Probing topology by "heating": Quantized circular dichroism in ultracold atoms.

abstract：:Immunoglobulin heavy chain (IgH) genes are assembled by two sequential DNA rearrangement events that are initiated by recombination activating gene products (RAG) 1 and 2. Diversity (DH) gene segments rearrange first, followed by variable (VH) gene rearrangements. Here, we provide evidence that each rearrangement step...

journal_title：Science advances

authors： Qiu X,Ma F,Zhao M,Cao Y,Shipp L,Liu A,Dutta A,Singh A,Braikia FZ,De S,Wood WH 3rd,Becker KG,Zhou W,Ji H,Zhao K,Atchison ML,Sen R

更新日期：2020-08-14 00:00:00

abstract：:Black phosphorus quantum dots (BPQDs) are proposed as effective seed-like sites to modulate the nucleation and growth of CsPbI2Br perovskite crystalline thin layers, allowing an enhanced crystallization and remarkable morphological improvement. We reveal that the lone-pair electrons of BPQDs can induce strong binding ...

journal_title：Science advances

authors： Gong X,Guan L,Li Q,Li Y,Zhang T,Pan H,Sun Q,Shen Y,Grätzel C,Zakeeruddin SM,Grätzel M,Wang M

更新日期：2020-04-10 00:00:00

abstract：:The single-span membrane protein KCNE3 modulates a variety of voltage-gated ion channels in diverse biological contexts. In epithelial cells, KCNE3 regulates the function of the KCNQ1 potassium ion (K(+)) channel to enable K(+) recycling coupled to transepithelial chloride ion (Cl(-)) secretion, a physiologically crit...

journal_title：Science advances

authors： Kroncke BM,Van Horn WD,Smith J,Kang C,Welch RC,Song Y,Nannemann DP,Taylor KC,Sisco NJ,George AL Jr,Meiler J,Vanoye CG,Sanders CR

更新日期：2016-09-09 00:00:00

abstract：:We examine the low-temperature states supported by the quasiperiodic host-guest structure of elemental bismuth at high pressure, Bi-III. Our electronic transport and magnetization experiments establish Bi-III as a rare example of type II superconductivity in an element, with a record upper critical field of ~ 2.5 T, u...

journal_title：Science advances

authors： Brown P,Semeniuk K,Wang D,Monserrat B,Pickard CJ,Grosche FM

更新日期：2018-04-13 00:00:00

abstract：:The social bond between parents and offspring is characterized by coadaptation and balance between altruistic and selfish tendencies. However, its underlying genetic mechanism remains poorly understood. Using transcriptomic screens in the subsocial European earwig, Forficula auricularia, we found the expression of mor...

journal_title：Science advances

authors： Wu M,Walser JC,Sun L,Kölliker M

更新日期：2020-01-03 00:00:00

abstract：:In the healthy kidney, specialized cells called podocytes form a sophisticated blood filtration apparatus that allows excretion of wastes and excess fluid from the blood while preventing loss of proteins such as albumin. To operate effectively, this filter is under substantial hydrostatic mechanical pressure. Given th...

journal_title：Science advances

authors： Haley KE,Kronenberg NM,Liehm P,Elshani M,Bell C,Harrison DJ,Gather MC,Reynolds PA

更新日期：2018-06-27 00:00:00

abstract：:Avian wing shape is highly variable across species but only coarsely associated with flight behavior, performance, and body mass. An underexplored but potentially explanatory feature is the ability of birds to actively change wing shape to meet aerodynamic and behavioral demands. Across 61 species, we found strong ass...

journal_title：Science advances

authors： Baliga VB,Szabo I,Altshuler DL

更新日期：2019-10-23 00:00:00

abstract：:Bacterial chemotaxis-a fundamental example of directional navigation in the living world-is key to many biological processes, including the spreading of bacterial infections. Many bacterial species were recently reported to exhibit several distinct swimming modes-the flagella may, for example, push the cell body or wr...

journal_title：Science advances

authors： Alirezaeizanjani Z,Großmann R,Pfeifer V,Hintsche M,Beta C

更新日期：2020-05-27 00:00:00

abstract：:Synthetic aperture radar is a well-known technique for improving resolution in radio imaging. Extending these synthetic aperture techniques to the visible light domain is not straightforward because optical receivers cannot measure phase information. We propose to use macroscopic Fourier ptychography (FP) as a practic...

journal_title：Science advances

authors： Holloway J,Wu Y,Sharma MK,Cossairt O,Veeraraghavan A

更新日期：2017-04-14 00:00:00

abstract：:Laser technology has developed and accelerated photo-induced nonequilibrium physics, from both the scientific and engineering viewpoints. Floquet engineering, i.e., controlling material properties and functionalities by time-periodic drives, is at the forefront of quantum physics of light-matter interaction. However, ...

journal_title：Science advances

authors： Ikeda TN,Sato M

更新日期：2020-07-03 00:00:00

abstract：:Rising sea levels will have overwhelmingly negative impacts on coastal communities globally. With previous research focused on how sea-level rise (SLR) affects storm-induced flooding, we show that SLR will also increase both the frequency and the intensity of tsunami-induced flooding, another significant coastal hazar...

