Interferon-γ signaling in human iPSC-derived neurons recapitulates neurodevelopmental disorder phenotypes.

abstract：:A trimer-of-hairpins motif has been identified in triggering virus-cell fusion within a variety of viral envelopes. Chemically manipulating such a motif represents current repertoire of viral fusion inhibitors. Here, we report that triterpenoids, a class of natural products, antagonize this trimer-of-hairpins via its ...

journal_title：Science advances

authors： Si L,Meng K,Tian Z,Sun J,Li H,Zhang Z,Soloveva V,Li H,Fu G,Xia Q,Xiao S,Zhang L,Zhou D

更新日期：2018-11-21 00:00:00

abstract：:Cytosolic RNA sensing is a prerequisite for initiation of innate immune response against RNA viral pathogens. Signaling through RIG-I (retinoic acid-inducible gene I)-like receptors (RLRs) to TBK1 (Tank-binding kinase 1)/IKKε (IκB kinase ε) kinases is transduced by mitochondria-associated MAVS (mitochondrial antiviral...

journal_title：Science advances

authors： Xiang W,Zhang Q,Lin X,Wu S,Zhou Y,Meng F,Fan Y,Shen T,Xiao M,Xia Z,Zou J,Feng XH,Xu P

更新日期：2016-07-01 00:00:00

abstract：:Solar-thermal desalination (STD) is a potentially low-cost, sustainable approach for providing high-quality fresh water in the absence of water and energy infrastructures. Despite recent efforts to advance STD by improving heat-absorbing materials and system designs, the best strategies for maximizing STD performance ...

journal_title：Science advances

authors： Wang Z,Horseman T,Straub AP,Yip NY,Li D,Elimelech M,Lin S

更新日期：2019-07-26 00:00:00

abstract：:Neural organoids provide a powerful tool for investigating neural development, modeling neural diseases, screening drugs, and developing cell-based therapies. Somatic cells have previously been reprogrammed by transcription factors (TFs) into sensory ganglion (SG) neurons but not SG organoids. We identify a combinatio...

journal_title：Science advances

authors： Xiao D,Deng Q,Guo Y,Huang X,Zou M,Zhong J,Rao P,Xu Z,Liu Y,Hu Y,Shen Y,Jin K,Xiang M

更新日期：2020-05-29 00:00:00

abstract：:Myofibroblasts orchestrate wound healing processes, and if they remain activated, they drive disease progression such as fibrosis and cancer. Besides growth factor signaling, the local extracellular matrix (ECM) and its mechanical properties are central regulators of these processes. It remains unknown whether transfo...

journal_title：Science advances

authors： Kollmannsberger P,Bidan CM,Dunlop JWC,Fratzl P,Vogel V

更新日期：2018-01-17 00:00:00

abstract：:Cholesterol-dependent cytolysins (CDCs) form pores in cholesterol-rich membranes, but cholesterol alone is insufficient to explain their cell and host tropism. Here, we show that all eight major CDCs have high-affinity lectin activity that identifies glycans as candidate cellular receptors. Streptolysin O, vaginolysin...

journal_title：Science advances

authors： Shewell LK,Day CJ,Jen FE,Haselhorst T,Atack JM,Reijneveld JF,Everest-Dass A,James DBA,Boguslawski KM,Brouwer S,Gillen CM,Luo Z,Kobe B,Nizet V,von Itzstein M,Walker MJ,Paton AW,Paton JC,Torres VJ,Jennings MP

更新日期：2020-05-22 00:00:00

abstract：:Computer vision (CV) has the potential to change medicine fundamentally. Expert knowledge provided by CV can enhance diagnosis. Unfortunately, existing algorithms often remain below expectations, as databases used for training are usually too small, incomplete, and heterogeneous in quality. Moreover, data protection i...

journal_title：Science advances

authors： Han T,Nebelung S,Haarburger C,Horst N,Reinartz S,Merhof D,Kiessling F,Schulz V,Truhn D

更新日期：2020-12-02 00:00:00

abstract：:Ultraviolet (UV) reception is useful for such basic behaviors as mate choice, foraging, predator avoidance, communication, and navigation, whereas violet reception improves visual resolution and subtle contrast detection. UV and violet reception are mediated by the short wavelength-sensitive (SWS1) pigments that absor...

journal_title：Science advances

authors： Yokoyama S,Altun A,Jia H,Yang H,Koyama T,Faggionato D,Liu Y,Starmer WT

更新日期：2015-09-18 00:00:00

abstract：:Changes in chromatin organization occur during aging. Overexpression of histones partially alleviates these changes and promotes longevity. We report that deletion of the histone H3-H4 minor locus HHT1-HHF1 extended the replicative life span of Saccharomyces cerevisiae. This longevity effect was mediated through TOR s...

journal_title：Science advances

authors： Yu R,Sun L,Sun Y,Han X,Qin L,Dang W

更新日期：2019-07-10 00:00:00

abstract：:Massive declines in population abundances of marine animals have been documented over century-long time scales. However, analogous loss of spatial extent of habitat-forming organisms is less well known because georeferenced data are rare over long time scales, particularly in subtidal, tropical marine regions. We use ...

