Intrinsic reconstruction of ice-I surfaces.

abstract：:Mucoadhesive particles (MAP) have been widely explored for pulmonary drug delivery because of their perceived benefits in improving particle residence in the lungs. However, retention of particles adhesively trapped in airway mucus may be limited by physiologic mucus clearance mechanisms. In contrast, particles that a...

journal_title：Science advances

authors： Schneider CS,Xu Q,Boylan NJ,Chisholm J,Tang BC,Schuster BS,Henning A,Ensign LM,Lee E,Adstamongkonkul P,Simons BW,Wang SS,Gong X,Yu T,Boyle MP,Suk JS,Hanes J

更新日期：2017-04-05 00:00:00

abstract：:Extinction of conditioned fear necessitates the dynamic involvement of hippocampus, medial prefrontal cortex (mPFC), and basolateral amygdala (BLA), but key molecular players that regulate these circuits to achieve fear extinction remain largely unknown. Here, we report that acid-sensing ion channel 1a (ASIC1a) is a c...

journal_title：Science advances

authors： Wang Q,Wang Q,Song XL,Jiang Q,Wu YJ,Li Y,Yuan TF,Zhang S,Xu NJ,Zhu MX,Li WG,Xu TL

更新日期：2018-10-24 00:00:00

abstract：:LmrA is a bacterial ATP-binding cassette (ABC) multidrug exporter that uses metabolic energy to transport ions, cytotoxic drugs, and lipids. Voltage clamping in a Port-a-Patch was used to monitor electrical currents associated with the transport of monovalent cationic HEPES+ by single-LmrA transporters and ensembles o...

journal_title：Science advances

authors： Agboh K,Lau CHF,Khoo YSK,Singh H,Raturi S,Nair AV,Howard J,Chiapello M,Feret R,Deery MJ,Murakami S,van Veen HW

更新日期：2018-09-19 00:00:00

abstract：:Goat domestication was critical for agriculture and civilization, but its underlying genetic changes and selection regimes remain unclear. Here, we analyze the genomes of worldwide domestic goats, wild caprid species, and historical remains, providing evidence of an ancient introgression event from a West Caucasian tu...

journal_title：Science advances

authors： Zheng Z,Wang X,Li M,Li Y,Yang Z,Wang X,Pan X,Gong M,Zhang Y,Guo Y,Wang Y,Liu J,Cai Y,Chen Q,Okpeku M,Colli L,Cai D,Wang K,Huang S,Sonstegard TS,Esmailizadeh A,Zhang W,Zhang T,Xu Y,Xu N,Yang Y,Han J,C

更新日期：2020-05-20 00:00:00

abstract：:Mobile genetic elements, such as human endogenous retroviruses (HERVs), produce proteins that regulate brain cell functions and synaptic transmission and have been implicated in the etiology of neurological and neurodevelopmental psychiatric disorders. However, the mechanisms by which these proteins of retroviral orig...

journal_title：Science advances

authors： Johansson EM,Bouchet D,Tamouza R,Ellul P,Morr AS,Avignone E,Germi R,Leboyer M,Perron H,Groc L

更新日期：2020-07-17 00:00:00

abstract：:Dewetting is a ubiquitous phenomenon in nature; many different thin films of organic and inorganic substances (such as liquids, polymers, metals, and semiconductors) share this shape instability driven by surface tension and mass transport. Via templated solid-state dewetting, we frame complex nanoarchitectures of mon...

journal_title：Science advances

authors： Naffouti M,Backofen R,Salvalaglio M,Bottein T,Lodari M,Voigt A,David T,Benkouider A,Fraj I,Favre L,Ronda A,Berbezier I,Grosso D,Abbarchi M,Bollani M

更新日期：2017-11-10 00:00:00

abstract：:The symmetry of metallic nanocolloids, typically envisaged as simple geometrical shapes, is rarely questioned. However, the symmetry considerations are so essential for understanding their electronic structure, optical properties, and biological effects that it is important to reexamine these foundational assumptions ...

journal_title：Science advances

authors： Kim JY,Han MG,Lien MB,Magonov S,Zhu Y,George H,Norris TB,Kotov NA

更新日期：2018-02-09 00:00:00

abstract：:Ammonia synthesis consumes 3 to 5% of the world's natural gas, making it a significant contributor to greenhouse gas emissions. Strategies for synthesizing ammonia that are not dependent on the energy-intensive and methane-based Haber-Bosch process are critically important for reducing global energy consumption and mi...

journal_title：Science advances

authors： Song Y,Johnson D,Peng R,Hensley DK,Bonnesen PV,Liang L,Huang J,Yang F,Zhang F,Qiao R,Baddorf AP,Tschaplinski TJ,Engle NL,Hatzell MC,Wu Z,Cullen DA,Meyer HM 3rd,Sumpter BG,Rondinone AJ

更新日期：2018-04-27 00:00:00

abstract：:[This corrects the article DOI: 10.1126/sciadv.aar3761.]. ...

