Matching cell lines with cancer type and subtype of origin via mutational, epigenomic, and transcriptomic patterns.

abstract：:Since Darwin's conception of sexual selection theory, scientists have struggled to identify the evolutionary forces underlying the pervasive differences between male and female behavior, morphology, and physiology. The Darwin-Bateman paradigm predicts that anisogamy imposes stronger sexual selection on males, which, i...

journal_title：Science advances

authors： Janicke T,Häderer IK,Lajeunesse MJ,Anthes N

更新日期：2016-02-12 00:00:00

abstract：:Low-dimensional materials usually exhibit mechanical properties from those of their bulk counterparts. Here, we show in two-dimensional (2D) rhenium disulfide (ReS2) that the fracture processes are dominated by a variety of previously unidentified phenomena, which are not present in bulk materials. Through direct tran...

journal_title：Science advances

authors： Huang L,Zheng F,Deng Q,Thi QH,Wong LW,Cai Y,Wang N,Lee CS,Lau SP,Ly TH,Zhao J

更新日期：2020-11-18 00:00:00

abstract：:The past few years have witnessed rapid advances in the synthesis of high-quality perovskite nanocrystals (PNCs). However, despite the impressive developments, the stability of PNCs remains a substantial challenge. The ability to reliably improve stability of PNCs while retaining their individual nanometer size repres...

journal_title：Science advances

authors： He Y,Yoon YJ,Harn YW,Biesold-McGee GV,Liang S,Lin CH,Tsukruk VV,Thadhani N,Kang Z,Lin Z

更新日期：2019-11-29 00:00:00

abstract：:Detecting associations between genomic changes and phenotypic differences is fundamental to understanding how phenotypes evolved. By systematically screening for parallel amino acid substitutions, we detected known as well as novel cases (Strc, Tecta, and Cabp2) of parallelism between echolocating bats and toothed wha...

journal_title：Science advances

authors： Lee JH,Lewis KM,Moural TW,Kirilenko B,Borgonovo B,Prange G,Koessl M,Huggenberger S,Kang C,Hiller M

更新日期：2018-09-26 00:00:00

abstract：:Correlating spatial chemical information with the morphology of closely packed nanostructures remains a challenge for the scientific community. For example, supramolecular self-assembly, which provides a powerful and low-cost way to create nanoscale patterns and engineered nanostructures, is not easily interrogated in...

journal_title：Science advances

authors： Nowak D,Morrison W,Wickramasinghe HK,Jahng J,Potma E,Wan L,Ruiz R,Albrecht TR,Schmidt K,Frommer J,Sanders DP,Park S

更新日期：2016-03-25 00:00:00

abstract：:The ability of cytosolic lipopolysaccharide (LPS) to activate caspase-11-dependent nonclassical inflammasome is intricately controlled to avoid excessive inflammatory responses. However, very little is known about the regulatory role of various metabolic pathways in the control of caspase-11 activation. Here, we demon...

journal_title：Science advances

authors： Chen R,Zeng L,Zhu S,Liu J,Zeh HJ,Kroemer G,Wang H,Billiar TR,Jiang J,Tang D,Kang R

更新日期：2019-05-22 00:00:00

abstract：:For natural microswimmers, the interplay of swimming activity and external flow can promote robust directed motion, for example, propulsion against (upstream rheotaxis) or perpendicular to the direction of flow. These effects are generally attributed to their complex body shapes and flagellar beat patterns. Using cata...

journal_title：Science advances

authors： Katuri J,Uspal WE,Simmchen J,Miguel-López A,Sánchez S

更新日期：2018-01-26 00:00:00

abstract：:The structure of many real-world systems is best captured by networks consisting of several interaction layers. Understanding how a multilayered structure of connections affects the synchronization properties of dynamical systems evolving on top of it is a highly relevant endeavor in mathematics and physics and has po...

journal_title：Science advances

authors： Del Genio CI,Gómez-Gardeñes J,Bonamassa I,Boccaletti S

更新日期：2016-11-16 00:00:00

abstract：:Bioacoustic networks could vastly expand the coverage of wildlife monitoring to complement satellite observations of climate and vegetation. This approach would enable global-scale understanding of how climate change influences phenomena such as migratory timing of avian species. The enormous data sets that autonomous...

journal_title：Science advances

authors： Oliver RY,Ellis DPW,Chmura HE,Krause JS,Pérez JH,Sweet SK,Gough L,Wingfield JC,Boelman NT

更新日期：2018-06-20 00:00:00

abstract：:Changes in CO2 emissions during the COVID-19 pandemic have been estimated from indicators on activities like transportation and electricity generation. Here, we instead use satellite observations together with bottom-up information to track the daily dynamics of CO2 emissions during the pandemic. Unlike activity data,...

journal_title：Science advances

authors： Zheng B,Geng G,Ciais P,Davis SJ,Martin RV,Meng J,Wu N,Chevallier F,Broquet G,Boersma F,van der A R,Lin J,Guan D,Lei Y,He K,Zhang Q

