Tunable and laser-reconfigurable 2D heterocrystals obtained by epitaxial stacking of crystallographically incommensurate Bi2Se3 and MoS2 atomic layers.

abstract：:Black phosphorus (BP) offers considerable promise for infrared and visible photonics. Efficient tuning of the bandgap and higher subbands in BP by modulation of the Fermi level or application of vertical electric fields has been previously demonstrated, allowing electrical control of its above-bandgap optical properti...

journal_title：Science advances

authors： Biswas S,Whitney WS,Grajower MY,Watanabe K,Taniguchi T,Bechtel HA,Rossman GR,Atwater HA

更新日期：2021-01-08 00:00:00

abstract：:Over millions of years, the oxidation of organic carbon contained within sedimentary rocks is one of the main sources of carbon dioxide to the atmosphere, yet the controls on this emission remain poorly constrained. We use rhenium to track the oxidation of rock-bound organic carbon in the mountain watersheds of New Ze...

journal_title：Science advances

authors： Horan K,Hilton RG,Selby D,Ottley CJ,Gröcke DR,Hicks M,Burton KW

更新日期：2017-10-04 00:00:00

abstract：:Chronic suppurative otitis media (CSOM) is a neglected pediatric disease affecting 330 million worldwide for which no new drugs have been introduced for over a decade. We developed a mouse model with utility in preclinical drug evaluation and antimicrobial discovery. Our model used immune-competent mice, tympanic memb...

journal_title：Science advances

authors： Khomtchouk KM,Kouhi A,Xia A,Bekale LA,Massa SM,Sweere JM,Pletzer D,Hancock RE,Bollyky PL,Santa Maria PL

更新日期：2020-08-14 00:00:00

abstract：:Optogenetics is a paradigm-changing new method to study and manipulate the behavior of cells with light. Following major advances of the used genetic constructs over the last decade, the light sources required for optogenetic control are now receiving increased attention. We report a novel optogenetic illumination pla...

journal_title：Science advances

authors： Steude A,Witts EC,Miles GB,Gather MC

更新日期：2016-05-06 00:00:00

abstract：:Human and murine skin wounding commonly results in fibrotic scarring, but the murine wounding model wound-induced hair neogenesis (WIHN) can frequently result in a regenerative repair response. Here, we show in single-cell RNA sequencing comparisons of semi-regenerative and fibrotic WIHN wounds, increased expression o...

journal_title：Science advances

authors： Gay D,Ghinatti G,Guerrero-Juarez CF,Ferrer RA,Ferri F,Lim CH,Murakami S,Gault N,Barroca V,Rombeau I,Mauffrey P,Irbah L,Treffeisen E,Franz S,Boissonnas A,Combadière C,Ito M,Plikus MV,Romeo PH

更新日期：2020-03-20 00:00:00

abstract：:We report a dual-mode organic photodetector (OPD) that has a trilayer visible light absorber/optical spacer/near-infrared (NIR) light absorber configuration. In the presence of NIR light, photocurrent is produced in the NIR light-absorbing layer due to the trap-assisted charge injection at the organic/cathode interfac...

journal_title：Science advances

authors： Lan Z,Lei Y,Chan WKE,Chen S,Luo D,Zhu F

更新日期：2020-01-31 00:00:00

abstract：:Using theory and experiments, we study the interface between two immiscible domains in a colloidal membrane composed of rigid rods of different lengths. Geometric considerations of rigid rod packing imply that a domain of sufficiently short rods in a background membrane of long rods is more susceptible to twist than t...

journal_title：Science advances

authors： Miller JM,Hall D,Robaszewski J,Sharma P,Hagan MF,Grason GM,Dogic Z

更新日期：2020-07-29 00:00:00

abstract：:Difunctionalization of alkenes is a valuable and versatile chemical transformation that could quickly build complex molecules. Extensive efforts have been made, and great achievement, such as Sharpless aminohydroxylation and dihydroxylation, has been reached. However, in marked contrast to the extensive research of am...

journal_title：Science advances

authors： Yuan Y,Chen Y,Tang S,Huang Z,Lei A

更新日期：2018-08-03 00:00:00

abstract：:Capabilities for assembly of three-dimensional (3D) micro/nanostructures in advanced materials have important implications across a broad range of application areas, reaching nearly every class of microsystem technology. Approaches that rely on the controlled, compressive buckling of 2D precursors are promising becaus...

journal_title：Science advances

authors： Yan Z,Zhang F,Liu F,Han M,Ou D,Liu Y,Lin Q,Guo X,Fu H,Xie Z,Gao M,Huang Y,Kim J,Qiu Y,Nan K,Kim J,Gutruf P,Luo H,Zhao A,Hwang KC,Huang Y,Zhang Y,Rogers JA

更新日期：2016-09-23 00:00:00

abstract：:The exceptionally long quantum coherence times of phosphorus donor nuclear spin qubits in silicon, coupled with the proven scalability of silicon-based nano-electronics, make them attractive candidates for large-scale quantum computing. However, the high threshold of topological quantum error correction can only be ca...

