cGAS suppresses genomic instability as a decelerator of replication forks.

abstract：:Lymphatic filariasis and onchocerciasis are two important neglected tropical diseases (NTDs) that cause severe disability. Control efforts are hindered by the lack of a safe macrofilaricidal drug. Targeting the Wolbachia bacterial endosymbionts in these parasites with doxycycline leads to a macrofilaricidal outcome, b...

journal_title：Science advances

authors： Johnston KL,Cook DAN,Berry NG,David Hong W,Clare RH,Goddard M,Ford L,Nixon GL,O'Neill PM,Ward SA,Taylor MJ

更新日期：2017-09-27 00:00:00

abstract：:The locally accumulated damage by tropical cyclones (TCs) can intensify substantially when these cyclones move more slowly. While some observational evidence suggests that TC motion might have slowed significantly since the mid-20th century (1), the robustness of the observed trend and its relation to anthropogenic wa...

journal_title：Science advances

authors： Zhang G,Murakami H,Knutson TR,Mizuta R,Yoshida K

更新日期：2020-04-22 00:00:00

abstract：:The homotrimeric molecular chaperone Skp of Gram-negative bacteria facilitates the transport of outer membrane proteins across the periplasm. It has been unclear how its activity is modulated during its functional cycle. Here, we report an atomic-resolution characterization of the Escherichia coli Skp monomer-trimer t...

journal_title：Science advances

authors： Mas G,Burmann BM,Sharpe T,Claudi B,Bumann D,Hiller S

更新日期：2020-10-21 00:00:00

abstract：:Monolithic strong magnetic induction at the mtesla to tesla level provides essential functionalities to physical, chemical, and medical systems. Current design options are constrained by existing capabilities in three-dimensional (3D) structure construction, current handling, and magnetic material integration. We repo...

journal_title：Science advances

authors： Huang W,Yang Z,Kraman MD,Wang Q,Ou Z,Rojo MM,Yalamarthy AS,Chen V,Lian F,Ni JH,Liu S,Yu H,Sang L,Michaels J,Sievers DJ,Eden JG,Braun PV,Chen Q,Gong S,Senesky DG,Pop E,Li X

更新日期：2020-01-17 00:00:00

abstract：:A growing body of empirical evidence is revealing the value of nature experience for mental health. With rapid urbanization and declines in human contact with nature globally, crucial decisions must be made about how to preserve and enhance opportunities for nature experience. Here, we first provide points of consensu...

journal_title：Science advances

authors： Bratman GN,Anderson CB,Berman MG,Cochran B,de Vries S,Flanders J,Folke C,Frumkin H,Gross JJ,Hartig T,Kahn PH Jr,Kuo M,Lawler JJ,Levin PS,Lindahl T,Meyer-Lindenberg A,Mitchell R,Ouyang Z,Roe J,Scarlett L,Smith JR,

更新日期：2019-07-24 00:00:00

abstract：:Spin caloritronics has recently emerged from the combination of spintronics and thermoelectricity. Here, we show that flexible, macroscopic spin caloritronic devices based on large-area interconnected magnetic nanowire networks can be used to enable controlled Peltier cooling of macroscopic electronic components with ...

journal_title：Science advances

authors： da Câmara Santa Clara Gomes T,Abreu Araujo F,Piraux L

更新日期：2019-03-01 00:00:00

abstract：:Microsupercapacitors (MSCs) have garnered considerable attention as a promising power source for microelectronics and miniaturized portable/wearable devices. However, their practical application has been hindered by the manufacturing complexity and dimensional limits. Here, we develop a new class of ultrahigh areal nu...

journal_title：Science advances

authors： Lee KH,Lee SS,Ahn DB,Lee J,Byun D,Lee SY

更新日期：2020-03-06 00:00:00

abstract：:The eastern oyster (Crassostrea virginica) is an important proxy for examining historical trajectories of coastal ecosystems. Measurement of ~40,000 oyster shells from archaeological sites along the Atlantic Coast of the United States provides a long-term record of oyster abundance and size. The data demonstrate incre...

journal_title：Science advances

authors： Thompson VD,Rick T,Garland CJ,Thomas DH,Smith KY,Bergh S,Sanger M,Tucker B,Lulewicz I,Semon AM,Schalles J,Hladik C,Alexander C,Ritchison BT

更新日期：2020-07-10 00:00:00

abstract：:G protein-coupled receptor 54 (GPR54), the key receptor for the neuropeptide hormone kisspeptin, plays essential roles in regulating puberty development and cancer metastasis. However, its role in the antiviral innate immune response is unknown. We report that virus-induced type I interferon (IFN-I) production was sig...

journal_title：Science advances

authors： Huang H,Xiong Q,Wang N,Chen R,Ren H,Siwko S,Han H,Liu M,Qian M,Du B

更新日期：2018-08-08 00:00:00

abstract：:The catalytic activity of alloy nanoparticles depends on the particle size and composition ratio of different metals. Alloy nanoparticles composed of Pd, Pt, and Au are widely used as catalysts for oxidation reactions. The catalytic activities of Pt and Au nanoparticles in oxidation reactions are known to increase as ...

