Onymity promotes cooperation in social dilemma experiments.

abstract：:The cyclic GMP-AMP synthase (cGAS), a sensor of cytosolic DNA, is critical for the innate immune response. Here, we show that loss of cGAS in untransformed and cancer cells results in uncontrolled DNA replication, hyperproliferation, and genomic instability. While the majority of cGAS is cytoplasmic, a fraction of cGA...

journal_title：Science advances

authors： Chen H,Chen H,Zhang J,Wang Y,Simoneau A,Yang H,Levine AS,Zou L,Chen Z,Lan L

更新日期：2020-10-14 00:00:00

abstract：:Forecasting fields of oceanic phenomena has long been dependent on physical equation-based numerical models. The challenge is that many natural processes need to be considered for understanding complicated phenomena. In contrast, rules of the processes are already embedded in the time-series observation itself. Thus, ...

journal_title：Science advances

authors： Zheng G,Li X,Zhang RH,Liu B

更新日期：2020-07-15 00:00:00

abstract：:Halide perovskites are promising materials for development in hot carrier (HC) solar cells, where the excess energy of above-bandgap photons is harvested before being wasted as heat to enhance device efficiency. Presently, HC separation and transfer processes at higher-energy states remain poorly understood. Here, we ...

journal_title：Science advances

authors： Lim SS,Giovanni D,Zhang Q,Solanki A,Jamaludin NF,Lim JWM,Mathews N,Mhaisalkar S,Pshenichnikov MS,Sum TC

更新日期：2019-11-15 00:00:00

abstract：:Over millions of years, the oxidation of organic carbon contained within sedimentary rocks is one of the main sources of carbon dioxide to the atmosphere, yet the controls on this emission remain poorly constrained. We use rhenium to track the oxidation of rock-bound organic carbon in the mountain watersheds of New Ze...

journal_title：Science advances

authors： Horan K,Hilton RG,Selby D,Ottley CJ,Gröcke DR,Hicks M,Burton KW

更新日期：2017-10-04 00:00:00

abstract：:Dual-comb spectroscopy allows for high-resolution spectra to be measured over broad bandwidths, but an essential requirement for coherent integration is the availability of a phase reference. Usually, this means that the combs' phase and timing errors must be measured and either minimized by stabilization or removed b...

journal_title：Science advances

authors： Burghoff D,Yang Y,Hu Q

更新日期：2016-11-11 00:00:00

abstract：:In this study, we report the existence of a communication system among human smooth muscle cells that uses mechanical forces to frequency modulate long-range calcium waves. An important consequence of this mechanical signaling is that changes in stiffness of the underlying extracellular matrix can interfere with the f...

journal_title：Science advances

authors： Stasiak SE,Jamieson RR,Bouffard J,Cram EJ,Parameswaran H

更新日期：2020-08-05 00:00:00

abstract：:Controlling the polarization state and the propagation direction of photons is a fundamental prerequisite for many nanophotonic devices and a precursor for future on-chip communication, where the emission properties of individual emitters are particularly relevant. Here, we report on the emission of partially circular...

journal_title：Science advances

authors： Neugebauer M,Banzer P,Nechayev S

更新日期：2019-06-28 00:00:00

abstract：:In 2018-2019, New York City experienced the largest measles outbreak in the United States in nearly three decades. To identify key contributing factors, we modeled the transmission dynamics of this outbreak. Results indicate that delayed vaccination of 1- to 4-year-olds enabled the initial spread and that increased in...

journal_title：Science advances

authors： Yang W

更新日期：2020-05-27 00:00:00

abstract：:Optical investigation and manipulation constitute the core of biological experiments. Here, we introduce a new borosilicate glass material that contains the rare-earth ion terbium(III) (Tb3+), which emits green fluorescence upon blue light excitation, similar to green fluorescent protein (GFP), and thus is widely comp...

journal_title：Science advances

authors： Okamoto K,Ebina T,Fujii N,Konishi K,Sato Y,Kashima T,Nakano R,Hioki H,Takeuchi H,Yumoto J,Matsuzaki M,Ikegaya Y

更新日期：2021-01-06 00:00:00

abstract：:The retinoic acid-inducible gene I (RIG-I) innate immune receptor is an important immunotherapeutic target, but we lack approaches for monitoring the physical basis for its activation in vitro. This gap in our understanding has led to confusion about mechanisms of RIG-I activation and difficulty discovering agonists a...

journal_title：Science advances

authors： Dickey TH,Song B,Pyle AM

更新日期：2019-10-02 00:00:00

abstract：:The tet methylcytosine dioxygenase 2 (TET2) enzyme catalyzes the conversion of the modified DNA base 5-methylcytosine to 5-hydroxymethylcytosine. TET2 is frequently mutated or dysregulated in multiple human cancers, and loss of TET2 is associated with changes in DNA methylation patterns. Here, using newly developed TE...

