Dose-dependent functions of SWI/SNF BAF in permitting and inhibiting cell proliferation in vivo.

abstract：:Estimating minimum ice volume during the last interglacial based on local sea-level indicators requires that these indicators are corrected for processes that alter local sea level relative to the global average. Although glacial isostatic adjustment is generally accounted for, global scale dynamic changes in topograp...

journal_title：Science advances

authors： Austermann J,Mitrovica JX,Huybers P,Rovere A

更新日期：2017-07-07 00:00:00

abstract：:The basic physics of earthquakes is such that strong ground motion cannot be expected from an earthquake unless the earthquake itself is very close or has grown to be very large. We use simple seismological relationships to calculate the minimum time that must elapse before such ground motion can be expected at a dist...

journal_title：Science advances

authors： Minson SE,Meier MA,Baltay AS,Hanks TC,Cochran ES

更新日期：2018-03-21 00:00:00

abstract：:A growing body of empirical evidence is revealing the value of nature experience for mental health. With rapid urbanization and declines in human contact with nature globally, crucial decisions must be made about how to preserve and enhance opportunities for nature experience. Here, we first provide points of consensu...

journal_title：Science advances

authors： Bratman GN,Anderson CB,Berman MG,Cochran B,de Vries S,Flanders J,Folke C,Frumkin H,Gross JJ,Hartig T,Kahn PH Jr,Kuo M,Lawler JJ,Levin PS,Lindahl T,Meyer-Lindenberg A,Mitchell R,Ouyang Z,Roe J,Scarlett L,Smith JR,

更新日期：2019-07-24 00:00:00

abstract：:Weyl semimetals are of great interest because they provide the first realization of the Weyl fermion, exhibit exotic quantum anomalies, and host Fermi arc surface states. The separation between Weyl nodes of opposite chirality gives a measure of the robustness of the Weyl semimetal state. To exploit the novel phenomen...

journal_title：Science advances

authors： Chang G,Xu SY,Sanchez DS,Huang SM,Lee CC,Chang TR,Bian G,Zheng H,Belopolski I,Alidoust N,Jeng HT,Bansil A,Lin H,Hasan MZ

更新日期：2016-06-24 00:00:00

abstract：:Cellular cross-talk between ubiquitination and other posttranslational modifications contributes to the regulation of numerous processes. One example is ADP-ribosylation of the carboxyl terminus of ubiquitin by the E3 DTX3L/ADP-ribosyltransferase PARP9 heterodimer, but the mechanism remains elusive. Here, we show that...

journal_title：Science advances

authors： Chatrin C,Gabrielsen M,Buetow L,Nakasone MA,Ahmed SF,Sumpton D,Sibbet GJ,Smith BO,Huang DT

更新日期：2020-09-18 00:00:00

abstract：:Granular dynamics govern earthquakes, avalanches, and landslides and are of fundamental importance in a variety of industries ranging from energy to pharmaceuticals to agriculture. Nonetheless, our understanding of the underlying physics is poor because we lack spatially and temporally resolved experimental measuremen...

journal_title：Science advances

authors： Penn A,Tsuji T,Brunner DO,Boyce CM,Pruessmann KP,Müller CR

更新日期：2017-09-15 00:00:00

abstract：:Previous identification of the inducible nitric oxide synthase (NOS2) gene as a risk allele for psoriasis (Ps) and psoriatic arthritis (PsA) suggests a possible pathogenic role of nitric oxide (NO). Using a mouse model of mannan-induced Ps and PsA (MIP), where macrophages play a regulatory role by releasing reactive o...

journal_title：Science advances

authors： Zhong J,Scholz T,Yau ACY,Guerard S,Hüffmeier U,Burkhardt H,Holmdahl R

更新日期：2018-05-16 00:00:00

abstract：:In the post-Moore era, an electrically driven monolithic optoelectronic integrated circuit (OEIC) fabricated from a single material is pursued globally to enable the construction of wafer-scale compact computing systems with powerful processing capabilities and low-power consumption. We report a monolithic plasmonic i...

