Robust quantum optimizer with full connectivity.

abstract：:Black phosphorus (BP) offers considerable promise for infrared and visible photonics. Efficient tuning of the bandgap and higher subbands in BP by modulation of the Fermi level or application of vertical electric fields has been previously demonstrated, allowing electrical control of its above-bandgap optical properti...

journal_title：Science advances

authors： Biswas S,Whitney WS,Grajower MY,Watanabe K,Taniguchi T,Bechtel HA,Rossman GR,Atwater HA

更新日期：2021-01-08 00:00:00

abstract：:Nanoparticles have been extensively used for inflammation imaging and photodynamic therapy of cancer. However, the major translational barriers to most nanoparticle-based imaging and therapy applications are the limited depth of tissue penetration, inevitable requirement of external irradiation, and poor biocompatibil...

journal_title：Science advances

authors： Xu X,An H,Zhang D,Tao H,Dou Y,Li X,Huang J,Zhang J

更新日期：2019-01-09 00:00:00

abstract：:Since Darwin's conception of sexual selection theory, scientists have struggled to identify the evolutionary forces underlying the pervasive differences between male and female behavior, morphology, and physiology. The Darwin-Bateman paradigm predicts that anisogamy imposes stronger sexual selection on males, which, i...

journal_title：Science advances

authors： Janicke T,Häderer IK,Lajeunesse MJ,Anthes N

更新日期：2016-02-12 00:00:00

abstract：:Monolithic strong magnetic induction at the mtesla to tesla level provides essential functionalities to physical, chemical, and medical systems. Current design options are constrained by existing capabilities in three-dimensional (3D) structure construction, current handling, and magnetic material integration. We repo...

journal_title：Science advances

authors： Huang W,Yang Z,Kraman MD,Wang Q,Ou Z,Rojo MM,Yalamarthy AS,Chen V,Lian F,Ni JH,Liu S,Yu H,Sang L,Michaels J,Sievers DJ,Eden JG,Braun PV,Chen Q,Gong S,Senesky DG,Pop E,Li X

更新日期：2020-01-17 00:00:00

abstract：:Changes in extreme weather, such as tropical cyclones, are one of the most serious ways society experiences the impact of climate change. Advance forecasted conditional attribution statements, using a numerical model, were made about the anthropogenic climate change influence on an individual tropical cyclone, Hurrica...

journal_title：Science advances

authors： Reed KA,Stansfield AM,Wehner MF,Zarzycki CM

更新日期：2020-01-01 00:00:00

abstract：:[This corrects the article DOI: 10.1126/sciadv.aar3761.]. ...

journal_title：Science advances

authors：

更新日期：2018-07-06 00:00:00

abstract：:Can a diverse crowd of individuals whose interests focus on distinct issues related to racial identity, class, gender, and sexuality mobilize around a shared issue? If so, how does this process work in practice? To date, limited research has explored intersectionality as a mobilization tool for social movements. This ...

journal_title：Science advances

authors： Fisher DR,Dow DM,Ray R

更新日期：2017-09-20 00:00:00

abstract：:Colloidal-scale assemblies that reconfigure on demand may serve as the next generation of soft "microbots," artificial muscles, and other biomimetic devices. This requires the precise arrangement of particles into structures that are preprogrammed to reversibly change shape when actuated by external fields. The design...

journal_title：Science advances

authors： Han K,Shields CW 4th,Diwakar NM,Bharti B,López GP,Velev OD

更新日期：2017-08-04 00:00:00

abstract：:The cyclic GMP-AMP synthase (cGAS), a sensor of cytosolic DNA, is critical for the innate immune response. Here, we show that loss of cGAS in untransformed and cancer cells results in uncontrolled DNA replication, hyperproliferation, and genomic instability. While the majority of cGAS is cytoplasmic, a fraction of cGA...

journal_title：Science advances

authors： Chen H,Chen H,Zhang J,Wang Y,Simoneau A,Yang H,Levine AS,Zou L,Chen Z,Lan L

更新日期：2020-10-14 00:00:00

abstract：:NSF (N-ethylmaleimide-sensitive factor) and α-SNAP (α-soluble NSF attachment protein) bind to the SNARE (soluble NSF attachment protein receptor) complex, the minimum machinery to mediate membrane fusion, to form a 20S complex, which disassembles the SNARE complex for reuse. We report the cryo-EM structures of the α-S...

journal_title：Science advances

authors： Huang X,Sun S,Wang X,Fan F,Zhou Q,Lu S,Cao Y,Wang QW,Dong MQ,Yao J,Sui SF

更新日期：2019-04-10 00:00:00

abstract：:Deforestation is the primary driver of carbon losses in tropical forests, but it does not operate alone. Forest fragmentation, a resulting feature of the deforestation process, promotes indirect carbon losses induced by edge effect. This process is not implicitly considered by policies for reducing carbon emissions in...

journal_title：Science advances

authors： Silva Junior CHL,Aragão LEOC,Anderson LO,Fonseca MG,Shimabukuro YE,Vancutsem C,Achard F,Beuchle R,Numata I,Silva CA,Maeda EE,Longo M,Saatchi SS

