Deep-reaching acceleration of global mean ocean circulation over the past two decades.

abstract：:Spatial patterns of gene expression in living organisms orchestrate cell decisions in development, homeostasis, and disease. However, most methods for reconstructing gene patterning in 3D cell culture and artificial tissues are restricted by patterning depth and scale. We introduce a depth- and scale-flexible method t...

journal_title：Science advances

authors： Corbett DC,Fabyan WB,Grigoryan B,O'Connor CE,Johansson F,Batalov I,Regier MC,DeForest CA,Miller JS,Stevens KR

更新日期：2020-09-30 00:00:00

abstract：:l-DOPA treatment for Parkinson's disease frequently leads to dyskinesias, the pathophysiology of which is poorly understood. We used MALDI-MSI to map the distribution of l-DOPA and monoaminergic pathways in brains of dyskinetic and nondyskinetic primates. We report elevated levels of l-DOPA, and its metabolite 3-O-met...

journal_title：Science advances

authors： Fridjonsdottir E,Shariatgorji R,Nilsson A,Vallianatou T,Odell LR,Schembri LS,Svenningsson P,Fernagut PO,Crossman AR,Bezard E,Andrén PE

更新日期：2021-01-06 00:00:00

abstract：:Super-resolution nanoscopy based on wide-field microscopic imaging provided high efficiency but limited resolution. Here, we demonstrate a general strategy to push its resolution down to ~50 nm, which is close to the range of single molecular localization microscopy, without sacrificing the wide-field imaging advantag...

journal_title：Science advances

authors： Liu C,Liu W,Wang S,Li H,Lv Z,Zhang F,Zhang D,Teng J,Zheng T,Li D,Zhang M,Xu P,Gong Q

更新日期：2020-04-17 00:00:00

abstract：:An understanding of the normal state in the high-temperature superconducting cuprates is crucial to the ultimate understanding of the long-standing problem of the origin of the superconductivity itself. This so-called "strange metal" state is thought to be associated with a quantum critical point (QCP) hidden beneath ...

journal_title：Science advances

authors： Sarkar T,Mandal PR,Poniatowski NR,Chan MK,Greene RL

更新日期：2019-05-17 00:00:00

abstract：:Achieving perovskite-based high-color purity blue-emitting light-emitting diodes (LEDs) is still challenging. Here, we report successful synthesis of a series of blue-emissive two-dimensional Ruddlesden-Popper phase single crystals and their high-color purity blue-emitting LED demonstrations. Although this approach su...

journal_title：Science advances

authors： Chen H,Lin J,Kang J,Kong Q,Lu D,Kang J,Lai M,Quan LN,Lin Z,Jin J,Wang LW,Toney MF,Yang P

更新日期：2020-01-24 00:00:00

abstract：:Nanoparticles have been extensively used for inflammation imaging and photodynamic therapy of cancer. However, the major translational barriers to most nanoparticle-based imaging and therapy applications are the limited depth of tissue penetration, inevitable requirement of external irradiation, and poor biocompatibil...

journal_title：Science advances

authors： Xu X,An H,Zhang D,Tao H,Dou Y,Li X,Huang J,Zhang J

更新日期：2019-01-09 00:00:00

abstract：:Oncogenic RAS mutant (RASMUT) proteins have been considered undruggable via conventional antibody regimens owing to the intracellular location restricting conventional-antibody accessibility. Here, we report a pan-RAS-targeting IgG antibody, inRas37, which directly targets the intracellularly activated form of various...

journal_title：Science advances

authors： Shin SM,Kim JS,Park SW,Jun SY,Kweon HJ,Choi DK,Lee D,Cho YB,Kim YS

更新日期：2020-01-15 00:00:00

abstract：:Cell chirality is a newly discovered intrinsic property of the cell, reflecting the bias of the cell to polarize in the left-right axis. Despite increasing evidence on its substantial role in the asymmetric development of embryos, little is known about implications of cell chirality in physiology and disease. We demon...

journal_title：Science advances

authors： Fan J,Ray P,Lu YW,Kaur G,Schwarz JJ,Wan LQ

更新日期：2018-10-24 00:00:00

abstract：:One of the most plausible scenarios of the origin of life assumes the preceding prebiotic autotrophic metabolism in sulfide-rich hydrothermal vent environments. However, geochemical mechanisms to harness the reductive power provided by hydrothermal systems remain to be elucidated. Here, we show that, under a geoelectr...

journal_title：Science advances

authors： Kitadai N,Nakamura R,Yamamoto M,Takai K,Yoshida N,Oono Y

更新日期：2019-06-19 00:00:00

abstract：:G protein-coupled receptors (GPCRs) play a fundamental role in the modulation of synaptic transmission. A pivotal example is provided by the metabotropic glutamate receptor type 4 (mGluR4), which inhibits glutamate release at presynaptic active zones (AZs). However, how GPCRs are organized within AZs to regulate neuro...

