Somatic cell reprogramming-free generation of genetically modified pigs.

abstract：:Wogonin and baicalein are bioactive flavones in the popular Chinese herbal remedy Huang-Qin (Scutellaria baicalensis Georgi). These specialized flavones lack a 4'-hydroxyl group on the B ring (4'-deoxyflavones) and induce apoptosis in a wide spectrum of human tumor cells in vitro and inhibit tumor growth in vivo in di...

journal_title：Science advances

authors： Zhao Q,Zhang Y,Wang G,Hill L,Weng JK,Chen XY,Xue H,Martin C

更新日期：2016-04-08 00:00:00

abstract：:The search for topological superconductors (TSCs) is one of the most urgent contemporary problems in condensed matter systems. TSCs are characterized by a full superconducting gap in the bulk and topologically protected gapless surface (or edge) states. Within each vortex core of TSCs, there exists the zero-energy Maj...

journal_title：Science advances

authors： Guan SY,Chen PJ,Chu MW,Sankar R,Chou F,Jeng HT,Chang CS,Chuang TM

更新日期：2016-11-23 00:00:00

abstract：:Polyphosphate, an energy-rich polymer conserved in all kingdoms of life, is integral to many cellular stress responses, including nutrient deprivation, and yet, the mechanisms that underlie its biological roles are not well understood. In this work, we elucidate the physiological function of this polymer in the acclim...

journal_title：Science advances

authors： Sanz-Luque E,Saroussi S,Huang W,Akkawi N,Grossman AR

更新日期：2020-09-30 00:00:00

abstract：:Unraveling the genetic and epigenetic determinants of phenotypes is critical for understanding and re-engineering biology and would benefit from improved methods to separate cells based on phenotypes. Here, we report SPOTlight, a versatile high-throughput technique to isolate individual yeast or human cells with uniqu...

journal_title：Science advances

authors： Lee J,Liu Z,Suzuki PH,Ahrens JF,Lai S,Lu X,Guan S,St-Pierre F

更新日期：2020-10-23 00:00:00

abstract：:Driven by advances in materials and computer science, researchers are attempting to design systems where the computer and material are one and the same entity. Using theoretical and computational modeling, we design a hybrid material system that can autonomously transduce chemical, mechanical, and electrical energy to...

journal_title：Science advances

authors： Fang Y,Yashin VV,Levitan SP,Balazs AC

更新日期：2016-09-02 00:00:00

abstract：:Although electromagnetic brain stimulation is a promising treatment in neurology and psychiatry, clinical outcomes are variable, and underlying mechanisms are ill-defined, which impedes the development of new effective stimulation protocols. Here, we show, in vivo and ex vivo, that repetitive transcranial magnetic sti...

journal_title：Science advances

authors： Dufor T,Grehl S,Tang AD,Doulazmi M,Traoré M,Debray N,Dubacq C,Deng ZD,Mariani J,Lohof AM,Sherrard RM

更新日期：2019-10-30 00:00:00

abstract：:Double seismic zones are two-layered distributions of intermediate-depth earthquakes that provide insight into the thermomechanical state of subducting slabs. We present new precise hypocenters of intermediate-depth earthquakes in the Tonga subduction zone obtained using data from local island-based, ocean-bottom, and...

journal_title：Science advances

authors： Wei SS,Wiens DA,van Keken PE,Cai C

更新日期：2017-01-11 00:00:00

abstract：:Oxygen isotope speleothem records exhibit coherent variability over the pan-Asian summer monsoon (AM) region. The hydroclimatic representation of these oxygen isotope records for the AM, however, has remained poorly understood. Here, combining an isotope-enabled Earth system model in transient experiments with proxy r...

journal_title：Science advances

authors： He C,Liu Z,Otto-Bliesner BL,Brady EC,Zhu C,Tomas R,Clark PU,Zhu J,Jahn A,Gu S,Zhang J,Nusbaumer J,Noone D,Cheng H,Wang Y,Yan M,Bao Y

更新日期：2021-01-22 00:00:00

abstract：:Dewetting is a ubiquitous phenomenon in nature; many different thin films of organic and inorganic substances (such as liquids, polymers, metals, and semiconductors) share this shape instability driven by surface tension and mass transport. Via templated solid-state dewetting, we frame complex nanoarchitectures of mon...

journal_title：Science advances

authors： Naffouti M,Backofen R,Salvalaglio M,Bottein T,Lodari M,Voigt A,David T,Benkouider A,Fraj I,Favre L,Ronda A,Berbezier I,Grosso D,Abbarchi M,Bollani M

更新日期：2017-11-10 00:00:00

abstract：:Perforin-2 (MPEG1) is thought to enable the killing of invading microbes engulfed by macrophages and other phagocytes, forming pores in their membranes. Loss of perforin-2 renders individual phagocytes and whole organisms significantly more susceptible to bacterial pathogens. Here, we reveal the mechanism of perforin-...

