Abstract:
:Triple-negative breast cancer (TNBC) is life-threatening because of limited therapies and lack of effective therapeutic targets. Here, we found that moesin (MSN) was significantly overexpressed in TNBC compared with other subtypes of breast cancer and was positively correlated with poor overall survival. However, little is known about the regulatory mechanisms of MSN in TNBC. We found that MSN significantly stimulated breast cancer cell proliferation and invasion in vitro and tumor growth in vivo, requiring the phosphorylation of MSN and a nucleoprotein NONO-assisted nuclear localization of phosphorylated MSN with protein kinase C (PKC) and then the phosphorylation activation of CREB signaling by PKC. Our study also demonstrated that targeting MSN, NONO, or CREB significantly inhibited breast tumor growth in vivo. These results introduce a new understanding of MSN function in breast cancer and provide favorable evidence that MSN or its downstream molecules might serve as new targets for TNBC treatment.
journal_name
Sci Advjournal_title
Science advancesauthors
Qin Y,Chen W,Jiang G,Zhou L,Yang X,Li H,He X,Wang HL,Zhou YB,Huang S,Liu Sdoi
10.1126/sciadv.aaw9960subject
Has Abstractpub_date
2020-02-19 00:00:00pages
eaaw9960issue
8issn
2375-2548pii
aaw9960journal_volume
6pub_type
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