Improved de novo genomic assembly for the domestic donkey.

abstract：:The cellular and the molecular mechanisms by which long noncoding RNAs (lncRNAs) may regulate presynaptic function and neuronal activity are largely unexplored. Here, we established an integrated screening strategy to discover lncRNAs implicated in neurotransmitter and synaptic vesicle release. With this approach, we ...

journal_title：Science advances

authors： Keihani S,Kluever V,Mandad S,Bansal V,Rahman R,Fritsch E,Gomes LC,Gärtner A,Kügler S,Urlaub H,Wren JD,Bonn S,Rizzoli SO,Fornasiero EF

更新日期：2019-12-18 00:00:00

abstract：:Solar-thermal desalination (STD) is a potentially low-cost, sustainable approach for providing high-quality fresh water in the absence of water and energy infrastructures. Despite recent efforts to advance STD by improving heat-absorbing materials and system designs, the best strategies for maximizing STD performance ...

journal_title：Science advances

authors： Wang Z,Horseman T,Straub AP,Yip NY,Li D,Elimelech M,Lin S

更新日期：2019-07-26 00:00:00

abstract：:We studied a bilayer system hosting two-dimensional electron systems (2DESs) in close proximity but isolated from one another by a thin barrier. One 2DES has low electron density and forms a Wigner solid (WS) at high magnetic fields. The other has much higher density and, in the same field, exhibits fractional quantum...

journal_title：Science advances

authors： Hatke AT,Deng H,Liu Y,Engel LW,Pfeiffer LN,West KW,Baldwin KW,Shayegan M

更新日期：2019-03-15 00:00:00

abstract：:There have been increasing attempts to reverse habitat degradation through active restoration, but few large-scale successes are reported to guide these efforts. Here, we report outcomes from a unique and very successful seagrass restoration project: Since 1999, over 70 million seeds of a marine angiosperm, eelgrass (...

journal_title：Science advances

authors： Orth RJ,Lefcheck JS,McGlathery KS,Aoki L,Luckenbach MW,Moore KA,Oreska MPJ,Snyder R,Wilcox DJ,Lusk B

更新日期：2020-10-07 00:00:00

abstract：:Copper-containing nitrite reductases (CuNiRs), encoded by nirK gene, are found in all kingdoms of life with only 5% of CuNiR denitrifiers having two or more copies of nirK Recently, we have identified two copies of nirK genes in several α-proteobacteria of the order Rhizobiales including Bradyrhizobium sp. ORS 375, en...

journal_title：Science advances

authors： Rose SL,Antonyuk SV,Sasaki D,Yamashita K,Hirata K,Ueno G,Ago H,Eady RR,Tosha T,Yamamoto M,Hasnain SS

更新日期：2021-01-01 00:00:00

abstract：:Honeybees use the waggle dance to share information about food-site locations with nestmates. However, the importance of this behavior in colony foraging success remains unclear. We tested whether spatial dance information affects colony foraging success in a human-modified temperate environment by comparing colonies ...

journal_title：Science advances

authors： I'Anson Price R,Dulex N,Vial N,Vincent C,Grüter C

更新日期：2019-02-13 00:00:00

abstract：:Human genome-wide association studies have linked single-nucleotide polymorphisms (SNPs) in NEMP1 (nuclear envelope membrane protein 1) with early menopause; however, it is unclear whether NEMP1 has any role in fertility. We show that whole-animal loss of NEMP1 homologs in Drosophila, Caenorhabditis elegans, zebrafish...

journal_title：Science advances

authors： Tsatskis Y,Rosenfeld R,Pearson JD,Boswell C,Qu Y,Kim K,Fabian L,Mohammad A,Wang X,Robson MI,Krchma K,Wu J,Gonçalves J,Hodzic D,Wu S,Potter D,Pelletier L,Dunham WH,Gingras AC,Sun Y,Meng J,Godt D,Schedl T,Ciru

更新日期：2020-08-28 00:00:00

abstract：:We present a physically inspired model and an efficient algorithm to infer hierarchical rankings of nodes in directed networks. It assigns real-valued ranks to nodes rather than simply ordinal ranks, and it formalizes the assumption that interactions are more likely to occur between individuals with similar ranks. It ...

journal_title：Science advances

authors： De Bacco C,Larremore DB,Moore C

更新日期：2018-07-20 00:00:00

abstract：:The attraction between electrons and holes in semiconductors forms excitons, which largely determine the optical properties of the hosting material, and hence the device performance, especially for low-dimensional systems. Mono- and few-layer black phosphorus (BP) are emerging two-dimensional (2D) semiconductors. Desp...

journal_title：Science advances

authors： Zhang G,Chaves A,Huang S,Wang F,Xing Q,Low T,Yan H

更新日期：2018-03-16 00:00:00

abstract：:The tetrapod neuronal protein ARC and its Drosophila melanogaster homolog, dARC1, have important but differing roles in neuronal development. Both are thought to originate through exaptation of ancient Ty3/Gypsy retrotransposon Gag, with their novel function relying on an original capacity for self-assembly and encaps...

