Triterpenoids manipulate a broad range of virus-host fusion via wrapping the HR2 domain prevalent in viral envelopes.

abstract：:Candida albicans is a pathogenic yeast that causes mucosal and systematic infections with high mortality. The absence of facile molecular genetics has been a major impediment to analysis of pathogenesis. The lack of meiosis coupled with the absence of plasmids makes genetic engineering cumbersome, especially for essen...

journal_title：Science advances

authors： Vyas VK,Barrasa MI,Fink GR

更新日期：2015-01-01 00:00:00

abstract：:Present-day dermatological diagnostic tools are expensive, time-consuming, require substantial operational expertise, and typically probe only the superficial layers of skin (~15 μm). We introduce a soft, battery-free, noninvasive, reusable skin hydration sensor (SHS) adherable to most of the body surface. The platfor...

journal_title：Science advances

authors： Madhvapathy SR,Wang H,Kong J,Zhang M,Lee JY,Park JB,Jang H,Xie Z,Cao J,Avila R,Wei C,D'Angelo V,Zhu J,Chung HU,Coughlin S,Patel M,Winograd J,Lim J,Banks A,Xu S,Huang Y,Rogers JA

更新日期：2020-12-04 00:00:00

abstract：:The design of single-molecule photoswitchable emitters was the first milestone toward the advent of single-molecule localization microscopy, setting a new paradigm in the field of optical imaging. Several photoswitchable emitters have been developed, but they all fluoresce in the visible or far-red ranges, missing the...

journal_title：Science advances

authors： Godin AG,Setaro A,Gandil M,Haag R,Adeli M,Reich S,Cognet L

更新日期：2019-09-27 00:00:00

abstract：:A new set of time-of-day-dependent global maps of the lunar near-infrared water/hydroxyl (H2O/OH) absorption band strength near 2.8 to 3.0 μm constructed on the basis of Moon Mineralogy Mapper (M3) data is presented. The analyzed absorption band near 2.8 to 3.0 μm indicates the presence of surficial H2O/OH. To remove ...

journal_title：Science advances

authors： Wöhler C,Grumpe A,Berezhnoy AA,Shevchenko VV

更新日期：2017-09-08 00:00:00

abstract：:Most crystalline inorganic materials, except for metals and some layer materials, exhibit bad flexibility because of strong ionic or covalent bonds, while amorphous materials usually display poor electrical properties due to structural disorders. Here, we report the simultaneous realization of extraordinary room tempe...

journal_title：Science advances

authors： He S,Li Y,Liu L,Jiang Y,Feng J,Zhu W,Zhang J,Dong Z,Deng Y,Luo J,Zhang W,Chen G

更新日期：2020-04-10 00:00:00

abstract：:Six percent of Americans, including 3 million high schoolers, use e-cigarettes, which contain potentially toxic substances, volatile organic compounds, and metals. We present the first human study on the effects of e-cigarette exposure in the oral cavity. By interrogating both immunoinflammatory responses and microbia...

journal_title：Science advances

authors： Ganesan SM,Dabdoub SM,Nagaraja HN,Scott ML,Pamulapati S,Berman ML,Shields PG,Wewers ME,Kumar PS

更新日期：2020-05-27 00:00:00

abstract：:Yearly, a quarter billion people are infected and a half a million killed by the mosquito-borne disease malaria. Lack of real-time observational tools for continuously assessing the unperturbed mosquito flight activity in situ limits progress toward improved vector control. We deployed a high-resolution entomological ...

journal_title：Science advances

authors： Brydegaard M,Jansson S,Malmqvist E,Mlacha YP,Gebru A,Okumu F,Killeen GF,Kirkeby C

更新日期：2020-05-13 00:00:00

abstract：:The wiring of vertebrate and invertebrate brains provides the anatomical skeleton for cognition and behavior. Connections among brain regions are characterized by heterogeneous strength that is parsimoniously described by the wiring cost and homophily principles. Moreover, brains exhibit a characteristic global networ...

journal_title：Science advances

authors： Goulas A,Betzel RF,Hilgetag CC

更新日期：2019-06-12 00:00:00

abstract：:User-interactive electronic skin is capable of spatially mapping touch via electric readout and providing visual output as a human-readable response. However, the high power consumption, complex structure, and high cost of user-interactive electronic skin are notable obstacles for practical application. Here, we repor...

journal_title：Science advances

authors： Zhao X,Zhang Z,Liao Q,Xun X,Gao F,Xu L,Kang Z,Zhang Y

更新日期：2020-07-08 00:00:00

abstract：:Human settlement of the Caribbean represents the only example in the Americas of peoples colonizing islands that were not visible from surrounding mainland areas or other islands. Unfortunately, many interpretive models have relied on radiocarbon determinations that do not meet standard criteria for reporting because ...

journal_title：Science advances

authors： Napolitano MF,DiNapoli RJ,Stone JH,Levin MJ,Jew NP,Lane BG,O'Connor JT,Fitzpatrick SM

