Slab temperature controls on the Tonga double seismic zone and slab mantle dehydration.

abstract：:The inherent specificity and electrochemical reversibility of enzymes poise them as the biorecognition element of choice for a wide range of metabolites. To use enzymes efficiently in biosensors, the redox centers of the protein should have good electrical communication with the transducing electrode, which requires e...

journal_title：Science advances

authors： Pappa AM,Ohayon D,Giovannitti A,Maria IP,Savva A,Uguz I,Rivnay J,McCulloch I,Owens RM,Inal S

更新日期：2018-06-22 00:00:00

abstract：:Ascomycota, the largest and most well-studied phylum of fungi, contains three subphyla: Saccharomycotina (budding yeasts), Pezizomycotina (filamentous fungi), and Taphrinomycotina (fission yeasts). Despite its importance, we lack a comprehensive genome-scale phylogeny or understanding of the similarities and differenc...

journal_title：Science advances

authors： Shen XX,Steenwyk JL,LaBella AL,Opulente DA,Zhou X,Kominek J,Li Y,Groenewald M,Hittinger CT,Rokas A

更新日期：2020-11-04 00:00:00

abstract：:Complex behaviors demand temporal coordination among functionally distinct brain regions. The basal forebrain's afferent and efferent structure suggests a capacity for mediating this coordination at a large scale. During performance of a spatial orientation task, synaptic activity in this region was dominated by four ...

journal_title：Science advances

authors： Tingley D,Alexander AS,Quinn LK,Chiba AA,Nitz D

更新日期：2018-08-01 00:00:00

abstract：:This study introduces new methods of screening for and tuning chiral space and in so doing identifies a promising set of chiral ligands for asymmetric synthesis. The carbafructopyranosyl-1,2-diamine(s) and salens constructed therefrom are particularly compelling. It is shown that by removing the native anomeric effect...

journal_title：Science advances

authors： Karukurichi KR,Fei X,Swyka RA,Broussy S,Shen W,Dey S,Roy SK,Berkowitz DB

更新日期：2015-07-01 00:00:00

abstract：:Mimicking subcellular compartments containing enzymes in organisms is considered a promising approach to substitute for missing or lost cellular functions. Inspired by the multicompartment structures of cellular architectures, we present a novel multienzyme system based on hollow hydrogel microcapsules with flexible e...

journal_title：Science advances

authors： Wang H,Zhao Z,Liu Y,Shao C,Bian F,Zhao Y

更新日期：2018-06-15 00:00:00

abstract：:Deforestation is the primary driver of carbon losses in tropical forests, but it does not operate alone. Forest fragmentation, a resulting feature of the deforestation process, promotes indirect carbon losses induced by edge effect. This process is not implicitly considered by policies for reducing carbon emissions in...

journal_title：Science advances

authors： Silva Junior CHL,Aragão LEOC,Anderson LO,Fonseca MG,Shimabukuro YE,Vancutsem C,Achard F,Beuchle R,Numata I,Silva CA,Maeda EE,Longo M,Saatchi SS

更新日期：2020-09-30 00:00:00

abstract：:G-quadruplex (G4) is one of the most important secondary structures in nucleic acids. Until recently, G4 RNAs have not been reported in any ribovirus, such as the hepatitis C virus. Our bioinformatics analysis reveals highly conserved guanine-rich consensus sequences within the core gene of hepatitis C despite the hig...

journal_title：Science advances

authors： Wang SR,Min YQ,Wang JQ,Liu CX,Fu BS,Wu F,Wu LY,Qiao ZX,Song YY,Xu GH,Wu ZG,Huang G,Peng NF,Huang R,Mao WX,Peng S,Chen YQ,Zhu Y,Tian T,Zhang XL,Zhou X

更新日期：2016-04-01 00:00:00

abstract：:A trimer-of-hairpins motif has been identified in triggering virus-cell fusion within a variety of viral envelopes. Chemically manipulating such a motif represents current repertoire of viral fusion inhibitors. Here, we report that triterpenoids, a class of natural products, antagonize this trimer-of-hairpins via its ...

