Abstract:
:In retinal detachment (RD), photoreceptor death and permanent vision loss are caused by neurosensory retina separating from the retinal pigment epithelium because of subretinal fluid (SRF), and successful surgical reattachment is not predictive of total visual recovery. As retinal iron overload exacerbates cell death in retinal diseases, we assessed iron as a predictive marker and therapeutic target for RD. In the vitreous and SRF from patients with RD, we measured increased iron and transferrin (TF) saturation that is correlated with poor visual recovery. In ex vivo and in vivo RD models, iron induces immediate necrosis and delayed apoptosis. We demonstrate that TF decreases both apoptosis and necroptosis induced by RD, and using RNA sequencing, pathways mediating the neuroprotective effects of TF are identified. Since toxic iron accumulates in RD, we propose TF supplementation as an adjunctive therapy to surgery for improving the visual outcomes of patients with RD.
journal_name
Sci Advjournal_title
Science advancesauthors
Daruich A,Le Rouzic Q,Jonet L,Naud MC,Kowalczuk L,Pournaras JA,Boatright JH,Thomas A,Turck N,Moulin A,Behar-Cohen F,Picard Edoi
10.1126/sciadv.aau9940subject
Has Abstractpub_date
2019-01-09 00:00:00pages
eaau9940issue
1issn
2375-2548pii
aau9940journal_volume
5pub_type
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