Arginine methylation expands the regulatory mechanisms and extends the genomic landscape under E2F control.

Abstract:

:E2F is a family of master transcription regulators involved in mediating diverse cell fates. Here, we show that residue-specific arginine methylation (meR) by PRMT5 enables E2F1 to regulate many genes at the level of alternative RNA splicing, rather than through its classical transcription-based mechanism. The p100/TSN tudor domain protein reads the meR mark on chromatin-bound E2F1, allowing snRNA components of the splicing machinery to assemble with E2F1. A large set of RNAs including spliced variants associate with E2F1 by virtue of the methyl mark. By focusing on the deSUMOylase SENP7 gene, which we identified as an E2F target gene, we establish that alternative splicing is functionally important for E2F1 activity. Our results reveal an unexpected consequence of arginine methylation, where reader-writer interplay widens the mechanism of control by E2F1, from transcription factor to regulator of alternative RNA splicing, thereby extending the genomic landscape under E2F1 control.

journal_name

Sci Adv

journal_title

Science advances

authors

Roworth AP,Carr SM,Liu G,Barczak W,Miller RL,Munro S,Kanapin A,Samsonova A,La Thangue NB

doi

10.1126/sciadv.aaw4640

subject

Has Abstract

pub_date

2019-06-26 00:00:00

pages

eaaw4640

issue

6

issn

2375-2548

pii

aaw4640

journal_volume

5

pub_type

杂志文章
  • Near-atomic-scale observation of grain boundaries in a layer-stacked two-dimensional polymer.

    abstract::Two-dimensional (2D) polymers hold great promise in the rational materials design tailored for next-generation applications. However, little is known about the grain boundaries in 2D polymers, not to mention their formation mechanisms and potential influences on the material's functionalities. Using aberration-correct...

    journal_title:Science advances

    pub_type: 杂志文章

    doi:10.1126/sciadv.abb5976

    authors: Qi H,Sahabudeen H,Liang B,Položij M,Addicoat MA,Gorelik TE,Hambsch M,Mundszinger M,Park S,Lotsch BV,Mannsfeld SCB,Zheng Z,Dong R,Heine T,Feng X,Kaiser U

    更新日期:2020-08-14 00:00:00

  • Negative-pressure polymorphs made by heterostructural alloying.

    abstract::The ability of a material to adopt multiple structures, known as polymorphism, is a fascinating natural phenomenon. Various polymorphs with unusual properties are routinely synthesized by compression under positive pressure. However, changing a material's structure by applying tension under negative pressure is much m...

    journal_title:Science advances

    pub_type: 杂志文章

    doi:10.1126/sciadv.aaq1442

    authors: Siol S,Holder A,Steffes J,Schelhas LT,Stone KH,Garten L,Perkins JD,Parilla PA,Toney MF,Huey BD,Tumas W,Lany S,Zakutayev A

    更新日期:2018-04-20 00:00:00

  • Giant gate-tunable bandgap renormalization and excitonic effects in a 2D semiconductor.

    abstract::Understanding the remarkable excitonic effects and controlling the exciton binding energies in two-dimensional (2D) semiconductors are crucial in unlocking their full potential for use in future photonic and optoelectronic devices. Here, we demonstrate large excitonic effects and gate-tunable exciton binding energies ...

    journal_title:Science advances

    pub_type: 杂志文章

    doi:10.1126/sciadv.aaw2347

    authors: Qiu Z,Trushin M,Fang H,Verzhbitskiy I,Gao S,Laksono E,Yang M,Lyu P,Li J,Su J,Telychko M,Watanabe K,Taniguchi T,Wu J,Neto AHC,Yang L,Eda G,Adam S,Lu J

    更新日期:2019-07-19 00:00:00

  • Keeping pace with climate change in global terrestrial protected areas.

    abstract::Protected areas (PAs) are essential to biodiversity conservation, but their static boundaries may undermine their potential for protecting species under climate change. We assessed how the climatic conditions within global terrestrial PAs may change over time. By 2070, protection is expected to decline in cold and war...

    journal_title:Science advances

    pub_type: 杂志文章

    doi:10.1126/sciadv.aay0814

    authors: Elsen PR,Monahan WB,Dougherty ER,Merenlender AM

    更新日期:2020-06-17 00:00:00

  • cGAS suppresses genomic instability as a decelerator of replication forks.

