Altered d-glucose in brain parenchyma and cerebrospinal fluid of early Alzheimer's disease detected by dynamic glucose-enhanced MRI.

abstract：:The control and use of light polarization in optical sciences and engineering are widespread. Despite remarkable developments in polarization-resolved imaging for life sciences, their transposition to strongly scattering media is currently not possible, because of the inherent depolarization effects arising from multi...

journal_title：Science advances

authors： de Aguiar HB,Gigan S,Brasselet S

更新日期：2017-09-01 00:00:00

abstract：:Changes in the Atlantic Meridional Overturning Circulation (AMOC) are moderate in most climate model projections under increasing greenhouse gas forcing. This intermodel consensus may be an artifact of common model biases that favor a stable AMOC. Observationally based freshwater budget analyses suggest that the AMOC ...

journal_title：Science advances

authors： Liu W,Xie SP,Liu Z,Zhu J

更新日期：2017-01-04 00:00:00

abstract：:Many applications in modern technology, such as self-cleaning surfaces and digital microfluidics, require control over individual fluid droplets on flat surfaces. Existing techniques may suffer from side effects resulting from high electric fields and high temperatures. Here, we introduce a markedly different method, ...

journal_title：Science advances

authors： De Jong E,Wang Y,Den Toonder JMJ,Onck PR

更新日期：2019-06-14 00:00:00

abstract：:Mucoadhesive particles (MAP) have been widely explored for pulmonary drug delivery because of their perceived benefits in improving particle residence in the lungs. However, retention of particles adhesively trapped in airway mucus may be limited by physiologic mucus clearance mechanisms. In contrast, particles that a...

journal_title：Science advances

authors： Schneider CS,Xu Q,Boylan NJ,Chisholm J,Tang BC,Schuster BS,Henning A,Ensign LM,Lee E,Adstamongkonkul P,Simons BW,Wang SS,Gong X,Yu T,Boyle MP,Suk JS,Hanes J

更新日期：2017-04-05 00:00:00

abstract：:Ocean circulation redistributes Earth's energy and water masses and influences global climate. Under historical greenhouse warming, regional ocean currents show diverse tendencies, but whether there is an emerging trend of the global mean ocean circulation system is not yet clear. Here, we show a statistically signifi...

journal_title：Science advances

authors： Hu S,Sprintall J,Guan C,McPhaden MJ,Wang F,Hu D,Cai W

更新日期：2020-02-05 00:00:00

abstract：:In retinal detachment (RD), photoreceptor death and permanent vision loss are caused by neurosensory retina separating from the retinal pigment epithelium because of subretinal fluid (SRF), and successful surgical reattachment is not predictive of total visual recovery. As retinal iron overload exacerbates cell death ...

journal_title：Science advances

authors： Daruich A,Le Rouzic Q,Jonet L,Naud MC,Kowalczuk L,Pournaras JA,Boatright JH,Thomas A,Turck N,Moulin A,Behar-Cohen F,Picard E

更新日期：2019-01-09 00:00:00

abstract：:Increasing occurrence of moderate to severe intrauterine adhesion (IUA) is seriously affecting the quality of human life. The aim of the study was to establish IUA models in nonhuman primates and to explore the dual repair effects of human umbilical cord-derived mesenchymal stem cells (huMSCs) loaded on autocrosslinke...

journal_title：Science advances

authors： Wang L,Yu C,Chang T,Zhang M,Song S,Xiong C,Su P,Xiang W

更新日期：2020-05-22 00:00:00

abstract：:To gain insights into neutrophil heterogeneity dynamics in the context of sterile inflammation and wound healing, we performed a pseudotime analysis of single-cell flow cytometry data using the spanning-tree progression analysis of density-normalized events algorithm. This enables us to view neutrophil transitional su...

journal_title：Science advances

authors： Turner TC,Sok MCP,Hymel LA,Pittman FS,York WY,Mac QD,Vyshnya S,Lim HS,Kwong GA,Qiu P,Botchwey EA

更新日期：2020-10-30 00:00:00

abstract：:The discovery of high-temperature superconductivity in cuprates ranks among the major scientific milestones of the past half century, yet pivotal questions regarding the complex phase diagram of these materials remain unanswered. Generally thought of as doped charge-transfer insulators, these complex oxides exhibit ps...

journal_title：Science advances

authors： Pelc D,Popčević P,Požek M,Greven M,Barišić N

更新日期：2019-01-25 00:00:00

abstract：:Controlling the polarization state and the propagation direction of photons is a fundamental prerequisite for many nanophotonic devices and a precursor for future on-chip communication, where the emission properties of individual emitters are particularly relevant. Here, we report on the emission of partially circular...

