Cellular backpacks for macrophage immunotherapy.

abstract：:Tropical forest fragmentation results in habitat and biodiversity loss and increased carbon emissions. Here, we link an increased likelihood of tropical forest loss to decreasing fragment size, particularly in primary forests. The relationship holds for protected areas, albeit with half the rate of loss compared with ...

journal_title：Science advances

authors： Hansen MC,Wang L,Song XP,Tyukavina A,Turubanova S,Potapov PV,Stehman SV

更新日期：2020-03-11 00:00:00

abstract：:Cheater viruses, also known as defective interfering viruses, cannot replicate on their own yet replicate faster than the wild type upon coinfection. While there is growing interest in using cheaters as antiviral therapeutics, the mechanisms underlying cheating have been rarely explored. During experimental evolution ...

journal_title：Science advances

authors： Meir M,Harel N,Miller D,Gelbart M,Eldar A,Gophna U,Stern A

更新日期：2020-08-21 00:00:00

abstract：:Photoresponsive liquid crystalline elastomers (LCEs) constitute ideal actuators for soft robots because their light-induced macroscopic shape changes can be harnessed to perform specific articulated motions. Conventional LCEs, however, do not typically exhibit complex modes of bending and twisting necessary to perform...

journal_title：Science advances

authors： Waters JT,Li S,Yao Y,Lerch MM,Aizenberg M,Aizenberg J,Balazs AC

更新日期：2020-03-27 00:00:00

abstract：:Improved constraints on lower-mantle composition are fundamental to understand the accretion, differentiation, and thermochemical evolution of our planet. Cosmochemical arguments indicate that lower-mantle rocks may be enriched in Si relative to upper-mantle pyrolite, whereas seismic tomography images suggest whole-ma...

journal_title：Science advances

authors： Ballmer MD,Schmerr NC,Nakagawa T,Ritsema J

更新日期：2015-12-10 00:00:00

abstract：:Can mating influence cognitive functions such as learning and memory in a permanent way? We have addressed this question using a combined behavioral and in vivo imaging approach, finding that aversive long-term memory performance strongly increases in Drosophila females in response to sperm transfer following mating. ...

journal_title：Science advances

authors： Scheunemann L,Lampin-Saint-Amaux A,Schor J,Preat T

更新日期：2019-11-20 00:00:00

abstract：:The homotrimeric molecular chaperone Skp of Gram-negative bacteria facilitates the transport of outer membrane proteins across the periplasm. It has been unclear how its activity is modulated during its functional cycle. Here, we report an atomic-resolution characterization of the Escherichia coli Skp monomer-trimer t...

journal_title：Science advances

authors： Mas G,Burmann BM,Sharpe T,Claudi B,Bumann D,Hiller S

更新日期：2020-10-21 00:00:00

abstract：:B cell activation is regulated by the stimulatory or inhibitory co-receptors of B cell receptors (BCRs). Here, we investigated the signaling mechanism of Fc receptor-like 1 (FcRL1), a newly identified BCR co-receptor. FcRL1 was passively recruited into B cell immunological synapses upon BCR engagement in the absence o...

journal_title：Science advances

authors： Zhao X,Xie H,Zhao M,Ahsan A,Li X,Wang F,Yi J,Yang Z,Wu C,Raman I,Li QZ,Kim TJ,Liu W

更新日期：2019-07-17 00:00:00

abstract：:Using a national longitudinal survey data set from the Higher Education Research Institute, this study tested whether students who identified as a sexual minority (for example, lesbian, gay, bisexual, or queer) were more or less likely to persist after 4 years in science, technology, engineering, and mathematics (STEM...

journal_title：Science advances

authors： Hughes BE

更新日期：2018-03-14 00:00:00

abstract：:The human transfer RNA methyltransferase 9-like gene (TRM9L, also known as KIAA1456) encodes a negative regulator of tumor growth that is frequently silenced in many forms of cancer. While TRM9L can inhibit tumor cell growth in vivo, the molecular mechanisms underlying the tumor inhibition activity of TRM9L are unknow...

journal_title：Science advances

authors： Gu C,Ramos J,Begley U,Dedon PC,Fu D,Begley TJ

更新日期：2018-07-11 00:00:00

abstract：:The natural selection and the evolutionary optimization of complex shapes in nature are closely related to their functions. Mechanostabilization of shape of biological structure via morphogenesis has several beautiful examples. With the help of simple mechanics-based modeling and experiments, we show an important caus...

journal_title：Science advances

authors： Tiwary CS,Kishore S,Sarkar S,Mahapatra DR,Ajayan PM,Chattopadhyay K

更新日期：2015-05-15 00:00:00

abstract：:Yearly, a quarter billion people are infected and a half a million killed by the mosquito-borne disease malaria. Lack of real-time observational tools for continuously assessing the unperturbed mosquito flight activity in situ limits progress toward improved vector control. We deployed a high-resolution entomological ...

