Lasting organ-level bone mechanoadaptation is unrelated to local strain.

Abstract:

:Bones adapt to mechanical forces according to strict principles predicting straight shape. Most bones are, however, paradoxically curved. To solve this paradox, we used computed tomography-based, four-dimensional imaging methods and computational analysis to monitor acute and chronic whole-bone shape adaptation and remodeling in vivo. We first confirmed that some acute load-induced structural changes are reversible, adhere to the linear strain magnitude regulation of remodeling activities, and are restricted to bone regions in which marked antiresorptive actions are evident. We make the novel observation that loading exerts significant lasting modifications in tibial shape and mass across extensive bone regions, underpinned by (re)modeling independent of local strain magnitude, occurring at sites where the initial response to load is principally osteogenic. This is the first report to demonstrate that bone loading stimulates nonlinear remodeling responses to strain that culminate in greater curvature adjusted for load predictability without sacrificing strength.

journal_name

Sci Adv

journal_title

Science advances

authors

Javaheri B,Razi H,Gohin S,Wylie S,Chang YM,Salmon P,Lee PD,Pitsillides AA

doi

10.1126/sciadv.aax8301

subject

Has Abstract

pub_date

2020-03-06 00:00:00

pages

eaax8301

issue

10

issn

2375-2548

pii

aax8301

journal_volume

6

pub_type

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