The abundance of metabolites related to protein methylation correlates with the metastatic capacity of human melanoma xenografts.

abstract：:Massive declines in population abundances of marine animals have been documented over century-long time scales. However, analogous loss of spatial extent of habitat-forming organisms is less well known because georeferenced data are rare over long time scales, particularly in subtidal, tropical marine regions. We use ...

journal_title：Science advances

authors： McClenachan L,O'Connor G,Neal BP,Pandolfi JM,Jackson JBC

更新日期：2017-09-06 00:00:00

abstract：:Ammonia synthesis consumes 3 to 5% of the world's natural gas, making it a significant contributor to greenhouse gas emissions. Strategies for synthesizing ammonia that are not dependent on the energy-intensive and methane-based Haber-Bosch process are critically important for reducing global energy consumption and mi...

journal_title：Science advances

authors： Song Y,Johnson D,Peng R,Hensley DK,Bonnesen PV,Liang L,Huang J,Yang F,Zhang F,Qiao R,Baddorf AP,Tschaplinski TJ,Engle NL,Hatzell MC,Wu Z,Cullen DA,Meyer HM 3rd,Sumpter BG,Rondinone AJ

更新日期：2018-04-27 00:00:00

abstract：:Organophosphate-based pesticides inhibit acetylcholinesterase (AChE), which plays a pivotal role in neuromuscular function. While spraying in the field, farmworkers get exposed to pesticides through the dermal route. Internalized pesticide inhibits AChE, which leads to neurotoxicity, cardiotoxicity, cognitive dysfunct...

journal_title：Science advances

authors： Thorat K,Pandey S,Chandrashekharappa S,Vavilthota N,Hiwale AA,Shah P,Sreekumar S,Upadhyay S,Phuntsok T,Mahato M,Mudnakudu-Nagaraju KK,Sunnapu O,Vemula PK

更新日期：2018-10-17 00:00:00

abstract：:Nanometer-scale skyrmions are prospective candidates for information bits in low-power consumption devices owing to their topological nature and controllability with low current density. Studies on skyrmion dynamics in different classes of materials have exploited the topological Hall effect and current-driven fast mo...

journal_title：Science advances

authors： Yu XZ,Morikawa D,Nakajima K,Shibata K,Kanazawa N,Arima T,Nagaosa N,Tokura Y

更新日期：2020-06-17 00:00:00

abstract：:Mucoadhesive particles (MAP) have been widely explored for pulmonary drug delivery because of their perceived benefits in improving particle residence in the lungs. However, retention of particles adhesively trapped in airway mucus may be limited by physiologic mucus clearance mechanisms. In contrast, particles that a...

journal_title：Science advances

authors： Schneider CS,Xu Q,Boylan NJ,Chisholm J,Tang BC,Schuster BS,Henning A,Ensign LM,Lee E,Adstamongkonkul P,Simons BW,Wang SS,Gong X,Yu T,Boyle MP,Suk JS,Hanes J

更新日期：2017-04-05 00:00:00

abstract：:Among the existing elemental characterization techniques, particle-induced x-ray emission (PIXE) and energy-dispersive x-ray (EDX) spectroscopy are two of the most widely used in different scientific and technological fields. Here, we present the first quantitative laser-driven PIXE and laser-driven EDX experimental i...

journal_title：Science advances

authors： Mirani F,Maffini A,Casamichiela F,Pazzaglia A,Formenti A,Dellasega D,Russo V,Vavassori D,Bortot D,Huault M,Zeraouli G,Ospina V,Malko S,Apiñaniz JI,Pérez-Hernández JA,De Luis D,Gatti G,Volpe L,Pola A,Passoni M

更新日期：2021-01-15 00:00:00

abstract：:Charge order is universal among high-Tc cuprates, but its relation to superconductivity is unclear. While static order competes with superconductivity, dynamic order may be favorable and even contribute to Cooper pairing. Using time-resolved resonant soft x-ray scattering at a free-electron laser, we show that the cha...