journal_title：Science advances

authors： Neugebauer M,Banzer P,Nechayev S

更新日期：2019-06-28 00:00:00

abstract：:Starvation is probably the most common stressful situation in nature. In vertebrates, elevation of the biogenic amine norepinephrine levels is common during starvation. However, the precise role of norepinephrine in nutrient deprivation remains largely unknown. We report that in the free-living nematode Caenorhabditis...

journal_title：Science advances

authors： Tao J,Ma YC,Yang ZS,Zou CG,Zhang KQ

更新日期：2016-05-06 00:00:00

abstract：:Ants (Hymenoptera: Formicidae) are diverse and ubiquitous, and their ability to sting is familiar to many of us. However, their venoms remain largely unstudied. We provide the first comprehensive characterization of a polypeptidic ant venom, that of the giant red bull ant, Myrmecia gulosa. We reveal a suite of novel p...

journal_title：Science advances

authors： Robinson SD,Mueller A,Clayton D,Starobova H,Hamilton BR,Payne RJ,Vetter I,King GF,Undheim EAB

更新日期：2018-09-12 00:00:00

abstract：:Bioengineered three-dimensional (3D) matrices expand our experimental repertoire to study tumor growth and progression in a biologically relevant, yet controlled, manner. Here, we used peptide amphiphiles (PAs) to coassemble with and organize extracellular matrix (ECM) proteins producing tunable 3D models of the tumor...

journal_title：Science advances

authors： Hedegaard CL,Redondo-Gómez C,Tan BY,Ng KW,Loessner D,Mata A

更新日期：2020-10-02 00:00:00

abstract：:Nitrogen oxides (NO x = NO + NO2) are a primary component of air pollution-a leading cause of premature death in humans and biodiversity declines worldwide. Although regulatory policies in California have successfully limited transportation sources of NO ...

journal_title：Science advances

authors： Almaraz M,Bai E,Wang C,Trousdell J,Conley S,Faloona I,Houlton BZ

更新日期：2018-01-31 00:00:00

abstract：:The Paris Agreement aims to mitigate the potential impacts of climate change on ecological and social systems. Using an ensemble of climate-marine ecosystem and economic models, we explore the effects of implementing the Agreement on fish, fishers, and seafood consumers worldwide. We find that implementing the Agreeme...

journal_title：Science advances

authors： Sumaila UR,Tai TC,Lam VWY,Cheung WWL,Bailey M,Cisneros-Montemayor AM,Chen OL,Gulati SS

更新日期：2019-02-27 00:00:00

abstract：:Nitrogen oxides, released from fossil fuel use and other combustion processes, affect air quality and climate. From the mid-1990s onward, nitrogen dioxide (NO2) has been monitored from space, and since 2004 with relatively high spatial resolution by the Ozone Monitoring Instrument. Strong upward NO2 trends have been o...

journal_title：Science advances

authors： Lelieveld J,Beirle S,Hörmann C,Stenchikov G,Wagner T

更新日期：2015-08-21 00:00:00

abstract：:The exceptionally long quantum coherence times of phosphorus donor nuclear spin qubits in silicon, coupled with the proven scalability of silicon-based nano-electronics, make them attractive candidates for large-scale quantum computing. However, the high threshold of topological quantum error correction can only be ca...

journal_title：Science advances

authors： Hill CD,Peretz E,Hile SJ,House MG,Fuechsle M,Rogge S,Simmons MY,Hollenberg LC

更新日期：2015-10-30 00:00:00

abstract：:The ability of a material to adopt multiple structures, known as polymorphism, is a fascinating natural phenomenon. Various polymorphs with unusual properties are routinely synthesized by compression under positive pressure. However, changing a material's structure by applying tension under negative pressure is much m...

journal_title：Science advances

authors： Siol S,Holder A,Steffes J,Schelhas LT,Stone KH,Garten L,Perkins JD,Parilla PA,Toney MF,Huey BD,Tumas W,Lany S,Zakutayev A

更新日期：2018-04-20 00:00:00

abstract：:The structure of many real-world systems is best captured by networks consisting of several interaction layers. Understanding how a multilayered structure of connections affects the synchronization properties of dynamical systems evolving on top of it is a highly relevant endeavor in mathematics and physics and has po...

journal_title：Science advances

authors： Del Genio CI,Gómez-Gardeñes J,Bonamassa I,Boccaletti S

更新日期：2016-11-16 00:00:00

abstract：:Human sleep is highly regulated by temperature. Might climate change-through increases in nighttime heat-disrupt sleep in the future? We conduct the inaugural investigation of the relationship between climatic anomalies, reports of insufficient sleep, and projected climate change. Using data from 765,000 U.S. survey r...

journal_title：Science advances

authors： Obradovich N,Migliorini R,Mednick SC,Fowler JH

更新日期：2017-05-26 00:00:00

abstract：:The locally accumulated damage by tropical cyclones (TCs) can intensify substantially when these cyclones move more slowly. While some observational evidence suggests that TC motion might have slowed significantly since the mid-20th century (1), the robustness of the observed trend and its relation to anthropogenic wa...