journal_title：Science advances

authors： Ni T,Jiao F,Yu X,Aden S,Ginger L,Williams SI,Bai F,Pražák V,Karia D,Stansfeld P,Zhang P,Munson G,Anderluh G,Scheuring S,Gilbert RJC

更新日期：2020-01-29 00:00:00

abstract：:When a dynamic system undergoes a cyclic evolution, a geometric phase that depends only on the path traversed in parameter space can arise in addition to the normal dynamical phase. These geometric phases have profound impacts in both quantum and classical physics. In addition to the geometric phase associated with ba...

journal_title：Science advances

authors： Wang S,Ma G,Chan CT

更新日期：2018-02-16 00:00:00

abstract：:Understanding the remarkable excitonic effects and controlling the exciton binding energies in two-dimensional (2D) semiconductors are crucial in unlocking their full potential for use in future photonic and optoelectronic devices. Here, we demonstrate large excitonic effects and gate-tunable exciton binding energies ...

journal_title：Science advances

authors： Qiu Z,Trushin M,Fang H,Verzhbitskiy I,Gao S,Laksono E,Yang M,Lyu P,Li J,Su J,Telychko M,Watanabe K,Taniguchi T,Wu J,Neto AHC,Yang L,Eda G,Adam S,Lu J

更新日期：2019-07-19 00:00:00

abstract：:We present results from a study in the Democratic Republic of the Congo that uses mobile money networks to run rotating savings and credit associations (ROSCAs), peer-to-peer finance groups ubiquitous across the developing world. We find high rates of contribution and ROSCA success. The unexpected success of such e-RO...

journal_title：Science advances

authors： Francois P,Squires M

更新日期：2021-01-01 00:00:00

abstract：:The established model-free methods for the processing of two-electron dipolar spectroscopy data [DEER (double electron-electron resonance), PELDOR (pulsed electron double resonance), DQ-EPR (double-quantum electron paramagnetic resonance), RIDME (relaxation-induced dipolar modulation enhancement), etc.] use regularize...

journal_title：Science advances

authors： Worswick SG,Spencer JA,Jeschke G,Kuprov I

更新日期：2018-08-24 00:00:00

abstract：:Approaching predators cast expanding shadows (i.e., looming) that elicit innate defensive responses in most animals. Where looming is first detected and how critical parameters of predatory approaches are extracted are unclear. In mice, we identify a retinal interneuron (the VG3 amacrine cell) that responds robustly t...

journal_title：Science advances

authors： Kim T,Shen N,Hsiang JC,Johnson KP,Kerschensteiner D

更新日期：2020-11-18 00:00:00

abstract：:Silicic volcanic activity has long been framed as either violently explosive or gently effusive. However, recent observations demonstrate that explosive and effusive behavior can occur simultaneously. Here, we propose that rhyolitic magma feeding subaerial eruptions generally fragments during ascent through the upper ...

journal_title：Science advances

authors： Wadsworth FB,Llewellin EW,Vasseur J,Gardner JE,Tuffen H

更新日期：2020-09-23 00:00:00

abstract：:Forecasting fields of oceanic phenomena has long been dependent on physical equation-based numerical models. The challenge is that many natural processes need to be considered for understanding complicated phenomena. In contrast, rules of the processes are already embedded in the time-series observation itself. Thus, ...

journal_title：Science advances

authors： Zheng G,Li X,Zhang RH,Liu B

更新日期：2020-07-15 00:00:00

abstract：:For natural microswimmers, the interplay of swimming activity and external flow can promote robust directed motion, for example, propulsion against (upstream rheotaxis) or perpendicular to the direction of flow. These effects are generally attributed to their complex body shapes and flagellar beat patterns. Using cata...

journal_title：Science advances

authors： Katuri J,Uspal WE,Simmchen J,Miguel-López A,Sánchez S

更新日期：2018-01-26 00:00:00

abstract：:Detecting associations between genomic changes and phenotypic differences is fundamental to understanding how phenotypes evolved. By systematically screening for parallel amino acid substitutions, we detected known as well as novel cases (Strc, Tecta, and Cabp2) of parallelism between echolocating bats and toothed wha...

journal_title：Science advances

authors： Lee JH,Lewis KM,Moural TW,Kirilenko B,Borgonovo B,Prange G,Koessl M,Huggenberger S,Kang C,Hiller M

更新日期：2018-09-26 00:00:00

abstract：:Quantum teleportation, which is the transfer of an unknown quantum state from one station to another over a certain distance with the help of nonlocal entanglement shared by a sender and a receiver, has been widely used as a fundamental element in quantum communication and quantum computation. Optical fibers are cruci...

