PPM1A silences cytosolic RNA sensing and antiviral defense through direct dephosphorylation of MAVS and TBK1.

abstract：:Development of composite indicators for integrated health in populations typically relies on a priori assumptions rather than model-free, data-driven evidence. Traditional variable selection processes tend not to consider relatedness and redundancy among variables, instead considering only individual correlations. In ...

journal_title：Science advances

authors： Servadio JL,Convertino M

更新日期：2018-02-02 00:00:00

abstract：:Rising sea levels will have overwhelmingly negative impacts on coastal communities globally. With previous research focused on how sea-level rise (SLR) affects storm-induced flooding, we show that SLR will also increase both the frequency and the intensity of tsunami-induced flooding, another significant coastal hazar...

journal_title：Science advances

authors： Li L,Switzer AD,Wang Y,Chan CH,Qiu Q,Weiss R

更新日期：2018-08-15 00:00:00

abstract：:Although electromagnetic brain stimulation is a promising treatment in neurology and psychiatry, clinical outcomes are variable, and underlying mechanisms are ill-defined, which impedes the development of new effective stimulation protocols. Here, we show, in vivo and ex vivo, that repetitive transcranial magnetic sti...

journal_title：Science advances

authors： Dufor T,Grehl S,Tang AD,Doulazmi M,Traoré M,Debray N,Dubacq C,Deng ZD,Mariani J,Lohof AM,Sherrard RM

更新日期：2019-10-30 00:00:00

abstract：:Altered cerebral glucose uptake is one of the hallmarks of Alzheimer's disease (AD). A dynamic glucose-enhanced (DGE) magnetic resonance imaging (MRI) approach was developed to simultaneously monitor d-glucose uptake and clearance in both brain parenchyma and cerebrospinal fluid (CSF). We observed substantially higher...

journal_title：Science advances

authors： Huang J,van Zijl PCM,Han X,Dong CM,Cheng GWY,Tse KH,Knutsson L,Chen L,Lai JHC,Wu EX,Xu J,Chan KWY

更新日期：2020-05-13 00:00:00

abstract：:Retreat from some areas will become unavoidable under intensifying climate change. Existing deployments of managed retreat are at small scale compared to potential future needs, leaving open questions about where, when, and how retreat under climate change will occur. Here, we analyze more than 40,000 voluntary buyout...

journal_title：Science advances

authors： Mach KJ,Kraan CM,Hino M,Siders AR,Johnston EM,Field CB

更新日期：2019-10-09 00:00:00

abstract：:Most crystalline inorganic materials, except for metals and some layer materials, exhibit bad flexibility because of strong ionic or covalent bonds, while amorphous materials usually display poor electrical properties due to structural disorders. Here, we report the simultaneous realization of extraordinary room tempe...

journal_title：Science advances

authors： He S,Li Y,Liu L,Jiang Y,Feng J,Zhu W,Zhang J,Dong Z,Deng Y,Luo J,Zhang W,Chen G

更新日期：2020-04-10 00:00:00

abstract：:Understanding the remarkable excitonic effects and controlling the exciton binding energies in two-dimensional (2D) semiconductors are crucial in unlocking their full potential for use in future photonic and optoelectronic devices. Here, we demonstrate large excitonic effects and gate-tunable exciton binding energies ...

journal_title：Science advances

authors： Qiu Z,Trushin M,Fang H,Verzhbitskiy I,Gao S,Laksono E,Yang M,Lyu P,Li J,Su J,Telychko M,Watanabe K,Taniguchi T,Wu J,Neto AHC,Yang L,Eda G,Adam S,Lu J

更新日期：2019-07-19 00:00:00

abstract：:The cyclic GMP-AMP synthase (cGAS), a sensor of cytosolic DNA, is critical for the innate immune response. Here, we show that loss of cGAS in untransformed and cancer cells results in uncontrolled DNA replication, hyperproliferation, and genomic instability. While the majority of cGAS is cytoplasmic, a fraction of cGA...

journal_title：Science advances

authors： Chen H,Chen H,Zhang J,Wang Y,Simoneau A,Yang H,Levine AS,Zou L,Chen Z,Lan L

更新日期：2020-10-14 00:00:00

abstract：:After European colonization, the ancestral remains of Indigenous people were often collected for scientific research or display in museum collections. For many decades, Indigenous people, including Native Americans and Aboriginal Australians, have fought for their return. However, many of these remains have no recorde...

journal_title：Science advances

authors： Wright JL,Wasef S,Heupink TH,Westaway MC,Rasmussen S,Pardoe C,Fourmile GG,Young M,Johnson T,Slade J,Kennedy R,Winch P,Pappin M Sr,Wales T,Bates WB,Hamilton S,Whyman N,van Holst Pellekaan S,McAllister PJ,Taçon PSC,

更新日期：2018-12-19 00:00:00

abstract：:Previous studies have extensively investigated the impact of Arctic sea ice anomalies on the midlatitude circulation and associated surface climate in winter. However, there is an ongoing scientific debate regarding whether and how sea ice retreat results in the observed cold anomaly over the adjacent continents. We p...

