Delivery of RIPK4 small interfering RNA for bladder cancer therapy using natural halloysite nanotubes.

abstract：:Spin caloritronics has recently emerged from the combination of spintronics and thermoelectricity. Here, we show that flexible, macroscopic spin caloritronic devices based on large-area interconnected magnetic nanowire networks can be used to enable controlled Peltier cooling of macroscopic electronic components with ...

journal_title：Science advances

authors： da Câmara Santa Clara Gomes T,Abreu Araujo F,Piraux L

更新日期：2019-03-01 00:00:00

abstract：:Microsupercapacitors (MSCs) have garnered considerable attention as a promising power source for microelectronics and miniaturized portable/wearable devices. However, their practical application has been hindered by the manufacturing complexity and dimensional limits. Here, we develop a new class of ultrahigh areal nu...

journal_title：Science advances

authors： Lee KH,Lee SS,Ahn DB,Lee J,Byun D,Lee SY

更新日期：2020-03-06 00:00:00

abstract：:Soft robotics may enable many new technologies in which humans and robots physically interact, yet the necessary high-performance soft actuators still do not exist. The optimal soft actuators need to be fast and forceful and have programmable shape changes. Furthermore, they should be energy efficient for untethered a...

journal_title：Science advances

authors： Davidson ZS,Shahsavan H,Aghakhani A,Guo Y,Hines L,Xia Y,Yang S,Sitti M

更新日期：2019-11-22 00:00:00

abstract：:The retinoic acid-inducible gene I (RIG-I) innate immune receptor is an important immunotherapeutic target, but we lack approaches for monitoring the physical basis for its activation in vitro. This gap in our understanding has led to confusion about mechanisms of RIG-I activation and difficulty discovering agonists a...

journal_title：Science advances

authors： Dickey TH,Song B,Pyle AM

更新日期：2019-10-02 00:00:00

abstract：:Goat domestication was critical for agriculture and civilization, but its underlying genetic changes and selection regimes remain unclear. Here, we analyze the genomes of worldwide domestic goats, wild caprid species, and historical remains, providing evidence of an ancient introgression event from a West Caucasian tu...

journal_title：Science advances

authors： Zheng Z,Wang X,Li M,Li Y,Yang Z,Wang X,Pan X,Gong M,Zhang Y,Guo Y,Wang Y,Liu J,Cai Y,Chen Q,Okpeku M,Colli L,Cai D,Wang K,Huang S,Sonstegard TS,Esmailizadeh A,Zhang W,Zhang T,Xu Y,Xu N,Yang Y,Han J,C

更新日期：2020-05-20 00:00:00

abstract：:Electron interferometry via phase-contrast microscopy, holography, or picodiffraction can provide a direct visualization of the static electric and magnetic fields inside or around a material at subatomic precision, but understanding the electromagnetic origin of light-matter interaction requires time resolution as we...

journal_title：Science advances

authors： Mohler KJ,Ehberger D,Gronwald I,Lange C,Huber R,Baum P

更新日期：2020-11-20 00:00:00

abstract：:Presently, the Indian Ocean (IO) resides in a climate state that prevents strong year-to-year climate variations. This may change under greenhouse warming, but the mechanisms remain uncertain, thus limiting our ability to predict future changes in climate extremes. Using climate model simulations, we uncover the emerg...

journal_title：Science advances

authors： DiNezio PN,Puy M,Thirumalai K,Jin FF,Tierney JE

更新日期：2020-05-06 00:00:00

abstract：:Super-resolution nanoscopy based on wide-field microscopic imaging provided high efficiency but limited resolution. Here, we demonstrate a general strategy to push its resolution down to ~50 nm, which is close to the range of single molecular localization microscopy, without sacrificing the wide-field imaging advantag...

journal_title：Science advances

authors： Liu C,Liu W,Wang S,Li H,Lv Z,Zhang F,Zhang D,Teng J,Zheng T,Li D,Zhang M,Xu P,Gong Q

更新日期：2020-04-17 00:00:00

abstract：:Previous breakthroughs in stretchable electronics stem from strain engineering and nanocomposite approaches. Routes toward intrinsically stretchable molecular materials remain scarce but, if successful, will enable simpler fabrication processes, such as direct printing and coating, mechanically robust devices, and mor...

journal_title：Science advances

authors： Wang Y,Zhu C,Pfattner R,Yan H,Jin L,Chen S,Molina-Lopez F,Lissel F,Liu J,Rabiah NI,Chen Z,Chung JW,Linder C,Toney MF,Murmann B,Bao Z

更新日期：2017-03-10 00:00:00

abstract：:Copper-containing nitrite reductases (CuNiRs), encoded by nirK gene, are found in all kingdoms of life with only 5% of CuNiR denitrifiers having two or more copies of nirK Recently, we have identified two copies of nirK genes in several α-proteobacteria of the order Rhizobiales including Bradyrhizobium sp. ORS 375, en...

journal_title：Science advances

authors： Rose SL,Antonyuk SV,Sasaki D,Yamashita K,Hirata K,Ueno G,Ago H,Eady RR,Tosha T,Yamamoto M,Hasnain SS

