A sperm peptide enhances long-term memory in female Drosophila.

Abstract:

:Can mating influence cognitive functions such as learning and memory in a permanent way? We have addressed this question using a combined behavioral and in vivo imaging approach, finding that aversive long-term memory performance strongly increases in Drosophila females in response to sperm transfer following mating. A peptide in the male sperm, the sex peptide, is known to cause marked changes in female reproductive behavior, as well as other behaviors such as dietary preference. Here, we demonstrate that this sex peptide enhances memory by acting on a single pair of serotonergic brain neurons, in which activation of the sex peptide receptor stimulates the cyclic adenosine monophosphate/protein kinase A pathway. We thus reveal a strong effect of mating on memory via the neuromodulatory action of a sperm peptide on the female brain.

journal_name

Sci Adv

journal_title

Science advances

authors

Scheunemann L,Lampin-Saint-Amaux A,Schor J,Preat T

doi

10.1126/sciadv.aax3432

subject

Has Abstract

pub_date

2019-11-20 00:00:00

pages

eaax3432

issue

11

issn

2375-2548

pii

aax3432

journal_volume

5

pub_type

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