journal_title：Science advances

authors： Liu Y,Zhang J,Liu H,Wang S,Peng LM

更新日期：2017-10-20 00:00:00

abstract：:The miraculously preserved 2000-year-old Dead Sea Scrolls, ancient texts of invaluable historical significance, were discovered in the mid-20th century in the caves of the Judean desert. The texts were mainly written on parchment and exhibit vast diversity in their states of preservation. One particular scroll, the 8-...

journal_title：Science advances

authors： Schuetz R,Maragh JM,Weaver JC,Rabin I,Masic A

更新日期：2019-09-06 00:00:00

abstract：:Cholesterol-dependent cytolysins (CDCs) form pores in cholesterol-rich membranes, but cholesterol alone is insufficient to explain their cell and host tropism. Here, we show that all eight major CDCs have high-affinity lectin activity that identifies glycans as candidate cellular receptors. Streptolysin O, vaginolysin...

journal_title：Science advances

authors： Shewell LK,Day CJ,Jen FE,Haselhorst T,Atack JM,Reijneveld JF,Everest-Dass A,James DBA,Boguslawski KM,Brouwer S,Gillen CM,Luo Z,Kobe B,Nizet V,von Itzstein M,Walker MJ,Paton AW,Paton JC,Torres VJ,Jennings MP

更新日期：2020-05-22 00:00:00

abstract：:Human genome-wide association studies have linked single-nucleotide polymorphisms (SNPs) in NEMP1 (nuclear envelope membrane protein 1) with early menopause; however, it is unclear whether NEMP1 has any role in fertility. We show that whole-animal loss of NEMP1 homologs in Drosophila, Caenorhabditis elegans, zebrafish...

journal_title：Science advances

authors： Tsatskis Y,Rosenfeld R,Pearson JD,Boswell C,Qu Y,Kim K,Fabian L,Mohammad A,Wang X,Robson MI,Krchma K,Wu J,Gonçalves J,Hodzic D,Wu S,Potter D,Pelletier L,Dunham WH,Gingras AC,Sun Y,Meng J,Godt D,Schedl T,Ciru

更新日期：2020-08-28 00:00:00

abstract：:Posthemorrhagic hydrocephalus (PHH) in premature infants is a common neurological disorder treated with invasive neurosurgical interventions. Patients with PHH lack effective therapeutic interventions and suffer chronic comorbidities. Here, we report a murine lysophosphatidic acid (LPA)-induced postnatal PHH model tha...

journal_title：Science advances

authors： Lummis NC,Sánchez-Pavón P,Kennedy G,Frantz AJ,Kihara Y,Blaho VA,Chun J

更新日期：2019-10-09 00:00:00

abstract：:Triple-negative breast cancer (TNBC) is life-threatening because of limited therapies and lack of effective therapeutic targets. Here, we found that moesin (MSN) was significantly overexpressed in TNBC compared with other subtypes of breast cancer and was positively correlated with poor overall survival. However, litt...

journal_title：Science advances

authors： Qin Y,Chen W,Jiang G,Zhou L,Yang X,Li H,He X,Wang HL,Zhou YB,Huang S,Liu S

更新日期：2020-02-19 00:00:00

abstract：:Ice-templating holds promise to become a powerful technique to construct high-performance bioinspired materials. Both ice nucleation and growth during the freezing process are crucial for the final architecture of the ice-templated material. However, effective ways to control these two very important factors are still...

journal_title：Science advances

authors： Zhao N,Li M,Gong H,Bai H

更新日期：2020-07-31 00:00:00

abstract：:We propose a method to use artificial neural networks to approximate light scattering by multilayer nanoparticles. We find that the network needs to be trained on only a small sampling of the data to approximate the simulation to high precision. Once the neural network is trained, it can simulate such optical processe...

