Abstract:
:Nanoparticles have been extensively used for inflammation imaging and photodynamic therapy of cancer. However, the major translational barriers to most nanoparticle-based imaging and therapy applications are the limited depth of tissue penetration, inevitable requirement of external irradiation, and poor biocompatibility of the nanoparticles. To overcome these critical limitations, we synthesized a sensitive, specific, biodegradable luminescent nanoparticle that is self-assembled from an amphiphilic polymeric conjugate with a luminescent donor (luminol) and a fluorescent acceptor [chlorin e6 (Ce6)] for in vivo luminescence imaging and photodynamic therapy in deep tissues. Mechanistically, reactive oxygen species (ROS) and myeloperoxidase generated in inflammatory sites or the tumor microenvironment trigger bioluminescence resonance energy transfer and the production of singlet oxygen (1O2) from the nanoparticle, enabling in vivo imaging and cancer therapy, respectively. This self-illuminating nanoparticle shows an excellent in vivo imaging capability with suitable tissue penetration and resolution in diverse animal models of inflammation. It is also proven to be a selective, potent, and safe antitumor nanomedicine that specifically kills cancer cells via in situ 1O2 produced in the tumor microenvironment, which contains a high level of ROS.
journal_name
Sci Advjournal_title
Science advancesauthors
Xu X,An H,Zhang D,Tao H,Dou Y,Li X,Huang J,Zhang Jdoi
10.1126/sciadv.aat2953subject
Has Abstractpub_date
2019-01-09 00:00:00pages
eaat2953issue
1issn
2375-2548pii
aat2953journal_volume
5pub_type
杂志文章相关文献
Science Advances文献大全abstract::Chronic suppurative otitis media (CSOM) is a neglected pediatric disease affecting 330 million worldwide for which no new drugs have been introduced for over a decade. We developed a mouse model with utility in preclinical drug evaluation and antimicrobial discovery. Our model used immune-competent mice, tympanic memb...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abc1828
更新日期:2020-08-14 00:00:00
abstract::We propose a method to use artificial neural networks to approximate light scattering by multilayer nanoparticles. We find that the network needs to be trained on only a small sampling of the data to approximate the simulation to high precision. Once the neural network is trained, it can simulate such optical processe...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aar4206
更新日期:2018-06-01 00:00:00
abstract::Despite the potential of photodynamic therapy (PDT), its comprehensive use in cancer treatment has not been achieved because of the nondegradable risks of photosensitizing drugs and limits of light penetration and instrumentation. Here, we present bioluminescence (BL)-induced proteinaceous PDT (BLiP-PDT), through the ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aba3009
更新日期:2020-09-11 00:00:00
abstract::Computer vision (CV) has the potential to change medicine fundamentally. Expert knowledge provided by CV can enhance diagnosis. Unfortunately, existing algorithms often remain below expectations, as databases used for training are usually too small, incomplete, and heterogeneous in quality. Moreover, data protection i...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb7973
更新日期:2020-12-02 00:00:00
abstract::Immotile cilia sense extracellular signals such as fluid flow, but whether Ca2+ plays a role in flow sensing has been unclear. Here, we examined the role of ciliary Ca2+ in the flow sensing that initiates the breaking of left-right (L-R) symmetry in the mouse embryo. Intraciliary and cytoplasmic Ca2+ transients were d...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aba1195
更新日期:2020-07-22 00:00:00
abstract::The wings of the black butterfly, Pachliopta aristolochiae, are covered by micro- and nanostructured scales that harvest sunlight over a wide spectral and angular range. Considering that these properties are particularly attractive for photovoltaic applications, we analyze the contribution of these micro- and nanostru...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1700232
更新日期:2017-10-20 00:00:00
abstract::Variations in Earth's orbit pace the glacial-interglacial cycles of the Quaternary, but the mechanisms that transform regional and seasonal variations in solar insolation into glacial-interglacial cycles are still elusive. Here, we present transient simulations of coevolution of climate, ice sheets, and carbon cycle o...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aav7337
更新日期:2019-04-03 00:00:00
