Abstract:
:Ultraviolet (UV) reception is useful for such basic behaviors as mate choice, foraging, predator avoidance, communication, and navigation, whereas violet reception improves visual resolution and subtle contrast detection. UV and violet reception are mediated by the short wavelength-sensitive (SWS1) pigments that absorb light maximally (λmax) at ~360 nm and ~395 to 440 nm, respectively. Because of strong nonadditive (epistatic) interactions among amino acid changes in the pigments, the adaptive evolutionary mechanisms of these phenotypes are not well understood. Evolution of the violet pigment of the African clawed frog (Xenopus laevis, λmax = 423 nm) from the UV pigment in the amphibian ancestor (λmax = 359 nm) can be fully explained by eight mutations in transmembrane (TM) I-III segments. We show that epistatic interactions involving the remaining TM IV-VII segments provided evolutionary potential for the frog pigment to gradually achieve its violet-light reception by tuning its color sensitivity in small steps. Mutants in these segments also impair pigments that would cause drastic spectral shifts and thus eliminate them from viable evolutionary pathways. The overall effects of epistatic interactions involving TM IV-VII segments have disappeared at the last evolutionary step and thus are not detectable by studying present-day pigments. Therefore, characterizing the genotype-phenotype relationship during each evolutionary step is the key to uncover the true nature of epistasis.
journal_name
Sci Advjournal_title
Science advancesauthors
Yokoyama S,Altun A,Jia H,Yang H,Koyama T,Faggionato D,Liu Y,Starmer WTdoi
10.1126/sciadv.1500162subject
Has Abstractpub_date
2015-09-18 00:00:00pages
e1500162issue
8issn
2375-2548pii
1500162journal_volume
1pub_type
杂志文章相关文献
Science Advances文献大全abstract::The retinoic acid-inducible gene I (RIG-I) innate immune receptor is an important immunotherapeutic target, but we lack approaches for monitoring the physical basis for its activation in vitro. This gap in our understanding has led to confusion about mechanisms of RIG-I activation and difficulty discovering agonists a...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aax3641
更新日期:2019-10-02 00:00:00
abstract::Traumatic spinal cord injury (SCI) brings numerous inflammatory cells, including macrophages, from the circulating blood to lesions, but pathophysiological impact resulting from spatiotemporal dynamics of macrophages is unknown. Here, we show that macrophages centripetally migrate toward the lesion epicenter after inf...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aav5086
更新日期:2019-05-15 00:00:00
abstract::Several forms of hair loss in humans are characterized by the inability of hair follicles to enter the growth phase (anagen) of the hair cycle after being arrested in the resting phase (telogen). Current pharmacologic therapies have been largely unsuccessful in targeting pathways that can be selectively modulated to i...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1500973
更新日期:2015-10-23 00:00:00
abstract::An immense demand in biomedical imaging is to develop efficient photoluminescent probes with high biocompatibility and quantum yield, as well as multiphoton absorption performance to improve penetration depth and spatial resolution. Here, iron selenide (FeSe) quantum dots (QDs) are reported to meet these criteria. The...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aay0044
更新日期:2019-12-06 00:00:00
abstract::We review recent advances in our understanding of magnetism in the solar nebula and protoplanetary disks (PPDs). We discuss the implications of theory, meteorite measurements, and astronomical observations for planetary formation and nebular evolution. Paleomagnetic measurements indicate the presence of fields of 0.54...