journal_title：Science advances

authors： Hill CD,Peretz E,Hile SJ,House MG,Fuechsle M,Rogge S,Simmons MY,Hollenberg LC

更新日期：2015-10-30 00:00:00

abstract：:Spectroscopic methods with nanoscale lateral resolution are becoming essential in the fields of physics, chemistry, geology, biology, and materials science. However, the lateral resolution of laser-based mass spectrometry imaging (MSI) techniques has so far been limited to the microscale. This report presents the deve...

journal_title：Science advances

authors： Liang Z,Zhang S,Li X,Wang T,Huang Y,Hang W,Yang Z,Li J,Tian Z

更新日期：2017-12-08 00:00:00

abstract：:The response to programmed cell death protein-1 (PD-1)/programmed death ligand-1 (PD-L1) blockade in cancer immunotherapy is limited because of multiple immune evasion mechanisms. Here, a previously unknown strategy is proposed to synergize the nuclear factor κB (NF-κB) inhibition and PD-1 blockade for antitumor immun...

journal_title：Science advances

authors： Xiao Z,Su Z,Han S,Huang J,Lin L,Shuai X

更新日期：2020-02-05 00:00:00

abstract：:The natural, prehuman abundance of most large predators is unknown because of the lack of historical data and a limited understanding of the natural factors that control their populations. Determining the supportable predator biomass at a given location (that is, the predator carrying capacity) would help managers to ...

journal_title：Science advances

authors： Valdivia A,Cox CE,Bruno JF

更新日期：2017-03-01 00:00:00

abstract：:Holoprosencephaly (HPE) is a congenital forebrain defect often associated with embryonic lethality and lifelong disabilities. Currently, therapeutic and diagnostic options are limited by lack of knowledge of potential disease-causing mutations. We have identified a new mutation in the PRDM15 gene (C844Y) associated wi...

journal_title：Science advances

authors： Mzoughi S,Di Tullio F,Low DHP,Motofeanu CM,Ong SLM,Wollmann H,Wun CM,Kruszka P,Muenke M,Hildebrandt F,Dunn NR,Messerschmidt DM,Guccione E

更新日期：2020-01-10 00:00:00

abstract：:Double seismic zones are two-layered distributions of intermediate-depth earthquakes that provide insight into the thermomechanical state of subducting slabs. We present new precise hypocenters of intermediate-depth earthquakes in the Tonga subduction zone obtained using data from local island-based, ocean-bottom, and...

journal_title：Science advances

authors： Wei SS,Wiens DA,van Keken PE,Cai C

更新日期：2017-01-11 00:00:00

abstract：:Photonic crystal nanocavities, which have modal volumes of the order of a cubic wavelength in the material, are of great interest as flexible platforms for manipulating photons. Recent developments in ultra-high quality factor nanocavities with long photon lifetimes have encouraged us to develop an ultra-compact and f...

journal_title：Science advances

authors： Konoike R,Nakagawa H,Nakadai M,Asano T,Tanaka Y,Noda S

更新日期：2016-05-20 00:00:00

abstract：:Nanoparticles have been extensively used for inflammation imaging and photodynamic therapy of cancer. However, the major translational barriers to most nanoparticle-based imaging and therapy applications are the limited depth of tissue penetration, inevitable requirement of external irradiation, and poor biocompatibil...

journal_title：Science advances

authors： Xu X,An H,Zhang D,Tao H,Dou Y,Li X,Huang J,Zhang J

更新日期：2019-01-09 00:00:00

abstract：:The tet methylcytosine dioxygenase 2 (TET2) enzyme catalyzes the conversion of the modified DNA base 5-methylcytosine to 5-hydroxymethylcytosine. TET2 is frequently mutated or dysregulated in multiple human cancers, and loss of TET2 is associated with changes in DNA methylation patterns. Here, using newly developed TE...

journal_title：Science advances

authors： Wang L,Ozark PA,Smith ER,Zhao Z,Marshall SA,Rendleman EJ,Piunti A,Ryan C,Whelan AL,Helmin KA,Morgan MA,Zou L,Singer BD,Shilatifard A

更新日期：2018-11-07 00:00:00

abstract：:Myofibroblasts orchestrate wound healing processes, and if they remain activated, they drive disease progression such as fibrosis and cancer. Besides growth factor signaling, the local extracellular matrix (ECM) and its mechanical properties are central regulators of these processes. It remains unknown whether transfo...

journal_title：Science advances

authors： Kollmannsberger P,Bidan CM,Dunlop JWC,Fratzl P,Vogel V

更新日期：2018-01-17 00:00:00

abstract：:Species interactions have long been predicted to increase in intensity toward the tropics and low elevations because of gradients in climate, productivity, or biodiversity. Despite their importance for understanding global ecological and evolutionary processes, plant-animal interaction gradients are particularly diffi...

