Abstract:
:Using a cell-based assay monitoring differential protein transport in the secretory pathway coupled to high-content screening, we have identified three molecules that specifically reduce the delivery of the major co-receptor for HIV-1, CCR5, to the plasma membrane. They have no effect on the closely related receptors CCR1 and CXCR4. These molecules are also potent in primary macrophages as they markedly decrease HIV entry. At the molecular level, two of these molecules inhibit the critical palmitoylation of CCR5 and thereby block CCR5 in the early secretory pathway. Our results open a clear therapeutics avenue based on trafficking control and demonstrate that preventing HIV infection can be performed at the level of its receptor delivery.
journal_name
Sci Advjournal_title
Science advancesauthors
Boncompain G,Herit F,Tessier S,Lescure A,Del Nery E,Gestraud P,Staropoli I,Fukata Y,Fukata M,Brelot A,Niedergang F,Perez Fdoi
10.1126/sciadv.aax0821subject
Has Abstractpub_date
2019-10-16 00:00:00pages
eaax0821issue
10issn
2375-2548pii
aax0821journal_volume
5pub_type
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