Scalable electrochromic nanopixels using plasmonics.

abstract：:A withdrawal-associated impairment in β-endorphin neurotransmission in the arcuate nucleus (ARC) of the hypothalamus is associated with alcohol dependence characterized by a chronic relapsing disorder. Although acupuncture activates β-endorphin neurons in the ARC projecting to the nucleus accumbens (NAc), a role for A...

journal_title：Science advances

authors： Chang S,Kim DH,Jang EY,Yoon SS,Gwak YS,Yi YJ,Lee JY,Ahn SH,Kim JM,Ryu YH,Kim SN,Roh HS,Lee MY,Kim SC,Lee BH,Kim HY,Yang CH

更新日期：2019-09-04 00:00:00

abstract：:Maternal immune activation increases the risk of neurodevelopmental disorders. Elevated cytokines, such as interferon-γ (IFN-γ), in offspring's brains play a central role. IFN-γ activates an antiviral cellular state, limiting viral entry and replication. Moreover, IFN-γ is implicated in brain development. We tested th...

journal_title：Science advances

authors： Warre-Cornish K,Perfect L,Nagy R,Duarte RRR,Reid MJ,Raval P,Mueller A,Evans AL,Couch A,Ghevaert C,McAlonan G,Loth E,Murphy D,Powell TR,Vernon AC,Srivastava DP,Price J

更新日期：2020-08-19 00:00:00

abstract：:The established model-free methods for the processing of two-electron dipolar spectroscopy data [DEER (double electron-electron resonance), PELDOR (pulsed electron double resonance), DQ-EPR (double-quantum electron paramagnetic resonance), RIDME (relaxation-induced dipolar modulation enhancement), etc.] use regularize...

journal_title：Science advances

authors： Worswick SG,Spencer JA,Jeschke G,Kuprov I

更新日期：2018-08-24 00:00:00

abstract：:Cues sent by political elites are known to influence public attitudes and behavior. Polarization in elite rhetoric may hinder effective responses to public health crises, when accurate information and rapid behavioral change can save lives. We examine polarization in cues sent to the public by current members of the U...

journal_title：Science advances

authors： Green J,Edgerton J,Naftel D,Shoub K,Cranmer SJ

更新日期：2020-07-10 00:00:00

abstract：:The human bronchial epithelium is composed of multiple distinct cell types that cooperate to defend against environmental insults. While studies have shown that smoking alters bronchial epithelial function and morphology, its precise effects on specific cell types and overall tissue composition are unclear. We used si...

journal_title：Science advances

authors： Duclos GE,Teixeira VH,Autissier P,Gesthalter YB,Reinders-Luinge MA,Terrano R,Dumas YM,Liu G,Mazzilli SA,Brandsma CA,van den Berge M,Janes SM,Timens W,Lenburg ME,Spira A,Campbell JD,Beane J

更新日期：2019-12-11 00:00:00

abstract：:Neurochemical dysregulation underlies many pathologies and can be monitored by measuring the composition of brain interstitial fluid (ISF). Existing in vivo tools for sampling ISF do not enable measuring large rare molecules, such as proteins and neuropeptides, and thus cannot generate a complete picture of the neuroc...

journal_title：Science advances

authors： Raman R,Rousseau EB,Wade M,Tong A,Cotler MJ,Kuang J,Lugo AA,Zhang E,Graybiel AM,White FM,Langer R,Cima MJ

更新日期：2020-09-25 00:00:00

abstract：:Using a national longitudinal survey data set from the Higher Education Research Institute, this study tested whether students who identified as a sexual minority (for example, lesbian, gay, bisexual, or queer) were more or less likely to persist after 4 years in science, technology, engineering, and mathematics (STEM...

journal_title：Science advances

authors： Hughes BE

更新日期：2018-03-14 00:00:00

abstract：:Quantum phenomena have the potential to speed up the solution of hard optimization problems. For example, quantum annealing, based on the quantum tunneling effect, has recently been shown to scale exponentially better with system size than classical simulated annealing. However, current realizations of quantum anneale...

journal_title：Science advances

authors： Nigg SE,Lörch N,Tiwari RP

更新日期：2017-04-07 00:00:00

abstract：:Toxins efficiently deliver cargo to cells by binding to cell surface ligands, initiating endocytosis, and escaping the endolysosomal pathway into the cytoplasm. We took advantage of this delivery pathway by conjugating an attenuated diphtheria toxin to siRNA, thereby achieving gene downregulation in patient-derived gl...

journal_title：Science advances

authors： Arnold AE,Smith LJ,Beilhartz GL,Bahlmann LC,Jameson E,Melnyk RA,Shoichet MS

更新日期：2020-05-01 00:00:00

abstract：:The transcriptional repressors Polycomb repressive complex 1 (PRC1) and PRC2 are required to maintain cell fate during embryonic development. PRC1 and PRC2 catalyze distinct histone modifications, establishing repressive chromatin at shared targets. How PRC1, which consists of canonical PRC1 (cPRC1) and variant PRC1 (...

