Abstract:
:Despite the potential of photodynamic therapy (PDT), its comprehensive use in cancer treatment has not been achieved because of the nondegradable risks of photosensitizing drugs and limits of light penetration and instrumentation. Here, we present bioluminescence (BL)-induced proteinaceous PDT (BLiP-PDT), through the combination of luciferase and a reactive oxygen species (ROS)-generating protein (Luc-RGP), which is self-luminescent and degradable. After exposure to coelenterazine-h as a substrate for luciferase without external light irradiation, Luc-RGP fused with a small lead peptide-induced breast cancer cell death through the generation of BL-sensitive ROS in the plasma membrane. Even with extremely low light energy, BLiP-PDT exhibited targeted effects in primary breast cancer cells from patients and in in vivo tumor xenograft mouse models. These findings suggest that BLiP-PDT is immediately useful as a promising theranostic approach against various cancers.
journal_name
Sci Advjournal_title
Science advancesauthors
Kim EH,Park S,Kim YK,Moon M,Park J,Lee KJ,Lee S,Kim YPdoi
10.1126/sciadv.aba3009subject
Has Abstractpub_date
2020-09-11 00:00:00issue
37issn
2375-2548pii
6/37/eaba3009journal_volume
6pub_type
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