Compositional mantle layering revealed by slab stagnation at ~1000-km depth.

abstract：:Human genome-wide association studies have linked single-nucleotide polymorphisms (SNPs) in NEMP1 (nuclear envelope membrane protein 1) with early menopause; however, it is unclear whether NEMP1 has any role in fertility. We show that whole-animal loss of NEMP1 homologs in Drosophila, Caenorhabditis elegans, zebrafish...

journal_title：Science advances

authors： Tsatskis Y,Rosenfeld R,Pearson JD,Boswell C,Qu Y,Kim K,Fabian L,Mohammad A,Wang X,Robson MI,Krchma K,Wu J,Gonçalves J,Hodzic D,Wu S,Potter D,Pelletier L,Dunham WH,Gingras AC,Sun Y,Meng J,Godt D,Schedl T,Ciru

更新日期：2020-08-28 00:00:00

abstract：:To gain insights into neutrophil heterogeneity dynamics in the context of sterile inflammation and wound healing, we performed a pseudotime analysis of single-cell flow cytometry data using the spanning-tree progression analysis of density-normalized events algorithm. This enables us to view neutrophil transitional su...

journal_title：Science advances

authors： Turner TC,Sok MCP,Hymel LA,Pittman FS,York WY,Mac QD,Vyshnya S,Lim HS,Kwong GA,Qiu P,Botchwey EA

更新日期：2020-10-30 00:00:00

abstract：:Human settlement of the Caribbean represents the only example in the Americas of peoples colonizing islands that were not visible from surrounding mainland areas or other islands. Unfortunately, many interpretive models have relied on radiocarbon determinations that do not meet standard criteria for reporting because ...

journal_title：Science advances

authors： Napolitano MF,DiNapoli RJ,Stone JH,Levin MJ,Jew NP,Lane BG,O'Connor JT,Fitzpatrick SM

更新日期：2019-12-18 00:00:00

abstract：:Low seismic velocity regions in the mantle and crust are commonly attributed to the presence of silicate melts. Determining melt volume and geometric distribution is fundamental to understanding planetary dynamics. We present a new model for seismic velocity reductions that accounts for the anomalous compressibility o...

journal_title：Science advances

authors： Clark AN,Lesher CE

更新日期：2017-12-13 00:00:00

abstract：:Maximizing the sustainable supercurrent density, J C, is crucial to high-current applications of superconductivity. To achieve this, preventing dissipative motion of quantized vortices is key. Irradiation of superconductors with high-energy heavy ions can be used to create nanoscale defects that act as deep pinning po...

journal_title：Science advances

authors： Massee F,Sprau PO,Wang YL,Davis JC,Ghigo G,Gu GD,Kwok WK

更新日期：2015-05-20 00:00:00

abstract：:Injection-induced earthquakes pose a serious seismic hazard but also offer an opportunity to gain insight into earthquake physics. Currently used models relating the maximum magnitude of injection-induced earthquakes to injection parameters do not incorporate rupture physics. We develop theoretical estimates, validate...

journal_title：Science advances

authors： Galis M,Ampuero JP,Mai PM,Cappa F

更新日期：2017-12-20 00:00:00

abstract：:Hypertrophic cardiomyopathy (HCM) is a heterogeneous genetic heart muscle disease characterized by hypertrophy with preserved or increased ejection fraction in the absence of secondary causes. However, recent studies have demonstrated that a substantial proportion of individuals with HCM also have comorbid diabetes me...

journal_title：Science advances

authors： Dhandapany PS,Kang S,Kashyap DK,Rajagopal R,Sundaresan NR,Singh R,Thangaraj K,Jayaprakash S,Manjunath CN,Shenthar J,Lebeche D

更新日期：2021-01-06 00:00:00

abstract：:A large body of previous neuroimaging studies suggests that multiple languages are processed and organized in a single neuroanatomical system in the bilingual brain, although differential activation may be seen in some studies because of different proficiency levels and/or age of acquisition of the two languages. Howe...

journal_title：Science advances

authors： Xu M,Baldauf D,Chang CQ,Desimone R,Tan LH

更新日期：2017-07-12 00:00:00

abstract：:Achieving perovskite-based high-color purity blue-emitting light-emitting diodes (LEDs) is still challenging. Here, we report successful synthesis of a series of blue-emissive two-dimensional Ruddlesden-Popper phase single crystals and their high-color purity blue-emitting LED demonstrations. Although this approach su...

journal_title：Science advances

authors： Chen H,Lin J,Kang J,Kong Q,Lu D,Kang J,Lai M,Quan LN,Lin Z,Jin J,Wang LW,Toney MF,Yang P

更新日期：2020-01-24 00:00:00

abstract：:Mineral exploitation has spread from land to shallow coastal waters and is now planned for the offshore, deep seabed. Large seafloor areas are being approved for exploration for seafloor mineral deposits, creating an urgent need for regional environmental management plans. Networks of areas where mining and mining imp...

journal_title：Science advances

authors： Dunn DC,Van Dover CL,Etter RJ,Smith CR,Levin LA,Morato T,Colaço A,Dale AC,Gebruk AV,Gjerde KM,Halpin PN,Howell KL,Johnson D,Perez JAA,Ribeiro MC,Stuckas H,Weaver P,SEMPIA Workshop Participants.