journal_title：Science advances

authors： Siddig S,Aufmkolk S,Doose S,Jobin ML,Werner C,Sauer M,Calebiro D

更新日期：2020-04-15 00:00:00

abstract：:Hypertrophic cardiomyopathy (HCM) is a heterogeneous genetic heart muscle disease characterized by hypertrophy with preserved or increased ejection fraction in the absence of secondary causes. However, recent studies have demonstrated that a substantial proportion of individuals with HCM also have comorbid diabetes me...

journal_title：Science advances

authors： Dhandapany PS,Kang S,Kashyap DK,Rajagopal R,Sundaresan NR,Singh R,Thangaraj K,Jayaprakash S,Manjunath CN,Shenthar J,Lebeche D

更新日期：2021-01-06 00:00:00

abstract：:Embodied models suggest that moral judgments are strongly intertwined with first-hand somatic experiences, with some pointing to disgust, and others arguing for a role of pain/harm. Both disgust and pain are unpleasant, arousing experiences, with strong relevance for survival, but with distinctive sensory qualities an...

journal_title：Science advances

authors： Sharvit G,Lin E,Vuilleumier P,Corradi-Dell'Acqua C

更新日期：2020-10-16 00:00:00

abstract：:Changes in CO2 emissions during the COVID-19 pandemic have been estimated from indicators on activities like transportation and electricity generation. Here, we instead use satellite observations together with bottom-up information to track the daily dynamics of CO2 emissions during the pandemic. Unlike activity data,...

journal_title：Science advances

authors： Zheng B,Geng G,Ciais P,Davis SJ,Martin RV,Meng J,Wu N,Chevallier F,Broquet G,Boersma F,van der A R,Lin J,Guan D,Lei Y,He K,Zhang Q

更新日期：2020-12-02 00:00:00

abstract：:The ability of cytosolic lipopolysaccharide (LPS) to activate caspase-11-dependent nonclassical inflammasome is intricately controlled to avoid excessive inflammatory responses. However, very little is known about the regulatory role of various metabolic pathways in the control of caspase-11 activation. Here, we demon...

journal_title：Science advances

authors： Chen R,Zeng L,Zhu S,Liu J,Zeh HJ,Kroemer G,Wang H,Billiar TR,Jiang J,Tang D,Kang R

更新日期：2019-05-22 00:00:00

abstract：:Previous identification of the inducible nitric oxide synthase (NOS2) gene as a risk allele for psoriasis (Ps) and psoriatic arthritis (PsA) suggests a possible pathogenic role of nitric oxide (NO). Using a mouse model of mannan-induced Ps and PsA (MIP), where macrophages play a regulatory role by releasing reactive o...

journal_title：Science advances

authors： Zhong J,Scholz T,Yau ACY,Guerard S,Hüffmeier U,Burkhardt H,Holmdahl R

更新日期：2018-05-16 00:00:00

abstract：:Animals, humans, and multi-robot systems operate in dynamic environments, where the ability to respond to changing circumstances is paramount. An effective collective response requires suitable information transfer among agents and thus critically depends on the interaction network. To investigate the influence of the...

journal_title：Science advances

authors： Mateo D,Horsevad N,Hassani V,Chamanbaz M,Bouffanais R

更新日期：2019-04-03 00:00:00

abstract：:Cyclosporine A (CsA) is a powerful immunosuppressant, but it is an ineffective stand-alone treatment for systemic lupus erythematosus (SLE) due to poor target tissue distribution and renal toxicity. We hypothesized that CD71 (transferrin receptor 1)-directed delivery of CsA to the lymphatic system would improve SLE ou...

journal_title：Science advances

authors： Ganugula R,Arora M,Zou D,Agarwal SK,Mohan C,Kumar MNVR

更新日期：2020-06-12 00:00:00

abstract：:Inputs of nitrogen into terrestrial ecosystems, mainly via the use of ammonium-based fertilizers in agroecosystems, are enormous, but the fate of this nitrogen under elevated atmospheric carbon dioxide (CO2) is not well understood. We have taken advantage of a 15-year free-air CO2 enrichment study to investigate the i...

journal_title：Science advances

authors： Xu C,Zhang K,Zhu W,Xiao J,Zhu C,Zhang N,Yu F,Li S,Zhu C,Tu Q,Chen X,Zhu J,Hu S,Koide RT,Firestone MK,Cheng L

更新日期：2020-10-16 00:00:00

abstract：:Two-dimensional (2D) semiconductors have shown great potential for electronic and optoelectronic applications. However, their development is limited by a large Schottky barrier (SB) at the metal-semiconductor junction (MSJ), which is difficult to tune by using conventional metals because of the effect of strong Fermi ...

journal_title：Science advances

authors： Liu Y,Stradins P,Wei SH

更新日期：2016-04-22 00:00:00

abstract：:Ontogenetic studies provide clues for understanding important paleobiological aspects of extinct species. When compared to that of modern humans, the adult Neanderthal thorax was shorter, deeper, and wider. This is related to the wide Neanderthal body and is consistent with their hypothetical large requirements for en...

journal_title：Science advances

authors： García-Martínez D,Bastir M,Gómez-Olivencia A,Maureille B,Golovanova L,Doronichev V,Akazawa T,Kondo O,Ishida H,Gascho D,Zollikofer CPE,de León MP,Heuzé Y

