Abstract:
:Regulatory T (Treg) cells are essential for peripheral tolerance and rely on the transcription factor (TF) Foxp3 for their generation and function. Several other TFs are critical for the Treg cell program. We found that mice deficient in Bcl11b TF solely in Treg cells developed fatal autoimmunity, and Bcl11b-deficient Treg cells had severely altered function. Bcl11b KO Treg cells showed decreased functional marker levels in homeostatic conditions, inflammation, and tumors. Bcl11b controlled expression of essential Treg program genes at steady state and in inflammation. Bcl11b bound to genomic regulatory regions of Treg program genes in both human and mouse Treg cells, overlapping with Foxp3 binding; these genes showed altered chromatin accessibility in the absence of Bcl11b. Additionally, Bcl11b restrained myeloid and NK cell programs in Treg cells. Our study provides new mechanistic insights on the Treg cell program and identity control, with major implications for therapies in autoimmunity and cancer.
journal_name
Sci Advjournal_title
Science advancesauthors
Drashansky TT,Helm E,Huo Z,Curkovic N,Kumar P,Luo X,Parthasarathy U,Zuniga A,Cho JJ,Lorentsen KJ,Xu Z,Uddin M,Moshkani S,Zhou L,Avram Ddoi
10.1126/sciadv.aaw0480subject
Has Abstractpub_date
2019-08-07 00:00:00pages
eaaw0480issue
8issn
2375-2548pii
aaw0480journal_volume
5pub_type
杂志文章相关文献
Science Advances文献大全abstract::Telomerase is a ribonucleoprotein complex that catalyzes addition of telomeric DNA repeats to maintain telomeres in replicating cells. Here, we demonstrate that the telomerase protein hTERT performs an additional role at telomeres that is independent of telomerase catalytic activity yet essential for telomere integrit...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aav4409
更新日期:2019-10-02 00:00:00
abstract::Massive declines in population abundances of marine animals have been documented over century-long time scales. However, analogous loss of spatial extent of habitat-forming organisms is less well known because georeferenced data are rare over long time scales, particularly in subtidal, tropical marine regions. We use ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1603155
更新日期:2017-09-06 00:00:00
abstract::Concern on the impacts of ocean acidification on calcifiers, such as bivalves, sea urchins, and foraminifers, has led to efforts to understand the controls on pH in their habitats, which include kelp forests and seagrass meadows. The metabolism of these habitats can lead to diel fluctuation in pH with increases during...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1501938
更新日期:2016-12-14 00:00:00
abstract::Dirac materials such as graphene and topological insulators (TIs) are known to have unique electronic and spintronic properties. We combine graphene with TIs in van der Waals heterostructures to demonstrate the emergence of a strong proximity-induced spin-orbit coupling in graphene. By performing spin transport and pr...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aat9349
更新日期:2018-09-21 00:00:00
abstract::Soil organic carbon (SOC) stored in permafrost across the high-latitude/altitude Northern Hemisphere represents an important potential carbon source under future warming. Here, we provide a comprehensive investigation on the spatiotemporal dynamics of SOC over the high-altitude Tibetan Plateau (TP), which has received...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaz3513
更新日期:2020-05-06 00:00:00
abstract::The histone demethylase LSD1 is deregulated in several tumors, including leukemias, providing the rationale for the clinical use of LSD1 inhibitors. In acute promyelocytic leukemia (APL), pharmacological doses of retinoic acid (RA) induce differentiation of APL cells, triggering degradation of the PML-RAR oncogene. AP...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aax2746
更新日期:2020-04-08 00:00:00
abstract::Students from underrepresented groups start college with the same level of interest in STEM majors as their peers, but leave STEM at higher rates. We tested the hypothesis that low grades in general chemistry contribute to this "weeding," using records from 25,768 students. In the first course of a general chemistry s...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaz5687
更新日期:2020-06-10 00:00:00
abstract::Photonic crystal nanocavities, which have modal volumes of the order of a cubic wavelength in the material, are of great interest as flexible platforms for manipulating photons. Recent developments in ultra-high quality factor nanocavities with long photon lifetimes have encouraged us to develop an ultra-compact and f...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1501690
更新日期:2016-05-20 00:00:00
abstract::Difunctionalization of alkenes is a valuable and versatile chemical transformation that could quickly build complex molecules. Extensive efforts have been made, and great achievement, such as Sharpless aminohydroxylation and dihydroxylation, has been reached. However, in marked contrast to the extensive research of am...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aat5312
更新日期:2018-08-03 00:00:00
abstract::Electrochemical analysis of sweat using soft bioelectronics on human skin provides a new route for noninvasive glucose monitoring without painful blood collection. However, sweat-based glucose sensing still faces many challenges, such as difficulty in sweat collection, activity variation of glucose oxidase due to lact...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1601314
更新日期:2017-03-08 00:00:00
abstract::The exceptionally long quantum coherence times of phosphorus donor nuclear spin qubits in silicon, coupled with the proven scalability of silicon-based nano-electronics, make them attractive candidates for large-scale quantum computing. However, the high threshold of topological quantum error correction can only be ca...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1500707
更新日期:2015-10-30 00:00:00
abstract::Oxygen isotope speleothem records exhibit coherent variability over the pan-Asian summer monsoon (AM) region. The hydroclimatic representation of these oxygen isotope records for the AM, however, has remained poorly understood. Here, combining an isotope-enabled Earth system model in transient experiments with proxy r...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abe2611
更新日期:2021-01-22 00:00:00
abstract::We tested how sediment trapping by hydroelectric dams affects tropical estuaries by comparing two dammed and two undammed rivers on Mexico's Pacific coast. We found that dams demonstrably affected the stability and productivity of the estuaries. The two rivers dammed for hydroelectricity had a rapid coastal recession ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aau9875
更新日期:2019-03-13 00:00:00