journal_title：Science advances

authors： Peurifoy J,Shen Y,Jing L,Yang Y,Cano-Renteria F,DeLacy BG,Joannopoulos JD,Tegmark M,Soljačić M

更新日期：2018-06-01 00:00:00

abstract：:The pathways and transformations of dense water overflows, which depend on small-scale interactions between flow dynamics and erosional-depositional processes, are a central piece in the ocean's large-scale circulation. A novel, high-resolution current and hydrographic data set highlights the intricate pathway travell...

journal_title：Science advances

authors： Sánchez-Leal RF,Bellanco MJ,Fernández-Salas LM,García-Lafuente J,Gasser-Rubinat M,González-Pola C,Hernández-Molina FJ,Pelegrí JL,Peliz A,Relvas P,Roque D,Ruiz-Villarreal M,Sammartino S,Sánchez-Garrido JC

更新日期：2017-11-15 00:00:00

abstract：:The key component currently missing for the next generation of transparent and flexible displays is a high-performance polymer material that is flexible, while showing optical and thermal properties of glass. It must be transparent to visible light and show a low coefficient of thermal expansion (CTE). While specialty...

journal_title：Science advances

authors： Kim SD,Lee B,Byun T,Chung IS,Park J,Shin I,Ahn NY,Seo M,Lee Y,Kim Y,Kim WY,Kwon H,Moon H,Yoo S,Kim SY

更新日期：2018-10-26 00:00:00

abstract：:Self-assembly of colloidal nanocrystals into complex superstructures offers notable opportunities to create functional devices and artificial materials with unusual properties. Anisotropic nanoparticles with nonspherical shapes, such as rods, plates, polyhedra, and multipods, enable the formation of a diverse range of...

journal_title：Science advances

authors： Wang Q,Wang Z,Li Z,Xiao J,Shan H,Fang Z,Qi L

更新日期：2017-10-27 00:00:00

abstract：:Demonstration of ultralow energy switching mechanisms is imperative for continued improvements in computing devices. Ferroelectric (FE) and multiferroic (MF) order and their manipulation promise an ideal combination of state variables to reach attojoule range for logic and memory (i.e., ~30× lower switching energy tha...

journal_title：Science advances

authors： Manipatruni S,Nikonov DE,Lin CC,Prasad B,Huang YL,Damodaran AR,Chen Z,Ramesh R,Young IA

更新日期：2018-11-23 00:00:00

abstract：:Dust condensation and coagulation in the early solar system are the first steps toward forming the terrestrial planets, but the time scales of these processes remain poorly constrained. Through isotopic analysis of small Ca-Al-rich inclusions (CAIs) (30 to 100 μm in size) found in one of the most pristine chondrites, ...

journal_title：Science advances

authors： Liu MC,Han J,Brearley AJ,Hertwig AT

更新日期：2019-09-11 00:00:00

abstract：:Students from underrepresented groups start college with the same level of interest in STEM majors as their peers, but leave STEM at higher rates. We tested the hypothesis that low grades in general chemistry contribute to this "weeding," using records from 25,768 students. In the first course of a general chemistry s...

journal_title：Science advances

authors： Harris RB,Mack MR,Bryant J,Theobald EJ,Freeman S

更新日期：2020-06-10 00:00:00

abstract：:A trimer-of-hairpins motif has been identified in triggering virus-cell fusion within a variety of viral envelopes. Chemically manipulating such a motif represents current repertoire of viral fusion inhibitors. Here, we report that triterpenoids, a class of natural products, antagonize this trimer-of-hairpins via its ...

journal_title：Science advances

authors： Si L,Meng K,Tian Z,Sun J,Li H,Zhang Z,Soloveva V,Li H,Fu G,Xia Q,Xiao S,Zhang L,Zhou D