journal_title：Science advances

authors： Zhang G,Murakami H,Knutson TR,Mizuta R,Yoshida K

更新日期：2020-04-22 00:00:00

abstract：:Confined to a two-dimensional plane, electrons in a strong magnetic field travel along the edge in one-dimensional quantum Hall channels that are protected against backscattering. These channels can be used as solid-state analogs of monochromatic beams of light, providing a unique platform for studying electron interf...

journal_title：Science advances

authors： Wei DS,van der Sar T,Sanchez-Yamagishi JD,Watanabe K,Taniguchi T,Jarillo-Herrero P,Halperin BI,Yacoby A

更新日期：2017-08-18 00:00:00

abstract：:Extinction of conditioned fear necessitates the dynamic involvement of hippocampus, medial prefrontal cortex (mPFC), and basolateral amygdala (BLA), but key molecular players that regulate these circuits to achieve fear extinction remain largely unknown. Here, we report that acid-sensing ion channel 1a (ASIC1a) is a c...

journal_title：Science advances

authors： Wang Q,Wang Q,Song XL,Jiang Q,Wu YJ,Li Y,Yuan TF,Zhang S,Xu NJ,Zhu MX,Li WG,Xu TL

更新日期：2018-10-24 00:00:00

abstract：:Bioacoustic networks could vastly expand the coverage of wildlife monitoring to complement satellite observations of climate and vegetation. This approach would enable global-scale understanding of how climate change influences phenomena such as migratory timing of avian species. The enormous data sets that autonomous...

journal_title：Science advances

authors： Oliver RY,Ellis DPW,Chmura HE,Krause JS,Pérez JH,Sweet SK,Gough L,Wingfield JC,Boelman NT

更新日期：2018-06-20 00:00:00

abstract：:Interactions between top-down and bottom-up processes in the cerebral cortex hold the key to understanding attentional processes, predictive coding, executive control, and a gamut of other brain functions. However, the underlying circuit mechanism remains poorly understood and represents a major challenge in neuroscie...

journal_title：Science advances

authors： Mejias JF,Murray JD,Kennedy H,Wang XJ

更新日期：2016-11-16 00:00:00

abstract：:During the Last Glacial Maximum, expansive continental ice sheets lowered globally averaged sea level ~130 m, exposing a land bridge at the Bering Strait. During the subsequent deglaciation, sea level rose rapidly and ultimately flooded the Bering Strait, linking the Arctic and Pacific Oceans. Observational records of...

journal_title：Science advances

authors： Pico T,Mitrovica JX,Mix AC

更新日期：2020-02-26 00:00:00

abstract：:The accelerating global spread of arboviruses, such as Zika virus (ZIKV), highlights the need for more proactive mosquito surveillance. However, a major challenge during arbovirus outbreaks has been the lack of rapid and affordable tests for pathogen detection in mosquitoes. We show for the first time that near-infrar...

journal_title：Science advances

authors： Fernandes JN,Dos Santos LMB,Chouin-Carneiro T,Pavan MG,Garcia GA,David MR,Beier JC,Dowell FE,Maciel-de-Freitas R,Sikulu-Lord MT

更新日期：2018-05-23 00:00:00

abstract：:Genetically modified pigs for biomedical applications have been mainly generated using the somatic cell nuclear transfer technique; however, this approach requires complex micromanipulation techniques and sometimes increases the risks of both prenatal and postnatal death by faulty epigenetic reprogramming of a donor s...

journal_title：Science advances

authors： Tanihara F,Takemoto T,Kitagawa E,Rao S,Do LT,Onishi A,Yamashita Y,Kosugi C,Suzuki H,Sembon S,Suzuki S,Nakai M,Hashimoto M,Yasue A,Matsuhisa M,Noji S,Fujimura T,Fuchimoto D,Otoi T

更新日期：2016-09-14 00:00:00

abstract：:Impaired mitochondrial dynamics and function are hallmarks of many neurological and psychiatric disorders, but direct screens for mitotherapeutics using neurons have not been reported. We developed a multiplexed and high-content screening assay using primary neurons and identified 67 small-molecule modulators of neuro...

journal_title：Science advances

authors： Varkuti BH,Kepiro M,Liu Z,Vick K,Avchalumov Y,Pacifico R,MacMullen CM,Kamenecka TM,Puthanveettil SV,Davis RL

更新日期：2020-01-08 00:00:00

abstract：:Cues sent by political elites are known to influence public attitudes and behavior. Polarization in elite rhetoric may hinder effective responses to public health crises, when accurate information and rapid behavioral change can save lives. We examine polarization in cues sent to the public by current members of the U...

journal_title：Science advances

authors： Green J,Edgerton J,Naftel D,Shoub K,Cranmer SJ

更新日期：2020-07-10 00:00:00