journal_title：Science advances

authors： Li L,Switzer AD,Wang Y,Chan CH,Qiu Q,Weiss R

更新日期：2018-08-15 00:00:00

abstract：:The inherent specificity and electrochemical reversibility of enzymes poise them as the biorecognition element of choice for a wide range of metabolites. To use enzymes efficiently in biosensors, the redox centers of the protein should have good electrical communication with the transducing electrode, which requires e...

journal_title：Science advances

authors： Pappa AM,Ohayon D,Giovannitti A,Maria IP,Savva A,Uguz I,Rivnay J,McCulloch I,Owens RM,Inal S

更新日期：2018-06-22 00:00:00

abstract：:Human and murine skin wounding commonly results in fibrotic scarring, but the murine wounding model wound-induced hair neogenesis (WIHN) can frequently result in a regenerative repair response. Here, we show in single-cell RNA sequencing comparisons of semi-regenerative and fibrotic WIHN wounds, increased expression o...

journal_title：Science advances

authors： Gay D,Ghinatti G,Guerrero-Juarez CF,Ferrer RA,Ferri F,Lim CH,Murakami S,Gault N,Barroca V,Rombeau I,Mauffrey P,Irbah L,Treffeisen E,Franz S,Boissonnas A,Combadière C,Ito M,Plikus MV,Romeo PH

更新日期：2020-03-20 00:00:00

abstract：:Variations in Earth's orbit pace the glacial-interglacial cycles of the Quaternary, but the mechanisms that transform regional and seasonal variations in solar insolation into glacial-interglacial cycles are still elusive. Here, we present transient simulations of coevolution of climate, ice sheets, and carbon cycle o...

journal_title：Science advances

authors： Willeit M,Ganopolski A,Calov R,Brovkin V

更新日期：2019-04-03 00:00:00

abstract：:Predator-prey interactions revealed by vertebrate trace fossils are extremely rare. We present footprint evidence from White Sands National Monument in New Mexico for the association of sloth and human trackways. Geologically, the sloth and human trackways were made contemporaneously, and the sloth trackways show evid...

journal_title：Science advances

authors： Bustos D,Jakeway J,Urban TM,Holliday VT,Fenerty B,Raichlen DA,Budka M,Reynolds SC,Allen BD,Love DW,Santucci VL,Odess D,Willey P,McDonald HG,Bennett MR

更新日期：2018-04-25 00:00:00

abstract：:Improved constraints on lower-mantle composition are fundamental to understand the accretion, differentiation, and thermochemical evolution of our planet. Cosmochemical arguments indicate that lower-mantle rocks may be enriched in Si relative to upper-mantle pyrolite, whereas seismic tomography images suggest whole-ma...

journal_title：Science advances

authors： Ballmer MD,Schmerr NC,Nakagawa T,Ritsema J

更新日期：2015-12-10 00:00:00

abstract：:The repair of DNA double-strand breaks occurs through nonhomologous end joining or homologous recombination in vertebrate cells-a choice that is thought to be decided by a competition between DNA-dependent protein kinase (DNA-PK) and the Mre11/Rad50/Nbs1 (MRN) complex but is not well understood. Using ensemble biochem...

journal_title：Science advances

authors： Deshpande RA,Myler LR,Soniat MM,Makharashvili N,Lee L,Lees-Miller SP,Finkelstein IJ,Paull TT

更新日期：2020-01-08 00:00:00

abstract：:Recent research on piezoelectric materials is predominantly devoted to enhancing the piezoelectric coefficient, but overlooks its sign, largely because almost all of them exhibit positive longitudinal piezoelectricity. The only experimentally known exception is ferroelectric polymer poly(vinylidene fluoride) and its c...

journal_title：Science advances

authors： You L,Zhang Y,Zhou S,Chaturvedi A,Morris SA,Liu F,Chang L,Ichinose D,Funakubo H,Hu W,Wu T,Liu Z,Dong S,Wang J

更新日期：2019-04-19 00:00:00

abstract：:Bioacoustic networks could vastly expand the coverage of wildlife monitoring to complement satellite observations of climate and vegetation. This approach would enable global-scale understanding of how climate change influences phenomena such as migratory timing of avian species. The enormous data sets that autonomous...

journal_title：Science advances

authors： Oliver RY,Ellis DPW,Chmura HE,Krause JS,Pérez JH,Sweet SK,Gough L,Wingfield JC,Boelman NT

更新日期：2018-06-20 00:00:00

abstract：:Calcium silicate hydrate (C-S-H) is the binder in concrete, the most used synthetic material in the world. The main weakness of concrete is the lack of elasticity and poor flexural strength considerably limiting its potential, making reinforcing steel constructions necessary. Although the properties of C-S-H could be ...

journal_title：Science advances

authors： Picker A,Nicoleau L,Burghard Z,Bill J,Zlotnikov I,Labbez C,Nonat A,Cölfen H