更新日期：2019-12-18 00:00:00

abstract：:Stroke is the most common cause of adult disability in developed countries, largely because spontaneous recovery is often incomplete, and no pharmacological means to hasten the recovery exist. It was recently shown that mesencephalic astrocyte-derived neurotrophic factor (MANF) induces alternative or M2 activation of ...

journal_title：Science advances

authors： Mätlik K,Anttila JE,Kuan-Yin T,Smolander OP,Pakarinen E,Lehtonen L,Abo-Ramadan U,Lindholm P,Zheng C,Harvey B,Arumäe U,Lindahl M,Airavaara M

更新日期：2018-05-23 00:00:00

abstract：:Topological superconductors are an interesting and frontier topic in condensed matter physics. In the superconducting state, an order parameter will be established with the basic or subsidiary symmetry of the crystalline lattice. In doped Bi2Se3 or Bi2Te3 with a basic threefold symmetry, it was predicted, however, tha...

journal_title：Science advances

authors： Chen M,Chen X,Yang H,Du Z,Wen HH

更新日期：2018-06-08 00:00:00

abstract：:Cheater viruses, also known as defective interfering viruses, cannot replicate on their own yet replicate faster than the wild type upon coinfection. While there is growing interest in using cheaters as antiviral therapeutics, the mechanisms underlying cheating have been rarely explored. During experimental evolution ...

journal_title：Science advances

authors： Meir M,Harel N,Miller D,Gelbart M,Eldar A,Gophna U,Stern A

更新日期：2020-08-21 00:00:00

abstract：:Regulatory T (Treg) cells are essential for peripheral tolerance and rely on the transcription factor (TF) Foxp3 for their generation and function. Several other TFs are critical for the Treg cell program. We found that mice deficient in Bcl11b TF solely in Treg cells developed fatal autoimmunity, and Bcl11b-deficient...

journal_title：Science advances

authors： Drashansky TT,Helm E,Huo Z,Curkovic N,Kumar P,Luo X,Parthasarathy U,Zuniga A,Cho JJ,Lorentsen KJ,Xu Z,Uddin M,Moshkani S,Zhou L,Avram D

更新日期：2019-08-07 00:00:00

abstract：:Passive radiative cooling functions by reflecting the solar spectrum and emitting infrared waves in broadband or selectively. However, cooling enclosed spaces that trap heat by greenhouse effect remains a challenge. We present a Janus emitter (JET) consisting of an Ag-polydimethylsiloxane layer on micropatterned quart...

journal_title：Science advances

authors： Heo SY,Lee GJ,Kim DH,Kim YJ,Ishii S,Kim MS,Seok TJ,Lee BJ,Lee H,Song YM

更新日期：2020-09-04 00:00:00

abstract：:Using a national longitudinal survey data set from the Higher Education Research Institute, this study tested whether students who identified as a sexual minority (for example, lesbian, gay, bisexual, or queer) were more or less likely to persist after 4 years in science, technology, engineering, and mathematics (STEM...

journal_title：Science advances

authors： Hughes BE

更新日期：2018-03-14 00:00:00

abstract：:Materials with a stochastic microstructure, like foams, typically exhibit low mechanical stiffness, whereas lattices with a designed microarchitecture often show notably improved stiffness. These periodic architected materials have previously been designed by rule, using the Maxwell criterion to ensure that their defo...

journal_title：Science advances

authors： Chen W,Watts S,Jackson JA,Smith WL,Tortorelli DA,Spadaccini CM

更新日期：2019-09-27 00:00:00

abstract：:To achieve global elimination of hepatitis C virus (HCV), an effective cross-genotype vaccine is needed. The HCV envelope glycoprotein E2 is the main target for neutralizing antibodies (nAbs), which aid in HCV clearance and protection. E2 is structurally flexible and functions in engaging host receptors. Many nAbs bin...

journal_title：Science advances

authors： Tzarum N,Giang E,Kadam RU,Chen F,Nagy K,Augestad EH,Velázquez-Moctezuma R,Keck ZY,Hua Y,Stanfield RL,Dreux M,Prentoe J,Foung SKH,Bukh J,Wilson IA,Law M

更新日期：2020-07-24 00:00:00

abstract：:Mobile genetic elements, such as human endogenous retroviruses (HERVs), produce proteins that regulate brain cell functions and synaptic transmission and have been implicated in the etiology of neurological and neurodevelopmental psychiatric disorders. However, the mechanisms by which these proteins of retroviral orig...

journal_title：Science advances

authors： Johansson EM,Bouchet D,Tamouza R,Ellul P,Morr AS,Avignone E,Germi R,Leboyer M,Perron H,Groc L

更新日期：2020-07-17 00:00:00

abstract：:Coherent interactions between electromagnetic and matter waves lie at the heart of quantum science and technology. However, the diffraction nature of light has limited the scalability of many atom-light-based quantum systems. We use the optical fields in a hollow-core photonic crystal fiber to spatially split, reflect...

journal_title：Science advances

authors： Xin M,Leong WS,Chen Z,Lan SY

更新日期：2018-01-19 00:00:00

abstract：:Adoptive cell transfers have emerged as a disruptive approach to treat disease in a manner that is more specific than using small-molecule drugs; however, unlike traditional drugs, cells are living entities that can alter their function in response to environmental cues. In the present study, we report an engineered p...