    abstract::The cyclic GMP-AMP synthase (cGAS), a sensor of cytosolic DNA, is critical for the innate immune response. Here, we show that loss of cGAS in untransformed and cancer cells results in uncontrolled DNA replication, hyperproliferation, and genomic instability. While the majority of cGAS is cytoplasmic, a fraction of cGA...

    journal_title:Science advances

    pub_type: 杂志文章

    doi:10.1126/sciadv.abb8941

    authors: Chen H,Chen H,Zhang J,Wang Y,Simoneau A,Yang H,Levine AS,Zou L,Chen Z,Lan L

    更新日期:2020-10-14 00:00:00

  • A two-dimensional semiconductor transistor with boosted gate control and sensing ability.

    abstract::Transistors with exfoliated two-dimensional (2D) materials on a SiO2/Si substrate have been applied and have been proven effective in a wide range of applications, such as circuits, memory, photodetectors, gas sensors, optical modulators, valleytronics, and spintronics. However, these devices usually suffer from limit...

    journal_title:Science advances

    pub_type: 杂志文章

    doi:10.1126/sciadv.1602246

    authors: Xu J,Chen L,Dai YW,Cao Q,Sun QQ,Ding SJ,Zhu H,Zhang DW

    更新日期:2017-05-19 00:00:00

  • Disentangling the size-dependent geometric and electronic effects of palladium nanocatalysts beyond selectivity.

    abstract::The prominent size effect of metal nanoparticles shapes decisively nanocatalysis, but entanglement of the corresponding geometric and electronic effects prevents exploiting their distinct functionalities. In this work, we demonstrate that in palladium (Pd)-catalyzed aerobic oxidation of benzyl alcohol, the geometric a...

    journal_title:Science advances

    pub_type: 杂志文章

    doi:10.1126/sciadv.aat6413

    authors: Wang H,Gu XK,Zheng X,Pan H,Zhu J,Chen S,Cao L,Li WX,Lu J

    更新日期:2019-01-18 00:00:00

  • Early development of the Neanderthal ribcage reveals a different body shape at birth compared to modern humans.

    abstract::Ontogenetic studies provide clues for understanding important paleobiological aspects of extinct species. When compared to that of modern humans, the adult Neanderthal thorax was shorter, deeper, and wider. This is related to the wide Neanderthal body and is consistent with their hypothetical large requirements for en...

    journal_title:Science advances

    pub_type: 杂志文章

    doi:10.1126/sciadv.abb4377

    authors: García-Martínez D,Bastir M,Gómez-Olivencia A,Maureille B,Golovanova L,Doronichev V,Akazawa T,Kondo O,Ishida H,Gascho D,Zollikofer CPE,de León MP,Heuzé Y

    更新日期:2020-10-07 00:00:00

  • Ancient DNA shows domestic horses were introduced in the southern Caucasus and Anatolia during the Bronze Age.

    abstract::Despite the important roles that horses have played in human history, particularly in the spread of languages and cultures, and correspondingly intensive research on this topic, the origin of domestic horses remains elusive. Several domestication centers have been hypothesized, but most of these have been invalidated ...

    journal_title:Science advances

    pub_type: 杂志文章

    doi:10.1126/sciadv.abb0030

    authors: Guimaraes S,Arbuckle BS,Peters J,Adcock SE,Buitenhuis H,Chazin H,Manaseryan N,Uerpmann HP,Grange T,Geigl EM

    更新日期:2020-09-16 00:00:00

  • Reconstructed storm tracks reveal three centuries of changing moisture delivery to North America.

    abstract::Moisture delivery to western North America is closely linked to variability in the westerly storm tracks of midlatitude cyclones, which are, in turn, modified by larger-scale features such as the El Niño-Southern Oscillation system. Instrumental and modeling data suggest that extratropical storm tracks may be intensif...

    journal_title:Science advances

    pub_type: 杂志文章

    doi:10.1126/sciadv.1602263

    authors: Wise EK,Dannenberg MP

    更新日期:2017-06-07 00:00:00

  • Kisspeptin/GPR54 signaling restricts antiviral innate immune response through regulating calcineurin phosphatase activity.

