The Arp1/11 minifilament of dynactin primes the endosomal Arp2/3 complex.

abstract：:Micrometer-scale acoustic waves are highly useful for refined optomechanical and acoustofluidic manipulation, where these fields are spatially localized along the transducer aperture but not along the acoustic propagation direction. In the case of acoustic tweezers, such a conventional acoustic standing wave results i...

journal_title：Science advances

authors： Collins DJ,Devendran C,Ma Z,Ng JW,Neild A,Ai Y

更新日期：2016-07-13 00:00:00

abstract：:Fluctuations in biodiversity, large and small, pervade the fossil record, yet we do not understand the processes generating them. Here, we extend theory from nonequilibrium statistical physics to describe the fat-tailed form of fluctuations in Phanerozoic marine invertebrate richness. Using this theory, known as super...

journal_title：Science advances

authors： Rominger AJ,Fuentes MA,Marquet PA

更新日期：2019-06-26 00:00:00

abstract：:For natural microswimmers, the interplay of swimming activity and external flow can promote robust directed motion, for example, propulsion against (upstream rheotaxis) or perpendicular to the direction of flow. These effects are generally attributed to their complex body shapes and flagellar beat patterns. Using cata...

journal_title：Science advances

authors： Katuri J,Uspal WE,Simmchen J,Miguel-López A,Sánchez S

更新日期：2018-01-26 00:00:00

abstract：:Maternal immune activation increases the risk of neurodevelopmental disorders. Elevated cytokines, such as interferon-γ (IFN-γ), in offspring's brains play a central role. IFN-γ activates an antiviral cellular state, limiting viral entry and replication. Moreover, IFN-γ is implicated in brain development. We tested th...

journal_title：Science advances

authors： Warre-Cornish K,Perfect L,Nagy R,Duarte RRR,Reid MJ,Raval P,Mueller A,Evans AL,Couch A,Ghevaert C,McAlonan G,Loth E,Murphy D,Powell TR,Vernon AC,Srivastava DP,Price J

更新日期：2020-08-19 00:00:00

abstract：:Previous breakthroughs in stretchable electronics stem from strain engineering and nanocomposite approaches. Routes toward intrinsically stretchable molecular materials remain scarce but, if successful, will enable simpler fabrication processes, such as direct printing and coating, mechanically robust devices, and mor...

journal_title：Science advances

authors： Wang Y,Zhu C,Pfattner R,Yan H,Jin L,Chen S,Molina-Lopez F,Lissel F,Liu J,Rabiah NI,Chen Z,Chung JW,Linder C,Toney MF,Murmann B,Bao Z

更新日期：2017-03-10 00:00:00

abstract：:Key issues for Na-ion batteries are the development of promising electrode materials with favorable sites for Na+ ion intercalation/deintercalation and an understanding of the reaction mechanisms due to its high activation energy and poor electrochemical reversibility. We first report a layered H0.43Ti0.93Nb1.07O5 as ...

journal_title：Science advances

authors： Park H,Kwon J,Choi H,Song T,Paik U

更新日期：2017-10-06 00:00:00

abstract：:Strong coupling between a cavity and transition dipole moments in emitters leads to vacuum Rabi splitting. Researchers have not reported strong coupling between a single emitter and a dielectric cavity at room temperature until now. In this study, we investigated the photoluminescence (PL) spectra of colloidal quantum...

journal_title：Science advances

authors： Xu X,Jin S

更新日期：2020-11-20 00:00:00

abstract：:Electron interferometry via phase-contrast microscopy, holography, or picodiffraction can provide a direct visualization of the static electric and magnetic fields inside or around a material at subatomic precision, but understanding the electromagnetic origin of light-matter interaction requires time resolution as we...

journal_title：Science advances

authors： Mohler KJ,Ehberger D,Gronwald I,Lange C,Huber R,Baum P

更新日期：2020-11-20 00:00:00

abstract：:The human bronchial epithelium is composed of multiple distinct cell types that cooperate to defend against environmental insults. While studies have shown that smoking alters bronchial epithelial function and morphology, its precise effects on specific cell types and overall tissue composition are unclear. We used si...

journal_title：Science advances

authors： Duclos GE,Teixeira VH,Autissier P,Gesthalter YB,Reinders-Luinge MA,Terrano R,Dumas YM,Liu G,Mazzilli SA,Brandsma CA,van den Berge M,Janes SM,Timens W,Lenburg ME,Spira A,Campbell JD,Beane J

更新日期：2019-12-11 00:00:00

abstract：:Sister chromatid cohesion requires cohesin to act as a protein linker to hold chromatids together. How cohesin tethers chromatids remains poorly understood. We have used optical tweezers to visualize cohesin as it holds DNA molecules. We show that cohesin complexes tether DNAs in the presence of Scc2/Scc4 and ATP demo...

journal_title：Science advances

authors： Gutierrez-Escribano P,Newton MD,Llauró A,Huber J,Tanasie L,Davy J,Aly I,Aramayo R,Montoya A,Kramer H,Stigler J,Rueda DS,Aragon L