journal_title：Science advances

authors： Zepeda-Martinez JA,Pribitzer C,Wang J,Bsteh D,Golumbeanu S,Zhao Q,Burkard TR,Reichholf B,Rhie SK,Jude J,Moussa HF,Zuber J,Bell O

更新日期：2020-04-01 00:00:00

abstract：:Two-dimensional (2D) layered hybrid organic-inorganic halide perovskite semiconductors form natural "multiple quantum wells" that have strong spin-orbit coupling due to the heavy elements in their building blocks. This may lead to "Rashba splitting" close to the extrema in the electron bands. We have used a plethora o...

journal_title：Science advances

authors： Zhai Y,Baniya S,Zhang C,Li J,Haney P,Sheng CX,Ehrenfreund E,Vardeny ZV

更新日期：2017-07-28 00:00:00

abstract：:The most abundant components of primitive meteorites (chondrites) are millimeter-sized glassy spherical chondrules formed by transient melting events in the solar protoplanetary disk. Using Pb-Pb dates of 22 individual chondrules, we show that primary production of chondrules in the early solar system was restricted t...

journal_title：Science advances

authors： Bollard J,Connelly JN,Whitehouse MJ,Pringle EA,Bonal L,Jørgensen JK,Nordlund Å,Moynier F,Bizzarro M

更新日期：2017-08-09 00:00:00

abstract：:We studied a bilayer system hosting two-dimensional electron systems (2DESs) in close proximity but isolated from one another by a thin barrier. One 2DES has low electron density and forms a Wigner solid (WS) at high magnetic fields. The other has much higher density and, in the same field, exhibits fractional quantum...

journal_title：Science advances

authors： Hatke AT,Deng H,Liu Y,Engel LW,Pfeiffer LN,West KW,Baldwin KW,Shayegan M

更新日期：2019-03-15 00:00:00

abstract：:Most crystalline inorganic materials, except for metals and some layer materials, exhibit bad flexibility because of strong ionic or covalent bonds, while amorphous materials usually display poor electrical properties due to structural disorders. Here, we report the simultaneous realization of extraordinary room tempe...

journal_title：Science advances

authors： He S,Li Y,Liu L,Jiang Y,Feng J,Zhu W,Zhang J,Dong Z,Deng Y,Luo J,Zhang W,Chen G

更新日期：2020-04-10 00:00:00

abstract：:Achieving perovskite-based high-color purity blue-emitting light-emitting diodes (LEDs) is still challenging. Here, we report successful synthesis of a series of blue-emissive two-dimensional Ruddlesden-Popper phase single crystals and their high-color purity blue-emitting LED demonstrations. Although this approach su...

journal_title：Science advances

authors： Chen H,Lin J,Kang J,Kong Q,Lu D,Kang J,Lai M,Quan LN,Lin Z,Jin J,Wang LW,Toney MF,Yang P

更新日期：2020-01-24 00:00:00

abstract：:Moisture delivery to western North America is closely linked to variability in the westerly storm tracks of midlatitude cyclones, which are, in turn, modified by larger-scale features such as the El Niño-Southern Oscillation system. Instrumental and modeling data suggest that extratropical storm tracks may be intensif...

journal_title：Science advances

authors： Wise EK,Dannenberg MP

更新日期：2017-06-07 00:00:00

abstract：:Triple-negative breast cancer (TNBC) is life-threatening because of limited therapies and lack of effective therapeutic targets. Here, we found that moesin (MSN) was significantly overexpressed in TNBC compared with other subtypes of breast cancer and was positively correlated with poor overall survival. However, litt...

journal_title：Science advances

authors： Qin Y,Chen W,Jiang G,Zhou L,Yang X,Li H,He X,Wang HL,Zhou YB,Huang S,Liu S

更新日期：2020-02-19 00:00:00

abstract：:The human gut microbiota established during infancy has persistent effects on health. In vitro studies have suggested that human milk oligosaccharides (HMOs) in breast milk promote the formation of a bifidobacteria-rich microbiota in infant guts; however, the underlying molecular mechanism remains elusive. Here, we ch...

journal_title：Science advances

authors： Sakanaka M,Hansen ME,Gotoh A,Katoh T,Yoshida K,Odamaki T,Yachi H,Sugiyama Y,Kurihara S,Hirose J,Urashima T,Xiao JZ,Kitaoka M,Fukiya S,Yokota A,Lo Leggio L,Abou Hachem M,Katayama T

更新日期：2019-08-28 00:00:00

abstract：:The advent of two-dimensional (2D) materials has led to extensive studies of heterostructures for novel applications. 2D lateral multiheterojunctions and superlattices have been recently demonstrated, but the available growth methods can only produce features with widths in the micrometer or, at best, 100-nm scale and...

journal_title：Science advances

authors： Zhou W,Zhang YY,Chen J,Li D,Zhou J,Liu Z,Chisholm MF,Pantelides ST,Loh KP

更新日期：2018-03-23 00:00:00

abstract：:The hydrogen atom-the smallest and most abundant atom-is of utmost importance in physics and chemistry. Although many analysis methods have been applied to its study, direct observation of hydrogen atoms in a single molecule remains largely unexplored. We use atomic force microscopy (AFM) to resolve the outermost hydr...