abstract::Chiral fermions in solid state feature "Fermi arc" states, connecting the surface projections of the bulk chiral nodes. The surface Fermi arc is a signature of nontrivial bulk topology. Unconventional chiral fermions with an extensive Fermi arc traversing the whole Brillouin zone have been theoretically proposed in Co...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaw9485
更新日期:2019-12-20 00:00:00
abstract::Although Al(III) hydrolysis, condensation, and nucleation play pivotal roles in the synthesis of Al-based compounds and determine their chemical behavior, we still lack experimental evidence regarding the chemistry of nucleation from solution. Here, by combining advanced titration assays, high-resolution transmission ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aba6878
更新日期:2020-06-03 00:00:00
abstract::Smart materials that are capable of memorizing a temporary shape, and morph in response to a stimulus, have the potential to revolutionize medicine and robotics. Here, we introduce an innovative method to program protein hydrogels and to induce shape changes in aqueous solutions at room temperature. We demonstrate our...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aba6112
更新日期:2020-04-29 00:00:00
abstract::A growing body of empirical evidence is revealing the value of nature experience for mental health. With rapid urbanization and declines in human contact with nature globally, crucial decisions must be made about how to preserve and enhance opportunities for nature experience. Here, we first provide points of consensu...
journal_title:Science advances
pub_type: 杂志文章,评审
doi:10.1126/sciadv.aax0903
更新日期:2019-07-24 00:00:00
abstract::Neurodegenerative disorders are caused by progressive neuronal loss, and there is no complete treatment available yet. Neuroinflammation is a common feature across neurodegenerative disorders and implicated in the progression of neurodegeneration. Dysregulated activation of microglia causes neuroinflammation and has b...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abc1428
更新日期:2020-11-13 00:00:00
abstract::The fabrication of three-dimensional (3D) objects by polymer self-assembly in solution is extremely challenging. Here, multi-tori mesostructures were obtained from the crystallization-driven self-assembly of a coil-crystalline block copolymer (BCP) in mixed solvents. The formation of these structures follows a multist...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaz7301
更新日期:2020-04-15 00:00:00
abstract::Microsupercapacitors (MSCs) have garnered considerable attention as a promising power source for microelectronics and miniaturized portable/wearable devices. However, their practical application has been hindered by the manufacturing complexity and dimensional limits. Here, we develop a new class of ultrahigh areal nu...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaz1692
更新日期:2020-03-06 00:00:00
abstract::The human transfer RNA methyltransferase 9-like gene (TRM9L, also known as KIAA1456) encodes a negative regulator of tumor growth that is frequently silenced in many forms of cancer. While TRM9L can inhibit tumor cell growth in vivo, the molecular mechanisms underlying the tumor inhibition activity of TRM9L are unknow...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aas9184
更新日期:2018-07-11 00:00:00
abstract::The eastern oyster (Crassostrea virginica) is an important proxy for examining historical trajectories of coastal ecosystems. Measurement of ~40,000 oyster shells from archaeological sites along the Atlantic Coast of the United States provides a long-term record of oyster abundance and size. The data demonstrate incre...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aba9652
更新日期:2020-07-10 00:00:00
abstract::Fractures and faults riddle the Earth's crust on all scales, and the deformation associated with them is presumed to have had significant effects on its petrological and structural evolution. However, despite the abundance of directly observable earthquake activity, unequivocal evidence for seismic slip rates along an...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1602067
更新日期:2017-02-22 00:00:00
abstract::Half-filled Landau levels host an emergent Fermi liquid that displays instability toward pairing, culminating in a gapped even-denominator fractional quantum Hall ground state. While this pairing may be probed by tuning the polarization of carriers in competing orbital and spin degrees of freedom, sufficiently high qu...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aat8742
更新日期:2018-09-14 00:00:00
abstract::Animals, humans, and multi-robot systems operate in dynamic environments, where the ability to respond to changing circumstances is paramount. An effective collective response requires suitable information transfer among agents and thus critically depends on the interaction network. To investigate the influence of the...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aau0999