更新日期：2018-07-04 00:00:00

abstract：:Soil organic carbon (SOC) stored in permafrost across the high-latitude/altitude Northern Hemisphere represents an important potential carbon source under future warming. Here, we provide a comprehensive investigation on the spatiotemporal dynamics of SOC over the high-altitude Tibetan Plateau (TP), which has received...

journal_title：Science advances

authors： Wang T,Yang D,Yang Y,Piao S,Li X,Cheng G,Fu B

更新日期：2020-05-06 00:00:00

abstract：:Fibulin-4 is a matricellular protein required for extracellular matrix (ECM) assembly. Mice deficient in fibulin-4 (Fbln4-/- ) have disrupted collagen and elastin fibers and die shortly after birth from aortic and diaphragmatic rupture. The function of fibulin-4 in ECM assembly, however, remains elusive. Here, we show...

journal_title：Science advances

authors： Noda K,Kitagawa K,Miki T,Horiguchi M,Akama TO,Taniguchi T,Taniguchi H,Takahashi K,Ogra Y,Mecham RP,Terajima M,Yamauchi M,Nakamura T

更新日期：2020-11-25 00:00:00

abstract：:Using a national longitudinal survey data set from the Higher Education Research Institute, this study tested whether students who identified as a sexual minority (for example, lesbian, gay, bisexual, or queer) were more or less likely to persist after 4 years in science, technology, engineering, and mathematics (STEM...

journal_title：Science advances

authors： Hughes BE

更新日期：2018-03-14 00:00:00

abstract：:Retreat from some areas will become unavoidable under intensifying climate change. Existing deployments of managed retreat are at small scale compared to potential future needs, leaving open questions about where, when, and how retreat under climate change will occur. Here, we analyze more than 40,000 voluntary buyout...

journal_title：Science advances

authors： Mach KJ,Kraan CM,Hino M,Siders AR,Johnston EM,Field CB

更新日期：2019-10-09 00:00:00

abstract：:Donkeys and horses share a common ancestor dating back to about 4 million years ago. Although a high-quality genome assembly at the chromosomal level is available for the horse, current assemblies available for the donkey are limited to moderately sized scaffolds. The absence of a better-quality assembly for the donke...

journal_title：Science advances

authors： Renaud G,Petersen B,Seguin-Orlando A,Bertelsen MF,Waller A,Newton R,Paillot R,Bryant N,Vaudin M,Librado P,Orlando L

更新日期：2018-04-04 00:00:00

abstract：:Nanometer-scale skyrmions are prospective candidates for information bits in low-power consumption devices owing to their topological nature and controllability with low current density. Studies on skyrmion dynamics in different classes of materials have exploited the topological Hall effect and current-driven fast mo...

journal_title：Science advances

authors： Yu XZ,Morikawa D,Nakajima K,Shibata K,Kanazawa N,Arima T,Nagaosa N,Tokura Y

更新日期：2020-06-17 00:00:00

abstract：:Carbon taxes are widely regarded as a potentially effective and economically efficient policy instrument for decarbonizing the global energy supply and thus limiting global warming. The main obstacle is political feasibility because of opposition from citizens and industry. Earmarking revenues from carbon taxation for...

journal_title：Science advances

authors： Beiser-McGrath LF,Bernauer T

更新日期：2019-09-18 00:00:00

abstract：:Topological superconductors are an interesting and frontier topic in condensed matter physics. In the superconducting state, an order parameter will be established with the basic or subsidiary symmetry of the crystalline lattice. In doped Bi2Se3 or Bi2Te3 with a basic threefold symmetry, it was predicted, however, tha...

journal_title：Science advances

authors： Chen M,Chen X,Yang H,Du Z,Wen HH

更新日期：2018-06-08 00:00:00

abstract：:Lymphatic filariasis and onchocerciasis are two important neglected tropical diseases (NTDs) that cause severe disability. Control efforts are hindered by the lack of a safe macrofilaricidal drug. Targeting the Wolbachia bacterial endosymbionts in these parasites with doxycycline leads to a macrofilaricidal outcome, b...

journal_title：Science advances

authors： Johnston KL,Cook DAN,Berry NG,David Hong W,Clare RH,Goddard M,Ford L,Nixon GL,O'Neill PM,Ward SA,Taylor MJ

更新日期：2017-09-27 00:00:00

abstract：:The key component currently missing for the next generation of transparent and flexible displays is a high-performance polymer material that is flexible, while showing optical and thermal properties of glass. It must be transparent to visible light and show a low coefficient of thermal expansion (CTE). While specialty...