更新日期：2017-11-29 00:00:00

abstract：:Coastal vertical land motion affects projections of sea-level rise, and subsidence exacerbates flooding hazards. Along the ~1350-km California coastline, records of high-resolution vertical land motion rates are scarce due to sparse instrumentation, and hazards to coastal communities are underestimated. Here, we consi...

journal_title：Science advances

authors： Blackwell E,Shirzaei M,Ojha C,Werth S

更新日期：2020-07-31 00:00:00

abstract：:Intrinsically disordered regions (IDRs) of proteins are implicated in key macromolecular interactions. However, the molecular forces underlying IDR function within multicomponent assemblies remain elusive. By combining thermodynamic and structural data, we have discovered an allostery-based mechanism regulating the so...

journal_title：Science advances

authors： Blus BJ,Koh J,Krolak A,Seo HS,Coutavas E,Blobel G

更新日期：2019-11-27 00:00:00

abstract：:A withdrawal-associated impairment in β-endorphin neurotransmission in the arcuate nucleus (ARC) of the hypothalamus is associated with alcohol dependence characterized by a chronic relapsing disorder. Although acupuncture activates β-endorphin neurons in the ARC projecting to the nucleus accumbens (NAc), a role for A...

journal_title：Science advances

authors： Chang S,Kim DH,Jang EY,Yoon SS,Gwak YS,Yi YJ,Lee JY,Ahn SH,Kim JM,Ryu YH,Kim SN,Roh HS,Lee MY,Kim SC,Lee BH,Kim HY,Yang CH

更新日期：2019-09-04 00:00:00

abstract：:Fundamental understanding of the charge transport physics of hybrid lead halide perovskite semiconductors is important for advancing their use in high-performance optoelectronics. We use field-effect transistors (FETs) to probe the charge transport mechanism in thin films of methylammonium lead iodide (MAPbI3). We sho...

journal_title：Science advances

authors： Senanayak SP,Yang B,Thomas TH,Giesbrecht N,Huang W,Gann E,Nair B,Goedel K,Guha S,Moya X,McNeill CR,Docampo P,Sadhanala A,Friend RH,Sirringhaus H

更新日期：2017-01-27 00:00:00

abstract：:Cyclosporine A (CsA) is a powerful immunosuppressant, but it is an ineffective stand-alone treatment for systemic lupus erythematosus (SLE) due to poor target tissue distribution and renal toxicity. We hypothesized that CD71 (transferrin receptor 1)-directed delivery of CsA to the lymphatic system would improve SLE ou...

journal_title：Science advances

authors： Ganugula R,Arora M,Zou D,Agarwal SK,Mohan C,Kumar MNVR

更新日期：2020-06-12 00:00:00

abstract：:Intrachain charge transport is unique to conjugated polymers distinct from inorganic and small molecular semiconductors and is key to achieving high-performance organic electronics. Polymer backbone planarity and thin film morphology sensitively modulate intrachain charge transport. However, simple, generic nonsynthet...

journal_title：Science advances

authors： Park KS,Kwok JJ,Dilmurat R,Qu G,Kafle P,Luo X,Jung SH,Olivier Y,Lee JK,Mei J,Beljonne D,Diao Y

更新日期：2019-08-09 00:00:00

abstract：:The ability of cytosolic lipopolysaccharide (LPS) to activate caspase-11-dependent nonclassical inflammasome is intricately controlled to avoid excessive inflammatory responses. However, very little is known about the regulatory role of various metabolic pathways in the control of caspase-11 activation. Here, we demon...

journal_title：Science advances

authors： Chen R,Zeng L,Zhu S,Liu J,Zeh HJ,Kroemer G,Wang H,Billiar TR,Jiang J,Tang D,Kang R

更新日期：2019-05-22 00:00:00

abstract：:Two-dimensional (2D) semiconductors have shown great potential for electronic and optoelectronic applications. However, their development is limited by a large Schottky barrier (SB) at the metal-semiconductor junction (MSJ), which is difficult to tune by using conventional metals because of the effect of strong Fermi ...

journal_title：Science advances

authors： Liu Y,Stradins P,Wei SH

更新日期：2016-04-22 00:00:00

abstract：:We have positionally cloned the Ym1 gene, with a duplication and a promoter polymorphism, as a major regulator of inflammation. Mice with the RIIIS/J haplotype, with the absence of Ym1 expression, showed reduced susceptibility to mannan-enhanced collagen antibody-induced arthritis and to chronic arthritis induced by i...

journal_title：Science advances

authors： Zhu W,Lönnblom E,Förster M,Johannesson M,Tao P,Meng L,Lu S,Holmdahl R

更新日期：2020-10-21 00:00:00

abstract：:The integration of structure and function for tissue engineering scaffolds is of great importance in mimicking native bone tissue. However, the complexity of hierarchical structures, the requirement for mechanical properties, and the diversity of bone resident cells are the major challenges in constructing biomimetic ...

journal_title：Science advances

authors： Zhang M,Lin R,Wang X,Xue J,Deng C,Feng C,Zhuang H,Ma J,Qin C,Wan L,Chang J,Wu C

更新日期：2020-03-20 00:00:00