journal_title：Science advances

authors： Shields CW 4th,Evans MA,Wang LL,Baugh N,Iyer S,Wu D,Zhao Z,Pusuluri A,Ukidve A,Pan DC,Mitragotri S

更新日期：2020-04-29 00:00:00

abstract：:The mid-infrared (MIR) spectral range, pertaining to important applications, such as molecular "fingerprint" imaging, remote sensing, free space telecommunication, and optical radar, is of particular scientific interest and technological importance. However, state-of-the-art materials for MIR detection are limited by ...

journal_title：Science advances

authors： Long M,Gao A,Wang P,Xia H,Ott C,Pan C,Fu Y,Liu E,Chen X,Lu W,Nilges T,Xu J,Wang X,Hu W,Miao F

更新日期：2017-06-30 00:00:00

abstract：:Plasmonic metasurfaces are a promising route for flat panel display applications due to their full color gamut and high spatial resolution. However, this plasmonic coloration cannot be readily tuned and requires expensive lithographic techniques. Here, we present scalable electrically driven color-changing metasurface...

journal_title：Science advances

authors： Peng J,Jeong HH,Lin Q,Cormier S,Liang HL,De Volder MFL,Vignolini S,Baumberg JJ

更新日期：2019-05-10 00:00:00

abstract：:Coordinatively unsaturated (CUS) iron sites are highly active in catalytic oxidation reactions; however, maintaining the CUS structure of iron during heterogeneous catalytic reactions is a great challenge. Here, we report a strategy to stabilize single-atom CUS iron sites by embedding highly dispersed FeN4 centers in ...

journal_title：Science advances

authors： Deng D,Chen X,Yu L,Wu X,Liu Q,Liu Y,Yang H,Tian H,Hu Y,Du P,Si R,Wang J,Cui X,Li H,Xiao J,Xu T,Deng J,Yang F,Duchesne PN,Zhang P,Zhou J,Sun L,Li J,Pan X,Bao X

更新日期：2015-12-04 00:00:00

abstract：:Maximizing the sustainable supercurrent density, J C, is crucial to high-current applications of superconductivity. To achieve this, preventing dissipative motion of quantized vortices is key. Irradiation of superconductors with high-energy heavy ions can be used to create nanoscale defects that act as deep pinning po...

journal_title：Science advances

authors： Massee F,Sprau PO,Wang YL,Davis JC,Ghigo G,Gu GD,Kwok WK

更新日期：2015-05-20 00:00:00

abstract：:Association of peripheral proteins with lipid bilayers regulates membrane signaling and dynamics. Pleckstrin homology (PH) domains bind to phosphatidylinositol phosphate (PIP) molecules in membranes. The effects of local PIP enrichment on the interaction of PH domains with membranes is unclear. Molecular dynamics simu...

journal_title：Science advances

authors： Yamamoto E,Domański J,Naughton FB,Best RB,Kalli AC,Stansfeld PJ,Sansom MSP

更新日期：2020-02-19 00:00:00

abstract：:Early identification of pathogens is essential for limiting development of therapy-resistant pathogens and mitigating infectious disease outbreaks. Most bacterial detection schemes use target-specific probes to differentiate pathogen species, creating time and cost inefficiencies in identifying newly discovered organi...

journal_title：Science advances

authors： Aghazadeh A,Lin AY,Sheikh MA,Chen AL,Atkins LM,Johnson CL,Petrosino JF,Drezek RA,Baraniuk RG

更新日期：2016-09-28 00:00:00

abstract：:The ability of a material to adopt multiple structures, known as polymorphism, is a fascinating natural phenomenon. Various polymorphs with unusual properties are routinely synthesized by compression under positive pressure. However, changing a material's structure by applying tension under negative pressure is much m...

journal_title：Science advances

authors： Siol S,Holder A,Steffes J,Schelhas LT,Stone KH,Garten L,Perkins JD,Parilla PA,Toney MF,Huey BD,Tumas W,Lany S,Zakutayev A

更新日期：2018-04-20 00:00:00

abstract：:Modern tropical forests harbor an enormous diversity of squamates, but fossilization in such environments is uncommon and little is known about tropical lizard assemblages of the Mesozoic. We report the oldest lizard assemblage preserved in amber, providing insight into the poorly preserved but potentially diverse mid...

journal_title：Science advances

authors： Daza JD,Stanley EL,Wagner P,Bauer AM,Grimaldi DA

更新日期：2016-03-04 00:00:00

abstract：:Vertical stacking is widely viewed as a promising approach for designing advanced functionalities using two-dimensional (2D) materials. Combining crystallographically commensurate materials in these 2D stacks has been shown to result in rich new electronic structure, magnetotransport, and optical properties. In this c...

journal_title：Science advances

authors： Vargas A,Liu F,Lane C,Rubin D,Bilgin I,Hennighausen Z,DeCapua M,Bansil A,Kar S

更新日期：2017-07-14 00:00:00