journal_title：Science advances

authors： Wang L,Ozark PA,Smith ER,Zhao Z,Marshall SA,Rendleman EJ,Piunti A,Ryan C,Whelan AL,Helmin KA,Morgan MA,Zou L,Singer BD,Shilatifard A

更新日期：2018-11-07 00:00:00

abstract：:Coordinatively unsaturated (CUS) iron sites are highly active in catalytic oxidation reactions; however, maintaining the CUS structure of iron during heterogeneous catalytic reactions is a great challenge. Here, we report a strategy to stabilize single-atom CUS iron sites by embedding highly dispersed FeN4 centers in ...

journal_title：Science advances

authors： Deng D,Chen X,Yu L,Wu X,Liu Q,Liu Y,Yang H,Tian H,Hu Y,Du P,Si R,Wang J,Cui X,Li H,Xiao J,Xu T,Deng J,Yang F,Duchesne PN,Zhang P,Zhou J,Sun L,Li J,Pan X,Bao X

更新日期：2015-12-04 00:00:00

abstract：:Functional materials with specific surface wettability play an important role in a wide variety of areas. Inspired by nature's Nepenthes pitcher plant, we present a novel slippery film with tunable wettability based on a shape-memory graphene sponge. The porous graphene sponge coated with shape-memory polymer was used...

journal_title：Science advances

authors： Wang J,Sun L,Zou M,Gao W,Liu C,Shang L,Gu Z,Zhao Y

更新日期：2017-06-02 00:00:00

abstract：:Fluid catalytic cracking (FCC) particles account for 40 to 45% of worldwide gasoline production. The hierarchical complex particle pore structure allows access of long-chain feedstock molecules into active catalyst domains where they are cracked into smaller, more valuable hydrocarbon products (for example, gasoline)....

journal_title：Science advances

authors： Meirer F,Kalirai S,Morris D,Soparawalla S,Liu Y,Mesu G,Andrews JC,Weckhuysen BM

更新日期：2015-04-03 00:00:00

abstract：:Immotile cilia sense extracellular signals such as fluid flow, but whether Ca2+ plays a role in flow sensing has been unclear. Here, we examined the role of ciliary Ca2+ in the flow sensing that initiates the breaking of left-right (L-R) symmetry in the mouse embryo. Intraciliary and cytoplasmic Ca2+ transients were d...

journal_title：Science advances

authors： Mizuno K,Shiozawa K,Katoh TA,Minegishi K,Ide T,Ikawa Y,Nishimura H,Takaoka K,Itabashi T,Iwane AH,Nakai J,Shiratori H,Hamada H

更新日期：2020-07-22 00:00:00

abstract：:Protected areas (PAs) are essential to biodiversity conservation, but their static boundaries may undermine their potential for protecting species under climate change. We assessed how the climatic conditions within global terrestrial PAs may change over time. By 2070, protection is expected to decline in cold and war...

journal_title：Science advances

authors： Elsen PR,Monahan WB,Dougherty ER,Merenlender AM

更新日期：2020-06-17 00:00:00

abstract：:Coastal vertical land motion affects projections of sea-level rise, and subsidence exacerbates flooding hazards. Along the ~1350-km California coastline, records of high-resolution vertical land motion rates are scarce due to sparse instrumentation, and hazards to coastal communities are underestimated. Here, we consi...

journal_title：Science advances

authors： Blackwell E,Shirzaei M,Ojha C,Werth S

更新日期：2020-07-31 00:00:00

abstract：:The role of sialyloligosaccharides on the surface of secreted glycoproteins is still unclear because of the difficulty in the preparation of sialylglycoproteins in a homogeneous form. We selected erythropoietin (EPO) as a target molecule and designed an efficient synthetic strategy for the chemical synthesis of a homo...

journal_title：Science advances

authors： Murakami M,Kiuchi T,Nishihara M,Tezuka K,Okamoto R,Izumi M,Kajihara Y

更新日期：2016-01-15 00:00:00

abstract：:Fundamental understanding of the charge transport physics of hybrid lead halide perovskite semiconductors is important for advancing their use in high-performance optoelectronics. We use field-effect transistors (FETs) to probe the charge transport mechanism in thin films of methylammonium lead iodide (MAPbI3). We sho...

journal_title：Science advances

authors： Senanayak SP,Yang B,Thomas TH,Giesbrecht N,Huang W,Gann E,Nair B,Goedel K,Guha S,Moya X,McNeill CR,Docampo P,Sadhanala A,Friend RH,Sirringhaus H

更新日期：2017-01-27 00:00:00

abstract：:To gain insights into neutrophil heterogeneity dynamics in the context of sterile inflammation and wound healing, we performed a pseudotime analysis of single-cell flow cytometry data using the spanning-tree progression analysis of density-normalized events algorithm. This enables us to view neutrophil transitional su...

journal_title：Science advances

authors： Turner TC,Sok MCP,Hymel LA,Pittman FS,York WY,Mac QD,Vyshnya S,Lim HS,Kwong GA,Qiu P,Botchwey EA

