Role of Ca2+ transients at the node of the mouse embryo in breaking of left-right symmetry.

abstract：:Self-assembly of colloidal nanocrystals into complex superstructures offers notable opportunities to create functional devices and artificial materials with unusual properties. Anisotropic nanoparticles with nonspherical shapes, such as rods, plates, polyhedra, and multipods, enable the formation of a diverse range of...

journal_title：Science advances

authors： Wang Q,Wang Z,Li Z,Xiao J,Shan H,Fang Z,Qi L

更新日期：2017-10-27 00:00:00

abstract：:Successful rehabilitation of oropharyngeal swallowing disorders (i.e., dysphagia) requires frequent performance of head/neck exercises that primarily rely on expensive biofeedback devices, often only available in large medical centers. This directly affects treatment compliance and outcomes, and highlights the need to...

journal_title：Science advances

authors： Kim MK,Kantarcigil C,Kim B,Baruah RK,Maity S,Park Y,Kim K,Lee S,Malandraki JB,Avlani S,Smith A,Sen S,Alam MA,Malandraki G,Lee CH

更新日期：2019-12-13 00:00:00

abstract：:Prosocial behavior is paradoxical because it often entails a cost to one's own welfare to benefit others. Theoretical models suggest that prosociality is driven by several forms of reciprocity. Although we know a great deal about how each of these forms operates in isolation, they are rarely isolated in the real world...

journal_title：Science advances

authors： Melamed D,Simpson B,Abernathy J

更新日期：2020-06-03 00:00:00

abstract：:Cell lines are commonly used as cancer models. The tissue of origin provides context for understanding biological mechanisms and predicting therapy response. We therefore systematically examined whether cancer cell lines exhibit features matching the presumed cancer type of origin. Gene expression and DNA methylation ...

journal_title：Science advances

authors： Salvadores M,Fuster-Tormo F,Supek F

更新日期：2020-07-01 00:00:00

abstract：:The formation of the biophotonic gyroid material in butterfly wing scales is an exceptional feat of evolutionary engineering of functional nanostructures. It is hypothesized that this nanostructure forms by chitin polymerization inside a convoluted membrane of corresponding shape in the endoplasmic reticulum. However,...

journal_title：Science advances

authors： Wilts BD,Apeleo Zubiri B,Klatt MA,Butz B,Fischer MG,Kelly ST,Spiecker E,Steiner U,Schröder-Turk GE

更新日期：2017-04-26 00:00:00

abstract：:Marine ecosystems are responsible for virtually all production of omega-3 (ω3) long-chain polyunsaturated fatty acids (PUFA), which are essential nutrients for vertebrates. Current consensus is that marine microbes account for this production, given their possession of key enzymes including methyl-end (or "ωx") desatu...

journal_title：Science advances

authors： Kabeya N,Fonseca MM,Ferrier DEK,Navarro JC,Bay LK,Francis DS,Tocher DR,Castro LFC,Monroig Ó

更新日期：2018-05-02 00:00:00

abstract：:Since its domestication in the Fertile Crescent ~8000 to 10,000 years ago, wheat has undergone a complex history of spread, adaptation, and selection. To get better insights into the wheat phylogeography and genetic diversity, we describe allele distribution through time using a set of 4506 landraces and cultivars ori...

journal_title：Science advances

authors： Balfourier F,Bouchet S,Robert S,De Oliveira R,Rimbert H,Kitt J,Choulet F,International Wheat Genome Sequencing Consortium.,BreedWheat Consortium.,Paux E

更新日期：2019-05-29 00:00:00

abstract：:The discovery of high-temperature superconductivity in cuprates ranks among the major scientific milestones of the past half century, yet pivotal questions regarding the complex phase diagram of these materials remain unanswered. Generally thought of as doped charge-transfer insulators, these complex oxides exhibit ps...

journal_title：Science advances

authors： Pelc D,Popčević P,Požek M,Greven M,Barišić N

更新日期：2019-01-25 00:00:00

abstract：:Perovskite oxides exhibit potential for use as electrocatalysts in the oxygen evolution reaction (OER). However, their low specific surface area is the main obstacle to realizing a high mass-specific activity that is required to be competitive against the state-of-the-art precious metal-based catalysts. We report the ...

journal_title：Science advances

authors： Chen G,Zhou W,Guan D,Sunarso J,Zhu Y,Hu X,Zhang W,Shao Z

更新日期：2017-06-21 00:00:00

abstract：:The wings of the black butterfly, Pachliopta aristolochiae, are covered by micro- and nanostructured scales that harvest sunlight over a wide spectral and angular range. Considering that these properties are particularly attractive for photovoltaic applications, we analyze the contribution of these micro- and nanostru...

journal_title：Science advances

authors： Siddique RH,Donie YJ,Gomard G,Yalamanchili S,Merdzhanova T,Lemmer U,Hölscher H