journal_title：Science advances

authors： Takahashi M,Koizumi H,Chun WJ,Kori M,Imaoka T,Yamamoto K

更新日期：2017-07-26 00:00:00

abstract：:Glucose-responsive insulin delivery systems with robust responsiveness that has been validated in animal models, especially in large animal models, remain elusive. Here, we exploit a new strategy to form a micro-sized complex between a charge-switchable polymer with a glucose-sensing moiety and insulin driven by elect...

journal_title：Science advances

authors： Wang J,Yu J,Zhang Y,Zhang X,Kahkoska AR,Chen G,Wang Z,Sun W,Cai L,Chen Z,Qian C,Shen Q,Khademhosseini A,Buse JB,Gu Z

更新日期：2019-07-10 00:00:00

abstract：:Dirac materials such as graphene and topological insulators (TIs) are known to have unique electronic and spintronic properties. We combine graphene with TIs in van der Waals heterostructures to demonstrate the emergence of a strong proximity-induced spin-orbit coupling in graphene. By performing spin transport and pr...

journal_title：Science advances

authors： Khokhriakov D,Cummings AW,Song K,Vila M,Karpiak B,Dankert A,Roche S,Dash SP

更新日期：2018-09-21 00:00:00

abstract：:Development of composite indicators for integrated health in populations typically relies on a priori assumptions rather than model-free, data-driven evidence. Traditional variable selection processes tend not to consider relatedness and redundancy among variables, instead considering only individual correlations. In ...

journal_title：Science advances

authors： Servadio JL,Convertino M

更新日期：2018-02-02 00:00:00

abstract：:Ice-templating holds promise to become a powerful technique to construct high-performance bioinspired materials. Both ice nucleation and growth during the freezing process are crucial for the final architecture of the ice-templated material. However, effective ways to control these two very important factors are still...

journal_title：Science advances

authors： Zhao N,Li M,Gong H,Bai H

更新日期：2020-07-31 00:00:00

abstract：:Quantum phenomena have the potential to speed up the solution of hard optimization problems. For example, quantum annealing, based on the quantum tunneling effect, has recently been shown to scale exponentially better with system size than classical simulated annealing. However, current realizations of quantum anneale...

journal_title：Science advances

authors： Nigg SE,Lörch N,Tiwari RP

更新日期：2017-04-07 00:00:00

abstract：:Dual-comb spectroscopy allows for high-resolution spectra to be measured over broad bandwidths, but an essential requirement for coherent integration is the availability of a phase reference. Usually, this means that the combs' phase and timing errors must be measured and either minimized by stabilization or removed b...

journal_title：Science advances

authors： Burghoff D,Yang Y,Hu Q

更新日期：2016-11-11 00:00:00

abstract：:G protein-coupled receptors (GPCRs) play a fundamental role in the modulation of synaptic transmission. A pivotal example is provided by the metabotropic glutamate receptor type 4 (mGluR4), which inhibits glutamate release at presynaptic active zones (AZs). However, how GPCRs are organized within AZs to regulate neuro...

journal_title：Science advances

authors： Siddig S,Aufmkolk S,Doose S,Jobin ML,Werner C,Sauer M,Calebiro D

更新日期：2020-04-15 00:00:00

abstract：:Altered cerebral glucose uptake is one of the hallmarks of Alzheimer's disease (AD). A dynamic glucose-enhanced (DGE) magnetic resonance imaging (MRI) approach was developed to simultaneously monitor d-glucose uptake and clearance in both brain parenchyma and cerebrospinal fluid (CSF). We observed substantially higher...

journal_title：Science advances

authors： Huang J,van Zijl PCM,Han X,Dong CM,Cheng GWY,Tse KH,Knutsson L,Chen L,Lai JHC,Wu EX,Xu J,Chan KWY

更新日期：2020-05-13 00:00:00

abstract：:Immune regulatory metabolites are key features of the tumor microenvironment (TME), yet with a few exceptions, their identities remain largely unknown. Here, we profiled tumor and T cells from tumor and ascites of patients with high-grade serous carcinoma (HGSC) to uncover the metabolomes of these distinct TME compart...

journal_title：Science advances

authors： Kilgour MK,MacPherson S,Zacharias LG,Ellis AE,Sheldon RD,Liu EY,Keyes S,Pauly B,Carleton G,Allard B,Smazynski J,Williams KS,Watson PH,Stagg J,Nelson BH,DeBerardinis RJ,Jones RG,Hamilton PT,Lum JJ

更新日期：2021-01-20 00:00:00

abstract：:The response to programmed cell death protein-1 (PD-1)/programmed death ligand-1 (PD-L1) blockade in cancer immunotherapy is limited because of multiple immune evasion mechanisms. Here, a previously unknown strategy is proposed to synergize the nuclear factor κB (NF-κB) inhibition and PD-1 blockade for antitumor immun...