    abstract::G protein-coupled receptor 54 (GPR54), the key receptor for the neuropeptide hormone kisspeptin, plays essential roles in regulating puberty development and cancer metastasis. However, its role in the antiviral innate immune response is unknown. We report that virus-induced type I interferon (IFN-I) production was sig...

    journal_title:Science advances

    pub_type: 杂志文章

    doi:10.1126/sciadv.aas9784

    authors: Huang H,Xiong Q,Wang N,Chen R,Ren H,Siwko S,Han H,Liu M,Qian M,Du B

    更新日期:2018-08-08 00:00:00

  • Optics-less focusing of XUV high-order harmonics.

    abstract::By experimentally studying high-order harmonic beams generated in gases, we show how the spatial characteristics of these ultrashort extreme-ultraviolet (XUV) beams can be finely controlled when a single fundamental beam generates harmonics in a thin gas medium. We demonstrate that these XUV beams can be emitted as co...

    journal_title:Science advances

    pub_type: 杂志文章

    doi:10.1126/sciadv.aau7175

    authors: Quintard L,Strelkov V,Vabek J,Hort O,Dubrouil A,Descamps D,Burgy F,Péjot C,Mével E,Catoire F,Constant E

    更新日期:2019-04-05 00:00:00

  • Ultrafast selective transport of alkali metal ions in metal organic frameworks with subnanometer pores.

    abstract::Porous membranes with ultrafast ion permeation and high ion selectivity are highly desirable for efficient mineral separation, water purification, and energy conversion, but it is still a huge challenge to efficiently separate monatomic ions of the same valence and similar sizes using synthetic membranes. We report me...

    journal_title:Science advances

    pub_type: 杂志文章

    doi:10.1126/sciadv.aaq0066

    authors: Zhang H,Hou J,Hu Y,Wang P,Ou R,Jiang L,Liu JZ,Freeman BD,Hill AJ,Wang H

    更新日期:2018-02-09 00:00:00

  • Erratum for the Research Article: Smoothened agonist sterosome immobilized hybrid scaffold for bone regeneration by C-S. Lee, S. Kim, J. Fan, H. S. Hwang, T. Aghaloo and M. Lee.

    abstract::[This corrects the article DOI: 10.1126/sciadv.aaz7822.]. ...

    journal_title:Science advances

    pub_type: 已发布勘误

    doi:10.1126/sciadv.abd5216

    authors:

    更新日期:2020-07-08 00:00:00

  • Nonequilibrium evolution of volatility in origination and extinction explains fat-tailed fluctuations in Phanerozoic biodiversity.

    abstract::Fluctuations in biodiversity, large and small, pervade the fossil record, yet we do not understand the processes generating them. Here, we extend theory from nonequilibrium statistical physics to describe the fat-tailed form of fluctuations in Phanerozoic marine invertebrate richness. Using this theory, known as super...

    journal_title:Science advances

    pub_type: 杂志文章

    doi:10.1126/sciadv.aat0122

    authors: Rominger AJ,Fuentes MA,Marquet PA

    更新日期:2019-06-26 00:00:00

  • Designing durable icephobic surfaces.

    abstract::Ice accretion has a negative impact on critical infrastructure, as well as a range of commercial and residential activities. Icephobic surfaces are defined by an ice adhesion strength τice < 100 kPa. However, the passive removal of ice requires much lower values of τice, such as on airplane wings or power lines (τice ...

    journal_title:Science advances

    pub_type: 杂志文章

    doi:10.1126/sciadv.1501496

    authors: Golovin K,Kobaku SP,Lee DH,DiLoreto ET,Mabry JM,Tuteja A

    更新日期:2016-03-11 00:00:00

  • Time-of-day-dependent global distribution of lunar surficial water/hydroxyl.

    abstract::A new set of time-of-day-dependent global maps of the lunar near-infrared water/hydroxyl (H2O/OH) absorption band strength near 2.8 to 3.0 μm constructed on the basis of Moon Mineralogy Mapper (M3) data is presented. The analyzed absorption band near 2.8 to 3.0 μm indicates the presence of surficial H2O/OH. To remove ...

    journal_title:Science advances

    pub_type: 杂志文章

    doi:10.1126/sciadv.1701286

    authors: Wöhler C,Grumpe A,Berezhnoy AA,Shevchenko VV

    更新日期:2017-09-08 00:00:00

  • Slow dynamics of electrons at a metal-Mott insulator boundary in an organic system with disorder.