journal_title:Science advances
pub_type: 杂志文章,评审
doi:10.1126/sciadv.aba5967
更新日期:2021-01-01 00:00:00
abstract::Metabolic reprogramming is a major factor in transformation, and particular metabolic phenotypes correlate with oncogenotype, tumor progression, and metastasis. By profiling metabolites in 17 patient-derived xenograft melanoma models, we identified durable metabolomic signatures that correlate with biological features...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aao5268
更新日期:2017-11-01 00:00:00
abstract::Infants' remarkable learning abilities allow them to rapidly acquire many complex skills. It has been suggested that infants achieve this learning by optimally allocating their attention to relevant stimuli in the environment, but the underlying mechanisms remain poorly understood. Here, we modeled infants' looking be...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb5053
更新日期:2020-09-23 00:00:00
abstract::Glutathione (GSH), the most abundant nonprotein thiol functioning as an antioxidant, plays critical roles in maintaining the core functions of mesenchymal stem cells (MSCs), which are used as a cellular immunotherapy for graft-versus-host disease (GVHD). However, the role of GSH dynamics in MSCs remains elusive. Genom...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aba1334
更新日期:2020-04-15 00:00:00
abstract::The lipid bilayer membrane, which is the foundation of life on Earth, is not viable outside of biology based on liquid water. This fact has caused astronomers who seek conditions suitable for life to search for exoplanets within the "habitable zone," the narrow band in which liquid water can exist. However, can cell m...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1400067
更新日期:2015-02-27 00:00:00
abstract::Interaction of swimming bacteria with flows controls their ability to explore complex environments, crucial to many societal and environmental challenges and relevant for microfluidic applications such as cell sorting. Combining experimental, numerical, and theoretical analysis, we present a comprehensive study of the...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb2012
更新日期:2020-07-10 00:00:00
abstract::The process of sheep and goat (caprine) domestication began by 9000 to 8000 BCE in Southwest Asia. The early Neolithic site at Aşıklı Höyük in central Turkey preserves early archaeological evidence of this transformation, such as culling by age and sex and use of enclosures inside the settlement. People's strategies f...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaw0038
更新日期:2019-04-17 00:00:00
abstract::Nanomaterials often surprise us with unexpected phenomena. Here, we report a discovery of the anti-twinning deformation, previously thought impossible, in nanoscale body-centered cubic (BCC) tungsten crystals. By conducting in situ transmission electron microscopy nanomechanical testing, we observed the nucleation and...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aay2792
更新日期:2020-06-03 00:00:00
abstract::Organic matter burial in mangrove forests results in the removal and long-term storage of atmospheric CO2, so-called "blue carbon." However, some of this organic matter is metabolized and returned to the atmosphere as CH4. Because CH4 has a higher global warming potential than the CO2 fixed in the organic matter, it c...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aao4985
更新日期:2018-06-13 00:00:00
abstract::Approaching predators cast expanding shadows (i.e., looming) that elicit innate defensive responses in most animals. Where looming is first detected and how critical parameters of predatory approaches are extracted are unclear. In mice, we identify a retinal interneuron (the VG3 amacrine cell) that responds robustly t...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abc9920
更新日期:2020-11-18 00:00:00
abstract::Adaptation is a fundamental property of sensory systems that can change subjective experiences in the context of recent information. Adaptation has been postulated to arise from recurrent circuit mechanisms or as a consequence of neuronally intrinsic suppression. However, it is unclear whether intrinsic suppression by...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abd4205
更新日期:2020-10-14 00:00:00
abstract::A novel, thin-film platform that preserves live viruses, bacteria, antibodies, and enzymes without refrigeration for extended periods of time is described. Studies with recombinant adenovirus in an optimized formulation that supports recovery of live virus through 16 freeze-thaw cycles revealed that production of an a...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aau4819
更新日期:2020-03-04 00:00:00
abstract::The repair of DNA double-strand breaks occurs through nonhomologous end joining or homologous recombination in vertebrate cells-a choice that is thought to be decided by a competition between DNA-dependent protein kinase (DNA-PK) and the Mre11/Rad50/Nbs1 (MRN) complex but is not well understood. Using ensemble biochem...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aay0922
更新日期:2020-01-08 00:00:00