更新日期：2020-09-30 00:00:00

abstract：:The endoplasmic reticulum (ER) is a highly dynamic network of membranes. Here, we combine live-cell microscopy with in situ cryo-electron tomography to directly visualize ER dynamics in several secretory cell types including pancreatic β-cells and neurons under near-native conditions. Using these imaging approaches, w...

journal_title：Science advances

authors： Carter SD,Hampton CM,Langlois R,Melero R,Farino ZJ,Calderon MJ,Li W,Wallace CT,Tran NH,Grassucci RA,Siegmund SE,Pemberton J,Morgenstern TJ,Eisenman L,Aguilar JI,Greenberg NL,Levy ES,Yi E,Mitchell WG,Rice WJ,Wigge

更新日期：2020-04-01 00:00:00

abstract：:Altered cerebral glucose uptake is one of the hallmarks of Alzheimer's disease (AD). A dynamic glucose-enhanced (DGE) magnetic resonance imaging (MRI) approach was developed to simultaneously monitor d-glucose uptake and clearance in both brain parenchyma and cerebrospinal fluid (CSF). We observed substantially higher...

journal_title：Science advances

authors： Huang J,van Zijl PCM,Han X,Dong CM,Cheng GWY,Tse KH,Knutsson L,Chen L,Lai JHC,Wu EX,Xu J,Chan KWY

更新日期：2020-05-13 00:00:00

abstract：:The Tulare Basin in Central California is a site of intensive agricultural activity and extraction of groundwater, with pronounced ground subsidence and degradation of water resources over the past century. Spatially extensive observations of ground displacements from satellite-based remote sensing allow us to infer t...

journal_title：Science advances

authors： Murray KD,Lohman RB

更新日期：2018-08-29 00:00:00

abstract：:Neurodegeneration in mitochondrial disorders is considered irreversible because of limited metabolic plasticity in neurons, yet the cell-autonomous implications of mitochondrial dysfunction for neuronal metabolism in vivo are poorly understood. Here, we profiled the cell-specific proteome of Purkinje neurons undergoin...

journal_title：Science advances

authors： Motori E,Atanassov I,Kochan SMV,Folz-Donahue K,Sakthivelu V,Giavalisco P,Toni N,Puyal J,Larsson NG

更新日期：2020-08-28 00:00:00

abstract：:Intrinsically disordered regions (IDRs) of proteins are implicated in key macromolecular interactions. However, the molecular forces underlying IDR function within multicomponent assemblies remain elusive. By combining thermodynamic and structural data, we have discovered an allostery-based mechanism regulating the so...

journal_title：Science advances

authors： Blus BJ,Koh J,Krolak A,Seo HS,Coutavas E,Blobel G

更新日期：2019-11-27 00:00:00

abstract：:Vertical stacking is widely viewed as a promising approach for designing advanced functionalities using two-dimensional (2D) materials. Combining crystallographically commensurate materials in these 2D stacks has been shown to result in rich new electronic structure, magnetotransport, and optical properties. In this c...

journal_title：Science advances

authors： Vargas A,Liu F,Lane C,Rubin D,Bilgin I,Hennighausen Z,DeCapua M,Bansil A,Kar S

更新日期：2017-07-14 00:00:00

abstract：:Although electromagnetic brain stimulation is a promising treatment in neurology and psychiatry, clinical outcomes are variable, and underlying mechanisms are ill-defined, which impedes the development of new effective stimulation protocols. Here, we show, in vivo and ex vivo, that repetitive transcranial magnetic sti...

journal_title：Science advances

authors： Dufor T,Grehl S,Tang AD,Doulazmi M,Traoré M,Debray N,Dubacq C,Deng ZD,Mariani J,Lohof AM,Sherrard RM

更新日期：2019-10-30 00:00:00

abstract：:We introduce two photochromic proteins for cell-specific in vivo optoacoustic (OA) imaging with signal unmixing in the temporal domain. We show highly sensitive, multiplexed visualization of T lymphocytes, bacteria, and tumors in the mouse body and brain. We developed machine learning-based software for commercial ima...

journal_title：Science advances

authors： Mishra K,Stankevych M,Fuenzalida-Werner JP,Grassmann S,Gujrati V,Huang Y,Klemm U,Buchholz VR,Ntziachristos V,Stiel AC

更新日期：2020-06-12 00:00:00

abstract：:Peptidyl arginine deiminase 4 (PAD4) is a nuclear enzyme that converts arginine residues to citrulline. Although increasingly implicated in inflammatory disease and cancer, the mechanism of action of PAD4 and its functionally relevant pathways remains unclear. E2F transcription factors are a family of master regulator...

journal_title：Science advances

authors： Ghari F,Quirke AM,Munro S,Kawalkowska J,Picaud S,McGouran J,Subramanian V,Muth A,Williams R,Kessler B,Thompson PR,Fillipakopoulos P,Knapp S,Venables PJ,La Thangue NB

