Abstract:
:Wearable sweat analysis devices for monitoring of multiple health-related biomarkers with high sensitivity are highly desired for noninvasive and real-time monitoring of human health. Here, we report a flexible sweat analysis patch based on a silk fabric-derived carbon textile for simultaneous detection of six health-related biomarkers. The intrinsically N-doped graphitic structure and the hierarchical woven, porous structure provided the carbon textile good electrical conductivity, rich active sites, and good water wettability for efficient electron transmission and abundant access to reactants, enabling it to serve as an excellent working electrode in electrochemical sensors. On the basis of the above, we fabricated a multiplex sweat analysis patch that is capable of simultaneous detection of glucose, lactate, ascorbic acid, uric acid, Na+, and K+. The integration of selective detectors with signal collection and transmission components in this device has enabled us to realize real-time analysis of sweat.
journal_name
Sci Advjournal_title
Science advancesauthors
He W,Wang C,Wang H,Jian M,Lu W,Liang X,Zhang X,Yang F,Zhang Ydoi
10.1126/sciadv.aax0649subject
Has Abstractpub_date
2019-11-08 00:00:00pages
eaax0649issue
11issn
2375-2548pii
aax0649journal_volume
5pub_type
杂志文章相关文献
Science Advances文献大全abstract::Two-dimensional (2D) layered hybrid organic-inorganic halide perovskite semiconductors form natural "multiple quantum wells" that have strong spin-orbit coupling due to the heavy elements in their building blocks. This may lead to "Rashba splitting" close to the extrema in the electron bands. We have used a plethora o...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1700704
更新日期:2017-07-28 00:00:00
abstract::Interactions between top-down and bottom-up processes in the cerebral cortex hold the key to understanding attentional processes, predictive coding, executive control, and a gamut of other brain functions. However, the underlying circuit mechanism remains poorly understood and represents a major challenge in neuroscie...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1601335
更新日期:2016-11-16 00:00:00
abstract::Forecasting fields of oceanic phenomena has long been dependent on physical equation-based numerical models. The challenge is that many natural processes need to be considered for understanding complicated phenomena. In contrast, rules of the processes are already embedded in the time-series observation itself. Thus, ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aba1482
更新日期:2020-07-15 00:00:00
abstract::Ice accretion has a negative impact on critical infrastructure, as well as a range of commercial and residential activities. Icephobic surfaces are defined by an ice adhesion strength τice < 100 kPa. However, the passive removal of ice requires much lower values of τice, such as on airplane wings or power lines (τice ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1501496
更新日期:2016-03-11 00:00:00
abstract::Detecting associations between genomic changes and phenotypic differences is fundamental to understanding how phenotypes evolved. By systematically screening for parallel amino acid substitutions, we detected known as well as novel cases (Strc, Tecta, and Cabp2) of parallelism between echolocating bats and toothed wha...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aat9660
更新日期:2018-09-26 00:00:00
abstract::Developing cost-effective, active, and durable electrocatalysts is one of the most important issues for the commercialization of fuel cells. Ultrathin Pt-Mo-Ni nanowires (NWs) with a diameter of ~2.5 nm and lengths of up to several micrometers were synthesized via a H2-assisted solution route (HASR). This catalyst was...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1603068
更新日期:2017-08-30 00:00:00
abstract::We introduce two photochromic proteins for cell-specific in vivo optoacoustic (OA) imaging with signal unmixing in the temporal domain. We show highly sensitive, multiplexed visualization of T lymphocytes, bacteria, and tumors in the mouse body and brain. We developed machine learning-based software for commercial ima...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaz6293
更新日期:2020-06-12 00:00:00
abstract::Many insects use nectar as their principal diet and have mouthparts specialized in nectarivory, whereas most nectar-feeding vertebrates are opportunistic users of floral resources and only a few species show distinct morphological specializations. Specialized nectar-feeding bats extract nectar from flowers using elong...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1500525
更新日期:2015-09-25 00:00:00
abstract::Mucoadhesive particles (MAP) have been widely explored for pulmonary drug delivery because of their perceived benefits in improving particle residence in the lungs. However, retention of particles adhesively trapped in airway mucus may be limited by physiologic mucus clearance mechanisms. In contrast, particles that a...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1601556
更新日期:2017-04-05 00:00:00
abstract::Despite the potential of photodynamic therapy (PDT), its comprehensive use in cancer treatment has not been achieved because of the nondegradable risks of photosensitizing drugs and limits of light penetration and instrumentation. Here, we present bioluminescence (BL)-induced proteinaceous PDT (BLiP-PDT), through the ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aba3009
更新日期:2020-09-11 00:00:00
abstract::B cell activation is regulated by the stimulatory or inhibitory co-receptors of B cell receptors (BCRs). Here, we investigated the signaling mechanism of Fc receptor-like 1 (FcRL1), a newly identified BCR co-receptor. FcRL1 was passively recruited into B cell immunological synapses upon BCR engagement in the absence o...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaw0315
更新日期:2019-07-17 00:00:00
abstract::Ciliary oscillations driven by molecular motors cause fluid motion at micron scale. Stable oscillations require a substantial source of dissipation to balance the energy input of motors. Conventionally, it stems from external fluid. We show, in contrast, that external fluid friction is negligible compared to internal ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb0503
更新日期:2020-08-12 00:00:00
abstract::The inherent specificity and electrochemical reversibility of enzymes poise them as the biorecognition element of choice for a wide range of metabolites. To use enzymes efficiently in biosensors, the redox centers of the protein should have good electrical communication with the transducing electrode, which requires e...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aat0911
更新日期:2018-06-22 00:00:00