abstract::Controlling the polarization state and the propagation direction of photons is a fundamental prerequisite for many nanophotonic devices and a precursor for future on-chip communication, where the emission properties of individual emitters are particularly relevant. Here, we report on the emission of partially circular...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aav7588
更新日期:2019-06-28 00:00:00
abstract::Mass loss from the West Antarctic ice shelves and glaciers has been linked to basal melt by ocean heat flux. The Totten Ice Shelf in East Antarctica, which buttresses a marine-based ice sheet with a volume equivalent to at least 3.5 m of global sea-level rise, also experiences rapid basal melt, but the role of ocean f...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1601610
更新日期:2016-12-16 00:00:00
abstract::The single-stranded RNA (ssRNA) bacteriophages are among the simplest known viruses with small genomes and exceptionally high mutation rates. The number of ssRNA phage isolates has remained very low, but recent metagenomic studies have uncovered an immense variety of distinct uncultured ssRNA phages. The coat proteins...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abc0023
更新日期:2020-09-02 00:00:00
abstract::Self-assembly of colloidal nanocrystals into complex superstructures offers notable opportunities to create functional devices and artificial materials with unusual properties. Anisotropic nanoparticles with nonspherical shapes, such as rods, plates, polyhedra, and multipods, enable the formation of a diverse range of...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1701183
更新日期:2017-10-27 00:00:00
abstract::We reveal an intriguing manifestation of topology, which appears in the depletion rate of topological states of matter in response to an external drive. This phenomenon is presented by analyzing the response of a generic two-dimensional (2D) Chern insulator subjected to a circular time-periodic perturbation. Because o...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1701207
更新日期:2017-08-18 00:00:00
abstract::The impact of the FMR1 premutation on human health is the subject of considerable controversy. A fundamental unanswered question is whether carrying the premutation allele is directly correlated with clinical phenotypes. A challenging problem in past genotype-phenotype studies of the FMR1 premutation is ascertainment ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaw7195
更新日期:2019-08-21 00:00:00
abstract::Chiral fermions in solid state feature "Fermi arc" states, connecting the surface projections of the bulk chiral nodes. The surface Fermi arc is a signature of nontrivial bulk topology. Unconventional chiral fermions with an extensive Fermi arc traversing the whole Brillouin zone have been theoretically proposed in Co...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaw9485
更新日期:2019-12-20 00:00:00
abstract::[This corrects the article e1602026 in vol. 3, PMID: 28246641.]. ...
journal_title:Science advances
pub_type: 杂志文章,已发布勘误
doi:10.1126/sciadv.aaq0565
更新日期:2017-09-29 00:00:00
abstract::Improved constraints on lower-mantle composition are fundamental to understand the accretion, differentiation, and thermochemical evolution of our planet. Cosmochemical arguments indicate that lower-mantle rocks may be enriched in Si relative to upper-mantle pyrolite, whereas seismic tomography images suggest whole-ma...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1500815
更新日期:2015-12-10 00:00:00
abstract::Metabolic reprogramming is widely considered a hallmark of cancer, and understanding metabolic dynamics described by the conversion rates or "fluxes" of metabolites can shed light onto biological processes of tumorigenesis and response to therapy. For real-time analysis of metabolic flux in intact cells or organisms, ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1700341
更新日期:2017-06-16 00:00:00
abstract::Modern tropical forests harbor an enormous diversity of squamates, but fossilization in such environments is uncommon and little is known about tropical lizard assemblages of the Mesozoic. We report the oldest lizard assemblage preserved in amber, providing insight into the poorly preserved but potentially diverse mid...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1501080
更新日期:2016-03-04 00:00:00
abstract::We have developed a way to map brain-wide networks using focal pulsed infrared neural stimulation in ultrahigh-field magnetic resonance imaging (MRI). The patterns of connections revealed are similar to those of connections previously mapped with anatomical tract tracing methods. These include connections between cort...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aau7046
更新日期:2019-04-24 00:00:00
abstract::Two-dimensional (2D) polymers hold great promise in the rational materials design tailored for next-generation applications. However, little is known about the grain boundaries in 2D polymers, not to mention their formation mechanisms and potential influences on the material's functionalities. Using aberration-correct...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb5976
更新日期:2020-08-14 00:00:00
abstract::Optogenetics is a paradigm-changing new method to study and manipulate the behavior of cells with light. Following major advances of the used genetic constructs over the last decade, the light sources required for optogenetic control are now receiving increased attention. We report a novel optogenetic illumination pla...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1600061
更新日期:2016-05-06 00:00:00
abstract::Leukemia is a complex heterogeneous disease often driven by the expression of oncogenic fusion proteins with different molecular and biochemical properties. Whereas several fusion proteins induce leukemogenesis by activating Hox gene expression (Hox-activating fusions), others impinge on different pathways that do not...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1600972
更新日期:2016-10-07 00:00:00
abstract::Changes in the Atlantic Meridional Overturning Circulation (AMOC) are moderate in most climate model projections under increasing greenhouse gas forcing. This intermodel consensus may be an artifact of common model biases that favor a stable AMOC. Observationally based freshwater budget analyses suggest that the AMOC ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1601666
更新日期:2017-01-04 00:00:00
abstract::Adoptive cell transfers have emerged as a disruptive approach to treat disease in a manner that is more specific than using small-molecule drugs; however, unlike traditional drugs, cells are living entities that can alter their function in response to environmental cues. In the present study, we report an engineered p...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaz6579
更新日期:2020-04-29 00:00:00