journal_title：Science advances

authors： Zhang P,Wu Y,Simpson IR,Smith KL,Zhang X,De B,Callaghan P

更新日期：2018-07-25 00:00:00

abstract：:Discovery of new adsorbent materials with a high CO2 working capacity could help reduce CO2 emissions from newly commissioned power plants using precombustion carbon capture. High-throughput computational screening efforts can accelerate the discovery of new adsorbents but sometimes require significant computational r...

journal_title：Science advances

authors： Chung YG,Gómez-Gualdrón DA,Li P,Leperi KT,Deria P,Zhang H,Vermeulen NA,Stoddart JF,You F,Hupp JT,Farha OK,Snurr RQ

更新日期：2016-10-14 00:00:00

abstract：:The urea channel of Helicobacterpylori (HpUreI) is an ideal drug target for preventing gastric cancer but incomplete understanding of its gating mechanism has hampered development of inhibitors for the eradication of H. pylori. Here, we present the cryo-EM structures of HpUreI in closed and open conformations, both at...

journal_title：Science advances

authors： Cui Y,Zhou K,Strugatsky D,Wen Y,Sachs G,Zhou ZH,Munson K

更新日期：2019-03-20 00:00:00

abstract：:Diets rich in sugar, salt, and fat alter taste perception and food preference, contributing to obesity and metabolic disorders, but the molecular mechanisms through which this occurs are unknown. Here, we show that in response to a high sugar diet, the epigenetic regulator Polycomb Repressive Complex 2.1 (PRC2.1) pers...

journal_title：Science advances

authors： Vaziri A,Khabiri M,Genaw BT,May CE,Freddolino PL,Dus M

更新日期：2020-11-11 00:00:00

abstract：:Natural genetic variation affects circadian rhythms across the evolutionary tree, but the underlying molecular mechanisms are poorly understood. We investigated population-level, molecular circadian clock variation by generating >700 tissue-specific transcriptomes of Drosophila melanogaster (w1118 ) and 141 Drosophila...

journal_title：Science advances

authors： Litovchenko M,Meireles-Filho ACA,Frochaux MV,Bevers RPJ,Prunotto A,Anduaga AM,Hollis B,Gardeux V,Braman VS,Russeil JMC,Kadener S,Dal Peraro M,Deplancke B

更新日期：2021-01-29 00:00:00

abstract：:By developing new computational models, we examine how enzymatic reactions on an underlying surface can be harnessed to direct the motion and organization of reagent-laden microcapsules in a fluid-filled microchannel. In the presence of appropriate reagents, surface-bound enzymes can act as pumps, which drive large-sc...

journal_title：Science advances

authors： Shklyaev OE,Shum H,Sen A,Balazs AC

更新日期：2016-03-18 00:00:00

abstract：:In 2015, more than 200,000 saiga antelopes died in 3 weeks in central Kazakhstan. The proximate cause of death is confirmed as hemorrhagic septicemia caused by the bacterium Pasteurella multocida type B, based on multiple strands of evidence. Statistical modeling suggests that there was unusually high relative humidit...

journal_title：Science advances

authors： Kock RA,Orynbayev M,Robinson S,Zuther S,Singh NJ,Beauvais W,Morgan ER,Kerimbayev A,Khomenko S,Martineau HM,Rystaeva R,Omarova Z,Wolfs S,Hawotte F,Radoux J,Milner-Gulland EJ

更新日期：2018-01-17 00:00:00

abstract：:The design of single-molecule photoswitchable emitters was the first milestone toward the advent of single-molecule localization microscopy, setting a new paradigm in the field of optical imaging. Several photoswitchable emitters have been developed, but they all fluoresce in the visible or far-red ranges, missing the...

journal_title：Science advances

authors： Godin AG,Setaro A,Gandil M,Haag R,Adeli M,Reich S,Cognet L

更新日期：2019-09-27 00:00:00

abstract：:Fractures and faults riddle the Earth's crust on all scales, and the deformation associated with them is presumed to have had significant effects on its petrological and structural evolution. However, despite the abundance of directly observable earthquake activity, unequivocal evidence for seismic slip rates along an...

journal_title：Science advances

authors： Austrheim H,Dunkel KG,Plümper O,Ildefonse B,Liu Y,Jamtveit B

更新日期：2017-02-22 00:00:00

abstract：:Weyl semimetals are of great interest because they provide the first realization of the Weyl fermion, exhibit exotic quantum anomalies, and host Fermi arc surface states. The separation between Weyl nodes of opposite chirality gives a measure of the robustness of the Weyl semimetal state. To exploit the novel phenomen...

journal_title：Science advances

authors： Chang G,Xu SY,Sanchez DS,Huang SM,Lee CC,Chang TR,Bian G,Zheng H,Belopolski I,Alidoust N,Jeng HT,Bansil A,Lin H,Hasan MZ

更新日期：2016-06-24 00:00:00

abstract：:Helicobacter pylori is a leading cause of peptic ulceration and gastric cancer worldwide. To achieve colonization of the stomach, this Gram-negative bacterium adheres to Lewis(b) (Le(b)) antigens in the gastric mucosa using its outer membrane protein BabA. Structural information for BabA has been elusive, and thus, it...