journal_title：Science advances

authors： Kim SD,Lee B,Byun T,Chung IS,Park J,Shin I,Ahn NY,Seo M,Lee Y,Kim Y,Kim WY,Kwon H,Moon H,Yoo S,Kim SY

更新日期：2018-10-26 00:00:00

abstract：:Protected areas (PAs) are essential to biodiversity conservation, but their static boundaries may undermine their potential for protecting species under climate change. We assessed how the climatic conditions within global terrestrial PAs may change over time. By 2070, protection is expected to decline in cold and war...

journal_title：Science advances

authors： Elsen PR,Monahan WB,Dougherty ER,Merenlender AM

更新日期：2020-06-17 00:00:00

abstract：:Sleep serves disparate functions, most notably neural repair, metabolite clearance and circuit reorganization. Yet the relative importance remains hotly debated. Here, we create a novel mechanistic framework for understanding and predicting how sleep changes during ontogeny and across phylogeny. We use this theory to ...

journal_title：Science advances

authors： Cao J,Herman AB,West GB,Poe G,Savage VM

更新日期：2020-09-18 00:00:00

abstract：:Campylobacter coli and Campylobacter jejuni are responsible for 400 million to 500 million cases of enteric disease each year and represent the most common cause of bacterial gastroenteritis worldwide. Despite its global importance, Campylobacter vaccine development has been hampered by the lack of animal models that ...

journal_title：Science advances

authors： Quintel BK,Prongay K,Lewis AD,Raué HP,Hendrickson S,Rhoades NS,Messaoudi I,Gao L,Slifka MK,Amanna IJ

更新日期：2020-06-24 00:00:00

abstract：:The histone demethylase LSD1 is deregulated in several tumors, including leukemias, providing the rationale for the clinical use of LSD1 inhibitors. In acute promyelocytic leukemia (APL), pharmacological doses of retinoic acid (RA) induce differentiation of APL cells, triggering degradation of the PML-RAR oncogene. AP...

journal_title：Science advances

authors： Ravasio R,Ceccacci E,Nicosia L,Hosseini A,Rossi PL,Barozzi I,Fornasari L,Zuffo RD,Valente S,Fioravanti R,Mercurio C,Varasi M,Mattevi A,Mai A,Pavesi G,Bonaldi T,Minucci S

更新日期：2020-04-08 00:00:00

abstract：:Wächtershäuser's proposal of the autotrophic origin of life theory and subsequent laboratory demonstrations of relevant organic reactions have opened a new gate for the exploration of the origin of life. However, this scenario remains controversial because, at present, it requires a high pressure of CO as a source of ...

journal_title：Science advances

authors： Kitadai N,Nakamura R,Yamamoto M,Takai K,Li Y,Yamaguchi A,Gilbert A,Ueno Y,Yoshida N,Oono Y

更新日期：2018-04-04 00:00:00

abstract：:Colloidal-scale assemblies that reconfigure on demand may serve as the next generation of soft "microbots," artificial muscles, and other biomimetic devices. This requires the precise arrangement of particles into structures that are preprogrammed to reversibly change shape when actuated by external fields. The design...

journal_title：Science advances

authors： Han K,Shields CW 4th,Diwakar NM,Bharti B,López GP,Velev OD

更新日期：2017-08-04 00:00:00

abstract：:Bioacoustic networks could vastly expand the coverage of wildlife monitoring to complement satellite observations of climate and vegetation. This approach would enable global-scale understanding of how climate change influences phenomena such as migratory timing of avian species. The enormous data sets that autonomous...

journal_title：Science advances

authors： Oliver RY,Ellis DPW,Chmura HE,Krause JS,Pérez JH,Sweet SK,Gough L,Wingfield JC,Boelman NT

更新日期：2018-06-20 00:00:00

abstract：:Double seismic zones are two-layered distributions of intermediate-depth earthquakes that provide insight into the thermomechanical state of subducting slabs. We present new precise hypocenters of intermediate-depth earthquakes in the Tonga subduction zone obtained using data from local island-based, ocean-bottom, and...

journal_title：Science advances

authors： Wei SS,Wiens DA,van Keken PE,Cai C

更新日期：2017-01-11 00:00:00

abstract：:Electrochemical analysis of sweat using soft bioelectronics on human skin provides a new route for noninvasive glucose monitoring without painful blood collection. However, sweat-based glucose sensing still faces many challenges, such as difficulty in sweat collection, activity variation of glucose oxidase due to lact...

journal_title：Science advances

authors： Lee H,Song C,Hong YS,Kim MS,Cho HR,Kang T,Shin K,Choi SH,Hyeon T,Kim DH

更新日期：2017-03-08 00:00:00

abstract：:Controlling the polarization state and the propagation direction of photons is a fundamental prerequisite for many nanophotonic devices and a precursor for future on-chip communication, where the emission properties of individual emitters are particularly relevant. Here, we report on the emission of partially circular...

journal_title：Science advances

authors： Neugebauer M,Banzer P,Nechayev S

更新日期：2019-06-28 00:00:00