journal_title：Science advances

authors： Brydegaard M,Jansson S,Malmqvist E,Mlacha YP,Gebru A,Okumu F,Killeen GF,Kirkeby C

更新日期：2020-05-13 00:00:00

abstract：:G-quadruplex (G4) is one of the most important secondary structures in nucleic acids. Until recently, G4 RNAs have not been reported in any ribovirus, such as the hepatitis C virus. Our bioinformatics analysis reveals highly conserved guanine-rich consensus sequences within the core gene of hepatitis C despite the hig...

journal_title：Science advances

authors： Wang SR,Min YQ,Wang JQ,Liu CX,Fu BS,Wu F,Wu LY,Qiao ZX,Song YY,Xu GH,Wu ZG,Huang G,Peng NF,Huang R,Mao WX,Peng S,Chen YQ,Zhu Y,Tian T,Zhang XL,Zhou X

更新日期：2016-04-01 00:00:00

abstract：:Nanometer-scale skyrmions are prospective candidates for information bits in low-power consumption devices owing to their topological nature and controllability with low current density. Studies on skyrmion dynamics in different classes of materials have exploited the topological Hall effect and current-driven fast mo...

journal_title：Science advances

authors： Yu XZ,Morikawa D,Nakajima K,Shibata K,Kanazawa N,Arima T,Nagaosa N,Tokura Y

更新日期：2020-06-17 00:00:00

abstract：:We examine the low-temperature states supported by the quasiperiodic host-guest structure of elemental bismuth at high pressure, Bi-III. Our electronic transport and magnetization experiments establish Bi-III as a rare example of type II superconductivity in an element, with a record upper critical field of ~ 2.5 T, u...

journal_title：Science advances

authors： Brown P,Semeniuk K,Wang D,Monserrat B,Pickard CJ,Grosche FM

更新日期：2018-04-13 00:00:00

abstract：:G protein-coupled receptors (GPCRs) play a fundamental role in the modulation of synaptic transmission. A pivotal example is provided by the metabotropic glutamate receptor type 4 (mGluR4), which inhibits glutamate release at presynaptic active zones (AZs). However, how GPCRs are organized within AZs to regulate neuro...

journal_title：Science advances

authors： Siddig S,Aufmkolk S,Doose S,Jobin ML,Werner C,Sauer M,Calebiro D

更新日期：2020-04-15 00:00:00

abstract：:The single-stranded RNA (ssRNA) bacteriophages are among the simplest known viruses with small genomes and exceptionally high mutation rates. The number of ssRNA phage isolates has remained very low, but recent metagenomic studies have uncovered an immense variety of distinct uncultured ssRNA phages. The coat proteins...

journal_title：Science advances

authors： Rūmnieks J,Liekniņa I,Kalniņš G,Šišovs M,Akopjana I,Bogans J,Tārs K

更新日期：2020-09-02 00:00:00

abstract：:Self-assembly of colloidal nanocrystals into complex superstructures offers notable opportunities to create functional devices and artificial materials with unusual properties. Anisotropic nanoparticles with nonspherical shapes, such as rods, plates, polyhedra, and multipods, enable the formation of a diverse range of...

journal_title：Science advances

authors： Wang Q,Wang Z,Li Z,Xiao J,Shan H,Fang Z,Qi L

更新日期：2017-10-27 00:00:00

abstract：:Using a cell-based assay monitoring differential protein transport in the secretory pathway coupled to high-content screening, we have identified three molecules that specifically reduce the delivery of the major co-receptor for HIV-1, CCR5, to the plasma membrane. They have no effect on the closely related receptors ...

journal_title：Science advances

authors： Boncompain G,Herit F,Tessier S,Lescure A,Del Nery E,Gestraud P,Staropoli I,Fukata Y,Fukata M,Brelot A,Niedergang F,Perez F

更新日期：2019-10-16 00:00:00

abstract：:Kozmin et al. contend that observations previously reported regarding the antimicrobial and antitumor activities of 6-N-hydroxy aminopurine (6-HAP) were incorrect. Their conclusions rely on poorly characterized reagents and focus strictly on in vitro techniques without validation in relevant mammalian model systems. W...

journal_title：Science advances

authors： Nakatsuji T,Fenical W,Gallo RL

更新日期：2019-09-11 00:00:00

abstract：:Nanomaterials often surprise us with unexpected phenomena. Here, we report a discovery of the anti-twinning deformation, previously thought impossible, in nanoscale body-centered cubic (BCC) tungsten crystals. By conducting in situ transmission electron microscopy nanomechanical testing, we observed the nucleation and...

journal_title：Science advances

authors： Wang J,Zeng Z,Wen M,Wang Q,Chen D,Zhang Y,Wang P,Wang H,Zhang Z,Mao SX,Zhu T