journal_title：Science advances

authors： Mitrano M,Lee S,Husain AA,Delacretaz L,Zhu M,de la Peña Munoz G,Sun SX,Joe YI,Reid AH,Wandel SF,Coslovich G,Schlotter W,van Driel T,Schneeloch J,Gu GD,Hartnoll S,Goldenfeld N,Abbamonte P

更新日期：2019-08-16 00:00:00

abstract：:Microbial communities are self-controlled by repertoires of lethal agents, the antibiotics. In their turn, these antibiotics are regulated by bioscavengers that are selected in the course of evolution. Kinase-mediated phosphorylation represents one of the general strategies for the emergence of antibiotic resistance. ...

journal_title：Science advances

authors： Terekhov SS,Mokrushina YA,Nazarov AS,Zlobin A,Zalevsky A,Bourenkov G,Golovin A,Belogurov A Jr,Osterman IA,Kulikova AA,Mitkevich VA,Lou HJ,Turk BE,Wilmanns M,Smirnov IV,Altman S,Gabibov AG

更新日期：2020-06-24 00:00:00

abstract：:Understanding the precise atomic structure of ice surfaces is critical for revealing the mechanisms of physical and chemical phenomena at the surfaces, such as ice growth, melting, and chemical reactions. Nevertheless, no conclusive structure has been established. In this study, noncontact atomic force microscopy was ...

journal_title：Science advances

authors： Kawakami N,Iwata K,Shiotari A,Sugimoto Y

更新日期：2020-09-11 00:00:00

abstract：:Implanted brain electrodes construct the only means to electrically interface with individual neurons in vivo, but their recording efficacy and biocompatibility pose limitations on scientific and clinical applications. We showed that nanoelectronic thread (NET) electrodes with subcellular dimensions, ultraflexibility,...

journal_title：Science advances

authors： Luan L,Wei X,Zhao Z,Siegel JJ,Potnis O,Tuppen CA,Lin S,Kazmi S,Fowler RA,Holloway S,Dunn AK,Chitwood RA,Xie C

更新日期：2017-02-15 00:00:00

abstract：:Hydrogen sulfide (H2S) is a gasotransmitter and a potential therapeutic agent. However, molecular targets relevant to its therapeutic actions remain enigmatic. Sulfide-quinone oxidoreductase (SQR) irreversibly oxidizes H2S. Therefore, SQR is assumed to inhibit H2S signaling. We now report that SQR-mediated oxidation o...

journal_title：Science advances

authors： Jia J,Wang Z,Zhang M,Huang C,Song Y,Xu F,Zhang J,Li J,He M,Li Y,Ao G,Hong C,Cao Y,Chin YE,Hua ZC,Cheng J

更新日期：2020-08-26 00:00:00

abstract：:Species interactions have long been predicted to increase in intensity toward the tropics and low elevations because of gradients in climate, productivity, or biodiversity. Despite their importance for understanding global ecological and evolutionary processes, plant-animal interaction gradients are particularly diffi...

journal_title：Science advances

authors： Hargreaves AL,Suárez E,Mehltreter K,Myers-Smith I,Vanderplank SE,Slinn HL,Vargas-Rodriguez YL,Haeussler S,David S,Muñoz J,Carlos Almazán-Núñez R,Loughnan D,Benning JW,Moeller DA,Brodie JF,Thomas HJD,Morales M PA

更新日期：2019-02-20 00:00:00

abstract：:Hypertrophic cardiomyopathy (HCM) is a heterogeneous genetic heart muscle disease characterized by hypertrophy with preserved or increased ejection fraction in the absence of secondary causes. However, recent studies have demonstrated that a substantial proportion of individuals with HCM also have comorbid diabetes me...

journal_title：Science advances

authors： Dhandapany PS,Kang S,Kashyap DK,Rajagopal R,Sundaresan NR,Singh R,Thangaraj K,Jayaprakash S,Manjunath CN,Shenthar J,Lebeche D

更新日期：2021-01-06 00:00:00

abstract：:The impact of the FMR1 premutation on human health is the subject of considerable controversy. A fundamental unanswered question is whether carrying the premutation allele is directly correlated with clinical phenotypes. A challenging problem in past genotype-phenotype studies of the FMR1 premutation is ascertainment ...