journal_title：Science advances

authors： Hargreaves AL,Suárez E,Mehltreter K,Myers-Smith I,Vanderplank SE,Slinn HL,Vargas-Rodriguez YL,Haeussler S,David S,Muñoz J,Carlos Almazán-Núñez R,Loughnan D,Benning JW,Moeller DA,Brodie JF,Thomas HJD,Morales M PA

更新日期：2019-02-20 00:00:00

abstract：:Interactions between top-down and bottom-up processes in the cerebral cortex hold the key to understanding attentional processes, predictive coding, executive control, and a gamut of other brain functions. However, the underlying circuit mechanism remains poorly understood and represents a major challenge in neuroscie...

journal_title：Science advances

authors： Mejias JF,Murray JD,Kennedy H,Wang XJ

更新日期：2016-11-16 00:00:00

abstract：:Students from underrepresented groups start college with the same level of interest in STEM majors as their peers, but leave STEM at higher rates. We tested the hypothesis that low grades in general chemistry contribute to this "weeding," using records from 25,768 students. In the first course of a general chemistry s...

journal_title：Science advances

authors： Harris RB,Mack MR,Bryant J,Theobald EJ,Freeman S

更新日期：2020-06-10 00:00:00

abstract：:The key component currently missing for the next generation of transparent and flexible displays is a high-performance polymer material that is flexible, while showing optical and thermal properties of glass. It must be transparent to visible light and show a low coefficient of thermal expansion (CTE). While specialty...

journal_title：Science advances

authors： Kim SD,Lee B,Byun T,Chung IS,Park J,Shin I,Ahn NY,Seo M,Lee Y,Kim Y,Kim WY,Kwon H,Moon H,Yoo S,Kim SY

更新日期：2018-10-26 00:00:00

abstract：:The progression in the hair follicle cycle from the telogen to the anagen phase is the key to regulating hair regrowth. Dermal papilla (DP) cells support hair growth and regulate the hair cycle. However, they gradually lose key inductive properties upon culture. DP cells can partially restore their capacity to promote...

journal_title：Science advances

authors： Hu S,Li Z,Lutz H,Huang K,Su T,Cores J,Dinh PC,Cheng K

更新日期：2020-07-24 00:00:00

abstract：:E2F is a family of master transcription regulators involved in mediating diverse cell fates. Here, we show that residue-specific arginine methylation (meR) by PRMT5 enables E2F1 to regulate many genes at the level of alternative RNA splicing, rather than through its classical transcription-based mechanism. The p100/TS...

journal_title：Science advances

authors： Roworth AP,Carr SM,Liu G,Barczak W,Miller RL,Munro S,Kanapin A,Samsonova A,La Thangue NB

更新日期：2019-06-26 00:00:00

abstract：:Nanofluidic platforms offering tunable material transport are applicable in biosensing, chemical detection, and filtration. Prior studies have achieved selective and controllable ion transport through electrical, optical, or chemical gating of complex nanostructures. Here, we mechanically control nanofluidic transport...

journal_title：Science advances

authors： Rabinowitz J,Whittier E,Liu Z,Jayant K,Frank J,Shepard K

更新日期：2020-11-13 00:00:00

abstract：:Despite the potential of photodynamic therapy (PDT), its comprehensive use in cancer treatment has not been achieved because of the nondegradable risks of photosensitizing drugs and limits of light penetration and instrumentation. Here, we present bioluminescence (BL)-induced proteinaceous PDT (BLiP-PDT), through the ...

journal_title：Science advances

authors： Kim EH,Park S,Kim YK,Moon M,Park J,Lee KJ,Lee S,Kim YP

更新日期：2020-09-11 00:00:00

abstract：:Quantum phenomena have the potential to speed up the solution of hard optimization problems. For example, quantum annealing, based on the quantum tunneling effect, has recently been shown to scale exponentially better with system size than classical simulated annealing. However, current realizations of quantum anneale...

journal_title：Science advances

authors： Nigg SE,Lörch N,Tiwari RP

更新日期：2017-04-07 00:00:00

abstract：:Transcriptional status determines the HIV replicative state in infected patients. However, the transcriptional mechanisms for proviral replication control remain unclear. In this study, we show that, apart from its function in HIV integration, LEDGF/p75 differentially regulates HIV transcription in latency and provira...

journal_title：Science advances

authors： Gao R,Bao J,Yan H,Xie L,Qin W,Ning H,Huang S,Cheng J,Zhi R,Li Z,Tucker B,Chen Y,Zhang K,Wu X,Liu Z,Gao X,Hu D

更新日期：2020-05-13 00:00:00

abstract：:We describe an approach to print composite polymers in high-resolution three-dimensional (3D) architectures that can be rapidly transformed to a new permanent configuration directly by heating. The permanent shape of a component results from the programmed time evolution of the printed shape upon heating via the desig...

journal_title：Science advances

authors： Ding Z,Yuan C,Peng X,Wang T,Qi HJ,Dunn ML

更新日期：2017-04-12 00:00:00