更新日期：2020-12-02 00:00:00

abstract：:Microbial fuel cells (MFCs) are able to directly convert about 50 to 90% of energy from oxidation of organic matters in waste to electricity and have great potential application in broad fields such as wastewater treatment. Unfortunately, the power density of the MFCs at present is significantly lower than the theoret...

journal_title：Science advances

authors： Zhao S,Li Y,Yin H,Liu Z,Luan E,Zhao F,Tang Z,Liu S

更新日期：2015-11-13 00:00:00

abstract：:The tet methylcytosine dioxygenase 2 (TET2) enzyme catalyzes the conversion of the modified DNA base 5-methylcytosine to 5-hydroxymethylcytosine. TET2 is frequently mutated or dysregulated in multiple human cancers, and loss of TET2 is associated with changes in DNA methylation patterns. Here, using newly developed TE...

journal_title：Science advances

authors： Wang L,Ozark PA,Smith ER,Zhao Z,Marshall SA,Rendleman EJ,Piunti A,Ryan C,Whelan AL,Helmin KA,Morgan MA,Zou L,Singer BD,Shilatifard A

更新日期：2018-11-07 00:00:00

abstract：:Diets rich in sugar, salt, and fat alter taste perception and food preference, contributing to obesity and metabolic disorders, but the molecular mechanisms through which this occurs are unknown. Here, we show that in response to a high sugar diet, the epigenetic regulator Polycomb Repressive Complex 2.1 (PRC2.1) pers...

journal_title：Science advances

authors： Vaziri A,Khabiri M,Genaw BT,May CE,Freddolino PL,Dus M

更新日期：2020-11-11 00:00:00

abstract：:B cell activation is regulated by the stimulatory or inhibitory co-receptors of B cell receptors (BCRs). Here, we investigated the signaling mechanism of Fc receptor-like 1 (FcRL1), a newly identified BCR co-receptor. FcRL1 was passively recruited into B cell immunological synapses upon BCR engagement in the absence o...

journal_title：Science advances

authors： Zhao X,Xie H,Zhao M,Ahsan A,Li X,Wang F,Yi J,Yang Z,Wu C,Raman I,Li QZ,Kim TJ,Liu W

更新日期：2019-07-17 00:00:00

abstract：:Humans and animals have a "number sense," an innate capability to intuitively assess the number of visual items in a set, its numerosity. This capability implies that mechanisms to extract numerosity indwell the brain's visual system, which is primarily concerned with visual object recognition. Here, we show that netw...

journal_title：Science advances

authors： Nasr K,Viswanathan P,Nieder A

更新日期：2019-05-08 00:00:00

abstract：:Immotile cilia sense extracellular signals such as fluid flow, but whether Ca2+ plays a role in flow sensing has been unclear. Here, we examined the role of ciliary Ca2+ in the flow sensing that initiates the breaking of left-right (L-R) symmetry in the mouse embryo. Intraciliary and cytoplasmic Ca2+ transients were d...

journal_title：Science advances

authors： Mizuno K,Shiozawa K,Katoh TA,Minegishi K,Ide T,Ikawa Y,Nishimura H,Takaoka K,Itabashi T,Iwane AH,Nakai J,Shiratori H,Hamada H

更新日期：2020-07-22 00:00:00

abstract：:Climatic conditions shift gradually over millennia, altering the rates at which carbon (C) is fixed from the atmosphere and stored in the soil. However, legacy impacts of past climates on current soil C stocks are poorly understood. We used data from more than 5000 terrestrial sites from three global and regional data...

journal_title：Science advances

authors： Delgado-Baquerizo M,Eldridge DJ,Maestre FT,Karunaratne SB,Trivedi P,Reich PB,Singh BK

更新日期：2017-04-12 00:00:00

abstract：:Dewetting is a ubiquitous phenomenon in nature; many different thin films of organic and inorganic substances (such as liquids, polymers, metals, and semiconductors) share this shape instability driven by surface tension and mass transport. Via templated solid-state dewetting, we frame complex nanoarchitectures of mon...

journal_title：Science advances

authors： Naffouti M,Backofen R,Salvalaglio M,Bottein T,Lodari M,Voigt A,David T,Benkouider A,Fraj I,Favre L,Ronda A,Berbezier I,Grosso D,Abbarchi M,Bollani M

更新日期：2017-11-10 00:00:00

abstract：:Forecasting fields of oceanic phenomena has long been dependent on physical equation-based numerical models. The challenge is that many natural processes need to be considered for understanding complicated phenomena. In contrast, rules of the processes are already embedded in the time-series observation itself. Thus, ...

journal_title：Science advances

authors： Zheng G,Li X,Zhang RH,Liu B

更新日期：2020-07-15 00:00:00

abstract：:Fifty years after its discovery, the ovonic threshold switching (OTS) phenomenon, a unique nonlinear conductivity behavior observed in some chalcogenide glasses, has been recently the source of a real technological breakthrough in the field of data storage memories. This breakthrough was achieved because of the succes...

journal_title：Science advances

authors： Noé P,Verdy A,d'Acapito F,Dory JB,Bernard M,Navarro G,Jager JB,Gaudin J,Raty JY