    abstract::The Mott transition-a metal-insulator transition caused by repulsive Coulomb interactions between electrons-is a central issue in condensed matter physics because it is the mother earth of various attractive phenomena. Outstanding examples are high-Tc (critical temperature) cuprates and manganites exhibiting colossal ...

    journal_title:Science advances

    pub_type: 杂志文章

    doi:10.1126/sciadv.1601594

    authors: Itou T,Watanabe E,Maegawa S,Tajima A,Tajima N,Kubo K,Kato R,Kanoda K

    更新日期:2017-08-11 00:00:00

  • Darwinian sex roles confirmed across the animal kingdom.

    abstract::Since Darwin's conception of sexual selection theory, scientists have struggled to identify the evolutionary forces underlying the pervasive differences between male and female behavior, morphology, and physiology. The Darwin-Bateman paradigm predicts that anisogamy imposes stronger sexual selection on males, which, i...

    journal_title:Science advances

    pub_type: 杂志文章,评审

    doi:10.1126/sciadv.1500983

    authors: Janicke T,Häderer IK,Lajeunesse MJ,Anthes N

    更新日期:2016-02-12 00:00:00

  • Superconductivity with twofold symmetry in Bi2Te3/FeTe0.55Se0.45 heterostructures.

    abstract::Topological superconductors are an interesting and frontier topic in condensed matter physics. In the superconducting state, an order parameter will be established with the basic or subsidiary symmetry of the crystalline lattice. In doped Bi2Se3 or Bi2Te3 with a basic threefold symmetry, it was predicted, however, tha...

    journal_title:Science advances

    pub_type: 杂志文章

    doi:10.1126/sciadv.aat1084

    authors: Chen M,Chen X,Yang H,Du Z,Wen HH

    更新日期:2018-06-08 00:00:00

  • Self-powered user-interactive electronic skin for programmable touch operation platform.

    abstract::User-interactive electronic skin is capable of spatially mapping touch via electric readout and providing visual output as a human-readable response. However, the high power consumption, complex structure, and high cost of user-interactive electronic skin are notable obstacles for practical application. Here, we repor...

    journal_title:Science advances

    pub_type: 杂志文章

    doi:10.1126/sciadv.aba4294

    authors: Zhao X,Zhang Z,Liao Q,Xun X,Gao F,Xu L,Kang Z,Zhang Y

    更新日期:2020-07-08 00:00:00

  • Silver(I) as a widely applicable, homogeneous catalyst for aerobic oxidation of aldehydes toward carboxylic acids in water-"silver mirror": From stoichiometric to catalytic.

    abstract::The first example of a homogeneous silver(I)-catalyzed aerobic oxidation of aldehydes in water is reported. More than 50 examples of different aliphatic and aromatic aldehydes, including natural products, were tested, and all of them successfully underwent aerobic oxidation to give the corresponding carboxylic acids i...

    journal_title:Science advances

    pub_type: 杂志文章

    doi:10.1126/sciadv.1500020

    authors: Liu M,Wang H,Zeng H,Li CJ

    更新日期:2015-03-27 00:00:00

  • Geoelectrochemical CO production: Implications for the autotrophic origin of life.

    abstract::Wächtershäuser's proposal of the autotrophic origin of life theory and subsequent laboratory demonstrations of relevant organic reactions have opened a new gate for the exploration of the origin of life. However, this scenario remains controversial because, at present, it requires a high pressure of CO as a source of ...

    journal_title:Science advances

    pub_type: 杂志文章

    doi:10.1126/sciadv.aao7265

    authors: Kitadai N,Nakamura R,Yamamoto M,Takai K,Li Y,Yamaguchi A,Gilbert A,Ueno Y,Yoshida N,Oono Y

    更新日期:2018-04-04 00:00:00

  • Imaging atomic-scale effects of high-energy ion irradiation on superconductivity and vortex pinning in Fe(Se,Te).

    abstract::Maximizing the sustainable supercurrent density, J C, is crucial to high-current applications of superconductivity. To achieve this, preventing dissipative motion of quantized vortices is key. Irradiation of superconductors with high-energy heavy ions can be used to create nanoscale defects that act as deep pinning po...