journal_title：Science advances

authors： Hage N,Howard T,Phillips C,Brassington C,Overman R,Debreczeni J,Gellert P,Stolnik S,Winkler GS,Falcone FH

更新日期：2015-08-14 00:00:00

abstract：:A large body of previous neuroimaging studies suggests that multiple languages are processed and organized in a single neuroanatomical system in the bilingual brain, although differential activation may be seen in some studies because of different proficiency levels and/or age of acquisition of the two languages. Howe...

journal_title：Science advances

authors： Xu M,Baldauf D,Chang CQ,Desimone R,Tan LH

更新日期：2017-07-12 00:00:00

abstract：:Here, an integrated cascade nanozyme with a formulation of Pt@PCN222-Mn is developed to eliminate excessive reactive oxygen species (ROS). This nanozyme mimics superoxide dismutase by incorporation of a Mn-[5,10,15,20-tetrakis(4-carboxyphenyl)porphyrinato]-based metal-organic framework compound capable of transforming...

journal_title：Science advances

authors： Liu Y,Cheng Y,Zhang H,Zhou M,Yu Y,Lin S,Jiang B,Zhao X,Miao L,Wei CW,Liu Q,Lin YW,Du Y,Butch CJ,Wei H

更新日期：2020-07-17 00:00:00

abstract：:Pathological cardiac hypertrophy eventually leads to heart failure without adequate treatment. The immunoproteasome is an inducible form of the proteasome that is intimately involved in inflammatory diseases. Here, we found that the expression and activity of immunoproteasome catalytic subunit β5i were significantly u...

journal_title：Science advances

authors： Xie X,Bi HL,Lai S,Zhang YL,Li N,Cao HJ,Han L,Wang HX,Li HH

更新日期：2019-05-08 00:00:00

abstract：:Interaction of swimming bacteria with flows controls their ability to explore complex environments, crucial to many societal and environmental challenges and relevant for microfluidic applications such as cell sorting. Combining experimental, numerical, and theoretical analysis, we present a comprehensive study of the...

journal_title：Science advances

authors： Jing G,Zöttl A,Clément É,Lindner A

更新日期：2020-07-10 00:00:00

abstract：:Maximizing the sustainable supercurrent density, J C, is crucial to high-current applications of superconductivity. To achieve this, preventing dissipative motion of quantized vortices is key. Irradiation of superconductors with high-energy heavy ions can be used to create nanoscale defects that act as deep pinning po...

journal_title：Science advances

authors： Massee F,Sprau PO,Wang YL,Davis JC,Ghigo G,Gu GD,Kwok WK

更新日期：2015-05-20 00:00:00

abstract：:Respiratory complex I is a redox-driven proton pump, accounting for a large part of the electrochemical gradient that powers mitochondrial adenosine triphosphate synthesis. Complex I dysfunction is associated with severe human diseases. Assembly of the one-megadalton complex I in the inner mitochondrial membrane requi...

journal_title：Science advances

authors： Parey K,Haapanen O,Sharma V,Köfeler H,Züllig T,Prinz S,Siegmund K,Wittig I,Mills DJ,Vonck J,Kühlbrandt W,Zickermann V

更新日期：2019-12-11 00:00:00

abstract：:Band structure theory plays an essential role in exploring physics in both solid-state systems and photonics. Here, we demonstrate a direct experimental measurement of the dynamic band structure in a synthetic space including the frequency axis of light, realized in a ring resonator under near-resonant dynamic modulat...

journal_title：Science advances

authors： Li G,Zheng Y,Dutt A,Yu D,Shan Q,Liu S,Yuan L,Fan S,Chen X

更新日期：2021-01-08 00:00:00

abstract：:Eruptive phenomena at all scales, from hydrothermal geysers to flood basalts, can potentially be initiated or modulated by external mechanical perturbations. We present evidence for the triggering of magmatism on a global scale by the Chicxulub meteorite impact at the Cretaceous-Paleogene (K-Pg) boundary, recorded by ...

journal_title：Science advances

authors： Byrnes JS,Karlstrom L

更新日期：2018-02-07 00:00:00

abstract：:Declines in commercial landings and increases in fishing fleet power have raised concerns over the continued provisioning of nutritional and economic services by tropical wild fisheries. Yet, because tropical fisheries are often data-poor, mechanisms that might buffer fishers to declines are not understood. This data ...

journal_title：Science advances

authors： Robinson JPW,Robinson J,Gerry C,Govinden R,Freshwater C,Graham NAJ

更新日期：2020-02-21 00:00:00

abstract：:Transistors with exfoliated two-dimensional (2D) materials on a SiO2/Si substrate have been applied and have been proven effective in a wide range of applications, such as circuits, memory, photodetectors, gas sensors, optical modulators, valleytronics, and spintronics. However, these devices usually suffer from limit...

journal_title：Science advances

authors： Xu J,Chen L,Dai YW,Cao Q,Sun QQ,Ding SJ,Zhu H,Zhang DW

更新日期：2017-05-19 00:00:00