更新日期：2020-02-28 00:00:00

abstract：:LmrA is a bacterial ATP-binding cassette (ABC) multidrug exporter that uses metabolic energy to transport ions, cytotoxic drugs, and lipids. Voltage clamping in a Port-a-Patch was used to monitor electrical currents associated with the transport of monovalent cationic HEPES+ by single-LmrA transporters and ensembles o...

journal_title：Science advances

authors： Agboh K,Lau CHF,Khoo YSK,Singh H,Raturi S,Nair AV,Howard J,Chiapello M,Feret R,Deery MJ,Murakami S,van Veen HW

更新日期：2018-09-19 00:00:00

abstract：:Several neurological disorders may benefit from gene therapy. However, even when using the lead vector candidate for intrathecal administration, adeno-associated virus serotype 9 (AAV9), the strength and distribution of gene transfer to the brain are inconsistent. On the basis of preliminary observations that standard...

journal_title：Science advances

authors： Castle MJ,Cheng Y,Asokan A,Tuszynski MH

更新日期：2018-11-14 00:00:00

abstract：:Unraveling the genetic and epigenetic determinants of phenotypes is critical for understanding and re-engineering biology and would benefit from improved methods to separate cells based on phenotypes. Here, we report SPOTlight, a versatile high-throughput technique to isolate individual yeast or human cells with uniqu...

journal_title：Science advances

authors： Lee J,Liu Z,Suzuki PH,Ahrens JF,Lai S,Lu X,Guan S,St-Pierre F

更新日期：2020-10-23 00:00:00

abstract：:Forest loss is one of the most pervasive land surface transformations on Earth, with drastic effects on global climate, ecosystems, and human well-being. As part of biodiversity conservation and climate change mitigation efforts, many countries, including China, have been implementing large-scale policies to conserve ...

journal_title：Science advances

authors： Viña A,McConnell WJ,Yang H,Xu Z,Liu J

更新日期：2016-03-18 00:00:00

abstract：:We introduce two photochromic proteins for cell-specific in vivo optoacoustic (OA) imaging with signal unmixing in the temporal domain. We show highly sensitive, multiplexed visualization of T lymphocytes, bacteria, and tumors in the mouse body and brain. We developed machine learning-based software for commercial ima...

journal_title：Science advances

authors： Mishra K,Stankevych M,Fuenzalida-Werner JP,Grassmann S,Gujrati V,Huang Y,Klemm U,Buchholz VR,Ntziachristos V,Stiel AC

更新日期：2020-06-12 00:00:00

abstract：:Following the onset of the strong 2014-2016 El Niño, a decade-long increase of the basin-wide sea level and heat content in the subtropical southern Indian Ocean (SIO) in 2004-2013 ended with an unprecedented drop, which quickly recovered during the weak 2017-2018 La Niña. Here, we show that the 2014-2016 El Niño cont...

journal_title：Science advances

authors： Volkov DL,Lee SK,Gordon AL,Rudko M

更新日期：2020-09-04 00:00:00

abstract：:Micrometer-scale acoustic waves are highly useful for refined optomechanical and acoustofluidic manipulation, where these fields are spatially localized along the transducer aperture but not along the acoustic propagation direction. In the case of acoustic tweezers, such a conventional acoustic standing wave results i...

journal_title：Science advances

authors： Collins DJ,Devendran C,Ma Z,Ng JW,Neild A,Ai Y

更新日期：2016-07-13 00:00:00

abstract：:Neurodegenerative disorders are caused by progressive neuronal loss, and there is no complete treatment available yet. Neuroinflammation is a common feature across neurodegenerative disorders and implicated in the progression of neurodegeneration. Dysregulated activation of microglia causes neuroinflammation and has b...

journal_title：Science advances

authors： Nakano-Kobayashi A,Fukumoto A,Morizane A,Nguyen DT,Le TM,Hashida K,Hosoya T,Takahashi R,Takahashi J,Hori O,Hagiwara M

更新日期：2020-11-13 00:00:00

abstract：:The single-span membrane protein KCNE3 modulates a variety of voltage-gated ion channels in diverse biological contexts. In epithelial cells, KCNE3 regulates the function of the KCNQ1 potassium ion (K(+)) channel to enable K(+) recycling coupled to transepithelial chloride ion (Cl(-)) secretion, a physiologically crit...

journal_title：Science advances

authors： Kroncke BM,Van Horn WD,Smith J,Kang C,Welch RC,Song Y,Nannemann DP,Taylor KC,Sisco NJ,George AL Jr,Meiler J,Vanoye CG,Sanders CR

更新日期：2016-09-09 00:00:00

abstract：:Precise protein folding is essential for the survival of all cells, and protein misfolding causes a number of diseases that lack effective therapies, yet the general principles governing protein folding in the cell remain poorly understood. In vivo, folding can begin cotranslationally and protein quality control at th...

journal_title：Science advances

authors： Samelson AJ,Bolin E,Costello SM,Sharma AK,O'Brien EP,Marqusee S

更新日期：2018-05-30 00:00:00