更新日期:2019-04-03 00:00:00
abstract::The spin-polarized surface states of topological insulators (TIs) are attractive for applications in spintronics and quantum computing. A central challenge with these materials is to reliably tune the chemical potential of their electrons with respect to the Dirac point and the bulk bands. We demonstrate persistent, b...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1500640
更新日期:2015-10-09 00:00:00
abstract::Driven by advances in materials and computer science, researchers are attempting to design systems where the computer and material are one and the same entity. Using theoretical and computational modeling, we design a hybrid material system that can autonomously transduce chemical, mechanical, and electrical energy to...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1601114
更新日期:2016-09-02 00:00:00
abstract::Copper-containing nitrite reductases (CuNiRs), encoded by nirK gene, are found in all kingdoms of life with only 5% of CuNiR denitrifiers having two or more copies of nirK Recently, we have identified two copies of nirK genes in several α-proteobacteria of the order Rhizobiales including Bradyrhizobium sp. ORS 375, en...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abd8523
更新日期:2021-01-01 00:00:00
abstract::Yearly, a quarter billion people are infected and a half a million killed by the mosquito-borne disease malaria. Lack of real-time observational tools for continuously assessing the unperturbed mosquito flight activity in situ limits progress toward improved vector control. We deployed a high-resolution entomological ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aay5487
更新日期:2020-05-13 00:00:00
abstract::Myofibroblasts orchestrate wound healing processes, and if they remain activated, they drive disease progression such as fibrosis and cancer. Besides growth factor signaling, the local extracellular matrix (ECM) and its mechanical properties are central regulators of these processes. It remains unknown whether transfo...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aao4881
更新日期:2018-01-17 00:00:00
abstract::Cellular cross-talk between ubiquitination and other posttranslational modifications contributes to the regulation of numerous processes. One example is ADP-ribosylation of the carboxyl terminus of ubiquitin by the E3 DTX3L/ADP-ribosyltransferase PARP9 heterodimer, but the mechanism remains elusive. Here, we show that...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abc0418
更新日期:2020-09-18 00:00:00
abstract::While the ecological impacts of fishing the waters beyond national jurisdiction (the "high seas") have been widely studied, the economic rationale is more difficult to ascertain because of scarce data on the costs and revenues of the fleets that fish there. Newly compiled satellite data and machine learning now allow ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aat2504
更新日期:2018-06-06 00:00:00
abstract::Changes in chromatin organization occur during aging. Overexpression of histones partially alleviates these changes and promotes longevity. We report that deletion of the histone H3-H4 minor locus HHT1-HHF1 extended the replicative life span of Saccharomyces cerevisiae. This longevity effect was mediated through TOR s...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aav1165
更新日期:2019-07-10 00:00:00
abstract::Ciliary oscillations driven by molecular motors cause fluid motion at micron scale. Stable oscillations require a substantial source of dissipation to balance the energy input of motors. Conventionally, it stems from external fluid. We show, in contrast, that external fluid friction is negligible compared to internal ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb0503
更新日期:2020-08-12 00:00:00
abstract::The process of sheep and goat (caprine) domestication began by 9000 to 8000 BCE in Southwest Asia. The early Neolithic site at Aşıklı Höyük in central Turkey preserves early archaeological evidence of this transformation, such as culling by age and sex and use of enclosures inside the settlement. People's strategies f...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaw0038
更新日期:2019-04-17 00:00:00
abstract::Intrachain charge transport is unique to conjugated polymers distinct from inorganic and small molecular semiconductors and is key to achieving high-performance organic electronics. Polymer backbone planarity and thin film morphology sensitively modulate intrachain charge transport. However, simple, generic nonsynthet...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaw7757
更新日期:2019-08-09 00:00:00