更新日期：2018-11-21 00:00:00

abstract：:Regulatory T (Treg) cells are essential for peripheral tolerance and rely on the transcription factor (TF) Foxp3 for their generation and function. Several other TFs are critical for the Treg cell program. We found that mice deficient in Bcl11b TF solely in Treg cells developed fatal autoimmunity, and Bcl11b-deficient...

journal_title：Science advances

authors： Drashansky TT,Helm E,Huo Z,Curkovic N,Kumar P,Luo X,Parthasarathy U,Zuniga A,Cho JJ,Lorentsen KJ,Xu Z,Uddin M,Moshkani S,Zhou L,Avram D

更新日期：2019-08-07 00:00:00

abstract：:We present a framework for quantifying the spatial and temporal co-occurrence of climate stresses in a nonstationary climate. We find that, globally, anthropogenic climate forcing has doubled the joint probability of years that are both warm and dry in the same location (relative to the 1961-1990 baseline). In additio...

journal_title：Science advances

authors： Sarhadi A,Ausín MC,Wiper MP,Touma D,Diffenbaugh NS

更新日期：2018-11-28 00:00:00

abstract：:Modeling a complex system is almost invariably a challenging task. The incorporation of experimental observations can be used to improve the quality of a model and thus to obtain better predictions about the behavior of the corresponding system. This approach, however, is affected by a variety of different errors, esp...

journal_title：Science advances

authors： Bonomi M,Camilloni C,Cavalli A,Vendruscolo M

更新日期：2016-01-22 00:00:00

abstract：:Changes in CO2 emissions during the COVID-19 pandemic have been estimated from indicators on activities like transportation and electricity generation. Here, we instead use satellite observations together with bottom-up information to track the daily dynamics of CO2 emissions during the pandemic. Unlike activity data,...

journal_title：Science advances

authors： Zheng B,Geng G,Ciais P,Davis SJ,Martin RV,Meng J,Wu N,Chevallier F,Broquet G,Boersma F,van der A R,Lin J,Guan D,Lei Y,He K,Zhang Q

更新日期：2020-12-02 00:00:00

abstract：:This study introduces new methods of screening for and tuning chiral space and in so doing identifies a promising set of chiral ligands for asymmetric synthesis. The carbafructopyranosyl-1,2-diamine(s) and salens constructed therefrom are particularly compelling. It is shown that by removing the native anomeric effect...

journal_title：Science advances

authors： Karukurichi KR,Fei X,Swyka RA,Broussy S,Shen W,Dey S,Roy SK,Berkowitz DB

更新日期：2015-07-01 00:00:00

abstract：:The glymphatic system is responsible for brain-wide delivery of nutrients and clearance of waste via influx of cerebrospinal fluid (CSF) alongside perivascular spaces and through the brain. Glymphatic system activity increases during sleep or ketamine/xylazine (K/X) anesthesia, yet the mechanism(s) facilitating CSF in...

journal_title：Science advances

authors： Hablitz LM,Vinitsky HS,Sun Q,Stæger FF,Sigurdsson B,Mortensen KN,Lilius TO,Nedergaard M

更新日期：2019-02-27 00:00:00

abstract：:The wiring of vertebrate and invertebrate brains provides the anatomical skeleton for cognition and behavior. Connections among brain regions are characterized by heterogeneous strength that is parsimoniously described by the wiring cost and homophily principles. Moreover, brains exhibit a characteristic global networ...

journal_title：Science advances

authors： Goulas A,Betzel RF,Hilgetag CC

更新日期：2019-06-12 00:00:00

abstract：:Macromolecules tend to respond to applied forces in many different ways. Chemistry at high shear forces can be intriguing, with relatively soft bonds becoming very stiff in specific force-loading geometries. Largely used in bionanotechnology, an important case is the streptavidin (SA)/biotin interaction. Although SA's...

journal_title：Science advances

authors： Sedlak SM,Schendel LC,Gaub HE,Bernardi RC

更新日期：2020-03-25 00:00:00