abstract::Deforestation is the primary driver of carbon losses in tropical forests, but it does not operate alone. Forest fragmentation, a resulting feature of the deforestation process, promotes indirect carbon losses induced by edge effect. This process is not implicitly considered by policies for reducing carbon emissions in...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaz8360
更新日期:2020-09-30 00:00:00
abstract::Microfluidic devices fabricated via soft lithography have demonstrated compelling applications such as lab-on-a-chip diagnostics, DNA microarrays, and cell-based assays. These technologies could be further developed by directly integrating microfluidics with electronic sensors and curvilinear substrates as well as imp...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abc9846
更新日期:2020-10-09 00:00:00
abstract::Improved constraints on lower-mantle composition are fundamental to understand the accretion, differentiation, and thermochemical evolution of our planet. Cosmochemical arguments indicate that lower-mantle rocks may be enriched in Si relative to upper-mantle pyrolite, whereas seismic tomography images suggest whole-ma...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1500815
更新日期:2015-12-10 00:00:00
abstract::Increasing occurrence of moderate to severe intrauterine adhesion (IUA) is seriously affecting the quality of human life. The aim of the study was to establish IUA models in nonhuman primates and to explore the dual repair effects of human umbilical cord-derived mesenchymal stem cells (huMSCs) loaded on autocrosslinke...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aba6357
更新日期:2020-05-22 00:00:00
abstract::After European colonization, the ancestral remains of Indigenous people were often collected for scientific research or display in museum collections. For many decades, Indigenous people, including Native Americans and Aboriginal Australians, have fought for their return. However, many of these remains have no recorde...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aau5064
更新日期:2018-12-19 00:00:00
abstract::The tendency to see life as zero-sum exacerbates political conflicts. Six studies (N = 3223) examine the relationship between political ideology and zero-sum thinking: the belief that one party's gains can only be obtained at the expense of another party's losses. We find that both liberals and conservatives view life...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aay3761
更新日期:2019-12-18 00:00:00
abstract::Demonstration of ultralow energy switching mechanisms is imperative for continued improvements in computing devices. Ferroelectric (FE) and multiferroic (MF) order and their manipulation promise an ideal combination of state variables to reach attojoule range for logic and memory (i.e., ~30× lower switching energy tha...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aat4229
更新日期:2018-11-23 00:00:00
abstract::Quantitative three-dimensional (3D) computed tomography (CT) imaging of living single cells enables orientation-independent morphometric analysis of the intricacies of cellular physiology. Since its invention, x-ray CT has become indispensable in the clinic for diagnostic and prognostic purposes due to its quantitativ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1602580
更新日期:2017-12-06 00:00:00
abstract::Diets rich in sugar, salt, and fat alter taste perception and food preference, contributing to obesity and metabolic disorders, but the molecular mechanisms through which this occurs are unknown. Here, we show that in response to a high sugar diet, the epigenetic regulator Polycomb Repressive Complex 2.1 (PRC2.1) pers...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abc8492
更新日期:2020-11-11 00:00:00
abstract::The fabrication of three-dimensional (3D) objects by polymer self-assembly in solution is extremely challenging. Here, multi-tori mesostructures were obtained from the crystallization-driven self-assembly of a coil-crystalline block copolymer (BCP) in mixed solvents. The formation of these structures follows a multist...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaz7301
更新日期:2020-04-15 00:00:00
abstract::Hydrogen sulfide (H2S) is a gasotransmitter and a potential therapeutic agent. However, molecular targets relevant to its therapeutic actions remain enigmatic. Sulfide-quinone oxidoreductase (SQR) irreversibly oxidizes H2S. Therefore, SQR is assumed to inhibit H2S signaling. We now report that SQR-mediated oxidation o...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaz5752
更新日期:2020-08-26 00:00:00
abstract::Perovskite oxides exhibit potential for use as electrocatalysts in the oxygen evolution reaction (OER). However, their low specific surface area is the main obstacle to realizing a high mass-specific activity that is required to be competitive against the state-of-the-art precious metal-based catalysts. We report the ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1603206
更新日期:2017-06-21 00:00:00
abstract::Transcription factors control gene expression in all life. This raises the question of what is the smallest protein that can support such activity. In nature, Cro from bacteriophage λ is one of the smallest known repressors (66 amino acids), and activators are typically much larger (e.g., λ cI, 237 amino acids). Previ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aba2728
更新日期:2020-06-10 00:00:00
abstract::Spider silk fiber rapidly assembles from spidroin protein in soluble state via an incompletely understood mechanism. Here, we present an integrated model for silk formation that incorporates the effects of multiple chemical and physical gradients on the different spidroin functional domains. Central to the process is ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb6030
更新日期:2020-11-04 00:00:00
abstract::Asymmetric interactions such as entropic (e.g., encoded by nonspherical shapes) or surface forces (e.g., encoded by patterned surface chemistry or DNA hybridization) provide access to functional states of colloidal matter, but versatile approaches for engineering asymmetric van der Waals interactions have the potentia...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb1327
更新日期:2020-06-19 00:00:00
abstract::The development of advanced chemical-to-electrical energy conversions requires fast and efficient electrocatalysis of multielectron/multiproton reactions, such as the oxygen reduction reaction (ORR). Using molecular catalysts, correlations between the reaction rate and energy efficiency have recently been identified. ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaz3318
更新日期:2020-03-13 00:00:00
abstract::The key to the development of advanced materials is to understand their electronic structure-property relationship. Utilization of this understanding to design new electronic materials with desired properties led to modern epitaxial growth approaches for synthesizing artificial lattices, which for almost half a centur...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1602754
更新日期:2017-06-07 00:00:00