更新日期：2019-11-27 00:00:00

abstract：:Metabolic reprogramming is a major factor in transformation, and particular metabolic phenotypes correlate with oncogenotype, tumor progression, and metastasis. By profiling metabolites in 17 patient-derived xenograft melanoma models, we identified durable metabolomic signatures that correlate with biological features...

journal_title：Science advances

authors： Shi X,Tasdogan A,Huang F,Hu Z,Morrison SJ,DeBerardinis RJ

更新日期：2017-11-01 00:00:00

abstract：:Microbial fuel cells (MFCs) are able to directly convert about 50 to 90% of energy from oxidation of organic matters in waste to electricity and have great potential application in broad fields such as wastewater treatment. Unfortunately, the power density of the MFCs at present is significantly lower than the theoret...

journal_title：Science advances

authors： Zhao S,Li Y,Yin H,Liu Z,Luan E,Zhao F,Tang Z,Liu S

更新日期：2015-11-13 00:00:00

abstract：:Approaching predators cast expanding shadows (i.e., looming) that elicit innate defensive responses in most animals. Where looming is first detected and how critical parameters of predatory approaches are extracted are unclear. In mice, we identify a retinal interneuron (the VG3 amacrine cell) that responds robustly t...

journal_title：Science advances

authors： Kim T,Shen N,Hsiang JC,Johnson KP,Kerschensteiner D

更新日期：2020-11-18 00:00:00

abstract：:Kozmin et al. contend that observations previously reported regarding the antimicrobial and antitumor activities of 6-N-hydroxy aminopurine (6-HAP) were incorrect. Their conclusions rely on poorly characterized reagents and focus strictly on in vitro techniques without validation in relevant mammalian model systems. W...

journal_title：Science advances

authors： Nakatsuji T,Fenical W,Gallo RL

更新日期：2019-09-11 00:00:00

abstract：:The formation of the Isthmus of Panama stands as one of the greatest natural events of the Cenozoic, driving profound biotic transformations on land and in the oceans. Some recent studies suggest that the Isthmus formed many millions of years earlier than the widely recognized age of approximately 3 million years ago ...

journal_title：Science advances

authors： O'Dea A,Lessios HA,Coates AG,Eytan RI,Restrepo-Moreno SA,Cione AL,Collins LS,de Queiroz A,Farris DW,Norris RD,Stallard RF,Woodburne MO,Aguilera O,Aubry MP,Berggren WA,Budd AF,Cozzuol MA,Coppard SE,Duque-Caro H,Finne

更新日期：2016-08-17 00:00:00

abstract：:Adaptation is a fundamental property of sensory systems that can change subjective experiences in the context of recent information. Adaptation has been postulated to arise from recurrent circuit mechanisms or as a consequence of neuronally intrinsic suppression. However, it is unclear whether intrinsic suppression by...

journal_title：Science advances

authors： Vinken K,Boix X,Kreiman G

更新日期：2020-10-14 00:00:00

abstract：:Bioengineered three-dimensional (3D) matrices expand our experimental repertoire to study tumor growth and progression in a biologically relevant, yet controlled, manner. Here, we used peptide amphiphiles (PAs) to coassemble with and organize extracellular matrix (ECM) proteins producing tunable 3D models of the tumor...

journal_title：Science advances

authors： Hedegaard CL,Redondo-Gómez C,Tan BY,Ng KW,Loessner D,Mata A

更新日期：2020-10-02 00:00:00

abstract：:The first example of a homogeneous silver(I)-catalyzed aerobic oxidation of aldehydes in water is reported. More than 50 examples of different aliphatic and aromatic aldehydes, including natural products, were tested, and all of them successfully underwent aerobic oxidation to give the corresponding carboxylic acids i...

journal_title：Science advances

authors： Liu M,Wang H,Zeng H,Li CJ

更新日期：2015-03-27 00:00:00

abstract：:Sedimentary hydrocarbon remnants of eukaryotic C26-C30 sterols can be used to reconstruct early algal evolution. Enhanced C29 sterol abundances provide algal cell membranes a density advantage in large temperature fluctuations. Here, we combined a literature review with new analyses to generate a comprehensive invento...

journal_title：Science advances

authors： Hoshino Y,Poshibaeva A,Meredith W,Snape C,Poshibaev V,Versteegh GJM,Kuznetsov N,Leider A,van Maldegem L,Neumann M,Naeher S,Moczydłowska M,Brocks JJ,Jarrett AJM,Tang Q,Xiao S,McKirdy D,Das SK,Alvaro JJ,Sansjofre P,

更新日期：2017-09-20 00:00:00

abstract：:The integration of structure and function for tissue engineering scaffolds is of great importance in mimicking native bone tissue. However, the complexity of hierarchical structures, the requirement for mechanical properties, and the diversity of bone resident cells are the major challenges in constructing biomimetic ...

journal_title：Science advances

authors： Zhang M,Lin R,Wang X,Xue J,Deng C,Feng C,Zhuang H,Ma J,Qin C,Wan L,Chang J,Wu C