更新日期：2020-06-03 00:00:00

abstract：:Recent research on piezoelectric materials is predominantly devoted to enhancing the piezoelectric coefficient, but overlooks its sign, largely because almost all of them exhibit positive longitudinal piezoelectricity. The only experimentally known exception is ferroelectric polymer poly(vinylidene fluoride) and its c...

journal_title：Science advances

authors： You L,Zhang Y,Zhou S,Chaturvedi A,Morris SA,Liu F,Chang L,Ichinose D,Funakubo H,Hu W,Wu T,Liu Z,Dong S,Wang J

更新日期：2019-04-19 00:00:00

abstract：:The importance of comets for the origin of life on Earth has been advocated for many decades. Amino acids are key ingredients in chemistry, leading to life as we know it. Many primitive meteorites contain amino acids, and it is generally believed that these are formed by aqueous alterations. In the collector aerogel a...

journal_title：Science advances

authors： Altwegg K,Balsiger H,Bar-Nun A,Berthelier JJ,Bieler A,Bochsler P,Briois C,Calmonte U,Combi MR,Cottin H,De Keyser J,Dhooghe F,Fiethe B,Fuselier SA,Gasc S,Gombosi TI,Hansen KC,Haessig M,Jäckel A,Kopp E,Korth A,Le

更新日期：2016-05-27 00:00:00

abstract：:Neurochemical dysregulation underlies many pathologies and can be monitored by measuring the composition of brain interstitial fluid (ISF). Existing in vivo tools for sampling ISF do not enable measuring large rare molecules, such as proteins and neuropeptides, and thus cannot generate a complete picture of the neuroc...

journal_title：Science advances

authors： Raman R,Rousseau EB,Wade M,Tong A,Cotler MJ,Kuang J,Lugo AA,Zhang E,Graybiel AM,White FM,Langer R,Cima MJ

更新日期：2020-09-25 00:00:00

abstract：:The spin Hall effect allows the generation of spin current when charge current is passed along materials with large spin-orbit coupling. It has been recently predicted that heat current in a nonmagnetic metal can be converted into spin current via a process referred to as the spin Nernst effect. We report the observat...

journal_title：Science advances

authors： Sheng P,Sakuraba Y,Lau YC,Takahashi S,Mitani S,Hayashi M

更新日期：2017-11-03 00:00:00

abstract：:The wings of the black butterfly, Pachliopta aristolochiae, are covered by micro- and nanostructured scales that harvest sunlight over a wide spectral and angular range. Considering that these properties are particularly attractive for photovoltaic applications, we analyze the contribution of these micro- and nanostru...

journal_title：Science advances

authors： Siddique RH,Donie YJ,Gomard G,Yalamanchili S,Merdzhanova T,Lemmer U,Hölscher H

更新日期：2017-10-20 00:00:00

abstract：:Understanding the principles that led to the current complexity of the genetic code is a central question in evolution. Expansion of the genetic code required the selection of new transfer RNAs (tRNAs) with specific recognition signals that allowed them to be matured, modified, aminoacylated, and processed by the ribo...

journal_title：Science advances

authors： Saint-Léger A,Bello C,Dans PD,Torres AG,Novoa EM,Camacho N,Orozco M,Kondrashov FA,Ribas de Pouplana L

更新日期：2016-04-29 00:00:00

abstract：:[This corrects the article DOI: 10.1126/sciadv.aaz7822.]. ...

journal_title：Science advances

authors：

更新日期：2020-07-08 00:00:00

abstract：:l-DOPA treatment for Parkinson's disease frequently leads to dyskinesias, the pathophysiology of which is poorly understood. We used MALDI-MSI to map the distribution of l-DOPA and monoaminergic pathways in brains of dyskinetic and nondyskinetic primates. We report elevated levels of l-DOPA, and its metabolite 3-O-met...

journal_title：Science advances

authors： Fridjonsdottir E,Shariatgorji R,Nilsson A,Vallianatou T,Odell LR,Schembri LS,Svenningsson P,Fernagut PO,Crossman AR,Bezard E,Andrén PE

更新日期：2021-01-06 00:00:00

abstract：:Earth's night sky continuously produces a faint chemiluminescence known as nightglow. Two prominent nighttime emissions around 90 km are the O2 Atmospheric and the OH Meinel band systems. Despite a plethora of studies since their identification seven decades ago, substantial gaps persist in our understanding of the me...

journal_title：Science advances

authors： Kalogerakis KS

更新日期：2019-03-20 00:00:00

abstract：:Spectroscopic methods with nanoscale lateral resolution are becoming essential in the fields of physics, chemistry, geology, biology, and materials science. However, the lateral resolution of laser-based mass spectrometry imaging (MSI) techniques has so far been limited to the microscale. This report presents the deve...

journal_title：Science advances

authors： Liang Z,Zhang S,Li X,Wang T,Huang Y,Hang W,Yang Z,Li J,Tian Z

更新日期：2017-12-08 00:00:00