journal_title：Science advances

authors： Movaghar A,Page D,Brilliant M,Baker MW,Greenberg J,Hong J,DaWalt LS,Saha K,Kuusisto F,Stewart R,Berry-Kravis E,Mailick MR

更新日期：2019-08-21 00:00:00

abstract：:Estimating minimum ice volume during the last interglacial based on local sea-level indicators requires that these indicators are corrected for processes that alter local sea level relative to the global average. Although glacial isostatic adjustment is generally accounted for, global scale dynamic changes in topograp...

journal_title：Science advances

authors： Austermann J,Mitrovica JX,Huybers P,Rovere A

更新日期：2017-07-07 00:00:00

abstract：:Yearly, a quarter billion people are infected and a half a million killed by the mosquito-borne disease malaria. Lack of real-time observational tools for continuously assessing the unperturbed mosquito flight activity in situ limits progress toward improved vector control. We deployed a high-resolution entomological ...

journal_title：Science advances

authors： Brydegaard M,Jansson S,Malmqvist E,Mlacha YP,Gebru A,Okumu F,Killeen GF,Kirkeby C

更新日期：2020-05-13 00:00:00

abstract：:By experimentally studying high-order harmonic beams generated in gases, we show how the spatial characteristics of these ultrashort extreme-ultraviolet (XUV) beams can be finely controlled when a single fundamental beam generates harmonics in a thin gas medium. We demonstrate that these XUV beams can be emitted as co...

journal_title：Science advances

authors： Quintard L,Strelkov V,Vabek J,Hort O,Dubrouil A,Descamps D,Burgy F,Péjot C,Mével E,Catoire F,Constant E

更新日期：2019-04-05 00:00:00

abstract：:We have developed a way to map brain-wide networks using focal pulsed infrared neural stimulation in ultrahigh-field magnetic resonance imaging (MRI). The patterns of connections revealed are similar to those of connections previously mapped with anatomical tract tracing methods. These include connections between cort...

journal_title：Science advances

authors： Xu AG,Qian M,Tian F,Xu B,Friedman RM,Wang J,Song X,Sun Y,Chernov MM,Cayce JM,Jansen ED,Mahadevan-Jansen A,Zhang X,Chen G,Roe AW

更新日期：2019-04-24 00:00:00

abstract：:Transplantation with donor corneas is the mainstay for treating corneal blindness, but a severe worldwide shortage necessitates the development of other treatment options. Corneal perforation from infection or inflammation is sealed with cyanoacrylate glue. However, the resulting cytotoxicity requires transplantation....

journal_title：Science advances

authors： McTiernan CD,Simpson FC,Haagdorens M,Samarawickrama C,Hunter D,Buznyk O,Fagerholm P,Ljunggren MK,Lewis P,Pintelon I,Olsen D,Edin E,Groleau M,Allan BD,Griffith M

更新日期：2020-06-17 00:00:00

abstract：:Nanomaterials often surprise us with unexpected phenomena. Here, we report a discovery of the anti-twinning deformation, previously thought impossible, in nanoscale body-centered cubic (BCC) tungsten crystals. By conducting in situ transmission electron microscopy nanomechanical testing, we observed the nucleation and...

journal_title：Science advances

authors： Wang J,Zeng Z,Wen M,Wang Q,Chen D,Zhang Y,Wang P,Wang H,Zhang Z,Mao SX,Zhu T

更新日期：2020-06-03 00:00:00

abstract：:Earthquake forecasting is the ultimate challenge for seismologists, because it condenses the scientific knowledge about the earthquake occurrence process, and it is an essential component of any sound risk mitigation planning. It is commonly assumed that, in the short term, trustworthy earthquake forecasts are possibl...

journal_title：Science advances

authors： Marzocchi W,Taroni M,Falcone G

更新日期：2017-09-13 00:00:00

abstract：:Wearable textile electronics are highly desirable for realizing personalized health management. However, most reported textile electronics can either periodically target a single physiological signal or miss the explicit details of the signals, leading to a partial health assessment. Furthermore, textiles with excelle...