journal_title：Science advances

authors：

更新日期：2018-07-06 00:00:00

abstract：:The control and use of light polarization in optical sciences and engineering are widespread. Despite remarkable developments in polarization-resolved imaging for life sciences, their transposition to strongly scattering media is currently not possible, because of the inherent depolarization effects arising from multi...

journal_title：Science advances

authors： de Aguiar HB,Gigan S,Brasselet S

更新日期：2017-09-01 00:00:00

abstract：:Soft robotics may enable many new technologies in which humans and robots physically interact, yet the necessary high-performance soft actuators still do not exist. The optimal soft actuators need to be fast and forceful and have programmable shape changes. Furthermore, they should be energy efficient for untethered a...

journal_title：Science advances

authors： Davidson ZS,Shahsavan H,Aghakhani A,Guo Y,Hines L,Xia Y,Yang S,Sitti M

更新日期：2019-11-22 00:00:00

abstract：:Large earthquakes occur in rocks undergoing high-pressure/low-temperature metamorphism during subduction. Rhythmic major-element zoning in garnet is a common product of such metamorphism, and one that must record a fundamental subduction process. We argue that rhythmic major-element zoning in subduction zone garnets f...

journal_title：Science advances

authors： Viete DR,Hacker BR,Allen MB,Seward GGE,Tobin MJ,Kelley CS,Cinque G,Duckworth AR

更新日期：2018-03-21 00:00:00

abstract：:Polyphosphate, an energy-rich polymer conserved in all kingdoms of life, is integral to many cellular stress responses, including nutrient deprivation, and yet, the mechanisms that underlie its biological roles are not well understood. In this work, we elucidate the physiological function of this polymer in the acclim...

journal_title：Science advances

authors： Sanz-Luque E,Saroussi S,Huang W,Akkawi N,Grossman AR

更新日期：2020-09-30 00:00:00

abstract：:Annexin-A1 (ANXA1) has recently been proposed to play a role in microglial activation after brain ischemia, but the underlying mechanism remains poorly understood. Here, we demonstrated that ANXA1 is modified by SUMOylation, and SUMOylated ANXA1 could promote the beneficial phenotype polarization of microglia. Mechani...

journal_title：Science advances

authors： Li X,Xia Q,Mao M,Zhou H,Zheng L,Wang Y,Zeng Z,Yan L,Zhao Y,Shi J

更新日期：2021-01-20 00:00:00

abstract：:In the post-Moore era, an electrically driven monolithic optoelectronic integrated circuit (OEIC) fabricated from a single material is pursued globally to enable the construction of wafer-scale compact computing systems with powerful processing capabilities and low-power consumption. We report a monolithic plasmonic i...

journal_title：Science advances

authors： Liu Y,Zhang J,Liu H,Wang S,Peng LM

更新日期：2017-10-20 00:00:00

abstract：:The hydrogen atom-the smallest and most abundant atom-is of utmost importance in physics and chemistry. Although many analysis methods have been applied to its study, direct observation of hydrogen atoms in a single molecule remains largely unexplored. We use atomic force microscopy (AFM) to resolve the outermost hydr...

journal_title：Science advances

authors： Kawai S,Nishiuchi T,Kodama T,Spijker P,Pawlak R,Meier T,Tracey J,Kubo T,Meyer E,Foster AS

更新日期：2017-05-12 00:00:00

abstract：:Calcium homeostasis modulator 1 (CALHM1) is a voltage-gated ATP release channel that plays an important role in neural gustatory signaling and the pathogenesis of Alzheimer's disease. Here, we present a cryo-electron microscopy structure of full-length Ca2+-free CALHM1 from Danio rerio at an overall resolution of 3.1 ...

journal_title：Science advances

authors： Ren Y,Wen T,Xi Z,Li S,Lu J,Zhang X,Yang X,Shen Y

更新日期：2020-07-17 00:00:00

abstract：:Mineralization is the most fundamental process in vertebrates. It is predominantly mediated by osteoblasts, which secrete mineral precursors, most likely through matrix vesicles (MVs). These vesicular structures are calcium and phosphate rich and contain organic material such as acidic proteins. However, it remains la...

journal_title：Science advances

authors： Iwayama T,Okada T,Ueda T,Tomita K,Matsumoto S,Takedachi M,Wakisaka S,Noda T,Ogura T,Okano T,Fratzl P,Ogura T,Murakami S

更新日期：2019-07-03 00:00:00

abstract：:Photoresponsive liquid crystalline elastomers (LCEs) constitute ideal actuators for soft robots because their light-induced macroscopic shape changes can be harnessed to perform specific articulated motions. Conventional LCEs, however, do not typically exhibit complex modes of bending and twisting necessary to perform...

journal_title：Science advances

authors： Waters JT,Li S,Yao Y,Lerch MM,Aizenberg M,Aizenberg J,Balazs AC

更新日期：2020-03-27 00:00:00

abstract：:Changes in extreme weather, such as tropical cyclones, are one of the most serious ways society experiences the impact of climate change. Advance forecasted conditional attribution statements, using a numerical model, were made about the anthropogenic climate change influence on an individual tropical cyclone, Hurrica...