更新日期：2017-10-20 00:00:00

abstract：:Since its first discovery in 2004, graphene has been found to host a plethora of unusual electronic transport phenomena, making it a fascinating system for fundamental studies in condensed matter physics as well as offering tremendous opportunities for future electronic and sensing devices. Typically, electronic trans...

journal_title：Science advances

authors： Tetienne JP,Dontschuk N,Broadway DA,Stacey A,Simpson DA,Hollenberg LCL

更新日期：2017-04-26 00:00:00

abstract：:Extinction of conditioned fear necessitates the dynamic involvement of hippocampus, medial prefrontal cortex (mPFC), and basolateral amygdala (BLA), but key molecular players that regulate these circuits to achieve fear extinction remain largely unknown. Here, we report that acid-sensing ion channel 1a (ASIC1a) is a c...

journal_title：Science advances

authors： Wang Q,Wang Q,Song XL,Jiang Q,Wu YJ,Li Y,Yuan TF,Zhang S,Xu NJ,Zhu MX,Li WG,Xu TL

更新日期：2018-10-24 00:00:00

abstract：:Amorphous solids, such as glasses, have complex responses to deformations, with substantial consequences in material design and applications. In this respect, two intertwined aspects are important: stability and reversibility. It is crucial to understand, on the one hand, how a glass may become unstable due to increas...

journal_title：Science advances

authors： Jin Y,Urbani P,Zamponi F,Yoshino H

更新日期：2018-12-07 00:00:00

abstract：:Traumatic spinal cord injury (SCI) brings numerous inflammatory cells, including macrophages, from the circulating blood to lesions, but pathophysiological impact resulting from spatiotemporal dynamics of macrophages is unknown. Here, we show that macrophages centripetally migrate toward the lesion epicenter after inf...

journal_title：Science advances

authors： Kobayakawa K,Ohkawa Y,Yoshizaki S,Tamaru T,Saito T,Kijima K,Yokota K,Hara M,Kubota K,Matsumoto Y,Harimaya K,Ozato K,Masuda T,Tsuda M,Tamura T,Inoue K,Edgerton VR,Iwamoto Y,Nakashima Y,Okada S

更新日期：2019-05-15 00:00:00

abstract：:In May 2014, the Balkans were hit by a Vb-type cyclone that brought disastrous flooding and severe damage to Bosnia and Herzegovina, Serbia, and Croatia. Vb cyclones migrate from the Mediterranean, where they absorb warm and moist air, to the north, often causing flooding in central/eastern Europe. Extreme rainfall ev...

journal_title：Science advances

authors： Stadtherr L,Coumou D,Petoukhov V,Petri S,Rahmstorf S

更新日期：2016-04-15 00:00:00

abstract：:At a time of heightened anxiety surrounding immigration, state governments have increasingly sought to manage immigrant and refugee flows. Yet the factors that influence where immigrants choose to settle after arrival remain unclear. We bring evidence to this question by analyzing population-level data for refugees re...

journal_title：Science advances

authors： Mossaad N,Ferwerda J,Lawrence D,Weinstein J,Hainmueller J

更新日期：2020-08-07 00:00:00

abstract：:Over the past decade, the Arctic has warmed by 0.75°C, far outpacing the global average, while Antarctic temperatures have remained comparatively stable. As Earth approaches 2°C warming, the Arctic and Antarctic may reach 4°C and 2°C mean annual warming, and 7°C and 3°C winter warming, respectively. Expected consequen...

journal_title：Science advances

authors： Post E,Alley RB,Christensen TR,Macias-Fauria M,Forbes BC,Gooseff MN,Iler A,Kerby JT,Laidre KL,Mann ME,Olofsson J,Stroeve JC,Ulmer F,Virginia RA,Wang M

更新日期：2019-12-04 00:00:00

abstract：:Avian wing shape is highly variable across species but only coarsely associated with flight behavior, performance, and body mass. An underexplored but potentially explanatory feature is the ability of birds to actively change wing shape to meet aerodynamic and behavioral demands. Across 61 species, we found strong ass...

journal_title：Science advances

authors： Baliga VB,Szabo I,Altshuler DL

更新日期：2019-10-23 00:00:00

abstract：:By experimentally studying high-order harmonic beams generated in gases, we show how the spatial characteristics of these ultrashort extreme-ultraviolet (XUV) beams can be finely controlled when a single fundamental beam generates harmonics in a thin gas medium. We demonstrate that these XUV beams can be emitted as co...

journal_title：Science advances

authors： Quintard L,Strelkov V,Vabek J,Hort O,Dubrouil A,Descamps D,Burgy F,Péjot C,Mével E,Catoire F,Constant E

更新日期：2019-04-05 00:00:00

abstract：:Mass loss from the West Antarctic ice shelves and glaciers has been linked to basal melt by ocean heat flux. The Totten Ice Shelf in East Antarctica, which buttresses a marine-based ice sheet with a volume equivalent to at least 3.5 m of global sea-level rise, also experiences rapid basal melt, but the role of ocean f...

journal_title：Science advances

authors： Rintoul SR,Silvano A,Pena-Molino B,van Wijk E,Rosenberg M,Greenbaum JS,Blankenship DD