journal_title：Science advances

authors： Xiao Z,Su Z,Han S,Huang J,Lin L,Shuai X

更新日期：2020-02-05 00:00:00

abstract：:Detection of amyloid-β (Aβ) aggregates contributes to the diagnosis of Alzheimer disease (AD). Plasma Aβ is deemed a less invasive and more accessible hallmark of AD, as Aβ can penetrate blood-brain barriers. However, correlations between biofluidic Aβ concentrations and AD progression has been tenuous. Here, we intro...

journal_title：Science advances

authors： Kim Y,Yoo YK,Kim HY,Roh JH,Kim J,Baek S,Lee JC,Kim HJ,Chae MS,Jeong D,Park D,Lee S,Jang H,Kim K,Lee JH,Byun BH,Park SY,Ha JH,Lee KC,Cho WW,Kim JS,Koh JY,Lim SM,Hwang KS

更新日期：2019-04-17 00:00:00

abstract：:Leukemia is a complex heterogeneous disease often driven by the expression of oncogenic fusion proteins with different molecular and biochemical properties. Whereas several fusion proteins induce leukemogenesis by activating Hox gene expression (Hox-activating fusions), others impinge on different pathways that do not...

journal_title：Science advances

authors： Rossi A,Ferrari KJ,Piunti A,Jammula S,Chiacchiera F,Mazzarella L,Scelfo A,Pelicci PG,Pasini D

更新日期：2016-10-07 00:00:00

abstract：:Eruptive phenomena at all scales, from hydrothermal geysers to flood basalts, can potentially be initiated or modulated by external mechanical perturbations. We present evidence for the triggering of magmatism on a global scale by the Chicxulub meteorite impact at the Cretaceous-Paleogene (K-Pg) boundary, recorded by ...

journal_title：Science advances

authors： Byrnes JS,Karlstrom L

更新日期：2018-02-07 00:00:00

abstract：:Intrinsically disordered regions (IDRs) of proteins are implicated in key macromolecular interactions. However, the molecular forces underlying IDR function within multicomponent assemblies remain elusive. By combining thermodynamic and structural data, we have discovered an allostery-based mechanism regulating the so...

journal_title：Science advances

authors： Blus BJ,Koh J,Krolak A,Seo HS,Coutavas E,Blobel G

更新日期：2019-11-27 00:00:00

abstract：:Yearly, a quarter billion people are infected and a half a million killed by the mosquito-borne disease malaria. Lack of real-time observational tools for continuously assessing the unperturbed mosquito flight activity in situ limits progress toward improved vector control. We deployed a high-resolution entomological ...

journal_title：Science advances

authors： Brydegaard M,Jansson S,Malmqvist E,Mlacha YP,Gebru A,Okumu F,Killeen GF,Kirkeby C

更新日期：2020-05-13 00:00:00

abstract：:Porous materials, which are characterized by the large surface area and percolated nature crucial for transport, play an important role in many technological applications including battery, ion exchange, catalysis, microelectronics, medical diagnosis, and oil recovery. Phase separation of a mixture in such a porous st...

journal_title：Science advances

authors： Shimizu R,Tanaka H

更新日期：2017-12-22 00:00:00

abstract：:The outbreak of the highly contagious and deadly severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also known as coronavirus disease 2019 (COVID-19), has posed a serious threat to public health across the globe, calling for the development of effective diagnostic markers and therapeutics. Here, we report a...

journal_title：Science advances

authors： Park HH,Kim HN,Kim H,Yoo Y,Shin H,Choi EY,Bae JS,Lee W

更新日期：2020-07-31 00:00:00

abstract：:Optogenetics is a paradigm-changing new method to study and manipulate the behavior of cells with light. Following major advances of the used genetic constructs over the last decade, the light sources required for optogenetic control are now receiving increased attention. We report a novel optogenetic illumination pla...

journal_title：Science advances

authors： Steude A,Witts EC,Miles GB,Gather MC

更新日期：2016-05-06 00:00:00

abstract：:Analog machine learning hardware platforms promise to be faster and more energy efficient than their digital counterparts. Wave physics, as found in acoustics and optics, is a natural candidate for building analog processors for time-varying signals. Here, we identify a mapping between the dynamics of wave physics and...

journal_title：Science advances

authors： Hughes TW,Williamson IAD,Minkov M,Fan S

更新日期：2019-12-20 00:00:00

abstract：:In May 2014, the Balkans were hit by a Vb-type cyclone that brought disastrous flooding and severe damage to Bosnia and Herzegovina, Serbia, and Croatia. Vb cyclones migrate from the Mediterranean, where they absorb warm and moist air, to the north, often causing flooding in central/eastern Europe. Extreme rainfall ev...

journal_title：Science advances

authors： Stadtherr L,Coumou D,Petoukhov V,Petri S,Rahmstorf S

更新日期：2016-04-15 00:00:00