journal_title：Science advances

authors： McClenachan L,O'Connor G,Neal BP,Pandolfi JM,Jackson JBC

更新日期：2017-09-06 00:00:00

abstract：:Detecting associations between genomic changes and phenotypic differences is fundamental to understanding how phenotypes evolved. By systematically screening for parallel amino acid substitutions, we detected known as well as novel cases (Strc, Tecta, and Cabp2) of parallelism between echolocating bats and toothed wha...

journal_title：Science advances

authors： Lee JH,Lewis KM,Moural TW,Kirilenko B,Borgonovo B,Prange G,Koessl M,Huggenberger S,Kang C,Hiller M

更新日期：2018-09-26 00:00:00

abstract：:Ice-templating holds promise to become a powerful technique to construct high-performance bioinspired materials. Both ice nucleation and growth during the freezing process are crucial for the final architecture of the ice-templated material. However, effective ways to control these two very important factors are still...

journal_title：Science advances

authors： Zhao N,Li M,Gong H,Bai H

更新日期：2020-07-31 00:00:00

abstract：:Although electromagnetic brain stimulation is a promising treatment in neurology and psychiatry, clinical outcomes are variable, and underlying mechanisms are ill-defined, which impedes the development of new effective stimulation protocols. Here, we show, in vivo and ex vivo, that repetitive transcranial magnetic sti...

journal_title：Science advances

authors： Dufor T,Grehl S,Tang AD,Doulazmi M,Traoré M,Debray N,Dubacq C,Deng ZD,Mariani J,Lohof AM,Sherrard RM

更新日期：2019-10-30 00:00:00

abstract：:Kozmin et al. contend that observations previously reported regarding the antimicrobial and antitumor activities of 6-N-hydroxy aminopurine (6-HAP) were incorrect. Their conclusions rely on poorly characterized reagents and focus strictly on in vitro techniques without validation in relevant mammalian model systems. W...

journal_title：Science advances

authors： Nakatsuji T,Fenical W,Gallo RL

更新日期：2019-09-11 00:00:00

abstract：:Optical investigation and manipulation constitute the core of biological experiments. Here, we introduce a new borosilicate glass material that contains the rare-earth ion terbium(III) (Tb3+), which emits green fluorescence upon blue light excitation, similar to green fluorescent protein (GFP), and thus is widely comp...

journal_title：Science advances

authors： Okamoto K,Ebina T,Fujii N,Konishi K,Sato Y,Kashima T,Nakano R,Hioki H,Takeuchi H,Yumoto J,Matsuzaki M,Ikegaya Y

更新日期：2021-01-06 00:00:00

abstract：:The design of single-molecule photoswitchable emitters was the first milestone toward the advent of single-molecule localization microscopy, setting a new paradigm in the field of optical imaging. Several photoswitchable emitters have been developed, but they all fluoresce in the visible or far-red ranges, missing the...

journal_title：Science advances

authors： Godin AG,Setaro A,Gandil M,Haag R,Adeli M,Reich S,Cognet L

更新日期：2019-09-27 00:00:00

abstract：:Recently, the complexity behind manipulations of reflected fields by metasurfaces has been addressed, showing that, even in the simplest scenarios, nonlocal response and excitation of auxiliary evanescent fields are required for perfect field control. In this work, we introduce purely local reflective metasurfaces for...

journal_title：Science advances

authors： Díaz-Rubio A,Li J,Shen C,Cummer SA,Tretyakov SA

更新日期：2019-02-15 00:00:00

abstract：:Transcription factors control gene expression in all life. This raises the question of what is the smallest protein that can support such activity. In nature, Cro from bacteriophage λ is one of the smallest known repressors (66 amino acids), and activators are typically much larger (e.g., λ cI, 237 amino acids). Previ...

journal_title：Science advances

authors： Brödel AK,Rodrigues R,Jaramillo A,Isalan M

更新日期：2020-06-10 00:00:00

abstract：:Injection-induced earthquakes pose a serious seismic hazard but also offer an opportunity to gain insight into earthquake physics. Currently used models relating the maximum magnitude of injection-induced earthquakes to injection parameters do not incorporate rupture physics. We develop theoretical estimates, validate...

journal_title：Science advances

authors： Galis M,Ampuero JP,Mai PM,Cappa F

更新日期：2017-12-20 00:00:00

abstract：:The process by which a zygote develops from a single cell into a multicellular organism is poorly understood. Advances are hindered by detection specificity and sensitivity limitations of single-cell protein tools and by challenges in integrating multimodal data. We introduce an open microfluidic tool expressly design...

journal_title：Science advances

authors： Rosàs-Canyelles E,Modzelewski AJ,Geldert A,He L,Herr AE

更新日期：2020-04-22 00:00:00

abstract：:NSF (N-ethylmaleimide-sensitive factor) and α-SNAP (α-soluble NSF attachment protein) bind to the SNARE (soluble NSF attachment protein receptor) complex, the minimum machinery to mediate membrane fusion, to form a 20S complex, which disassembles the SNARE complex for reuse. We report the cryo-EM structures of the α-S...