journal_title：Science advances

authors： Si L,Meng K,Tian Z,Sun J,Li H,Zhang Z,Soloveva V,Li H,Fu G,Xia Q,Xiao S,Zhang L,Zhou D

更新日期：2018-11-21 00:00:00

abstract：:Detecting associations between genomic changes and phenotypic differences is fundamental to understanding how phenotypes evolved. By systematically screening for parallel amino acid substitutions, we detected known as well as novel cases (Strc, Tecta, and Cabp2) of parallelism between echolocating bats and toothed wha...

journal_title：Science advances

authors： Lee JH,Lewis KM,Moural TW,Kirilenko B,Borgonovo B,Prange G,Koessl M,Huggenberger S,Kang C,Hiller M

更新日期：2018-09-26 00:00:00

abstract：:The response to programmed cell death protein-1 (PD-1)/programmed death ligand-1 (PD-L1) blockade in cancer immunotherapy is limited because of multiple immune evasion mechanisms. Here, a previously unknown strategy is proposed to synergize the nuclear factor κB (NF-κB) inhibition and PD-1 blockade for antitumor immun...

journal_title：Science advances

authors： Xiao Z,Su Z,Han S,Huang J,Lin L,Shuai X

更新日期：2020-02-05 00:00:00

abstract：:Coordinatively unsaturated (CUS) iron sites are highly active in catalytic oxidation reactions; however, maintaining the CUS structure of iron during heterogeneous catalytic reactions is a great challenge. Here, we report a strategy to stabilize single-atom CUS iron sites by embedding highly dispersed FeN4 centers in ...

journal_title：Science advances

authors： Deng D,Chen X,Yu L,Wu X,Liu Q,Liu Y,Yang H,Tian H,Hu Y,Du P,Si R,Wang J,Cui X,Li H,Xiao J,Xu T,Deng J,Yang F,Duchesne PN,Zhang P,Zhou J,Sun L,Li J,Pan X,Bao X

更新日期：2015-12-04 00:00:00

abstract：:The impact of the FMR1 premutation on human health is the subject of considerable controversy. A fundamental unanswered question is whether carrying the premutation allele is directly correlated with clinical phenotypes. A challenging problem in past genotype-phenotype studies of the FMR1 premutation is ascertainment ...

journal_title：Science advances

authors： Movaghar A,Page D,Brilliant M,Baker MW,Greenberg J,Hong J,DaWalt LS,Saha K,Kuusisto F,Stewart R,Berry-Kravis E,Mailick MR

更新日期：2019-08-21 00:00:00

abstract：:A withdrawal-associated impairment in β-endorphin neurotransmission in the arcuate nucleus (ARC) of the hypothalamus is associated with alcohol dependence characterized by a chronic relapsing disorder. Although acupuncture activates β-endorphin neurons in the ARC projecting to the nucleus accumbens (NAc), a role for A...

journal_title：Science advances

authors： Chang S,Kim DH,Jang EY,Yoon SS,Gwak YS,Yi YJ,Lee JY,Ahn SH,Kim JM,Ryu YH,Kim SN,Roh HS,Lee MY,Kim SC,Lee BH,Kim HY,Yang CH

更新日期：2019-09-04 00:00:00

abstract：:The urea channel of Helicobacterpylori (HpUreI) is an ideal drug target for preventing gastric cancer but incomplete understanding of its gating mechanism has hampered development of inhibitors for the eradication of H. pylori. Here, we present the cryo-EM structures of HpUreI in closed and open conformations, both at...

journal_title：Science advances

authors： Cui Y,Zhou K,Strugatsky D,Wen Y,Sachs G,Zhou ZH,Munson K

更新日期：2019-03-20 00:00:00

abstract：:Holoprosencephaly (HPE) is a congenital forebrain defect often associated with embryonic lethality and lifelong disabilities. Currently, therapeutic and diagnostic options are limited by lack of knowledge of potential disease-causing mutations. We have identified a new mutation in the PRDM15 gene (C844Y) associated wi...