更新日期：2020-10-07 00:00:00

abstract：:Low-dimensional perovskites offer a rare opportunity to investigate lattice dynamics and charge carrier behavior in bulk quantum-confined solids, in addition to them being the leading materials in optoelectronic applications. In particular, zero-dimensional (0D) inorganic perovskites of the Cs4PbX6 (X = Cl, Br, or I) ...

journal_title：Science advances

authors： Yin J,Maity P,De Bastiani M,Dursun I,Bakr OM,Brédas JL,Mohammed OF

更新日期：2017-12-15 00:00:00

abstract：:Ammonia synthesis consumes 3 to 5% of the world's natural gas, making it a significant contributor to greenhouse gas emissions. Strategies for synthesizing ammonia that are not dependent on the energy-intensive and methane-based Haber-Bosch process are critically important for reducing global energy consumption and mi...

journal_title：Science advances

authors： Song Y,Johnson D,Peng R,Hensley DK,Bonnesen PV,Liang L,Huang J,Yang F,Zhang F,Qiao R,Baddorf AP,Tschaplinski TJ,Engle NL,Hatzell MC,Wu Z,Cullen DA,Meyer HM 3rd,Sumpter BG,Rondinone AJ

更新日期：2018-04-27 00:00:00

abstract：:Detecting associations between genomic changes and phenotypic differences is fundamental to understanding how phenotypes evolved. By systematically screening for parallel amino acid substitutions, we detected known as well as novel cases (Strc, Tecta, and Cabp2) of parallelism between echolocating bats and toothed wha...

journal_title：Science advances

authors： Lee JH,Lewis KM,Moural TW,Kirilenko B,Borgonovo B,Prange G,Koessl M,Huggenberger S,Kang C,Hiller M

更新日期：2018-09-26 00:00:00

abstract：:Here, an integrated cascade nanozyme with a formulation of Pt@PCN222-Mn is developed to eliminate excessive reactive oxygen species (ROS). This nanozyme mimics superoxide dismutase by incorporation of a Mn-[5,10,15,20-tetrakis(4-carboxyphenyl)porphyrinato]-based metal-organic framework compound capable of transforming...

journal_title：Science advances

authors： Liu Y,Cheng Y,Zhang H,Zhou M,Yu Y,Lin S,Jiang B,Zhao X,Miao L,Wei CW,Liu Q,Lin YW,Du Y,Butch CJ,Wei H

更新日期：2020-07-17 00:00:00

abstract：:Behavioral and clinical studies suggest a critical role of substance P (SP)/neurokinin-1 receptor (NK-1R) signaling in alcohol dependence. Here, we examined regulation of GABA transmission in the medial subdivision of the central amygdala (CeM) by the SP/NK-1R system, and its neuroadaptation following chronic alcohol ...

journal_title：Science advances

authors： Khom S,Steinkellner T,Hnasko TS,Roberto M

更新日期：2020-03-18 00:00:00

abstract：:The attraction between electrons and holes in semiconductors forms excitons, which largely determine the optical properties of the hosting material, and hence the device performance, especially for low-dimensional systems. Mono- and few-layer black phosphorus (BP) are emerging two-dimensional (2D) semiconductors. Desp...

journal_title：Science advances

authors： Zhang G,Chaves A,Huang S,Wang F,Xing Q,Low T,Yan H

更新日期：2018-03-16 00:00:00

abstract：:In this study, we report the existence of a communication system among human smooth muscle cells that uses mechanical forces to frequency modulate long-range calcium waves. An important consequence of this mechanical signaling is that changes in stiffness of the underlying extracellular matrix can interfere with the f...

journal_title：Science advances

authors： Stasiak SE,Jamieson RR,Bouffard J,Cram EJ,Parameswaran H

更新日期：2020-08-05 00:00:00

abstract：:The outbreak of the highly contagious and deadly severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also known as coronavirus disease 2019 (COVID-19), has posed a serious threat to public health across the globe, calling for the development of effective diagnostic markers and therapeutics. Here, we report a...

journal_title：Science advances

authors： Park HH,Kim HN,Kim H,Yoo Y,Shin H,Choi EY,Bae JS,Lee W

更新日期：2020-07-31 00:00:00

abstract：:Smart materials that are capable of memorizing a temporary shape, and morph in response to a stimulus, have the potential to revolutionize medicine and robotics. Here, we introduce an innovative method to program protein hydrogels and to induce shape changes in aqueous solutions at room temperature. We demonstrate our...

journal_title：Science advances

authors： Khoury LR,Slawinski M,Collison DR,Popa I

更新日期：2020-04-29 00:00:00

abstract：:There have been increasing attempts to reverse habitat degradation through active restoration, but few large-scale successes are reported to guide these efforts. Here, we report outcomes from a unique and very successful seagrass restoration project: Since 1999, over 70 million seeds of a marine angiosperm, eelgrass (...

journal_title：Science advances

authors： Orth RJ,Lefcheck JS,McGlathery KS,Aoki L,Luckenbach MW,Moore KA,Oreska MPJ,Snyder R,Wilcox DJ,Lusk B

更新日期：2020-10-07 00:00:00