journal_title：Science advances

authors： Fan W,He Q,Meng K,Tan X,Zhou Z,Zhang G,Yang J,Wang ZL

更新日期：2020-03-13 00:00:00

abstract：:The control of product distribution in a multistep catalytic selective hydrogenation reaction is challenging. For instance, the deep hydrogenation of dimethyl oxalate (DMO) is inclined to proceed over Cu/SiO2 catalysts because of inevitable coexistence of Cu+ and Cu0, leading to hard acquisition of the preliminary hyd...

journal_title：Science advances

authors： Sun J,Yu J,Ma Q,Meng F,Wei X,Sun Y,Tsubaki N

更新日期：2018-12-21 00:00:00

abstract：:Variations in Earth's orbit pace the glacial-interglacial cycles of the Quaternary, but the mechanisms that transform regional and seasonal variations in solar insolation into glacial-interglacial cycles are still elusive. Here, we present transient simulations of coevolution of climate, ice sheets, and carbon cycle o...

journal_title：Science advances

authors： Willeit M,Ganopolski A,Calov R,Brovkin V

更新日期：2019-04-03 00:00:00

abstract：:Previous breakthroughs in stretchable electronics stem from strain engineering and nanocomposite approaches. Routes toward intrinsically stretchable molecular materials remain scarce but, if successful, will enable simpler fabrication processes, such as direct printing and coating, mechanically robust devices, and mor...

journal_title：Science advances

authors： Wang Y,Zhu C,Pfattner R,Yan H,Jin L,Chen S,Molina-Lopez F,Lissel F,Liu J,Rabiah NI,Chen Z,Chung JW,Linder C,Toney MF,Murmann B,Bao Z

更新日期：2017-03-10 00:00:00

abstract：:The natural selection and the evolutionary optimization of complex shapes in nature are closely related to their functions. Mechanostabilization of shape of biological structure via morphogenesis has several beautiful examples. With the help of simple mechanics-based modeling and experiments, we show an important caus...

journal_title：Science advances

authors： Tiwary CS,Kishore S,Sarkar S,Mahapatra DR,Ajayan PM,Chattopadhyay K

更新日期：2015-05-15 00:00:00

abstract：:Characterizing and understanding the emergence of multiple macroscopically ordered electronic phases through subtle tuning of temperature, pressure, and chemical doping has been a long-standing central issue for complex materials research. We report the first comprehensive studies of optical doping-induced emergence o...

journal_title：Science advances

authors： Han TR,Zhou F,Malliakas CD,Duxbury PM,Mahanti SD,Kanatzidis MG,Ruan CY

更新日期：2015-06-26 00:00:00

abstract：:The single-stranded RNA (ssRNA) bacteriophages are among the simplest known viruses with small genomes and exceptionally high mutation rates. The number of ssRNA phage isolates has remained very low, but recent metagenomic studies have uncovered an immense variety of distinct uncultured ssRNA phages. The coat proteins...

journal_title：Science advances

authors： Rūmnieks J,Liekniņa I,Kalniņš G,Šišovs M,Akopjana I,Bogans J,Tārs K

更新日期：2020-09-02 00:00:00

abstract：:Impaired mitochondrial dynamics and function are hallmarks of many neurological and psychiatric disorders, but direct screens for mitotherapeutics using neurons have not been reported. We developed a multiplexed and high-content screening assay using primary neurons and identified 67 small-molecule modulators of neuro...

journal_title：Science advances

authors： Varkuti BH,Kepiro M,Liu Z,Vick K,Avchalumov Y,Pacifico R,MacMullen CM,Kamenecka TM,Puthanveettil SV,Davis RL

更新日期：2020-01-08 00:00:00

abstract：:Porous membranes with ultrafast ion permeation and high ion selectivity are highly desirable for efficient mineral separation, water purification, and energy conversion, but it is still a huge challenge to efficiently separate monatomic ions of the same valence and similar sizes using synthetic membranes. We report me...

journal_title：Science advances

authors： Zhang H,Hou J,Hu Y,Wang P,Ou R,Jiang L,Liu JZ,Freeman BD,Hill AJ,Wang H

更新日期：2018-02-09 00:00:00