更新日期：2016-12-16 00:00:00

abstract：:Natively paired sequencing (NPS) of B cell receptors [variable heavy (VH) and light (VL)] and T cell receptors (TCRb and TCRa) is essential for the understanding of adaptive immunity in health and disease. Despite many recent technical advances, determining the VH:VL or TCRb:a repertoire with high accuracy and through...

journal_title：Science advances

authors： Tanno H,McDaniel JR,Stevens CA,Voss WN,Li J,Durrett R,Lee J,Gollihar J,Tanno Y,Delidakis G,Pothukuchy A,Ellefson JW,Goronzy JJ,Maynard JA,Ellington AD,Ippolito GC,Georgiou G

更新日期：2020-04-22 00:00:00

abstract：:Fluid commonly flows in response to an external pressure gradient. However, when a tunnel-containing hydrogel is immersed in water, spontaneous flow occurs through the tunnel without any pressure gradient. We confirmed this flow in a wide range of plant- and animal-derived hydrogels. The flow appears to be driven by a...

journal_title：Science advances

authors： Li Z,Pollack GH

更新日期：2020-05-08 00:00:00

abstract：:Bones adapt to mechanical forces according to strict principles predicting straight shape. Most bones are, however, paradoxically curved. To solve this paradox, we used computed tomography-based, four-dimensional imaging methods and computational analysis to monitor acute and chronic whole-bone shape adaptation and re...

journal_title：Science advances

authors： Javaheri B,Razi H,Gohin S,Wylie S,Chang YM,Salmon P,Lee PD,Pitsillides AA

更新日期：2020-03-06 00:00:00

abstract：:One of the most plausible scenarios of the origin of life assumes the preceding prebiotic autotrophic metabolism in sulfide-rich hydrothermal vent environments. However, geochemical mechanisms to harness the reductive power provided by hydrothermal systems remain to be elucidated. Here, we show that, under a geoelectr...

journal_title：Science advances

authors： Kitadai N,Nakamura R,Yamamoto M,Takai K,Yoshida N,Oono Y

更新日期：2019-06-19 00:00:00

abstract：:Planarians exhibit traits of cephalization but are unique among bilaterians in that they ingest food by means of goal-directed movements of a trunk-positioned pharynx, following protrusion of the pharynx out of the body, raising the question of how planarians control such a complex set of body movements for achieving ...

journal_title：Science advances

authors： Miyamoto M,Hattori M,Hosoda K,Sawamoto M,Motoishi M,Hayashi T,Inoue T,Umesono Y

更新日期：2020-04-08 00:00:00

abstract：:Adoptive cell transfers have emerged as a disruptive approach to treat disease in a manner that is more specific than using small-molecule drugs; however, unlike traditional drugs, cells are living entities that can alter their function in response to environmental cues. In the present study, we report an engineered p...

journal_title：Science advances

authors： Shields CW 4th,Evans MA,Wang LL,Baugh N,Iyer S,Wu D,Zhao Z,Pusuluri A,Ukidve A,Pan DC,Mitragotri S

更新日期：2020-04-29 00:00:00

abstract：:The search for topological superconductors (TSCs) is one of the most urgent contemporary problems in condensed matter systems. TSCs are characterized by a full superconducting gap in the bulk and topologically protected gapless surface (or edge) states. Within each vortex core of TSCs, there exists the zero-energy Maj...

journal_title：Science advances

authors： Guan SY,Chen PJ,Chu MW,Sankar R,Chou F,Jeng HT,Chang CS,Chuang TM

更新日期：2016-11-23 00:00:00

abstract：:Spider silk fiber rapidly assembles from spidroin protein in soluble state via an incompletely understood mechanism. Here, we present an integrated model for silk formation that incorporates the effects of multiple chemical and physical gradients on the different spidroin functional domains. Central to the process is ...

journal_title：Science advances

authors： Malay AD,Suzuki T,Katashima T,Kono N,Arakawa K,Numata K

更新日期：2020-11-04 00:00:00

abstract：:Optical investigation and manipulation constitute the core of biological experiments. Here, we introduce a new borosilicate glass material that contains the rare-earth ion terbium(III) (Tb3+), which emits green fluorescence upon blue light excitation, similar to green fluorescent protein (GFP), and thus is widely comp...

journal_title：Science advances

authors： Okamoto K,Ebina T,Fujii N,Konishi K,Sato Y,Kashima T,Nakano R,Hioki H,Takeuchi H,Yumoto J,Matsuzaki M,Ikegaya Y

更新日期：2021-01-06 00:00:00

abstract：:In addition to their conventional uses, metal-organic frameworks (MOFs) have recently emerged as an interesting class of functional materials and precursors of inorganic materials for electrochemical energy storage and conversion technologies. This class of MOF-related materials can be broadly categorized into two gro...

journal_title：Science advances

authors： Wu HB,Lou XWD

更新日期：2017-12-01 00:00:00