journal_title：Science advances

authors： Cottee MA,Letham SC,Young GR,Stoye JP,Taylor IA

更新日期：2020-01-01 00:00:00

abstract：:Traumatic spinal cord injury (SCI) brings numerous inflammatory cells, including macrophages, from the circulating blood to lesions, but pathophysiological impact resulting from spatiotemporal dynamics of macrophages is unknown. Here, we show that macrophages centripetally migrate toward the lesion epicenter after inf...

journal_title：Science advances

authors： Kobayakawa K,Ohkawa Y,Yoshizaki S,Tamaru T,Saito T,Kijima K,Yokota K,Hara M,Kubota K,Matsumoto Y,Harimaya K,Ozato K,Masuda T,Tsuda M,Tamura T,Inoue K,Edgerton VR,Iwamoto Y,Nakashima Y,Okada S

更新日期：2019-05-15 00:00:00

abstract：:When a dynamic system undergoes a cyclic evolution, a geometric phase that depends only on the path traversed in parameter space can arise in addition to the normal dynamical phase. These geometric phases have profound impacts in both quantum and classical physics. In addition to the geometric phase associated with ba...

journal_title：Science advances

authors： Wang S,Ma G,Chan CT

更新日期：2018-02-16 00:00:00

abstract：:By introducing a superconducting gap in Weyl or Dirac semimetals, the superconducting state inherits the nontrivial topology of their electronic structure. As a result, Weyl superconductors are expected to host exotic phenomena, such as nonzero-momentum pairing due to their chiral node structure, or zero-energy Majora...

journal_title：Science advances

authors： Bachmann MD,Nair N,Flicker F,Ilan R,Meng T,Ghimire NJ,Bauer ED,Ronning F,Analytis JG,Moll PJW

更新日期：2017-05-24 00:00:00

abstract：:The glymphatic system is responsible for brain-wide delivery of nutrients and clearance of waste via influx of cerebrospinal fluid (CSF) alongside perivascular spaces and through the brain. Glymphatic system activity increases during sleep or ketamine/xylazine (K/X) anesthesia, yet the mechanism(s) facilitating CSF in...

journal_title：Science advances

authors： Hablitz LM,Vinitsky HS,Sun Q,Stæger FF,Sigurdsson B,Mortensen KN,Lilius TO,Nedergaard M

更新日期：2019-02-27 00:00:00

abstract：:Catalytic dehydrogenation and hydrogenation of amines and alcohols are important in the synthesis of fine chemicals. Despite several efficient homogeneous catalysts having been identified, highly active heterogeneous catalysts remain elusive, although they would meet an unmet need. Here, we show that bimetallic Pd-Au ...

journal_title：Science advances

authors： Cui X,Huang Z,van Muyden AP,Fei Z,Wang T,Dyson PJ

更新日期：2020-07-01 00:00:00

abstract：:G protein-coupled receptors (GPCRs) play a fundamental role in the modulation of synaptic transmission. A pivotal example is provided by the metabotropic glutamate receptor type 4 (mGluR4), which inhibits glutamate release at presynaptic active zones (AZs). However, how GPCRs are organized within AZs to regulate neuro...

journal_title：Science advances

authors： Siddig S,Aufmkolk S,Doose S,Jobin ML,Werner C,Sauer M,Calebiro D

更新日期：2020-04-15 00:00:00

abstract：:The control and use of light polarization in optical sciences and engineering are widespread. Despite remarkable developments in polarization-resolved imaging for life sciences, their transposition to strongly scattering media is currently not possible, because of the inherent depolarization effects arising from multi...

journal_title：Science advances

authors： de Aguiar HB,Gigan S,Brasselet S

更新日期：2017-09-01 00:00:00

abstract：:Dirac materials such as graphene and topological insulators (TIs) are known to have unique electronic and spintronic properties. We combine graphene with TIs in van der Waals heterostructures to demonstrate the emergence of a strong proximity-induced spin-orbit coupling in graphene. By performing spin transport and pr...

journal_title：Science advances

authors： Khokhriakov D,Cummings AW,Song K,Vila M,Karpiak B,Dankert A,Roche S,Dash SP

更新日期：2018-09-21 00:00:00

abstract：:Recent research on piezoelectric materials is predominantly devoted to enhancing the piezoelectric coefficient, but overlooks its sign, largely because almost all of them exhibit positive longitudinal piezoelectricity. The only experimentally known exception is ferroelectric polymer poly(vinylidene fluoride) and its c...

journal_title：Science advances

authors： You L,Zhang Y,Zhou S,Chaturvedi A,Morris SA,Liu F,Chang L,Ichinose D,Funakubo H,Hu W,Wu T,Liu Z,Dong S,Wang J

更新日期：2019-04-19 00:00:00

abstract：:Here, we demonstrate the use of pump-probe microscopy for high-resolution studies of vermilion degradation. Vermilion (mostly α-HgS), an important red pigment used in historical paintings, blackens over time, and metallic Hg and β-HgS have been implicated as possible degradation products. Conventional analysis techniq...