更新日期：2020-03-20 00:00:00

abstract：:Achieving perovskite-based high-color purity blue-emitting light-emitting diodes (LEDs) is still challenging. Here, we report successful synthesis of a series of blue-emissive two-dimensional Ruddlesden-Popper phase single crystals and their high-color purity blue-emitting LED demonstrations. Although this approach su...

journal_title：Science advances

authors： Chen H,Lin J,Kang J,Kong Q,Lu D,Kang J,Lai M,Quan LN,Lin Z,Jin J,Wang LW,Toney MF,Yang P

更新日期：2020-01-24 00:00:00

abstract：:Soil organic carbon (SOC) stored in permafrost across the high-latitude/altitude Northern Hemisphere represents an important potential carbon source under future warming. Here, we provide a comprehensive investigation on the spatiotemporal dynamics of SOC over the high-altitude Tibetan Plateau (TP), which has received...

journal_title：Science advances

authors： Wang T,Yang D,Yang Y,Piao S,Li X,Cheng G,Fu B

更新日期：2020-05-06 00:00:00

abstract：:By introducing a superconducting gap in Weyl or Dirac semimetals, the superconducting state inherits the nontrivial topology of their electronic structure. As a result, Weyl superconductors are expected to host exotic phenomena, such as nonzero-momentum pairing due to their chiral node structure, or zero-energy Majora...

journal_title：Science advances

authors： Bachmann MD,Nair N,Flicker F,Ilan R,Meng T,Ghimire NJ,Bauer ED,Ronning F,Analytis JG,Moll PJW

更新日期：2017-05-24 00:00:00

abstract：:Changes in chromatin organization occur during aging. Overexpression of histones partially alleviates these changes and promotes longevity. We report that deletion of the histone H3-H4 minor locus HHT1-HHF1 extended the replicative life span of Saccharomyces cerevisiae. This longevity effect was mediated through TOR s...

journal_title：Science advances

authors： Yu R,Sun L,Sun Y,Han X,Qin L,Dang W

更新日期：2019-07-10 00:00:00

abstract：:Glass-forming ability (GFA) is the ability of a liquid to avoid crystallization during cooling. Metal-organic frameworks (MOFs) are a new class of glass formers (1-3), with hitherto unknown dynamic and thermodynamic properties. We report the discovery of a new series of tetrahedral glass systems, zeolitic imidazolate ...

journal_title：Science advances

authors： Qiao A,Bennett TD,Tao H,Krajnc A,Mali G,Doherty CM,Thornton AW,Mauro JC,Greaves GN,Yue Y

更新日期：2018-03-09 00:00:00

abstract：:Immune regulatory metabolites are key features of the tumor microenvironment (TME), yet with a few exceptions, their identities remain largely unknown. Here, we profiled tumor and T cells from tumor and ascites of patients with high-grade serous carcinoma (HGSC) to uncover the metabolomes of these distinct TME compart...

journal_title：Science advances

authors： Kilgour MK,MacPherson S,Zacharias LG,Ellis AE,Sheldon RD,Liu EY,Keyes S,Pauly B,Carleton G,Allard B,Smazynski J,Williams KS,Watson PH,Stagg J,Nelson BH,DeBerardinis RJ,Jones RG,Hamilton PT,Lum JJ

更新日期：2021-01-20 00:00:00

abstract：:Animals, humans, and multi-robot systems operate in dynamic environments, where the ability to respond to changing circumstances is paramount. An effective collective response requires suitable information transfer among agents and thus critically depends on the interaction network. To investigate the influence of the...

journal_title：Science advances

authors： Mateo D,Horsevad N,Hassani V,Chamanbaz M,Bouffanais R

更新日期：2019-04-03 00:00:00

abstract：:Candida albicans is a pathogenic yeast that causes mucosal and systematic infections with high mortality. The absence of facile molecular genetics has been a major impediment to analysis of pathogenesis. The lack of meiosis coupled with the absence of plasmids makes genetic engineering cumbersome, especially for essen...

journal_title：Science advances

authors： Vyas VK,Barrasa MI,Fink GR

更新日期：2015-01-01 00:00:00

abstract：:Behavioral and clinical studies suggest a critical role of substance P (SP)/neurokinin-1 receptor (NK-1R) signaling in alcohol dependence. Here, we examined regulation of GABA transmission in the medial subdivision of the central amygdala (CeM) by the SP/NK-1R system, and its neuroadaptation following chronic alcohol ...

journal_title：Science advances

authors： Khom S,Steinkellner T,Hnasko TS,Roberto M

更新日期：2020-03-18 00:00:00

abstract：:Surface plasmon resonance microscopy (SPRM) with single-direction illumination is a powerful platform for biomedical imaging because of its wide-field, label-free, and high-surface-sensitivity imaging capabilities. However, two disadvantages prevent wider use of SPRM. The first is its poor spatial resolution that can ...

journal_title：Science advances

authors： Kuai Y,Chen J,Tang X,Xiang Y,Lu F,Kuang C,Xu L,Shen W,Cheng J,Gui H,Zou G,Wang P,Ming H,Liu J,Liu X,Lakowicz JR,Zhang D

更新日期：2019-03-29 00:00:00