journal_title：Science advances

authors： Mzoughi S,Di Tullio F,Low DHP,Motofeanu CM,Ong SLM,Wollmann H,Wun CM,Kruszka P,Muenke M,Hildebrandt F,Dunn NR,Messerschmidt DM,Guccione E

更新日期：2020-01-10 00:00:00

abstract：:Two-dimensional (2D) layered hybrid organic-inorganic halide perovskite semiconductors form natural "multiple quantum wells" that have strong spin-orbit coupling due to the heavy elements in their building blocks. This may lead to "Rashba splitting" close to the extrema in the electron bands. We have used a plethora o...

journal_title：Science advances

authors： Zhai Y,Baniya S,Zhang C,Li J,Haney P,Sheng CX,Ehrenfreund E,Vardeny ZV

更新日期：2017-07-28 00:00:00

abstract：:Ice accretion has a negative impact on critical infrastructure, as well as a range of commercial and residential activities. Icephobic surfaces are defined by an ice adhesion strength τice < 100 kPa. However, the passive removal of ice requires much lower values of τice, such as on airplane wings or power lines (τice ...

journal_title：Science advances

authors： Golovin K,Kobaku SP,Lee DH,DiLoreto ET,Mabry JM,Tuteja A

更新日期：2016-03-11 00:00:00

abstract：:E2F is a family of master transcription regulators involved in mediating diverse cell fates. Here, we show that residue-specific arginine methylation (meR) by PRMT5 enables E2F1 to regulate many genes at the level of alternative RNA splicing, rather than through its classical transcription-based mechanism. The p100/TS...

journal_title：Science advances

authors： Roworth AP,Carr SM,Liu G,Barczak W,Miller RL,Munro S,Kanapin A,Samsonova A,La Thangue NB

更新日期：2019-06-26 00:00:00

abstract：:Granular dynamics govern earthquakes, avalanches, and landslides and are of fundamental importance in a variety of industries ranging from energy to pharmaceuticals to agriculture. Nonetheless, our understanding of the underlying physics is poor because we lack spatially and temporally resolved experimental measuremen...

journal_title：Science advances

authors： Penn A,Tsuji T,Brunner DO,Boyce CM,Pruessmann KP,Müller CR

更新日期：2017-09-15 00:00:00

abstract：:We have developed a way to map brain-wide networks using focal pulsed infrared neural stimulation in ultrahigh-field magnetic resonance imaging (MRI). The patterns of connections revealed are similar to those of connections previously mapped with anatomical tract tracing methods. These include connections between cort...

journal_title：Science advances

authors： Xu AG,Qian M,Tian F,Xu B,Friedman RM,Wang J,Song X,Sun Y,Chernov MM,Cayce JM,Jansen ED,Mahadevan-Jansen A,Zhang X,Chen G,Roe AW

更新日期：2019-04-24 00:00:00

abstract：:Hydroxyapatite (HA) has been widely applied in bone repair because of its superior biocompatibility. Recently, a proliferation-suppressive effect of HA nanoparticles (n-HA) against various cancer cells was reported. This study was aimed at assessing the translational value of n-HA both as a bone-regenerating material ...

journal_title：Science advances

authors： Zhang K,Zhou Y,Xiao C,Zhao W,Wu H,Tang J,Li Z,Yu S,Li X,Min L,Yu Z,Wang G,Wang L,Zhang K,Yang X,Zhu X,Tu C,Zhang X

更新日期：2019-08-02 00:00:00

abstract：:Topological superconductors are exotic phases of matter featuring robust surface states that could be leveraged for topological quantum computation. A useful guiding principle for the search of topological superconductors is to relate the topological invariants with the behavior of the pairing order parameter on the n...