    journal_title:Science advances

    pub_type: 杂志文章

    doi:10.1126/sciadv.1500033

    authors: Massee F,Sprau PO,Wang YL,Davis JC,Ghigo G,Gu GD,Kwok WK

    更新日期:2015-05-20 00:00:00

  • Polarization recovery through scattering media.

    abstract::The control and use of light polarization in optical sciences and engineering are widespread. Despite remarkable developments in polarization-resolved imaging for life sciences, their transposition to strongly scattering media is currently not possible, because of the inherent depolarization effects arising from multi...

    journal_title:Science advances

    pub_type: 杂志文章

    doi:10.1126/sciadv.1600743

    authors: de Aguiar HB,Gigan S,Brasselet S

    更新日期:2017-09-01 00:00:00

  • Universal microbial diagnostics using random DNA probes.

    abstract::Early identification of pathogens is essential for limiting development of therapy-resistant pathogens and mitigating infectious disease outbreaks. Most bacterial detection schemes use target-specific probes to differentiate pathogen species, creating time and cost inefficiencies in identifying newly discovered organi...

    journal_title:Science advances

    pub_type: 杂志文章

    doi:10.1126/sciadv.1600025

    authors: Aghazadeh A,Lin AY,Sheikh MA,Chen AL,Atkins LM,Johnson CL,Petrosino JF,Drezek RA,Baraniuk RG

    更新日期:2016-09-28 00:00:00

  • Unprecedented reduction and quick recovery of the South Indian Ocean heat content and sea level in 2014-2018.

    abstract::Following the onset of the strong 2014-2016 El Niño, a decade-long increase of the basin-wide sea level and heat content in the subtropical southern Indian Ocean (SIO) in 2004-2013 ended with an unprecedented drop, which quickly recovered during the weak 2017-2018 La Niña. Here, we show that the 2014-2016 El Niño cont...

    journal_title:Science advances

    pub_type: 杂志文章

    doi:10.1126/sciadv.abc1151

    authors: Volkov DL,Lee SK,Gordon AL,Rudko M

    更新日期:2020-09-04 00:00:00

  • The prevalence of kilometer-scale heterogeneity in the source region of MORB upper mantle.

    abstract::The source regions of mid-ocean ridge basalts (MORB) are heterogeneous, consisting of chemically and lithologically distinct domains of variable size. Partial melting of such heterogeneous mantle sources gives rise to diverse isotopic compositions of MORB and abyssal peridotites. Variations in radiogenic isotope ratio...

    journal_title:Science advances

    pub_type: 杂志文章

    doi:10.1126/sciadv.1701872

    authors: Liu B,Liang Y

    更新日期:2017-11-22 00:00:00

  • Tip-enhanced ablation and ionization mass spectrometry for nanoscale chemical analysis.

    abstract::Spectroscopic methods with nanoscale lateral resolution are becoming essential in the fields of physics, chemistry, geology, biology, and materials science. However, the lateral resolution of laser-based mass spectrometry imaging (MSI) techniques has so far been limited to the microscale. This report presents the deve...

    journal_title:Science advances

    pub_type: 杂志文章

    doi:10.1126/sciadv.aaq1059

    authors: Liang Z,Zhang S,Li X,Wang T,Huang Y,Hang W,Yang Z,Li J,Tian Z

    更新日期:2017-12-08 00:00:00

  • Cryogenian evolution of stigmasteroid biosynthesis.

    abstract::Sedimentary hydrocarbon remnants of eukaryotic C26-C30 sterols can be used to reconstruct early algal evolution. Enhanced C29 sterol abundances provide algal cell membranes a density advantage in large temperature fluctuations. Here, we combined a literature review with new analyses to generate a comprehensive invento...

    journal_title:Science advances

    pub_type: 杂志文章,评审

    doi:10.1126/sciadv.1700887

    authors: Hoshino Y,Poshibaeva A,Meredith W,Snape C,Poshibaev V,Versteegh GJM,Kuznetsov N,Leider A,van Maldegem L,Neumann M,Naeher S,Moczydłowska M,Brocks JJ,Jarrett AJM,Tang Q,Xiao S,McKirdy D,Das SK,Alvaro JJ,Sansjofre P,

    更新日期:2017-09-20 00:00:00