrangement events that are initiated by recombination activating gene products (RAG) 1 and 2. Diversity (DH) gene segments rearrange first, followed by variable (VH) gene rearrangements. Here, we provide evidence that each rearrangement step...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaz8850
更新日期:2020-08-14 00:00:00
abstract::Natural genetic variation affects circadian rhythms across the evolutionary tree, but the underlying molecular mechanisms are poorly understood. We investigated population-level, molecular circadian clock variation by generating >700 tissue-specific transcriptomes of Drosophila melanogaster (w1118 ) and 141 Drosophila...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abc3781
更新日期:2021-01-29 00:00:00
abstract::The spin-polarized surface states of topological insulators (TIs) are attractive for applications in spintronics and quantum computing. A central challenge with these materials is to reliably tune the chemical potential of their electrons with respect to the Dirac point and the bulk bands. We demonstrate persistent, b...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1500640
更新日期:2015-10-09 00:00:00
abstract::Porous membranes with ultrafast ion permeation and high ion selectivity are highly desirable for efficient mineral separation, water purification, and energy conversion, but it is still a huge challenge to efficiently separate monatomic ions of the same valence and similar sizes using synthetic membranes. We report me...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaq0066
更新日期:2018-02-09 00:00:00
abstract::We present a physically inspired model and an efficient algorithm to infer hierarchical rankings of nodes in directed networks. It assigns real-valued ranks to nodes rather than simply ordinal ranks, and it formalizes the assumption that interactions are more likely to occur between individuals with similar ranks. It ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aar8260
更新日期:2018-07-20 00:00:00
abstract::Hypertrophic cardiomyopathy (HCM) is a heterogeneous genetic heart muscle disease characterized by hypertrophy with preserved or increased ejection fraction in the absence of secondary causes. However, recent studies have demonstrated that a substantial proportion of individuals with HCM also have comorbid diabetes me...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb3991
更新日期:2021-01-06 00:00:00
abstract::Analog machine learning hardware platforms promise to be faster and more energy efficient than their digital counterparts. Wave physics, as found in acoustics and optics, is a natural candidate for building analog processors for time-varying signals. Here, we identify a mapping between the dynamics of wave physics and...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aay6946
更新日期:2019-12-20 00:00:00
abstract::Low-dimensional materials usually exhibit mechanical properties from those of their bulk counterparts. Here, we show in two-dimensional (2D) rhenium disulfide (ReS2) that the fracture processes are dominated by a variety of previously unidentified phenomena, which are not present in bulk materials. Through direct tran...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abc2282
更新日期:2020-11-18 00:00:00
abstract::Neurochemical dysregulation underlies many pathologies and can be monitored by measuring the composition of brain interstitial fluid (ISF). Existing in vivo tools for sampling ISF do not enable measuring large rare molecules, such as proteins and neuropeptides, and thus cannot generate a complete picture of the neuroc...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb0657
更新日期:2020-09-25 00:00:00
abstract::Nanomaterials often surprise us with unexpected phenomena. Here, we report a discovery of the anti-twinning deformation, previously thought impossible, in nanoscale body-centered cubic (BCC) tungsten crystals. By conducting in situ transmission electron microscopy nanomechanical testing, we observed the nucleation and...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aay2792
更新日期:2020-06-03 00:00:00
abstract::A major challenge in modern physics is to accurately describe strongly interacting quantum many-body systems. One-dimensional systems provide fundamental insights because they are often amenable to exact methods. However, no exact solution is known for the experimentally relevant case of external confinement. We propo...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1500197
更新日期:2015-07-24 00:00:00
abstract::Glucose-responsive insulin delivery systems with robust responsiveness that has been validated in animal models, especially in large animal models, remain elusive. Here, we exploit a new strategy to form a micro-sized complex between a charge-switchable polymer with a glucose-sensing moiety and insulin driven by elect...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaw4357
更新日期:2019-07-10 00:00:00
abstract::[This corrects the article e1602026 in vol. 3, PMID: 28246641.]. ...
journal_title:Science advances
pub_type: 杂志文章,已发布勘误
doi:10.1126/sciadv.aaq0565
更新日期:2017-09-29 00:00:00
abstract::Climate change threatens agricultural productivity worldwide, resulting in higher food prices. Associated economic gains and losses differ not only by region but also between producers and consumers and are affected by market dynamics. On the basis of an impact modeling chain, starting with 19 different climate projec...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1501452
更新日期:2016-08-24 00:00:00
abstract::Solar-thermal desalination (STD) is a potentially low-cost, sustainable approach for providing high-quality fresh water in the absence of water and energy infrastructures. Despite recent efforts to advance STD by improving heat-absorbing materials and system designs, the best strategies for maximizing STD performance ...
journal_title:Science advances
pub_type: 杂志文章,评审
doi:10.1126/sciadv.aax0763
更新日期:2019-07-26 00:00:00
abstract::SN2-type halide substitution and hydrolysis are two of the most ubiquitous reactions in chemistry. The interplay between these processes is fundamental in atmospheric chemistry through reactions of N2O5 and seawater. N2O5 plays a major role in regulating levels of O3, OH, NO x ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aav6503
更新日期:2019-06-05 00:00:00
abstract::One of the most plausible scenarios of the origin of life assumes the preceding prebiotic autotrophic metabolism in sulfide-rich hydrothermal vent environments. However, geochemical mechanisms to harness the reductive power provided by hydrothermal systems remain to be elucidated. Here, we show that, under a geoelectr...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aav7848
更新日期:2019-06-19 00:00:00
abstract::Triple-negative breast cancer (TNBC) is life-threatening because of limited therapies and lack of effective therapeutic targets. Here, we found that moesin (MSN) was significantly overexpressed in TNBC compared with other subtypes of breast cancer and was positively correlated with poor overall survival. However, litt...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaw9960
更新日期:2020-02-19 00:00:00
abstract::After European colonization, the ancestral remains of Indigenous people were often collected for scientific research or display in museum collections. For many decades, Indigenous people, including Native Americans and Aboriginal Australians, have fought for their return. However, many of these remains have no recorde...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aau5064
更新日期:2018-12-19 00:00:00
abstract::Discovery of new adsorbent materials with a high CO2 working capacity could help reduce CO2 emissions from newly commissioned power plants using precombustion carbon capture. High-throughput computational screening efforts can accelerate the discovery of new adsorbents but sometimes require significant computational r...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1600909
更新日期:2016-10-14 00:00:00
abstract::The ongoing conservation treatment program of the Ghent Altarpiece by Hubert and Jan Van Eyck, one of the iconic paintings of the west, has revealed that the designs of the paintings were changed several times, first by the original artists, and then during later restorations. The central motif, The Lamb of God, repre...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb3379
更新日期:2020-07-29 00:00:00