journal_title：Science advances

authors： Ono S,Po HC,Watanabe H

更新日期：2020-05-01 00:00:00

abstract：:Oxygen activation is a critical step in ubiquitous heterogeneous oxidative processes, most prominently in catalysis, electrolysis, and pharmaceutical applications. We present here our findings on metal-free O2 activation on covalent triazine frameworks (CTFs) as an important class of N-rich materials. The O2 activatio...

journal_title：Science advances

authors： Abednatanzi S,Gohari Derakhshandeh P,Leus K,Vrielinck H,Callens F,Schmidt J,Savateev A,Van Der Voort P

更新日期：2020-04-03 00:00:00

abstract：:G protein-coupled receptors (GPCRs) play a fundamental role in the modulation of synaptic transmission. A pivotal example is provided by the metabotropic glutamate receptor type 4 (mGluR4), which inhibits glutamate release at presynaptic active zones (AZs). However, how GPCRs are organized within AZs to regulate neuro...

journal_title：Science advances

authors： Siddig S,Aufmkolk S,Doose S,Jobin ML,Werner C,Sauer M,Calebiro D

更新日期：2020-04-15 00:00:00

abstract：:The Tulare Basin in Central California is a site of intensive agricultural activity and extraction of groundwater, with pronounced ground subsidence and degradation of water resources over the past century. Spatially extensive observations of ground displacements from satellite-based remote sensing allow us to infer t...

journal_title：Science advances

authors： Murray KD,Lohman RB

更新日期：2018-08-29 00:00:00

abstract：:Oxygen isotope speleothem records exhibit coherent variability over the pan-Asian summer monsoon (AM) region. The hydroclimatic representation of these oxygen isotope records for the AM, however, has remained poorly understood. Here, combining an isotope-enabled Earth system model in transient experiments with proxy r...

journal_title：Science advances

authors： He C,Liu Z,Otto-Bliesner BL,Brady EC,Zhu C,Tomas R,Clark PU,Zhu J,Jahn A,Gu S,Zhang J,Nusbaumer J,Noone D,Cheng H,Wang Y,Yan M,Bao Y

更新日期：2021-01-22 00:00:00

abstract：:The paramyxovirus RNA-dependent RNA-polymerase (RdRp) complex loads onto the nucleocapsid protein (N)-encapsidated viral N:RNA genome for RNA synthesis. Binding of the RdRp of measles virus (MeV), a paramyxovirus archetype, is mediated through interaction with a molecular recognition element (MoRE) located near the en...

journal_title：Science advances

authors： Cox RM,Krumm SA,Thakkar VD,Sohn M,Plemper RK

更新日期：2017-02-03 00:00:00

abstract：:Polyphosphate, an energy-rich polymer conserved in all kingdoms of life, is integral to many cellular stress responses, including nutrient deprivation, and yet, the mechanisms that underlie its biological roles are not well understood. In this work, we elucidate the physiological function of this polymer in the acclim...

journal_title：Science advances

authors： Sanz-Luque E,Saroussi S,Huang W,Akkawi N,Grossman AR

更新日期：2020-09-30 00:00:00

abstract：:Fluctuations in biodiversity, large and small, pervade the fossil record, yet we do not understand the processes generating them. Here, we extend theory from nonequilibrium statistical physics to describe the fat-tailed form of fluctuations in Phanerozoic marine invertebrate richness. Using this theory, known as super...

journal_title：Science advances

authors： Rominger AJ,Fuentes MA,Marquet PA

更新日期：2019-06-26 00:00:00

abstract：:Band structure theory plays an essential role in exploring physics in both solid-state systems and photonics. Here, we demonstrate a direct experimental measurement of the dynamic band structure in a synthetic space including the frequency axis of light, realized in a ring resonator under near-resonant dynamic modulat...

journal_title：Science advances

authors： Li G,Zheng Y,Dutt A,Yu D,Shan Q,Liu S,Yuan L,Fan S,Chen X

更新日期：2021-01-08 00:00:00