journal_title：Science advances

authors： Kawai S,Nishiuchi T,Kodama T,Spijker P,Pawlak R,Meier T,Tracey J,Kubo T,Meyer E,Foster AS

更新日期：2017-05-12 00:00:00

abstract：:Researchers have documented race and gender inequality in science, technology, engineering, and math (STEM) for decades. Do lesbian, gay, bisexual, transgender, and queer (LGBTQ) professionals face parallel experiences of disadvantage in STEM? Using representative survey data from 21 STEM professional societies (Nsamp...

journal_title：Science advances

authors： Cech EA,Waidzunas TJ

更新日期：2021-01-15 00:00:00

abstract：:B cell activation is regulated by the stimulatory or inhibitory co-receptors of B cell receptors (BCRs). Here, we investigated the signaling mechanism of Fc receptor-like 1 (FcRL1), a newly identified BCR co-receptor. FcRL1 was passively recruited into B cell immunological synapses upon BCR engagement in the absence o...

journal_title：Science advances

authors： Zhao X,Xie H,Zhao M,Ahsan A,Li X,Wang F,Yi J,Yang Z,Wu C,Raman I,Li QZ,Kim TJ,Liu W

更新日期：2019-07-17 00:00:00

abstract：:Proinflammatory activation and accumulation of adipose tissue macrophages (ATMs) are associated with increased risk of insulin resistance in obesity. Here, we described the previously unidentified role of selenocysteine insertion sequence-binding protein 2 (SBP2) in maintaining insulin sensitivity in obesity. SBP2 was...

journal_title：Science advances

authors： Wang N,Tan HY,Li S,Wang D,Xu Y,Zhang C,Xia W,Che CM,Feng Y

更新日期：2019-08-14 00:00:00

abstract：:Nitrogen oxides (NO x ) emitted from human activities are believed to regulate the atmospheric oxidation capacity of the troposphere. However, observational evidence is limited for the low-to-median NO x concentrations prevalen...

journal_title：Science advances

authors： Liu Y,Seco R,Kim S,Guenther AB,Goldstein AH,Keutsch FN,Springston SR,Watson TB,Artaxo P,Souza RAF,McKinney KA,Martin ST

更新日期：2018-04-11 00:00:00

abstract：:Can mating influence cognitive functions such as learning and memory in a permanent way? We have addressed this question using a combined behavioral and in vivo imaging approach, finding that aversive long-term memory performance strongly increases in Drosophila females in response to sperm transfer following mating. ...

journal_title：Science advances

authors： Scheunemann L,Lampin-Saint-Amaux A,Schor J,Preat T

更新日期：2019-11-20 00:00:00

abstract：:Iron deficiency and anemia are prominent contributors to the preventable disease burden worldwide. A substantial proportion of people with inadequate dietary iron rely on rice as a staple food, but fortification efforts are limited by low iron bioavailability. Furthermore, using high iron fortification dosages may not...

journal_title：Science advances

authors： Hackl LS,Abizari AR,Speich C,Zungbey-Garti H,Cercamondi CI,Zeder C,Zimmermann MB,Moretti D

更新日期：2019-03-27 00:00:00

abstract：:The pathways and transformations of dense water overflows, which depend on small-scale interactions between flow dynamics and erosional-depositional processes, are a central piece in the ocean's large-scale circulation. A novel, high-resolution current and hydrographic data set highlights the intricate pathway travell...

journal_title：Science advances

authors： Sánchez-Leal RF,Bellanco MJ,Fernández-Salas LM,García-Lafuente J,Gasser-Rubinat M,González-Pola C,Hernández-Molina FJ,Pelegrí JL,Peliz A,Relvas P,Roque D,Ruiz-Villarreal M,Sammartino S,Sánchez-Garrido JC

更新日期：2017-11-15 00:00:00

abstract：:Posthemorrhagic hydrocephalus (PHH) in premature infants is a common neurological disorder treated with invasive neurosurgical interventions. Patients with PHH lack effective therapeutic interventions and suffer chronic comorbidities. Here, we report a murine lysophosphatidic acid (LPA)-induced postnatal PHH model tha...

journal_title：Science advances

authors： Lummis NC,Sánchez-Pavón P,Kennedy G,Frantz AJ,Kihara Y,Blaho VA,Chun J

更新日期：2019-10-09 00:00:00

abstract：:Analog machine learning hardware platforms promise to be faster and more energy efficient than their digital counterparts. Wave physics, as found in acoustics and optics, is a natural candidate for building analog processors for time-varying signals. Here, we identify a mapping between the dynamics of wave physics and...

journal_title：Science advances

authors： Hughes TW,Williamson IAD,Minkov M,Fan S

更新日期：2019-12-20 00:00:00

abstract：:It is fascinating but challenging for nanoscientists to organize nanoparticles (NPs) into ordered architectures just as it is for chemists to manipulate atoms and molecules to form functional molecules and supramolecules. We explore a strategy to assemble anisotropic NPs into open frame-like superstructures via orient...

journal_title：Science advances

authors： Nai J,Guan BY,Yu L,Lou XWD

更新日期：2017-08-23 00:00:00