journal_title：Science advances

authors： Huang X,Sun S,Wang X,Fan F,Zhou Q,Lu S,Cao Y,Wang QW,Dong MQ,Yao J,Sui SF

更新日期：2019-04-10 00:00:00

abstract：:Triple-negative breast cancer (TNBC) is life-threatening because of limited therapies and lack of effective therapeutic targets. Here, we found that moesin (MSN) was significantly overexpressed in TNBC compared with other subtypes of breast cancer and was positively correlated with poor overall survival. However, litt...

journal_title：Science advances

authors： Qin Y,Chen W,Jiang G,Zhou L,Yang X,Li H,He X,Wang HL,Zhou YB,Huang S,Liu S

更新日期：2020-02-19 00:00:00

abstract：:E2F is a family of master transcription regulators involved in mediating diverse cell fates. Here, we show that residue-specific arginine methylation (meR) by PRMT5 enables E2F1 to regulate many genes at the level of alternative RNA splicing, rather than through its classical transcription-based mechanism. The p100/TS...

journal_title：Science advances

authors： Roworth AP,Carr SM,Liu G,Barczak W,Miller RL,Munro S,Kanapin A,Samsonova A,La Thangue NB

更新日期：2019-06-26 00:00:00

abstract：:In sickle cell disease, the aberrant assembly of hemoglobin fibers induces changes in red blood cell morphology and stiffness, which leads to downstream symptoms of the disease. Therefore, understanding of this assembly process will be important for the treatment of sickle cell disease. By performing the highest spati...

journal_title：Science advances

authors： Castle BT,Odde DJ,Wood DK

更新日期：2019-03-13 00:00:00

abstract：:Gravel-bed river floodplains in mountain landscapes disproportionately concentrate diverse habitats, nutrient cycling, productivity of biota, and species interactions. Although stream ecologists know that river channel and floodplain habitats used by aquatic organisms are maintained by hydrologic regimes that mobilize...

journal_title：Science advances

authors： Hauer FR,Locke H,Dreitz VJ,Hebblewhite M,Lowe WH,Muhlfeld CC,Nelson CR,Proctor MF,Rood SB

更新日期：2016-06-24 00:00:00

abstract：:Conjugated polymer-polyelectrolyte blends combine and couple electronic semiconductor functionality with selective ionic transport, making them attractive as the active material in organic biosensors and bioelectronics, electrochromic displays, neuromorphic computing, and energy conversion and storage. Although extens...

journal_title：Science advances

authors： Tybrandt K,Zozoulenko IV,Berggren M

更新日期：2017-12-15 00:00:00

abstract：:Capabilities for assembly of three-dimensional (3D) micro/nanostructures in advanced materials have important implications across a broad range of application areas, reaching nearly every class of microsystem technology. Approaches that rely on the controlled, compressive buckling of 2D precursors are promising becaus...

journal_title：Science advances

authors： Yan Z,Zhang F,Liu F,Han M,Ou D,Liu Y,Lin Q,Guo X,Fu H,Xie Z,Gao M,Huang Y,Kim J,Qiu Y,Nan K,Kim J,Gutruf P,Luo H,Zhao A,Hwang KC,Huang Y,Zhang Y,Rogers JA

更新日期：2016-09-23 00:00:00

abstract：:Advanced molecular materials that combine two or more physical properties are typically constructed by combining different molecules, each being responsible for one of the properties required. Ideally, single molecules could take care of this combined functionality, provided they are self-assembled correctly and endow...

journal_title：Science advances

authors： Gorbunov AV,Garcia Iglesias M,Guilleme J,Cornelissen TD,Roelofs WSC,Torres T,González-Rodríguez D,Meijer EW,Kemerink M

更新日期：2017-09-29 00:00:00

abstract：:Fundamental understanding of the charge transport physics of hybrid lead halide perovskite semiconductors is important for advancing their use in high-performance optoelectronics. We use field-effect transistors (FETs) to probe the charge transport mechanism in thin films of methylammonium lead iodide (MAPbI3). We sho...

journal_title：Science advances

authors： Senanayak SP,Yang B,Thomas TH,Giesbrecht N,Huang W,Gann E,Nair B,Goedel K,Guha S,Moya X,McNeill CR,Docampo P,Sadhanala A,Friend RH,Sirringhaus H

更新日期：2017-01-27 00:00:00

abstract：:The response to programmed cell death protein-1 (PD-1)/programmed death ligand-1 (PD-L1) blockade in cancer immunotherapy is limited because of multiple immune evasion mechanisms. Here, a previously unknown strategy is proposed to synergize the nuclear factor κB (NF-κB) inhibition and PD-1 blockade for antitumor immun...

journal_title：Science advances

authors： Xiao Z,Su Z,Han S,Huang J,Lin L,Shuai X

更新日期：2020-02-05 00:00:00