abstract::Organic carbonyl compounds represent a promising class of electrode materials for secondary batteries; however, the storage mechanism still remains unclear. We take Na2C6H2O4 as an example to unravel the mechanism. It consists of alternating Na-O octahedral inorganic layer and π-stacked benzene organic layer in spatia...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1500330
更新日期:2015-09-18 00:00:00
abstract::Ice accretion has a negative impact on critical infrastructure, as well as a range of commercial and residential activities. Icephobic surfaces are defined by an ice adhesion strength τice < 100 kPa. However, the passive removal of ice requires much lower values of τice, such as on airplane wings or power lines (τice ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1501496
更新日期:2016-03-11 00:00:00
abstract::Cost-benefit trade-offs for individuals participating in social behaviors are the basis for current theories on the evolution of social behaviors and societies. However, research on social strategies has largely ignored solitary animals, in which we assume that rare interactions are explained by courtship or territori...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1701218
更新日期:2017-10-11 00:00:00
abstract::The fabrication of three-dimensional (3D) objects by polymer self-assembly in solution is extremely challenging. Here, multi-tori mesostructures were obtained from the crystallization-driven self-assembly of a coil-crystalline block copolymer (BCP) in mixed solvents. The formation of these structures follows a multist...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaz7301
更新日期:2020-04-15 00:00:00
abstract::The transcriptional repressors Polycomb repressive complex 1 (PRC1) and PRC2 are required to maintain cell fate during embryonic development. PRC1 and PRC2 catalyze distinct histone modifications, establishing repressive chromatin at shared targets. How PRC1, which consists of canonical PRC1 (cPRC1) and variant PRC1 (...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aax5692
更新日期:2020-04-01 00:00:00
abstract::NSF (N-ethylmaleimide-sensitive factor) and α-SNAP (α-soluble NSF attachment protein) bind to the SNARE (soluble NSF attachment protein receptor) complex, the minimum machinery to mediate membrane fusion, to form a 20S complex, which disassembles the SNARE complex for reuse. We report the cryo-EM structures of the α-S...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aau8164
更新日期:2019-04-10 00:00:00
abstract::Black phosphorus (BP) offers considerable promise for infrared and visible photonics. Efficient tuning of the bandgap and higher subbands in BP by modulation of the Fermi level or application of vertical electric fields has been previously demonstrated, allowing electrical control of its above-bandgap optical properti...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abd4623
更新日期:2021-01-08 00:00:00
abstract::Plants produce a myriad of taxonomically restricted specialized metabolites. This diversity-and our ability to correlate genotype with phenotype-makes the evolution of these ecologically and medicinally important compounds interesting and experimentally tractable. Trichomes of tomato and other nightshade family plants...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaw3754
更新日期:2019-04-24 00:00:00
abstract::A withdrawal-associated impairment in β-endorphin neurotransmission in the arcuate nucleus (ARC) of the hypothalamus is associated with alcohol dependence characterized by a chronic relapsing disorder. Although acupuncture activates β-endorphin neurons in the ARC projecting to the nucleus accumbens (NAc), a role for A...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aax1342
更新日期:2019-09-04 00:00:00
abstract::Ascomycota, the largest and most well-studied phylum of fungi, contains three subphyla: Saccharomycotina (budding yeasts), Pezizomycotina (filamentous fungi), and Taphrinomycotina (fission yeasts). Despite its importance, we lack a comprehensive genome-scale phylogeny or understanding of the similarities and differenc...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abd0079
更新日期:2020-11-04 00:00:00
abstract::Fluid catalytic cracking (FCC) particles account for 40 to 45% of worldwide gasoline production. The hierarchical complex particle pore structure allows access of long-chain feedstock molecules into active catalyst domains where they are cracked into smaller, more valuable hydrocarbon products (for example, gasoline)....
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1400199
更新日期:2015-04-03 00:00:00
abstract::Dual-comb spectroscopy allows for high-resolution spectra to be measured over broad bandwidths, but an essential requirement for coherent integration is the availability of a phase reference. Usually, this means that the combs' phase and timing errors must be measured and either minimized by stabilization or removed b...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1601227
更新日期:2016-11-11 00:00:00
abstract::After European colonization, the ancestral remains of Indigenous people were often collected for scientific research or display in museum collections. For many decades, Indigenous people, including Native Americans and Aboriginal Australians, have fought for their return. However, many of these remains have no recorde...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aau5064
更新日期:2018-12-19 00:00:00