Abstract:
:In this study, we report the existence of a communication system among human smooth muscle cells that uses mechanical forces to frequency modulate long-range calcium waves. An important consequence of this mechanical signaling is that changes in stiffness of the underlying extracellular matrix can interfere with the frequency modulation of Ca2+ waves, causing smooth muscle cells from healthy human donors to falsely perceive a much higher agonist dose than they actually received. This aberrant sensing of contractile agonist dose on stiffer matrices is completely absent in isolated smooth muscle cells, although the isolated cells can sense matrix rigidity. We show that the intercellular communication that enables this collective Ca2+ response in smooth muscle cells does not involve transport across gap junctions or extracellular diffusion of signaling molecules. Instead, our data support a collective model in which mechanical signaling among smooth muscle cells regulates their response to contractile agonists.
journal_name
Sci Advjournal_title
Science advancesauthors
Stasiak SE,Jamieson RR,Bouffard J,Cram EJ,Parameswaran Hdoi
10.1126/sciadv.aba1149subject
Has Abstractpub_date
2020-08-05 00:00:00pages
eaba1149issue
32issn
2375-2548pii
aba1149journal_volume
6pub_type
杂志文章相关文献
Science Advances文献大全abstract::The high-lying vibrational states of the magnesium dimer (Mg2), which has been recognized as an important system in studies of ultracold and collisional phenomena, have eluded experimental characterization for half a century. Until now, only the first 14 vibrational states of Mg2 have been experimentally resolved, alt...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aay4058
更新日期:2020-04-03 00:00:00
abstract::Weyl semimetals are of great interest because they provide the first realization of the Weyl fermion, exhibit exotic quantum anomalies, and host Fermi arc surface states. The separation between Weyl nodes of opposite chirality gives a measure of the robustness of the Weyl semimetal state. To exploit the novel phenomen...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1600295
更新日期:2016-06-24 00:00:00
abstract::Previous breakthroughs in stretchable electronics stem from strain engineering and nanocomposite approaches. Routes toward intrinsically stretchable molecular materials remain scarce but, if successful, will enable simpler fabrication processes, such as direct printing and coating, mechanically robust devices, and mor...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1602076
更新日期:2017-03-10 00:00:00
abstract::Selective nerve transfers surgically rewire motor neurons and are used in extremity reconstruction to restore muscle function or to facilitate intuitive prosthetic control. We investigated the neurophysiological effects of rewiring motor axons originating from spinal motor neuron pools into target muscles with lower i...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aau2956
更新日期:2019-01-02 00:00:00
abstract::Sister chromatid cohesion requires cohesin to act as a protein linker to hold chromatids together. How cohesin tethers chromatids remains poorly understood. We have used optical tweezers to visualize cohesin as it holds DNA molecules. We show that cohesin complexes tether DNAs in the presence of Scc2/Scc4 and ATP demo...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aay6804
更新日期:2019-11-27 00:00:00
abstract::Metabolic engineering uses enzymes to produce small molecules with industrial, pharmaceutical, and energy applications. However, efforts to optimize enzymatic pathways for commercial production are limited by the throughput of assays for quantifying metabolic intermediates and end products. We developed a multiplexed ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaw9180
更新日期:2019-06-05 00:00:00
abstract::Monolithic strong magnetic induction at the mtesla to tesla level provides essential functionalities to physical, chemical, and medical systems. Current design options are constrained by existing capabilities in three-dimensional (3D) structure construction, current handling, and magnetic material integration. We repo...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aay4508
更新日期:2020-01-17 00:00:00
abstract::Improved constraints on lower-mantle composition are fundamental to understand the accretion, differentiation, and thermochemical evolution of our planet. Cosmochemical arguments indicate that lower-mantle rocks may be enriched in Si relative to upper-mantle pyrolite, whereas seismic tomography images suggest whole-ma...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1500815
更新日期:2015-12-10 00:00:00
abstract::The outbreak of the highly contagious and deadly severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also known as coronavirus disease 2019 (COVID-19), has posed a serious threat to public health across the globe, calling for the development of effective diagnostic markers and therapeutics. Here, we report a...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abc1564
更新日期:2020-07-31 00:00:00
abstract::In a recent paper, Lechner, Hauke, and Zoller (LHZ) described a means to translate a Hamiltonian of N spin-1/2 particles with "all-to-all" interactions into a larger physical lattice with only on-site energies and local parity constraints. LHZ used this mapping to propose a novel form of quantum annealing. We provide ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1601246
更新日期:2016-10-21 00:00:00
abstract::Cytosolic RNA sensing is a prerequisite for initiation of innate immune response against RNA viral pathogens. Signaling through RIG-I (retinoic acid-inducible gene I)-like receptors (RLRs) to TBK1 (Tank-binding kinase 1)/IKKε (IκB kinase ε) kinases is transduced by mitochondria-associated MAVS (mitochondrial antiviral...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1501889
更新日期:2016-07-01 00:00:00
abstract::Fibrosis, characterized by aberrant tissue scarring from activated myofibroblasts, is often untreatable. Although the extracellular matrix becomes increasingly stiff and fibrous during disease progression, how these physical cues affect myofibroblast differentiation in 3D is poorly understood. Here, we describe a mult...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb5069
更新日期:2020-09-09 00:00:00
abstract::Interactions between top-down and bottom-up processes in the cerebral cortex hold the key to understanding attentional processes, predictive coding, executive control, and a gamut of other brain functions. However, the underlying circuit mechanism remains poorly understood and represents a major challenge in neuroscie...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1601335
更新日期:2016-11-16 00:00:00