更新日期：2016-02-05 00:00:00

abstract：:A large body of previous neuroimaging studies suggests that multiple languages are processed and organized in a single neuroanatomical system in the bilingual brain, although differential activation may be seen in some studies because of different proficiency levels and/or age of acquisition of the two languages. Howe...

journal_title：Science advances

authors： Xu M,Baldauf D,Chang CQ,Desimone R,Tan LH

更新日期：2017-07-12 00:00:00

abstract：:Biogenesis in prokaryotes and eukaryotes requires the insertion of α-helical proteins into cellular membranes for which they use universally conserved cellular machineries. In bacterial inner membranes, insertion is facilitated by YidC insertase and SecYEG translocon working individually or cooperatively. How insertas...

journal_title：Science advances

authors： Serdiuk T,Steudle A,Mari SA,Manioglu S,Kaback HR,Kuhn A,Müller DJ

更新日期：2019-01-30 00:00:00

abstract：:Organic carbonyl compounds represent a promising class of electrode materials for secondary batteries; however, the storage mechanism still remains unclear. We take Na2C6H2O4 as an example to unravel the mechanism. It consists of alternating Na-O octahedral inorganic layer and π-stacked benzene organic layer in spatia...

journal_title：Science advances

authors： Wu X,Jin S,Zhang Z,Jiang L,Mu L,Hu YS,Li H,Chen X,Armand M,Chen L,Huang X

更新日期：2015-09-18 00:00:00

abstract：:Moisture delivery to western North America is closely linked to variability in the westerly storm tracks of midlatitude cyclones, which are, in turn, modified by larger-scale features such as the El Niño-Southern Oscillation system. Instrumental and modeling data suggest that extratropical storm tracks may be intensif...

journal_title：Science advances

authors： Wise EK,Dannenberg MP

更新日期：2017-06-07 00:00:00

abstract：:Human and murine skin wounding commonly results in fibrotic scarring, but the murine wounding model wound-induced hair neogenesis (WIHN) can frequently result in a regenerative repair response. Here, we show in single-cell RNA sequencing comparisons of semi-regenerative and fibrotic WIHN wounds, increased expression o...

journal_title：Science advances

authors： Gay D,Ghinatti G,Guerrero-Juarez CF,Ferrer RA,Ferri F,Lim CH,Murakami S,Gault N,Barroca V,Rombeau I,Mauffrey P,Irbah L,Treffeisen E,Franz S,Boissonnas A,Combadière C,Ito M,Plikus MV,Romeo PH

更新日期：2020-03-20 00:00:00

abstract：:Ice-templating holds promise to become a powerful technique to construct high-performance bioinspired materials. Both ice nucleation and growth during the freezing process are crucial for the final architecture of the ice-templated material. However, effective ways to control these two very important factors are still...

journal_title：Science advances

authors： Zhao N,Li M,Gong H,Bai H

更新日期：2020-07-31 00:00:00

abstract：:Immotile cilia sense extracellular signals such as fluid flow, but whether Ca2+ plays a role in flow sensing has been unclear. Here, we examined the role of ciliary Ca2+ in the flow sensing that initiates the breaking of left-right (L-R) symmetry in the mouse embryo. Intraciliary and cytoplasmic Ca2+ transients were d...

journal_title：Science advances

authors： Mizuno K,Shiozawa K,Katoh TA,Minegishi K,Ide T,Ikawa Y,Nishimura H,Takaoka K,Itabashi T,Iwane AH,Nakai J,Shiratori H,Hamada H

更新日期：2020-07-22 00:00:00

abstract：:Asymmetric interactions such as entropic (e.g., encoded by nonspherical shapes) or surface forces (e.g., encoded by patterned surface chemistry or DNA hybridization) provide access to functional states of colloidal matter, but versatile approaches for engineering asymmetric van der Waals interactions have the potentia...

journal_title：Science advances

authors： Fuster HA,Wang X,Wang X,Bukusoglu E,Spagnolie SE,Abbott NL

更新日期：2020-06-19 00:00:00

abstract：:E2F is a family of master transcription regulators involved in mediating diverse cell fates. Here, we show that residue-specific arginine methylation (meR) by PRMT5 enables E2F1 to regulate many genes at the level of alternative RNA splicing, rather than through its classical transcription-based mechanism. The p100/TS...

journal_title：Science advances

authors： Roworth AP,Carr SM,Liu G,Barczak W,Miller RL,Munro S,Kanapin A,Samsonova A,La Thangue NB

更新日期：2019-06-26 00:00:00

abstract：:We report a dual-mode organic photodetector (OPD) that has a trilayer visible light absorber/optical spacer/near-infrared (NIR) light absorber configuration. In the presence of NIR light, photocurrent is produced in the NIR light-absorbing layer due to the trap-assisted charge injection at the organic/cathode interfac...

journal_title：Science advances

authors： Lan Z,Lei Y,Chan WKE,Chen S,Luo D,Zhu F

更新日期：2020-01-31 00:00:00