更新日期：2020-10-30 00:00:00

abstract：:Identifying key players in coupled individual systems is a fundamental problem in network theory. We investigate synchronizable network-coupled dynamical systems such as high-voltage electric power grids and coupled oscillators on complex networks. We define key players as nodes that, once perturbed, generate the larg...

journal_title：Science advances

authors： Tyloo M,Pagnier L,Jacquod P

更新日期：2019-11-22 00:00:00

abstract：:Unraveling the genetic and epigenetic determinants of phenotypes is critical for understanding and re-engineering biology and would benefit from improved methods to separate cells based on phenotypes. Here, we report SPOTlight, a versatile high-throughput technique to isolate individual yeast or human cells with uniqu...

journal_title：Science advances

authors： Lee J,Liu Z,Suzuki PH,Ahrens JF,Lai S,Lu X,Guan S,St-Pierre F

更新日期：2020-10-23 00:00:00

abstract：:The investigation of materials that exhibit quantum phase transition provides valuable insights into fundamental problems in physics. We present neutron scattering under pressure in a triangular-lattice antiferromagnet that has a quantum disorder in the low-pressure phase and a noncollinear structure in the high-press...

journal_title：Science advances

authors： Hayashida S,Matsumoto M,Hagihala M,Kurita N,Tanaka H,Itoh S,Hong T,Soda M,Uwatoko Y,Masuda T

更新日期：2019-10-18 00:00:00

abstract：:Triple-negative breast cancer (TNBC) is life-threatening because of limited therapies and lack of effective therapeutic targets. Here, we found that moesin (MSN) was significantly overexpressed in TNBC compared with other subtypes of breast cancer and was positively correlated with poor overall survival. However, litt...

journal_title：Science advances

authors： Qin Y,Chen W,Jiang G,Zhou L,Yang X,Li H,He X,Wang HL,Zhou YB,Huang S,Liu S

更新日期：2020-02-19 00:00:00

abstract：:Implanted brain electrodes construct the only means to electrically interface with individual neurons in vivo, but their recording efficacy and biocompatibility pose limitations on scientific and clinical applications. We showed that nanoelectronic thread (NET) electrodes with subcellular dimensions, ultraflexibility,...

journal_title：Science advances

authors： Luan L,Wei X,Zhao Z,Siegel JJ,Potnis O,Tuppen CA,Lin S,Kazmi S,Fowler RA,Holloway S,Dunn AK,Chitwood RA,Xie C

更新日期：2017-02-15 00:00:00

abstract：:The endoplasmic reticulum (ER) is a highly dynamic network of membranes. Here, we combine live-cell microscopy with in situ cryo-electron tomography to directly visualize ER dynamics in several secretory cell types including pancreatic β-cells and neurons under near-native conditions. Using these imaging approaches, w...

journal_title：Science advances

authors： Carter SD,Hampton CM,Langlois R,Melero R,Farino ZJ,Calderon MJ,Li W,Wallace CT,Tran NH,Grassucci RA,Siegmund SE,Pemberton J,Morgenstern TJ,Eisenman L,Aguilar JI,Greenberg NL,Levy ES,Yi E,Mitchell WG,Rice WJ,Wigge

更新日期：2020-04-01 00:00:00

abstract：:Polyphosphate, an energy-rich polymer conserved in all kingdoms of life, is integral to many cellular stress responses, including nutrient deprivation, and yet, the mechanisms that underlie its biological roles are not well understood. In this work, we elucidate the physiological function of this polymer in the acclim...

journal_title：Science advances

authors： Sanz-Luque E,Saroussi S,Huang W,Akkawi N,Grossman AR

更新日期：2020-09-30 00:00:00

abstract：:Adaptation is a fundamental property of sensory systems that can change subjective experiences in the context of recent information. Adaptation has been postulated to arise from recurrent circuit mechanisms or as a consequence of neuronally intrinsic suppression. However, it is unclear whether intrinsic suppression by...

journal_title：Science advances

authors： Vinken K,Boix X,Kreiman G

更新日期：2020-10-14 00:00:00

abstract：:The wiring of vertebrate and invertebrate brains provides the anatomical skeleton for cognition and behavior. Connections among brain regions are characterized by heterogeneous strength that is parsimoniously described by the wiring cost and homophily principles. Moreover, brains exhibit a characteristic global networ...

journal_title：Science advances

authors： Goulas A,Betzel RF,Hilgetag CC

更新日期：2019-06-12 00:00:00

abstract：:Behavioral and clinical studies suggest a critical role of substance P (SP)/neurokinin-1 receptor (NK-1R) signaling in alcohol dependence. Here, we examined regulation of GABA transmission in the medial subdivision of the central amygdala (CeM) by the SP/NK-1R system, and its neuroadaptation following chronic alcohol ...

journal_title：Science advances

authors： Khom S,Steinkellner T,Hnasko TS,Roberto M

更新日期：2020-03-18 00:00:00