abstract::Ornithine transcarbamylase (OTC) deficiency is an X-linked urea cycle disorder associated with high mortality. Although a promising treatment for late-onset OTC deficiency, adeno-associated virus (AAV) neonatal gene therapy would only provide short-term therapeutic effects as the non-integrated genome gets lost during...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aax5701
更新日期:2020-02-12 00:00:00
abstract::Like most homeostatic systems, adiposity in mammals is defended between upper and lower boundary conditions. While leptin and melanocortin-4 receptor (MC4R) signaling are required for defending energy set point, mechanisms controlling upper and lower homeostatic boundaries are less well understood. In contrast to the ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aat0866
更新日期:2018-08-22 00:00:00
abstract::The past few years have witnessed rapid advances in the synthesis of high-quality perovskite nanocrystals (PNCs). However, despite the impressive developments, the stability of PNCs remains a substantial challenge. The ability to reliably improve stability of PNCs while retaining their individual nanometer size repres...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aax4424
更新日期:2019-11-29 00:00:00
abstract::Understanding the precise atomic structure of ice surfaces is critical for revealing the mechanisms of physical and chemical phenomena at the surfaces, such as ice growth, melting, and chemical reactions. Nevertheless, no conclusive structure has been established. In this study, noncontact atomic force microscopy was ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb7986
更新日期:2020-09-11 00:00:00
abstract::Human and murine skin wounding commonly results in fibrotic scarring, but the murine wounding model wound-induced hair neogenesis (WIHN) can frequently result in a regenerative repair response. Here, we show in single-cell RNA sequencing comparisons of semi-regenerative and fibrotic WIHN wounds, increased expression o...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aay3704
更新日期:2020-03-20 00:00:00
abstract::The control and use of light polarization in optical sciences and engineering are widespread. Despite remarkable developments in polarization-resolved imaging for life sciences, their transposition to strongly scattering media is currently not possible, because of the inherent depolarization effects arising from multi...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1600743
更新日期:2017-09-01 00:00:00
abstract::Embodied models suggest that moral judgments are strongly intertwined with first-hand somatic experiences, with some pointing to disgust, and others arguing for a role of pain/harm. Both disgust and pain are unpleasant, arousing experiences, with strong relevance for survival, but with distinctive sensory qualities an...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aat4390
更新日期:2020-10-16 00:00:00
abstract::Among the existing elemental characterization techniques, particle-induced x-ray emission (PIXE) and energy-dispersive x-ray (EDX) spectroscopy are two of the most widely used in different scientific and technological fields. Here, we present the first quantitative laser-driven PIXE and laser-driven EDX experimental i...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abc8660
更新日期:2021-01-15 00:00:00
abstract::The Wiedemann-Franz (WF) law has been tested in numerous solids, but the extent of its relevance to the anomalous transverse transport and the topological nature of the wave function, remains an open question. Here, we present a study of anomalous transverse response in the noncollinear antiferromagnet Mn3Ge extended ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaz3522
更新日期:2020-04-24 00:00:00
abstract::Nitrogen oxides, released from fossil fuel use and other combustion processes, affect air quality and climate. From the mid-1990s onward, nitrogen dioxide (NO2) has been monitored from space, and since 2004 with relatively high spatial resolution by the Ozone Monitoring Instrument. Strong upward NO2 trends have been o...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1500498
更新日期:2015-08-21 00:00:00
abstract::A trimer-of-hairpins motif has been identified in triggering virus-cell fusion within a variety of viral envelopes. Chemically manipulating such a motif represents current repertoire of viral fusion inhibitors. Here, we report that triterpenoids, a class of natural products, antagonize this trimer-of-hairpins via its ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aau8408
更新日期:2018-11-21 00:00:00
abstract::Dendritic cells (DCs) are adept at cross-presentation and initiation of antigen-specific immunity. Clinically, however, DCs produced by in vitro differentiation of monocytes in the presence of exogenous cytokines have been met with limited success. We hypothesized that DCs produced in a physiological manner may be mor...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaz1580
更新日期:2020-03-11 00:00:00
abstract::Mass loss from the West Antarctic ice shelves and glaciers has been linked to basal melt by ocean heat flux. The Totten Ice Shelf in East Antarctica, which buttresses a marine-based ice sheet with a volume equivalent to at least 3.5 m of global sea-level rise, also experiences rapid basal melt, but the role of ocean f...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1601610
更新日期:2016-12-16 00:00:00
abstract::Over the past decade, the Arctic has warmed by 0.75°C, far outpacing the global average, while Antarctic temperatures have remained comparatively stable. As Earth approaches 2°C warming, the Arctic and Antarctic may reach 4°C and 2°C mean annual warming, and 7°C and 3°C winter warming, respectively. Expected consequen...
journal_title:Science advances
pub_type: 杂志文章,评审
doi:10.1126/sciadv.aaw9883
更新日期:2019-12-04 00:00:00
abstract::Microbial communities are self-controlled by repertoires of lethal agents, the antibiotics. In their turn, these antibiotics are regulated by bioscavengers that are selected in the course of evolution. Kinase-mediated phosphorylation represents one of the general strategies for the emergence of antibiotic resistance. ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaz9861
更新日期:2020-06-24 00:00:00
abstract::The inherent specificity and electrochemical reversibility of enzymes poise them as the biorecognition element of choice for a wide range of metabolites. To use enzymes efficiently in biosensors, the redox centers of the protein should have good electrical communication with the transducing electrode, which requires e...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aat0911
更新日期:2018-06-22 00:00:00
abstract::Energy band engineering is of fundamental importance in nanoelectronics. Compared to chemical approaches such as doping and surface functionalization, electrical and optical methods provide greater flexibility that enables continuous, reversible, and in situ band tuning on electronic devices of various kinds. In this ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aav3430
更新日期:2019-05-03 00:00:00