更新日期：2021-01-01 00:00:00

abstract：:Prosocial behavior is paradoxical because it often entails a cost to one's own welfare to benefit others. Theoretical models suggest that prosociality is driven by several forms of reciprocity. Although we know a great deal about how each of these forms operates in isolation, they are rarely isolated in the real world...

journal_title：Science advances

authors： Melamed D,Simpson B,Abernathy J

更新日期：2020-06-03 00:00:00

abstract：:SWI/SNF (switch/sucrose nonfermenting) complexes regulate transcription through chromatin remodeling and opposing gene silencing by Polycomb group (PcG) proteins. Genes encoding SWI/SNF components are critical for normal development and frequently mutated in human cancer. We characterized the in vivo contributions of ...

journal_title：Science advances

authors： van der Vaart A,Godfrey M,Portegijs V,van den Heuvel S

更新日期：2020-05-20 00:00:00

abstract：:We have positionally cloned the Ym1 gene, with a duplication and a promoter polymorphism, as a major regulator of inflammation. Mice with the RIIIS/J haplotype, with the absence of Ym1 expression, showed reduced susceptibility to mannan-enhanced collagen antibody-induced arthritis and to chronic arthritis induced by i...

journal_title：Science advances

authors： Zhu W,Lönnblom E,Förster M,Johannesson M,Tao P,Meng L,Lu S,Holmdahl R

更新日期：2020-10-21 00:00:00

abstract：:Regulatory T (Treg) cells are essential for peripheral tolerance and rely on the transcription factor (TF) Foxp3 for their generation and function. Several other TFs are critical for the Treg cell program. We found that mice deficient in Bcl11b TF solely in Treg cells developed fatal autoimmunity, and Bcl11b-deficient...

journal_title：Science advances

authors： Drashansky TT,Helm E,Huo Z,Curkovic N,Kumar P,Luo X,Parthasarathy U,Zuniga A,Cho JJ,Lorentsen KJ,Xu Z,Uddin M,Moshkani S,Zhou L,Avram D

更新日期：2019-08-07 00:00:00

abstract：:Half-filled Landau levels host an emergent Fermi liquid that displays instability toward pairing, culminating in a gapped even-denominator fractional quantum Hall ground state. While this pairing may be probed by tuning the polarization of carriers in competing orbital and spin degrees of freedom, sufficiently high qu...

journal_title：Science advances

authors： Falson J,Tabrea D,Zhang D,Sodemann I,Kozuka Y,Tsukazaki A,Kawasaki M,von Klitzing K,Smet JH

更新日期：2018-09-14 00:00:00

abstract：:The tet methylcytosine dioxygenase 2 (TET2) enzyme catalyzes the conversion of the modified DNA base 5-methylcytosine to 5-hydroxymethylcytosine. TET2 is frequently mutated or dysregulated in multiple human cancers, and loss of TET2 is associated with changes in DNA methylation patterns. Here, using newly developed TE...

journal_title：Science advances

authors： Wang L,Ozark PA,Smith ER,Zhao Z,Marshall SA,Rendleman EJ,Piunti A,Ryan C,Whelan AL,Helmin KA,Morgan MA,Zou L,Singer BD,Shilatifard A

更新日期：2018-11-07 00:00:00

abstract：:Nanofluidic platforms offering tunable material transport are applicable in biosensing, chemical detection, and filtration. Prior studies have achieved selective and controllable ion transport through electrical, optical, or chemical gating of complex nanostructures. Here, we mechanically control nanofluidic transport...

journal_title：Science advances

authors： Rabinowitz J,Whittier E,Liu Z,Jayant K,Frank J,Shepard K

更新日期：2020-11-13 00:00:00

abstract：:Ocean circulation redistributes Earth's energy and water masses and influences global climate. Under historical greenhouse warming, regional ocean currents show diverse tendencies, but whether there is an emerging trend of the global mean ocean circulation system is not yet clear. Here, we show a statistically signifi...

journal_title：Science advances

authors： Hu S,Sprintall J,Guan C,McPhaden MJ,Wang F,Hu D,Cai W

更新日期：2020-02-05 00:00:00

abstract：:In vitro selection of antibodies from large repertoires of immunoglobulin (Ig) combining sites using combinatorial libraries is a powerful tool, with great potential for generating in vivo scavengers for toxins. However, addition of a maturation function is necessary to enable these selected antibodies to more closely...

journal_title：Science advances

authors： Smirnov IV,Golovin AV,Chatziefthimiou SD,Stepanova AV,Peng Y,Zolotareva OI,Belogurov AA Jr,Kurkova IN,Ponomarenko NA,Wilmanns M,Blackburn GM,Gabibov AG,Lerner RA

更新日期：2016-10-19 00:00:00

abstract：:Hydrogen sulfide (H2S) is a gasotransmitter and a potential therapeutic agent. However, molecular targets relevant to its therapeutic actions remain enigmatic. Sulfide-quinone oxidoreductase (SQR) irreversibly oxidizes H2S. Therefore, SQR is assumed to inhibit H2S signaling. We now report that SQR-mediated oxidation o...