journal_title：Science advances

authors： Reed KA,Stansfield AM,Wehner MF,Zarzycki CM

更新日期：2020-01-01 00:00:00

abstract：:RNA interference (RNAi) technology can specifically silence the expression of a target gene and has emerged as a promising therapeutic method to treat cancer. In the present study, we showed that natural halloysite nanotube (HNT)-assisted delivery of an active small interfering RNA (siRNA) targeting receptor-interacti...

journal_title：Science advances

authors： Liu J,Zhang Y,Zeng Q,Zeng H,Liu X,Wu P,Xie H,He L,Long Z,Lu X,Xiao M,Zhu Y,Bo H,Cao K

更新日期：2019-09-25 00:00:00

abstract：:Cytosolic RNA sensing is a prerequisite for initiation of innate immune response against RNA viral pathogens. Signaling through RIG-I (retinoic acid-inducible gene I)-like receptors (RLRs) to TBK1 (Tank-binding kinase 1)/IKKε (IκB kinase ε) kinases is transduced by mitochondria-associated MAVS (mitochondrial antiviral...

journal_title：Science advances

authors： Xiang W,Zhang Q,Lin X,Wu S,Zhou Y,Meng F,Fan Y,Shen T,Xiao M,Xia Z,Zou J,Feng XH,Xu P

更新日期：2016-07-01 00:00:00

abstract：:Electron interferometry via phase-contrast microscopy, holography, or picodiffraction can provide a direct visualization of the static electric and magnetic fields inside or around a material at subatomic precision, but understanding the electromagnetic origin of light-matter interaction requires time resolution as we...

journal_title：Science advances

authors： Mohler KJ,Ehberger D,Gronwald I,Lange C,Huber R,Baum P

更新日期：2020-11-20 00:00:00

abstract：:Fibrosis, characterized by aberrant tissue scarring from activated myofibroblasts, is often untreatable. Although the extracellular matrix becomes increasingly stiff and fibrous during disease progression, how these physical cues affect myofibroblast differentiation in 3D is poorly understood. Here, we describe a mult...

journal_title：Science advances

authors： Matera DL,DiLillo KM,Smith MR,Davidson CD,Parikh R,Said M,Wilke CA,Lombaert IM,Arnold KB,Moore BB,Baker BM

更新日期：2020-09-09 00:00:00

abstract：:Half-filled Landau levels host an emergent Fermi liquid that displays instability toward pairing, culminating in a gapped even-denominator fractional quantum Hall ground state. While this pairing may be probed by tuning the polarization of carriers in competing orbital and spin degrees of freedom, sufficiently high qu...

journal_title：Science advances

authors： Falson J,Tabrea D,Zhang D,Sodemann I,Kozuka Y,Tsukazaki A,Kawasaki M,von Klitzing K,Smet JH

更新日期：2018-09-14 00:00:00

abstract：:Nitrogen oxides (NO x ) emitted from human activities are believed to regulate the atmospheric oxidation capacity of the troposphere. However, observational evidence is limited for the low-to-median NO x concentrations prevalen...

journal_title：Science advances

authors： Liu Y,Seco R,Kim S,Guenther AB,Goldstein AH,Keutsch FN,Springston SR,Watson TB,Artaxo P,Souza RAF,McKinney KA,Martin ST

更新日期：2018-04-11 00:00:00

abstract：:Planarians exhibit traits of cephalization but are unique among bilaterians in that they ingest food by means of goal-directed movements of a trunk-positioned pharynx, following protrusion of the pharynx out of the body, raising the question of how planarians control such a complex set of body movements for achieving ...

journal_title：Science advances

authors： Miyamoto M,Hattori M,Hosoda K,Sawamoto M,Motoishi M,Hayashi T,Inoue T,Umesono Y

更新日期：2020-04-08 00:00:00

abstract：:We present an ab initio computational approach for the calculation of resonant Raman intensities, including both excitonic and nonadiabatic effects. Our diagrammatic approach, which we apply to two prototype, semiconducting layered materials, allows a detailed analysis of the impact of phonon-mediated exciton-exciton ...

journal_title：Science advances

authors： Reichardt S,Wirtz L

更新日期：2020-08-07 00:00:00

abstract：:Hybrid organic-inorganic halide perovskites have shown remarkable optoelectronic properties, exhibiting an impressive tolerance to defects believed to originate from correlated motion of charge carriers and the polar lattice forming large polarons. Few experimental techniques are capable of directly probing these corr...

journal_title：Science advances

authors： Lan Y,Dringoli BJ,Valverde-Chávez DA,Ponseca CS Jr,Sutton M,He Y,Kanatzidis MG,Cooke DG

更新日期：2019-05-31 00:00:00

abstract：:The lipid bilayer membrane, which is the foundation of life on Earth, is not viable outside of biology based on liquid water. This fact has caused astronomers who seek conditions suitable for life to search for exoplanets within the "habitable zone," the narrow band in which liquid water can exist. However, can cell m...

journal_title：Science advances

authors： Stevenson J,Lunine J,Clancy P

更新日期：2015-02-27 00:00:00