Abstract:
:Understanding the principles that led to the current complexity of the genetic code is a central question in evolution. Expansion of the genetic code required the selection of new transfer RNAs (tRNAs) with specific recognition signals that allowed them to be matured, modified, aminoacylated, and processed by the ribosome without compromising the fidelity or efficiency of protein synthesis. We show that saturation of recognition signals blocks the emergence of new tRNA identities and that the rate of nucleotide substitutions in tRNAs is higher in species with fewer tRNA genes. We propose that the growth of the genetic code stalled because a limit was reached in the number of identity elements that can be effectively used in the tRNA structure.
journal_name
Sci Advjournal_title
Science advancesauthors
Saint-Léger A,Bello C,Dans PD,Torres AG,Novoa EM,Camacho N,Orozco M,Kondrashov FA,Ribas de Pouplana Ldoi
10.1126/sciadv.1501860subject
Has Abstractpub_date
2016-04-29 00:00:00pages
e1501860issue
4issn
2375-2548pii
1501860journal_volume
2pub_type
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