journal_title：Science advances

authors： Yu J,Warren WS,Fischer MC

更新日期：2019-06-21 00:00:00

abstract：:One of the most plausible scenarios of the origin of life assumes the preceding prebiotic autotrophic metabolism in sulfide-rich hydrothermal vent environments. However, geochemical mechanisms to harness the reductive power provided by hydrothermal systems remain to be elucidated. Here, we show that, under a geoelectr...

journal_title：Science advances

authors： Kitadai N,Nakamura R,Yamamoto M,Takai K,Yoshida N,Oono Y

更新日期：2019-06-19 00:00:00

abstract：:Complex behaviors demand temporal coordination among functionally distinct brain regions. The basal forebrain's afferent and efferent structure suggests a capacity for mediating this coordination at a large scale. During performance of a spatial orientation task, synaptic activity in this region was dominated by four ...

journal_title：Science advances

authors： Tingley D,Alexander AS,Quinn LK,Chiba AA,Nitz D

更新日期：2018-08-01 00:00:00

abstract：:Functionally graded materials (FGMs) enable applications in fields such as biomedicine and architecture, but their fabrication suffers from shortcomings in gradient continuity, interfacial bonding, and directional freedom. In addition, most commercial design software fail to incorporate property gradient data, hinderi...

journal_title：Science advances

authors： Giachini PAGS,Gupta SS,Wang W,Wood D,Yunusa M,Baharlou E,Sitti M,Menges A

更新日期：2020-02-21 00:00:00

abstract：:The degradation of cadmium sulfide (CdS)-based oil paints is a phenomenon potentially threatening the iconic painting The Scream (ca. 1910) by Edvard Munch (Munch Museum, Oslo) that is still poorly understood. Here, we provide evidence for the presence of cadmium sulfate and sulfites as alteration products of the orig...

journal_title：Science advances

authors： Monico L,Cartechini L,Rosi F,Chieli A,Grazia C,De Meyer S,Nuyts G,Vanmeert F,Janssens K,Cotte M,De Nolf W,Falkenberg G,Sandu ICA,Tveit ES,Mass J,de Freitas RP,Romani A,Miliani C

更新日期：2020-05-15 00:00:00

abstract：:Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is an unexplained incapacitating illness that may affect up to 4 million people in the United States alone. There are no validated laboratory tests for diagnosis or management despite global efforts to find biomarkers of disease. We considered the possibility...

journal_title：Science advances

authors： Hornig M,Montoya JG,Klimas NG,Levine S,Felsenstein D,Bateman L,Peterson DL,Gottschalk CG,Schultz AF,Che X,Eddy ML,Komaroff AL,Lipkin WI

更新日期：2015-02-01 00:00:00

abstract：:Six percent of Americans, including 3 million high schoolers, use e-cigarettes, which contain potentially toxic substances, volatile organic compounds, and metals. We present the first human study on the effects of e-cigarette exposure in the oral cavity. By interrogating both immunoinflammatory responses and microbia...

journal_title：Science advances

authors： Ganesan SM,Dabdoub SM,Nagaraja HN,Scott ML,Pamulapati S,Berman ML,Shields PG,Wewers ME,Kumar PS

更新日期：2020-05-27 00:00:00

abstract：:Plasmonic metasurfaces are a promising route for flat panel display applications due to their full color gamut and high spatial resolution. However, this plasmonic coloration cannot be readily tuned and requires expensive lithographic techniques. Here, we present scalable electrically driven color-changing metasurface...

journal_title：Science advances

authors： Peng J,Jeong HH,Lin Q,Cormier S,Liang HL,De Volder MFL,Vignolini S,Baumberg JJ

更新日期：2019-05-10 00:00:00

abstract：:Large-scale modes of climate variability can force widespread crop yield anomalies and are therefore often presented as a risk to food security. We quantify how modes of climate variability contribute to crop production variance. We find that the El Niño Southern Oscillation (ENSO), the Indian Ocean Dipole (IOD), trop...

journal_title：Science advances

authors： Anderson WB,Seager R,Baethgen W,Cane M,You L

更新日期：2019-07-03 00:00:00

abstract：:Dust condensation and coagulation in the early solar system are the first steps toward forming the terrestrial planets, but the time scales of these processes remain poorly constrained. Through isotopic analysis of small Ca-Al-rich inclusions (CAIs) (30 to 100 μm in size) found in one of the most pristine chondrites, ...

journal_title：Science advances

authors： Liu MC,Han J,Brearley AJ,Hertwig AT

更新日期：2019-09-11 00:00:00

abstract：:The impact of the FMR1 premutation on human health is the subject of considerable controversy. A fundamental unanswered question is whether carrying the premutation allele is directly correlated with clinical phenotypes. A challenging problem in past genotype-phenotype studies of the FMR1 premutation is ascertainment ...

journal_title：Science advances

authors： Movaghar A,Page D,Brilliant M,Baker MW,Greenberg J,Hong J,DaWalt LS,Saha K,Kuusisto F,Stewart R,Berry-Kravis E,Mailick MR

更新日期：2019-08-21 00:00:00