journal_title：Science advances

authors： Huo M,Qin J,Cheng J,Yan Z,Qin Z,Su X,Jia X,Xie C,Peng K

更新日期：2018-10-19 00:00:00

abstract：:Mesoscale turbulence in the ocean strongly affects the circulation, water mass formation, and transport of tracers. Little is known, however, about how mixing varies on climate timescales. We present the first time-resolved global dataset of lateral mesoscale eddy diffusivities at the ocean surface, obtained by applyi...

journal_title：Science advances

authors： Busecke JJM,Abernathey RP

更新日期：2019-01-23 00:00:00

abstract：:A trimer-of-hairpins motif has been identified in triggering virus-cell fusion within a variety of viral envelopes. Chemically manipulating such a motif represents current repertoire of viral fusion inhibitors. Here, we report that triterpenoids, a class of natural products, antagonize this trimer-of-hairpins via its ...

journal_title：Science advances

authors： Si L,Meng K,Tian Z,Sun J,Li H,Zhang Z,Soloveva V,Li H,Fu G,Xia Q,Xiao S,Zhang L,Zhou D

更新日期：2018-11-21 00:00:00

abstract：:Association of peripheral proteins with lipid bilayers regulates membrane signaling and dynamics. Pleckstrin homology (PH) domains bind to phosphatidylinositol phosphate (PIP) molecules in membranes. The effects of local PIP enrichment on the interaction of PH domains with membranes is unclear. Molecular dynamics simu...

journal_title：Science advances

authors： Yamamoto E,Domański J,Naughton FB,Best RB,Kalli AC,Stansfeld PJ,Sansom MSP

更新日期：2020-02-19 00:00:00

abstract：:Annexin-A1 (ANXA1) has recently been proposed to play a role in microglial activation after brain ischemia, but the underlying mechanism remains poorly understood. Here, we demonstrated that ANXA1 is modified by SUMOylation, and SUMOylated ANXA1 could promote the beneficial phenotype polarization of microglia. Mechani...

journal_title：Science advances

authors： Li X,Xia Q,Mao M,Zhou H,Zheng L,Wang Y,Zeng Z,Yan L,Zhao Y,Shi J

更新日期：2021-01-20 00:00:00

abstract：:Functional materials with specific surface wettability play an important role in a wide variety of areas. Inspired by nature's Nepenthes pitcher plant, we present a novel slippery film with tunable wettability based on a shape-memory graphene sponge. The porous graphene sponge coated with shape-memory polymer was used...

journal_title：Science advances

authors： Wang J,Sun L,Zou M,Gao W,Liu C,Shang L,Gu Z,Zhao Y

更新日期：2017-06-02 00:00:00

abstract：:Maximizing the sustainable supercurrent density, J C, is crucial to high-current applications of superconductivity. To achieve this, preventing dissipative motion of quantized vortices is key. Irradiation of superconductors with high-energy heavy ions can be used to create nanoscale defects that act as deep pinning po...

journal_title：Science advances

authors： Massee F,Sprau PO,Wang YL,Davis JC,Ghigo G,Gu GD,Kwok WK

更新日期：2015-05-20 00:00:00

abstract：:Ciliary oscillations driven by molecular motors cause fluid motion at micron scale. Stable oscillations require a substantial source of dissipation to balance the energy input of motors. Conventionally, it stems from external fluid. We show, in contrast, that external fluid friction is negligible compared to internal ...

journal_title：Science advances

authors： Mondal D,Adhikari R,Sharma P

更新日期：2020-08-12 00:00:00

abstract：:Ultraviolet (UV) reception is useful for such basic behaviors as mate choice, foraging, predator avoidance, communication, and navigation, whereas violet reception improves visual resolution and subtle contrast detection. UV and violet reception are mediated by the short wavelength-sensitive (SWS1) pigments that absor...

journal_title：Science advances

authors： Yokoyama S,Altun A,Jia H,Yang H,Koyama T,Faggionato D,Liu Y,Starmer WT

更新日期：2015-09-18 00:00:00

abstract：:Development of composite indicators for integrated health in populations typically relies on a priori assumptions rather than model-free, data-driven evidence. Traditional variable selection processes tend not to consider relatedness and redundancy among variables, instead considering only individual correlations. In ...

journal_title：Science advances

authors： Servadio JL,Convertino M

更新日期：2018-02-02 00:00:00

abstract：:In traditional models of heteroepitaxy, the substrate serves mainly as a crystalline template for the thin-film lattice, dictating the initial roughness of the film and the degree of coherent strain. Here, performing in situ surface x-ray diffraction during the heteroepitaxial growth of LaTiO3 on SrTiO3 (001), we find...

journal_title：Science advances

authors： Cook S,Letchworth-Weaver K,Tung IC,Andersen TK,Hong H,Marks LD,Fong DD

更新日期：2019-04-12 00:00:00