journal_title：Science advances

authors： Jia J,Wang Z,Zhang M,Huang C,Song Y,Xu F,Zhang J,Li J,He M,Li Y,Ao G,Hong C,Cao Y,Chin YE,Hua ZC,Cheng J

更新日期：2020-08-26 00:00:00

abstract：:The essence of turbulent flow is the conveyance of energy through the formation, interaction, and destruction of eddies over a wide range of spatial scales-from the largest scales where energy is injected down to the smallest scales where it is dissipated through viscosity. Currently, there is no mechanistic framework...

journal_title：Science advances

authors： McKeown R,Ostilla-Mónico R,Pumir A,Brenner MP,Rubinstein SM

更新日期：2020-02-28 00:00:00

abstract：:Protected areas (PAs) are essential to biodiversity conservation, but their static boundaries may undermine their potential for protecting species under climate change. We assessed how the climatic conditions within global terrestrial PAs may change over time. By 2070, protection is expected to decline in cold and war...

journal_title：Science advances

authors： Elsen PR,Monahan WB,Dougherty ER,Merenlender AM

更新日期：2020-06-17 00:00:00

abstract：:Demonstration of ultralow energy switching mechanisms is imperative for continued improvements in computing devices. Ferroelectric (FE) and multiferroic (MF) order and their manipulation promise an ideal combination of state variables to reach attojoule range for logic and memory (i.e., ~30× lower switching energy tha...

journal_title：Science advances

authors： Manipatruni S,Nikonov DE,Lin CC,Prasad B,Huang YL,Damodaran AR,Chen Z,Ramesh R,Young IA

更新日期：2018-11-23 00:00:00

abstract：:Black phosphorus (BP) offers considerable promise for infrared and visible photonics. Efficient tuning of the bandgap and higher subbands in BP by modulation of the Fermi level or application of vertical electric fields has been previously demonstrated, allowing electrical control of its above-bandgap optical properti...

journal_title：Science advances

authors： Biswas S,Whitney WS,Grajower MY,Watanabe K,Taniguchi T,Bechtel HA,Rossman GR,Atwater HA

更新日期：2021-01-08 00:00:00

abstract：:Mimicking subcellular compartments containing enzymes in organisms is considered a promising approach to substitute for missing or lost cellular functions. Inspired by the multicompartment structures of cellular architectures, we present a novel multienzyme system based on hollow hydrogel microcapsules with flexible e...

journal_title：Science advances

authors： Wang H,Zhao Z,Liu Y,Shao C,Bian F,Zhao Y

更新日期：2018-06-15 00:00:00

abstract：:Spectroscopic methods with nanoscale lateral resolution are becoming essential in the fields of physics, chemistry, geology, biology, and materials science. However, the lateral resolution of laser-based mass spectrometry imaging (MSI) techniques has so far been limited to the microscale. This report presents the deve...

journal_title：Science advances

authors： Liang Z,Zhang S,Li X,Wang T,Huang Y,Hang W,Yang Z,Li J,Tian Z

更新日期：2017-12-08 00:00:00

abstract：:The ability of a material to adopt multiple structures, known as polymorphism, is a fascinating natural phenomenon. Various polymorphs with unusual properties are routinely synthesized by compression under positive pressure. However, changing a material's structure by applying tension under negative pressure is much m...

journal_title：Science advances

authors： Siol S,Holder A,Steffes J,Schelhas LT,Stone KH,Garten L,Perkins JD,Parilla PA,Toney MF,Huey BD,Tumas W,Lany S,Zakutayev A

更新日期：2018-04-20 00:00:00

abstract：:Oocyte numbers, a critical determinant of female reproductive fitness, are highly regulated, yet the mechanisms underlying this regulation remain largely undefined. In the Caenorhabditis elegans gonad, RAS/extracellular signal-regulated kinase (ERK) signaling regulates oocyte numbers; mechanisms are unknown. We show t...

journal_title：Science advances

authors： Das D,Chen SY,Arur S

更新日期：2020-10-30 00:00:00

abstract：:We develop biohybrid magnetic microrobots by electrostatic self-assembly of nonmotile sperm cells and magnetic nanoparticles. Incorporating a biological entity into microrobots entails many functional advantages beyond shape templating, such as the facile uptake of chemotherapeutic agents to achieve targeted drug deli...

journal_title：Science advances

authors： Magdanz V,Khalil ISM,Simmchen J,Furtado GP,Mohanty S,Gebauer J,Xu H,Klingner A,Aziz A,Medina-Sánchez M,Schmidt OG,Misra S

更新日期：2020-07-08 00:00:00

abstract：:Anti-programmed cell death 1 ligand 1 (PD-L1) therapy is extraordinarily effective in select patients with cancer. However, insufficient lymphocytic infiltration, weak T cell-induced inflammation, and immunosuppressive cell accumulation in the tumor microenvironment (TME) may greatly diminish the efficacy. Here, we re...

journal_title：Science advances

authors： Li Z,Wang Y,Shen Y,Qian C,Oupicky D,Sun M

更新日期：2020-05-15 00:00:00